检索结果-南通市图书馆

Luteolin attenuates diabetic nephropathy via inhibition of metalloenzymes in rats

Asian Pacific Journal of Tropical Biomedicine 2023年第12期13卷 507-520,I0002,I0003页

作者： R.B.Daude rajendra bhadane J.S.Shah Department of Pharmacy Government PolytechnicJalgaon-425001MaharashtraIndia Structural Bioinformatics Laboratory Faculty of Science and EngineeringBiochemistryAbo Akademi UniversityFI-20520 TurkuFinland Pharmaceutical Sciences Laboratory Faculty of Science and EngineeringPharmacyÅbo Akademi UniversityFI-20520 TurkuFinland Institute of Biomedicine Research Unit for Infection and ImmunityUniversity of TurkuFI-20520 TurkuFinland Department of Pharmacology Institute of PharmacyNirma UniversityAhmedabad-382481GujratIndia

Objective:To investigate the renoprotective effects of luteolin on diabetes in ***:One week after administration of streptozotocin 55 mg/kg intraperitoneally,rats were given 25,50,and 75 mg/kg/day of luteolin orally for another eight *** the end of the experiment,body weight,blood glucose level,biochemical parameters for renal function(serum creatinine,blood urea nitrogen,uric acid,serum albumin,and total protein),kidney histology,matrix metalloproteinase(MMP)-2,MMP-9,and histone deacetylase 2(HDAC-2)expression,and malondialdehyde,myeloperoxidase,and hydroxyproline content in renal tissue were *** glucose-induced damage using NRK-52E cell line was studied to evaluate cell viability and metalloenzyme ***,in silico studies including docking and molecular dynamics simulations were ***:MMP-2,MMP-9,and HDAC-2 expressions were significantly increased in high glucose-induced NRK-52E cells and the renal tissue of diabetic ***,these changes were reversed by luteolin at the administered ***,luteolin significantly reduced oxidative stress,inflammation,and fibrosis,as well as improved biochemical parameters in diabetic ***,luteolin at the examined doses markedly alleviated diabetes-induced histopathological changes in renal ***:Luteolin effectively attenuates streptozotocin-induced diabetic nephropathy in rats by inhibiting MMP-2,MMP-9,and HDAC-2 expression,and reducing oxidative stress and inflammation.

关键词： MMPs HDAC-2 Luteolin NRK-52E Diabetic nephropathy Docking Molecular dynamic simulations

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Silica Nanoparticles with Virus-Mimetic Spikes Enable Efficient siRNA Delivery In Vitro and In Vivo

引用

Research 2023年第3期2022卷 281-294页

作者： Jianye Fu Wenwei Han Xue Zhang Yutong Sun rajendra bhadane Bo Wei Li Li Liangmin Yu Jinbo Yang Jessica MRosenholm Outi MHSalo-Ahen Taojian Fan Bin Zhang Wageh Swelm Ahmed AAl-Ghamdi Lin Xia Han Zhang Meng Qiu Hongbo Zhang Xin Wang Key Laboratory of Marine Drugs Chinese Ministry of EducationSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China Collaborative Innovation Center for Optoelectronic Science&Technology International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of EducationInstitute of Microscale OptoelectronicsCollege of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China Key Laboratory of Marine Chemistry Theory and Technology(Ocean University of China) Ministry of EducationQingdao 266100China College of Chemistry and Chemical Engineering China University of PetroleumQingdao 266555China. Pharmaceutical Sciences Laboratory Åbo Akademi University20520 TurkuFinland Structural Bioinformatics Laboratory BiochemistryÅbo Akademi University20520 TurkuFinland. Center for Innovation Marine Drug Screening&Evaluation Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China Marine Biomedical Research Institute of Qingdao Qingdao 266100China Department of Physics Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia Hangzhou No.14 High School Hangzhou 310000China Turku Bioscience Centre University of Turku andÅbo Akademi University20520 TurkuFinland

Oligonucleotide-based therapy has experienced remarkable development in the past 2 decades,but its broad applications are severely hampered by delivery *** used viral vectors and lipid nanovectors are suffering from immune clearance after repeating usage or requiring refrigerated transportation and storage,*** this work,amino-modified virus-mimetic spike silica nanoparticles(NH_(2)-SSNs)were fabricated using a 1-pot surfactant-free approach with controlled spike lengths,which were demonstrated with excellent delivery performance and biosafety in nearly all cell types and *** indicated that NH2-SSNs entered cells by spike-dependent cell membrane docking and dynamin-dependent *** positively charged spikes with proper length on the surface can facilitate the efficient encapsulation of RNAs,protect the loaded RNAs from degradation,and trigger an early endosome escape during intracellular trafficking,similarly to the cellular internalization mechanism of *** the fantastic properties of NH_(2)-SSNs in nucleic acid delivery,it revealed that nanoparticles with solid spikes on the surface would be excellent vehicles for gene therapy,presenting self-evident advantages in storage,transportation,modification,and quality control in large-scale production compared to lipid nanovectors.

关键词： surfactant loaded transportation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Contrasting lipid biomarkers in mountain rivers in the Nepal Himalayas: Organic matter characteristics and contribution to the fluvial carbon pool

引用

Geoscience Frontiers 2021年第6期12卷 1-15页

作者： rajendra Bhandari Joyanto Routh Subodh Sharma rajendra Joshi Department of Thematic Studies–Environmental Change Linköping UniversitySweden Aquatic Ecology Center Kathmandu UniversityNepal Department of Environmental Science and Engineering Kathmandu UniversityNepal Department of Chemical Science and Engineering Kathmandu UniversityNepal

The Nepal Himalayas is the source of many glacial and spring-fed river systems crisscrossing the mountainous *** is an increasing recognition of small mountain rivers(SMRs)to have a significant combined export of dissolved and particulate organic carbon to the global carbon *** analyzed fluvial sediments from two SMRs and compared the results with two large mountain rivers(LMRs)in *** investigated the organic matter(OM),its compositional variability,and seasonal export using a suite of lipid biomarkers,namely n-alkanes,n-alkanoic acids,n-alkanols,and *** SMRs indicated a similarity in lipid distribution and were affected by a strong seasonal *** LMRs showed a distinct contrast in the distribution of lipids in suspended *** sediments in SMRs were derived from diverse sources with weak terrigenous dominance all-year-round compared to the suspended *** lipids(n-alkanoic acids and n-alkanols)were the major constituents in SMR sediments,indicating better *** contrast,n-alkane concentration dominated over other fractions in suspended sediments retrieved from *** biomarker trends differentiate SMRs from LMRs with lower transformed/degraded OM in SMRs.A common observation was the strong presence of even carbon compounds in short-chain n-alkanes in SMR bedload sediments and their predominance in suspended sediments in *** an unusual trend is attributed to specific biomarker sources from the catchment and ongoing processes in fluvial *** colonized by fungal species under moist acidic conditions and autochthonous bacteria contributes to the organic matter pool in shallow *** LMRs,the contribution from thermally mature sedimentary hydrocarbons and the diagenetic reduction of nalkanoic acids to n-alkanes are additional contributors to the allochthonous carbon *** differences in lipid concentrations,their distribution,seasonality,and the size of rivers suggest differential

关键词： Fluvial sediments Bedload Suspended load Monsoon Biomarkers Biogeochemistry

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Punjabi DeConverter for generating Punjabi from Universal Networking Language

引用

Journal of Zhejiang University-Science C(Computers and Electronics) 2013年第3期14卷 179-196页

作者： Parteek KUMAR rajendra Kumar SHARMA Department of Computer Science & Engineering Thapar University School of Mathematics & Computer Applications Thapar University

DeConverter is core software in a Universal Networking Language(UNL) system.A UNL system has EnConverter and DeConverter as its two major *** is used to convert a natural language sentence into an equivalent UNL expression,and DeConverter is used to generate a natural language sentence from an input UNL *** paper presents design and development of a Punjabi *** describes five phases of the proposed Punjabi DeConverter,i.e.,UNL parser,lexeme selection,morphology generation,function word insertion,and syntactic *** paper also illustrates all these phases of the Punjabi DeConverter with a special focus on syntactic linearization issues of the Punjabi *** linearization is the process of defining arrangements of words in generated *** algorithms and pseudocodes for implementation of syntactic linearization of a simple UNL graph,a UNL graph with scope nodes and a node having un-traversed parents or multiple parents in a UNL graph have been discussed in this *** cases of syntactic linearization with respect to Punjabi language for UNL relations like 'and','or','fmt','cnt',and 'seq' have also been presented in this *** paper also provides implementation results of the proposed Punjabi *** DeConverter has been tested on 1000 UNL expressions by considering a Spanish UNL language server and agricultural domain threads developed by Indian Institute of Technology(IIT),Bombay,India,as *** proposed system generates 89.0% grammatically correct sentences,92.0% faithful sentences to the original sentences,and has a fluency score of 3.61 and an adequacy score of 3.70 on a 4-point *** system is also able to achieve a bilingual evaluation understudy(BLEU) score of 0.72.

关键词： DeConverter EnConverter Machine translation Universal Networking Language(UNL) Syntactic linearization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Test Case Prioritization in Unit and Integration Testing:A Shuffled-Frog-Leaping Approach

引用

Computers, Materials & Continua 2023年第3期74卷 5369-5387页

作者： Atulya Gupta rajendra Prasad Mahapatra Department of Computer Science and Engineering SRMISTDelhi-NCR CampusGhaziabad201204India

Both unit and integration testing are incredibly crucial for almost any software application because each of them operates a distinct process to examine the *** to resource constraints,when software is subjected to modifications,the drastic increase in the count of test cases forces the testers to opt for a test optimization *** such strategy is test case prioritization(TCP).Existing works have propounded various methodologies that re-order the system-level test cases intending to boost either the fault detection capabilities or the coverage efficacy at the ***,singularity in objective functions and the lack of dissimilitude among the re-ordered test sequences have degraded the cogency of their *** such gaps and scenarios when the meteoric and continuous updations in the software make the intensive unit and integration testing process more fragile,this study has introduced a memetics-inspired methodology for *** proposed structure is first embedded with diverse parameters,and then traditional steps of the shuffled-frog-leaping approach(SFLA)are followed to prioritize the test cases at unit and integration *** 5 standard test functions,a comparative analysis is conducted between the established algorithms and the proposed approach,where the latter enhances the coverage rate and fault detection of re-ordered test *** results related to the mean average percentage of fault detection(APFD)confirmed that the proposed approach exceeds the memetic,basic multi-walk,PSO,and optimized multi-walk by 21.7%,13.99%,12.24%,and 11.51%,respectively.

关键词： Test case prioritization unit testing shuffled frog leaping approach memetic based optimization algorithm integration testing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Experimental investigation and optimization of weld bead characteristics during submerged arc welding of AISI 1023 steel

引用

Defence Technology（防务技术） 2019年第1期15卷 72-82页

作者： Ankush Choudhary Manoj Kumar Deepak rajendra Unune Department of Mechanical-Mechatronics Engineering The LNM Institute of Information Technology

Submerged arc welding(SAW), owing to its high deposition rate and high welding quality, is widely used in the fabrication of pressure vessel, marine vessel, pipelines and offshore structures. However, selection of an optimum combination of welding parameters is critical in achieving high weld quality and productivity. In this work, initially, the SAW experiments were performed using fractional factorial design to analyze the effect of direct and indirect input parameters, namely, welding voltage, wire feed rate,welding speed, nozzle to plate distance, flux condition, and plate thickness on weld bead geometrical responses viz. bead width, reinforcement, and penetration. The bead on plate technique was used to deposit weld metal on AISI 1023 steel plates. The effect of SAW input parameters on response variables were analyzed using main and interaction effects. The linear regression was used to develop the mathematical models for the response variable. Then, the multi-objective optimization of input parameters was carried out using desirability approach, genetic algorithm and Jaya algorithm. The Jaya algorithm offered better optimization results as compared to desirability approach, genetic algorithm.

关键词： Submerged arc welding Optimization Regression Genetic algorithm Jaya algorithm

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Identification of crack in a structural member using improved radial basis function(IRBF)neural networks

引用

International Journal of Intelligent Computing and Cybernetics 2013年第2期6卷 182-211页

作者： rajendra Machavaram Shankar Krishnapillai Department of Mechanical Engineering Indian Institute of Technology MadrasChennaiIndia

Purpose–The purpose of this paper is to provide an effective and simple technique to structural damage identification,particularly to identify a crack in a *** neural networks approach is an alternative to identify the extent and location of the damage over the classical *** basis function(RBF)networks are good at function mapping and generalization ability among the various neural network *** neural networks are chosen for the present study of crack ***/methodology/approach–Analyzing the vibration response of a structure is an effective way to monitor its health and even to detect the damage.A novel two-stage improved radial basis function(IRBF)neural network methodology with conventional RBF in the first stage and a reduced search space moving technique in the second stage is proposed to identify the crack in a cantilever beam structure in the frequency *** hypercube sampling(LHS)technique is used in both stages to sample the frequency modal patterns to train the proposed *** is also conducted with and without addition of 5%white noise to the input patterns to simulate the experimental ***–The results show a significant improvement in identifying the location and magnitude of a crack by the proposed IRBF method,in comparison with conventional RBF method and other classical *** case of crack location in a beam,the average identification error over 12 test cases was 0.69 per cent by IRBF network compared to 4.88 per cent by conventional *** improvements are reported when compared to hybrid CPN BPN *** also requires much less computational effort as compared to other hybrid neural network approaches and classical ***/value–The proposed novel IRBF crack identification technique is unique in originality and not reported *** can identify the crack location and crack depth with very good accuracy,less computational effort and ease of imp

关键词： Structures Stress(materials) Mechanical behaviour of materials Beams Structural members Crack identification Structural damage Frequency domain Latin hypercube sampling Improved radial basis function neural networks Reduced search space moving technique

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Circadian rhythms of hormone secretion and obesity

引用

World Journal of Diabetes 2018年第11期9卷 195-198页

作者： rajendra Raghow Department of Veterans Affairs Medical Center MemphisTN 38104United States Department of Pharmacology University of Tennessee Health Science CenterMemphisTN 38163United States

The adipose tissue homeostasis is profoundly affected by circadian rhythms of corticosteroid secretion and chronic loss of hormonal oscillations is associated with obesity. How adipose tissue differentially responds to pulsatile vs continuous presence of glucocorticoids is poorly defined. To address this question, Bahrami-Nejad et al studied differentiation of pre-adipocytes, containing endogenously tagged CCAAT/enhancer binding protein and peroxisome proliferator-activated receptor(PPAR) γ(key regulators of adipocyte differentiation), in response to corticosteroids that were delivered either in an oscillatory fashion or continuously. The authors show that the bi-stable state of differentiation of pre-adipocytes and adipocytes was regulated by a combination of fast and slow positive feedback networks, that determined unique threshold of PPARγ in these cells. Evidently, pre-adipocytes used the fast feedback loop to reject differentiation cues of oscillating pulses of glucocorticoids and failed to differentiate into fat cells. In contrast, when glucocorticoids were delivered continuously, precursor cells exploited the slow feedback loop to embark on a path of maximal differentiation. This differential differentiation response of pre-adipocytes to pulsatile vs continuous exposure to glucocorticoids was corroborated in vivo. Thus, mice receiving non-oscillating doses of exogenous glucocorticoids, for 21 d, elicited excessive accumulation of visceral and subcutaneous fat. These data shed new light on the mechanisms of obesity caused by putative misalignment of circadian secretion of glucocorticoids or their persistently high levels due to chronic stress or Cushing's disease.

关键词： Circadian rhythms Glucocorticoids Adipose tissue Pre-adipocytes Stem cells Terminal differentiation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Gut-brain crosstalk regulates craving for fatty food

引用

World Journal of Diabetes 2017年第12期8卷 484-488页

作者： rajendra Raghow Department of Veterans Affairs Medical Center Department of Pharmacology University of Tennessee Health Science CenterMemphisTN 38163United States

Patients undergoing Roux-en-Y gastric bypass(RYGB)surgery elicit striking loss of body weight. Anatomical restructuring of the gastrointestinal(GI) tract, leading to reduced caloric intake and changes in food preference, are thought to be the primary drivers of weight loss in bariatric surgery patients. However, the mechanisms by which RYGB surgery causes a reduced preference for fatty foods remain elusive. In a recent report, Hankir et al described how RYGB surgery modulated lipid nutrient signals in the intestine of rats to blunt their craving for fatty food. The authors reported that RYGB surgery restored an endogenous fat-satiety signaling pathway, mediated via oleoylethanolamide(OEA), that was greatly blunted in obese animals. In RYGB rats, high fat diet(HFD) led to increased production of OEA that activated the intestinal peroxisome proliferation activator receptors-α(PPARα). In RYGB rats, activation of PPARα by OEA was accompanied by enhanced dopamine neurotransmission in the dorsal striatum and reduced preference for HFD. The authors showed that OEA-mediated signals to the midbrain were transmitted via the vagus nerve. Interfering with either the production of OEA in enterocytes, or blocking of vagal and striatal D1 receptors signals eliminated the decreased craving for fat in RYGB rats. These studies demonstrated that bariatric surgery led to alterations in the reward circuitry of the brain in RYGB rats and reduced their preference for HFD.

关键词： Roux-en-Y gastric bypass surgery Dietary lipids Dopamine D1 receptors Peroxisome proliferator activated receptor-alpha Oleoylethanolamide

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Statins redux:A re-assessment of how statins lower plasma cholesterol

引用

World Journal of Diabetes 2017年第6期8卷 230-234页

作者： rajendra Raghow Department of Veterans Affairs Medical Center Department of Pharmacology University of Tennessee Health Science CenterMemphisTN 38163United States

Obesity associated dyslipidemia and its negative effects on the heart and blood vessels have emerged as a major healthcare challenge around the globe. The use of statins, potent inhibitors of hydroxyl-methyl glutaryl (HMG) Co-A reductase, a rate-limiting enzyme in cholesterol biosynthesis, has significantly reduced the rates of cardiovascular and general mortality in patients with coronary artery disease. How statins lower plasma cholesterol levels presents a mechanistic conundrum since persistent exposure to these drugs in vitro or in vivo is known to induce overexpression of the HMG Co-A reductase gene and protein. In an attempt to solve this mechanistic puzzle, Schonewille et al, studied detailed metabolic parameters of cholesterol synthesis, inter-organ flux and excretion in mice treated with 3 common statins, rosuvastatin, atorvastatin or lovastatin, each with its unique pharmacokinetics. From the measurements of the rates of heavy water (D2O) and [13C]-acetate incorporation into lipids, the authors calculated the rates of whole body and organ-specific cholesterol synthesis in control and statin-treated mice. These analyses revealed dramatic enhancement in the rates of hepatic cholesterol biosynthesis in statin-treated mice that concomitantly elicited lower levels of cholesterol in their plasma. The authors have provided strong evidence to indicate that statin treatment in mice led to induction of compensatory metabolic pathways that apparently mitigated an excessive accumulation of cholesterol in the body. It was noted however that changes in cholesterol metabolism induced by 3 statins were not identical. While sustained delivery of all 3 statins led to enhanced rates of biliary excretion of cholesterol and its fecal elimination, only atorvastatin treated mice elicited enhanced trans-intestinal cholesterol excretion. Thus, blockade of HMGCR by statins in mice was associated with profound metabolic adaptations that reset their cholesterol

关键词： Statins Atorvastatin Lovastatin Rosuvastatin Cholesterol synthesis Hydroxyl-methyl glutaryl-CoA reductase

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：