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Nanozyme‑Engineered Hydrogels for Anti‑Inflammation and Skin Regeneration

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Nano-Micro Letters 2024年第6期16卷 127-179页

作者： Amal George kurian rajendra k.Singh Varsha Sagar Jung‑Hwan Lee Hae‑Won kim Institute of Tissue Regeneration Engineering(ITREN) Dankook UniversityCheonan 31116Republic of Korea Department of Nanobiomedical Science&Bk21 NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonan 31116Republic of Korea Department of Biomaterials Science School of DentistryDankook UniversityCheonan 31116Republic of Korea UCL Eastman‑korea Dental Medicine Innovation Centre Dankook UniversityCheonan 31116Republic of Korea Cell and Matter Institute Dankook UniversityCheonan 31116Republic of Korea Mechanobiology Dental Medicine Research Center Dankook UniversityCheonan 31116Republic of Korea

Inflammatory skin disorders can cause chronic scarring and functional impairments,posing a significant burden on patients and the healthcare *** therapies,such as corticosteroids and nonsteroidal anti-inflammatory drugs,are limited in efficacy and associated with adverse ***,nanozyme(NZ)-based hydrogels have shown great promise in addressing these ***-based hydrogels possess unique therapeutic abilities by combining the therapeutic benefits of redox nanomaterials with enzymatic activity and the water-retaining capacity of *** multifaceted therapeutic effects of these hydrogels include scavenging reactive oxygen species and other inflammatory mediators modulating immune responses toward a pro-regenerative environment and enhancing regenerative potential by triggering cell migration and *** review highlights the current state of the art in NZ-engineered hydrogels(NZ@hydrogels)for anti-inflammatory and skin regeneration *** also discusses the underlying chemo-mechano-biological mechanisms behind their ***,the challenges and future directions in this ground,particularly their clinical translation,are *** insights provided in this review can aid in the design and engineering of novel NZ-based hydrogels,offering new possibilities for targeted and personalized skin-care therapies.

关键词： Nanozymes Hydrogels ROS scavenging Anti-inflammation Skin regeneration

Impact factors and pathways of halonitromethanes formation from aspartic acid during LED-UV_(265)/chlorine disinfection

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Frontiers of Environmental Science & Engineering 2024年第1期18卷 129-144页

作者： Liangwen Zhu Tao Wang Qian Tang Qing Wang Lin Deng Jun Hu Chaoqun Tan rajendra Prasad Singh key Laboratory of Concrete and Prestressed Concrete Structures of Ministry of Education School of Civil EngineeringSoutheast UniversityNanjing 211189China College of Environment Zhejiang University of TechnologyHangzhou 310014China

Light emitting diode (LED-UV)/chlorine disinfection can replace UV/chlorine disinfection in wastewater treatment plants and water supply plants. Halonitromethanes (HNMs) are a class of novel nitrogenous disinfection by-products, which are characterized by higher cytotoxicity and genotoxicity than regulated disinfection by-products. Herein, the impact factors and pathways of HNMs formation from aspartic acid (ASP) were investigated during LED-UV_(265)/chlorine disinfection. The results showed that three types of chlorinated-HNMs (Cl-HNMs) were found during LED-UV265/chlorine disinfection, and their concentrations increased first and then declined as the reaction progressed. Cl-HNMs yields increased with increasing LED-UV_(265) intensity, free chlorine dosage, and ASP concentration, which declined with increasing pH (6.0–8.0). Meantime, the important impact of the coexisting ions contained in water matrices on HNMs formation from ASP was observed during LED-UV_(265)/chlorine disinfection. It was found that copper ions (Cu^(2+)) promoted Cl-HNMs formation. Furthermore, when bromide (Br–) appeared during LED-UV265/chlorine disinfection, nine types of HNMs were detected simultaneously. Moreover, Br– not only converted Cl-HNMs toward brominated (chlorinated)-HNMs and brominated-HNMs but also showed a marked effect on HNMs concentrations and species. Subsequently, the possible pathways of HNMs formation from ASP were proposed during LED-UV_(265)/chlorine disinfection. At last, it was proved that the formation trends of HNMs obtained in the real waters were similar to those in simulated waters. This work elaborated on the influence factors and pathways of HNMs formation, which is conducive to controlling the HNMs produced during LED-UV_(265)/chlorine disinfection.

关键词： LED-UV265 chlorine HNMs Aspartic acid Bromide Copper ions

Structural Characteristics of the Andaman Forearc Inferred from Interpretation of Multichannel Seismic Reflection Data

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Acta Geologica Sinica(English Edition) 2014年第4期88卷 1145-1156页

作者： Anitha GOLI Dhananjai k.pandey National Centre for Antarctic and Ocean Research

The Andaman Forearc Basin （AFB） is asymmetric in configuration and filled with a-6 km-thick pile of Neogene to Recent sediments （-4 s in two-way travel time： TWT） with distinct zonation. It shows gradual thinning up to -3 km （0.8 s in TWT） towards the eastern end with a seabed gradient of 1：30. Thick deformed sediments -2 s （TWT） of the Outerarc are associated with intense faulting and occasional folding caused by recent tectonics. Development of a series of faults within the upwarped sedimentary column of Oligocene top to Recent is observed with a rotated fault block. These features are manifestations of Recent igneous intrusion, and reveal the presence of a mild N-S compressional regime. Its effect on the AFB resulted in further uplift of sediments, which can now be seen as the Invisible Bank. Forward gravity modelling supporting our seismic interpretation reveals that it is associated with igneous intrusion from the Moho （-9 km depth）, and also suggests that continental crust underlies the AFB. Strong Bottom Simulating Reflector （BSR）-like features in the Miocene sediments of Outerarc and Forearc basin at a depth of 0.6 s below the seabed suggest the inferred probable occurrence of gas hydrates in the AFB.

关键词： Structural geology tectonics Tertiary hydrocarbon potential upwarp Andaman Indian Ocean

Direct-Seeded Rice: Genetic Improvement of Game-Changing Traits for Better Adaption

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Rice science 2024年第4期31卷 417-433页

作者： Priyanka NEGI Jagadish RANE rajendra Sadashiv WAGH Tukaram Jayaram BHOR Dipti Digambar GODSE Priyanka JADHAV C.ANILkUMAR Dasari SREEkANTH k.SAMMI REDDY Sharad Ramrao GADAkH k.M.BORAIH C.B.HARISHA P.S.BASAVARAJ Indian Council of Agricultural Research(ICAR)-National Institute of Abiotic Stress Management Baramati 413115India Mahatma Phule krishi Vidyapeeth Rahuri 413722India ICAR-Central Institute for Arid Horticulture Bikaner 334006India ICAR-National Rice Research Institute Cuttack 753006India ICAR-Directorate of Weed Research Jabalpur 482004India Dr.Panjabrao Deshmukh krishi Vidyapeeth Akola 444104India

The sustainability of rice production continues to be a subject of uncertainty and inquiry attributed to shifts in climatic conditions. In light of the impending climate change crisis and the high labor and water costs accompanying it, direct-seeded rice(DSR) is unquestionably one of the most practical solutions. Despite its resource and climate-friendly advantages, early maturing rice faces weed competitiveness and seedling establishment challenges. Resolving these issues is crucial for promoting its wider adoption among farmers, presenting it as a more effective sustainable rice cultivation method globally. Diverse traditional and contemporary breeding methods are employed to mitigate the limitations of the DSR approach, leveraging advanced techniques such as speed breeding and genome editing. Focusing on key traits like mesocotyl length elongation, early seedling vigor, root system architecture, and weed competitiveness holds promise for transformative improvements in DSR adaptation at a broader scale within farming communities. This review aims to summarize how these features contribute to increased crop production in DSR conditions and explore the research efforts focusing on enhancing DSR adaptation through these traits. Emphasizing the pivotal role of these game-changing traits in DSR adaptation, our analysis sheds light on their potential transformative impact and offers valuable insights for advancing DSR practices.

关键词： climate change direct-seeded rice aerobic rice early vigor trait

Seismic stratigraphy and the sedimentation history in the Laxmi Basin of the eastern Arabian Sea:Constraints from IODP Expedition 355

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Geoscience Frontiers 2021年第3期12卷 489-502页

作者： Nisha Nair Dhananjai k.pandey Anju pandey R.Prerna National Centre for Polar and Ocean Research(NCPOR) Ministry of Earth SciencesVasco-da-GamaGoa 403804India H-V3-NCPOR Campus Vasco-da-GamaGoa 403804India

Detailed interpretation of seismic stratigraphic sequences in the Laxmi Basin of the eastern Arabian Sea are presented in this study using closely spaced high resolution multi-channel seismic(MCS)*** stratigraphic interpretation is further corroborated using recent drilling results in the Laxmi Basin,derived from the long sediment cores collected during International Ocean Discovery Program(IODP)Expedition *** core-log interpretation discussed in the present study,offer important insights about the lithostratigraphic variations in this *** of multi-channel seismic reflection data reveal five depositional sequences(ranging from Paleocene to Recent)that led to the development of this marginal basin since the Cenozoic *** igneous basement is successfully imaged,which was also validated by deep sea coring during the IODP Expedition *** the present study,we primarily focus on the post-rift sedimentation in the Laxmi Basin and its possible *** detailed interpretation in the prevailing tectonic framework of the basin suggests that near-shelf oldest volcaniclastic sedimentation immediately overlying the acoustic basement is linked to the onset of India-Madagascar and India-Seychelles rifting activities during the Late Cretaceous ***,during the Early-Mid to Late Miocene,the basin received maximum sedimentation dominantly through an extensive mass transport mechanism implying possible large-scale deformation on the Indian *** sediment input to the basin appears to have been fed variably via the Indus Fan as well as coastal discharge from the Indian *** total sediment thickness in the Laxmi Basin ranges from 1.1 to 3.5 *** stratigraphic information and sediment isopach maps presented here provide vital information about syn-and post-rift sedimentation pattern in the region and their long term tectonic implications.

关键词： Seismic stratigraphy Laxmi Basin Arabian Sea Site U1456 Site U1457 IODP Expedition 355

Late Cenozoic seismic stratigraphy of the Andaman Forearc Basin,Indian Ocean

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Petroleum Science 2017年第4期14卷 648-661页

作者： Dhananjai k.pandey Goli Anitha Ramesh Prerna Anju pandey ESSO-National Centre for Antarctic and Ocean Research Headland SadaVasco da GamaGoa 403 804India

Interpretation of new multichannel seismic reflection data from the Andaman Forearc Basin(AFB) in the northern Indian Ocean is presented here. The highquality multichannel seismic data from the Andaman Forearc region enable us to examine the seismic characters and to demarcate seismic sequences bounded by distinct unconformities. Ages of marked seismic horizons have been calibrated with available litholog data from nearby industry boreholes. Seismic interpretation of new data shows that the AFB is filled with * 4.5-s-two way travel time(TWT) thick Neogene to Recent sediments. The entire basin assemblage exhibits two distinct major sequences pertaining to the Neogene and Quaternary times. A large part of the basin is filled with intermittent mass transport deposits(MTD). We infer that the episodic uplift of the Invisible Bank, protuberance of the outerarc and regular deformation through reactivation of preexisting normal faults since the Pleistocene could be attributed as causal mechanisms for the MTDs. Strong bottom simulating reflectors are identified in the Late Miocene and younger sediments of the outerarc and AFB at a depth of * 0.6 s TWT and correspond to the presence of gas hydrates in this region. Our interpretations have significant implications for geodynamic as well as resource exploration in the AFB.

关键词： Andaman Forearc Basin Neogene Uplift Invisible Bank Outerarc Stratigraphy

Arthroscopic scene segmentation using multispectral reconstructed frames and deep learning

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Intelligent Medicine 2023年第4期3卷 243-251页

作者： Shahnewaz Ali Ross Crawford Ajay k.pandey School of Electrical Engineering and Robotics Faculty of EngineeringQueensland University of TechnologyGardens PointBrisbaneQLD 4000Australia

Background knee arthroscopy is one of the most complex minimally invasive surgeries,and it is routinelyperformed to treat a range of ailments and injuries to the knee *** complex ergonomic design imposesvisualization and navigation constraints,consequently leading to unintended tissue damage and a steep learningcurve before surgeons gain *** lack of robust visual texture and landmark frame features furtherlimits the success of image-guided approaches to knee arthroscopy Feature-and texture-less tissue structures ofknee anatomy,lighting conditions,noise,blur,debris,lack of accurate ground-truth label,tissue degeneration,and injury make semantic segmentation an extremely challenging *** address this complex research problem,this study reported the utility of reconstructed surface reflectance as a viable piece of information that could beused with cutting-edge deep learning technique to achieve highly accurate segmented *** We proposed an intraoperative,two-tier deep learning method that makes full use of tissue reflectanceinformation present within an RGB frame to segment texture-less images into multiple tissue types from kneearthroscopy video *** study included several cadaver knees experiments at the Medical and EngineeringResearch Facility,located within the Prince Charles Hospital campus,Brisbane *** were collectedfrom a total of five cadaver knees,three were males and one from a *** age range of the donors was 56–93 ***-related tissue degeneration and some anterior cruciate ligament injury were observed in mostcadaver *** arthroscopic image dataset was created and subsequently labeled by clinical *** also included validation of a prototype stereo arthroscope,along with conventional arthroscope,to attainlarger field of view and stereo *** reconstructed surface reflectance from camera responses that exhibiteddistinct spatial features at different wavelengths ranging from 3

关键词： knee arthroscopy Segmentation Multispectral reconstructed Deep learning

Biological,pathological,and multifaceted therapeutic functions of exosomes to target cancer

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Oncology Research 2024年第1期32卷 73-94页

作者： VIGNESH BALAJI E DIVYA RAMESH MANISHA CHUNGAN SHAJU AkSHARA kUMAR SAMYAk.pandey RAkSHA NAYAk V.ALkA SRISHTI MUNJAL AMIR SALIMI k.SREEDHARA RANGANATH PAI SHANkAR M.BAkkANNAVAR Department of Pharmacology Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Department of Forensic Medicine and Toxicology Kasturba Medical CollegeManipal Academy of Higher EducationManipalKarnataka576104India School of Health and Community Services Durham CollegeOshawaOntarioL1G2G5Canada Department of Pharmaceutical Regulatory Affairs and Management Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Department of Clinical Psychology Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Department of Speech and Hearing Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Department of Pharmacy Practice Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India

Exosomes,small tiny vesicle contains a large number of intracellular particles that employ to cause various diseases and prevent several pathological events as well in the human *** is considered a“double-edged sword”,and depending on its biological source,the action of exosomes varies under physiological ***,the isolation and characterization of the exosomes should be performed accurately and the methodology also will vary depending on the exosome ***,the uptake of exosomes from the recipients’cells is a vital and initial step for all the physiological *** are different mechanisms present in the exosomes’cellular uptake to deliver their cargo to acceptor *** the exosomal uptake takes place,it releases the intracellular particles that leads to activate the physiological *** though exosomes have lavish functions,there are some challenges associated with every step of their preparation to bring potential therapeutic ***,overcoming the pitfalls would give a desired quantity of exosomes with high purity.

关键词： Exosomes Physiology Cancer Therapeutics Challenges

Trace fossils of an amalgamated storm-bed succession from the Jurassic of the kachchh Basin,India:The significance of time-averaging in ichnology

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Journal of Palaeogeography 2018年第1期7卷 14-31页

作者： Franz To Fürsich Alfred Uchman Matthias Alberti Dhirendra k.pandey GeoZentrum Nordbayern Fachgruppe PalaoUmweltFriedrich-Alexander-Universitat Erlangen-Numberg Loewenichstra■e 2891054 ErlangenGermany Institute of Geological Sciences Jagiellonian UniversityGronostajowa 3a30-387KrakowPoland Institut fur Geowissenschaften Christian-Albrechts-Universitat zu KielLudewig-Meyn-Stral3e 1024118Kiel Germany Earth and Planetary Sciences GrouplPalaeontology Manipal Center for Natural SciencesManipal University Manipal 576104KarnatakaIndia

The uppermost part of the Upper Bathonian Sponge Limestone member, Patcham Formation, of the Jhura Dome of kachchh Mainland is a thickening-and shallowing-upward succession topped by medium-to thick-bedded hummocky cross-stratified grainstones deposited by storm waves. Occasionally, thin, commonly lenticular, intraclastic-bioclastic silty marl intercalations between the grainstones are highly bioturbated, in contrast to the grainstones, in which, for the most part, trace fossils occur scattered. Large exposures of bedding planes of the grainstones allow the detailed investigation of ichnological features, whereas the high density of traces in the soft marls precludes the identification of any ichnotaxa. Eighteen ichnotaxa have been recorded including Ophiomorpha, Thalassinoides, Taenidium, Gyrophyllites, Chondrites, Dactyloidites, Teichichnus, Bolonia, and Ancorichnus. Except for Ophiomorpha nodosa and Thalassinoides, which generally indicate moderate to high energy conditions and are the dwelling burrows of suspension-feeding to omnivorous crustaceans, the ichnotaxa represent a deposit-feeding behaviour of their producers and thus are characteristic of low-energy environments. The trace fossils form three ichnoassemblages characterized by(1) Ophiomorpha nodosa and Thalassinoides suevicus,(2)?Thalassinoides isp. A, Taenidium, and Bolonia lata,and(3) Ancorichnus. The dominance of traces of deposit-feeders in rocks indicative of high-energy events is counterintuitive and points to their non-contemporaneity. The sediments were deposited during brief highenergy events, whereas the trace fossils were produced when, after waning of storms low-energy conditions prevailed. This time-averaging is particularly pronounced in trace fossils that extend vertically downwards and may reach strata deposited under distinctly different conditions. Thus, environmental interpretations based on trace fossils should refer to colonisation surfaces rather than to the sediment surrounding th

关键词： Trace fossils Middle Jurassic kachchh Basin Taxonomy Time averaging Ichnology