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Covalent Bond Based Android Malware Detection Using Permission and System Call Pairs

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Computers, Materials & Continua 2024年第3期78卷 4283-4301页

作者： Rahul gupta kapil Sharma R.k.Garg Department of Information Technology Delhi Technological UniversityNew Delhi110042India Department of Mechanical Engineering Deenbandhu Chhotu Ram University of Science and TechnologyMurthal131039India

The prevalence of smartphones is deeply embedded in modern society,impacting various aspects of our *** versatility and functionalities have fundamentally changed how we communicate,work,seek entertainment,and access *** the many smartphones available,those operating on the Android platform dominate,being the most widely used *** widespread adoption of the Android OS has significantly contributed to increased malware attacks targeting the Android ecosystem in recent ***,there is an urgent need to develop new methods for detecting Android *** literature contains numerous works related to Android malware *** far as our understanding extends,we are the first ones to identify dangerous combinations of permissions and system calls to uncover malicious behavior in Android *** introduce a novel methodology that pairs permissions and system calls to distinguish between benign and malicious *** approach combines the advantages of static and dynamic analysis,offering a more comprehensive understanding of an application’s *** establish covalent bonds between permissions and system calls to assess their combined *** introduce a novel technique to determine these pairs’Covalent Bond Strength *** pair is assigned two scores,one for malicious behavior and another for benign *** scores serve as the basis for classifying applications as benign or *** correlating permissions with system calls,the study enables a detailed examination of how an app utilizes its requested permissions,aiding in differentiating legitimate and potentially harmful *** comprehensive analysis provides a robust framework for Android malware detection,marking a significant contribution to the *** results of our experiments demonstrate a remarkable overall accuracy of 97.5%,surpassing various state-of-the-art detection techniques proposed in the current literature.

关键词： Android malware android security hybrid analysis permission and system call pairs

SARS-CoV-2 and innate immunity:the good,the bad,and the"goldilocks"

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Cellular & Molecular Immunology 2024年第2期21卷 171-183页

作者： Benjamin L.Sievers mark T.k.Cheng kata Csiba Bo Meng Ravindra k.gupta Department of Medicine University of CambridgeCambridgeUK Cambridge Institute of Therapeutic Immunology&Infectious Disease(CITID) Department of MedicineUniversity of CambridgeCambridgeUk

An ancient conflict between hosts and pathogens has driven the innate and adaptive arms of *** about this interplay can not only help us identify biological mechanisms but also reveal pathogen vulnerabilities that can be leveraged *** humoral response to SARS-CoV-2 infection has been the focus of intense research,and the role of the innate immune system has received significantly less ***,we review current knowledge of the innate immune response to SARS-CoV-2 infection and the various means SARS-CoV-2 employs to evade innate defense *** also consider the role of innate immunity in SARS-CoV-2 vaccines and in the phenomenon of long COVID.

关键词： SARS-CoV-2 Innate immune response Interferon Cytokines Inflammation Antiviral targets

Unleashing the Power of Multi-Agent Reinforcement Learning for Algorithmic Trading in the Digital Financial Frontier and Enterprise Information Systems

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Computers, Materials & Continua 2024年第8期80卷 3123-3138页

作者： Saket Sarin Sunil k.Singh Sudhakar k.mar Shivam Goyal Brij Bhooshan gupta Wadee Alhalabi Varsha Arya Chandigarh College of Engineering and Technology Chandigarh160019India Department of Computer Science and Information Engineering Asia UniversityTaichung413Taiwan Symbiosis Centre for Information Technology(SCIT) Symbiosis International UniversityPune411057India Center for Interdisciplinary Research University of Petroleum and Energy Studies(UPES)Dehradun248007India Department of Computer Science Immersive Virtual Reality Research GroupKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Business Administration Asia UniversityTaichung413Taiwan Department of Electrical and Computer Engineering Lebanese American UniversityBeirut11022801Lebanon UCRD Chandigarh UniversityChandigarh140413India

In the rapidly evolving landscape of today’s digital economy,Financial Technology(Fintech)emerges as a trans-formative force,propelled by the dynamic synergy between Artificial Intelligence(AI)and Algorithmic *** in-depth investigation delves into the intricacies of merging Multi-Agent Reinforcement Learning(marL)and Explainable AI(XAI)within Fintech,aiming to refine Algorithmic Trading *** meticulous examination,we uncover the nuanced interactions of AI-driven agents as they collaborate and compete within the financial realm,employing sophisticated deep learning techniques to enhance the clarity and adaptability of trading *** AI-infused Fintech platforms harness collective intelligence to unearth trends,mitigate risks,and provide tailored financial guidance,fostering benefits for individuals and enterprises navigating the digital *** research holds the potential to revolutionize finance,opening doors to fresh avenues for investment and asset management in the digital ***,our statistical evaluation yields encouraging results,with metrics such as Accuracy=0.85,Precision=0.88,and F1 Score=0.86,reaffirming the efficacy of our approach within Fintech and emphasizing its reliability and innovative prowess.

关键词： Neurodynamic Fintech multi-agent reinforcement learning algorithmic trading digital financial frontier

Smart tailoring of molecular catalysts:Mounting approach to oxygen reduction reaction

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Journal of Materials Science & Technology 2024年第1期168卷 169-184页

作者： Anuj k.mar Mohd Ubaidullah Guoxin Zhang Jasvinder kaur Saira Ajmal Mudassir Hasan krishna k.mar Yadav Hafiz M.Adeel Sharif Ram k.gupta Ghulam Yasin Nano-Technology Research Laboratory Department of ChemistryGLA UniversityMathuraUttar Pradesh 281406India Department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Department of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdaoShandong 266590China Institute for Advanced Study Shenzhen UniversityShenzhenGuangdong 518060China Department of Chemistry Kansas Polymer Research CenterPittsburg State UniversityPittsburgKS 66762United States Faculty of Science and Technology Madhyanchal Professional UniversityRatibadBhopal 462044India Environmental and Atmospheric Sciences Research Group Scientific Research CenterAl-Ayen UniversityThi-QarNasiriyah 64001Iraq Department of Chemical Engineering king khalid University Saudi Arabia Department of Chemistry School of SciencesIFTM UniversityMoradabadUttar Pradesh 244102India Research Center for Eco-Environmental Engineering Dongguan University of TechnologyDongguan 523808China School of Environment and Civil Engineering Dongguan University of TechnologyDongguanGuangdong 523808China

Efficient electrocatalytic rupture of energy-rich molecules(H_(2)and O_(2))is a green approach for gener-ating clean energy for modern *** this context,porphyry-type molecular electrocatalysts act intelligently toward oxygen reduction reaction(ORR),a fundamental process in fuel cells,due to their redox-rich chemistry,which involves core metal ions and macrocyclic *** concerned scientific community has tried many times to correlate the ORR intermediates with their formation kinetics and simplify the associated multi H+/e-stages during the ORR process,constructing several volcano plots be-tween catalytic Tafel data,turnover frequencies,and overpotentials for many *** the fact that many review articles on molecular electrocatalysts for ORR have been published,understanding the strategic implications and molecular catalyst intelligence towards homogenous ORR has been poorly *** review examined the relationships between volcano plots of current *** parameters and the Sabatier principle in order to explain the intelligence of molecular electrocatalysts and approaches for their creation,as well as the difficulties and potential prospects of molecular *** facts distinguish this review from previously published articles and will pique the scien-tific community’s interest in avoiding trial-and-error procedures for catalyst creation while also allowing for more exact evaluations of the molecular catalyst’s performance.

关键词： Electrocatalysis Molecular catalysts Oxygen reduction reaction Sabatier principle

Early Paleozoic basement diorite of arc-magmatism from kutch basin, Western India

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Acta Geochimica 2024年第2期43卷 296-307页

作者： Piyush gupta Sandeep Singh Shakti Singh Rathore Argha Narayan Sarkar Geochronology Laboratory KDMIPEOil and Natural Gas Corporation Ltd.9Kaulagarh RoadDehradun 248195India Department of Earth Sciences Indian Institute of TechnologyRoorkee 247667India

In this study,we report for theﬁrst time an Early Palaeozoic basement diorite from the drilled well Nirona-A in the Banni Half-Graben of the kutch basin,western *** 40Ar–39Ar dates provided a plateau age of 441.84±2.66 Ma and another pseudo plateau of 441.28±5.82 to 388.08±16.65 Ma for the basement *** ages constrain the basement formation age to the Late Ordovician-Early Silurian *** obtained basement ages are correlatable with the later part of Cambro-Ordovician alkaline magmatism that has been reported from the Huqf area in Central Oman,whereas their lithological and petrographic correlativity with base-ment diorites occurring in the Dinsi Body of Nagar Parkar igneous complex in Pakistan can also be *** geochemical studies characterized the diorite with enrich-ment of LILE(Rb,Ba,and k)and LREE(La,Ce,Nd),strong depletion of HFSE(Nb,Sr,P,and Ti),along with weakly negative Eu *** geochemical signatures indicate their petrogenetic afﬁliation with mantle-derived magmas,as well as their tectonic setting to be arc-related,having post-collisional continental-arc type afﬁ****440 Ma basement of kutch,therefore,appears to rep-resent the later thermal event associated with the reworked Neoproterozoic subduction-related suite from Greater India’s northwest edge,which has implications for Gond-wana assembly in the northwest Indian subcontinent.

关键词： kutch basin 40Ar–39Ar ages Early palaeozoic basement Continental-arc magmatism Calc-alkaline magmatism

SCN1A rs6732655A/T polymorphism:Diagnostic and therapeutic insights for drug-resistant epilepsy

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World Journal of Experimental Medicine 2024年第3期14卷 72-79页

作者： Aroop Viswas Pradeep k Dabla Dharmsheel Shrivastav Swapan gupta Manisha Yadav Subhash Yadav Bidhan Chandra koner Department of Biochemistry Govind Ballabh Pant Institute of Postgraduate Medical Education and ResearchNew Delhi 110002DelhiIndia Department of Neurology Govind Ballabh Pant Institute of Postgraduate Medical Education and ResearchNew Delhi 110002DelhiIndia Multi-disciplinary Research Unit Maulana Azad Medical CollegeNew Delhi 110002DelhiIndia Department of Biotechnology Amity University GwaliorGwalior 474005Madhya PradeshIndia Department of Biochemistry Maulana Azad Medical CollegeNew Delhi 110002DelhiIndia

BACkGROUND A significant subset of individuals with epilepsy fails to respond to currently available antiepileptic drugs,resulting in heightened mortality rates,psychosocial challenges,and a diminished quality of *** factors,particularly within the SCN1A gene,and the pro-inflammatory cytokine response is important in intricating the drug resistance in idiopathic epilepsy *** this extended study,we determined the correlation of rs6732655A/T single nucleotide polymorphism to understand the causative association of SCN1A gene with epilepsy drug resistance and inflammatory *** To find the correlation of SCN1A gene rs6732655A/T polymorphism with the drug-resistant epilepsy and inflammatory *** The study enrolled 100 age and sex-matched patients of both drug-resistant and drug-responsive epilepsy *** analysed the rs6732655A/T polymorphism to study its association and causative role in drug-resistant epilepsy cases using restriction fragment length polymorphism *** diagnostic performance of interleukin(IL)-1β,IL-6,and high mobility group box 1(HMGB1)protein levels was evaluated in conjunction with genotypic outcome receiver operating characteristic *** AT and AA genotypes of rs6732655 SCN1A gene polymorphism were associated with higher risk of drug resistance *** biomarkers IL-6,IL1βand HMGB1 demonstrated diagnostic potential,with cutoff values of 4.63 pg/mL,59.52 pg/mL and 7.99 ng/mL,respectively,offering valuable tools for epilepsy ***,specific genotypes(AA and AT)were found to be linked to the elevated levels of IL-1βand IL-6 and potentially reflecting increased oxidative stress and neuro-inflammation in drug-resistant cases supporting the previous reported outcome of high inflammatory markers response in drug resistance *** SCN1A genotypes AA and AT are linked to higher drug-resistant epilepsy *** findings underscore the potential influence of inflammation

关键词： Epilepsy Drug resistance SCN1A gene Pro-inflammatory cytokines Genetic factors

The diagnostic conundrum in necrotizing otitis externa

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 59-65页

作者： Abiya A.Ahmed Shaan Rashid Vinay k.gupta Neil C.Molony keshav k.gupta Bradford Royal Infirmary Bradford Teaching Hospitals NHS Foundation TrustWest BromwichWest YorkshireUK Sandwell and West Birmingham Hospitals NHS Trust West BromwichUK Russells Hall Hospital DudleyUK

Necrotizing otitis externa(NOE)is an aggressive and fast‐evolving infection of the external auditory *** diagnoses and untreated cases can lead to severe,even fatal consequences and so early diagnosis and treatment are *** is a notoriously challenging diagnosis to *** is therefore important to understand what diagnostic modalities are available and how otolaryngologists can use them to accurately treat such an aggressive *** review aims to evaluate the different diagnostic options available in NOE and discuss their advantages and limitations,thus,providing an up‐to‐date picture of the multimodal approach required in the diagnosis of this disease.

关键词： diagnostic malignant otitis externa necrotizing osteomyelitis skull base osteomyelitis temporal bone osteomyelitis

Brillouin expanded time-domain analysis based on dual optical frequency combs

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Light(Science & Applications) 2024年第8期13卷 1534-1544页

作者： Jae Hyeong Youn kwang Yong Song Sonia martin-Lopez Miguel Gonzalez-Herraez maría R.Fernández-Ruiz Dept.of Physics Chung-Ang UniversitySeoulKorea Dept.of Electronics Universidad de AlcaláMadridSpain

Brillouin Optical Time-Domain Analysis(BOTDA)is a widely-used distributed optical fiber sensing technology employing pulse-modulated pump waves for local information retrieval of the Brillouin gain or loss *** spatial resolution of BOTDA systems is intrinsically linked to pulse duration,so high-resolution measurements demand high electronic bandwidths inversely proportional to the *** paper introduces Brillouin Expanded Time-Domain Analysis(BETDA)as a modified BOTDA system,simultaneously achieving high spatial resolution and low detection *** two optical frequency combs(OFCs)with different frequency intervals as pump and probe,local Brillouin gain spectra are recorded by their spectral beating traces in an expanded time domain.A 2-cm-long hotspot located in a 230m single-mode fiber is successfully measured in the time domain with a detection bandwidth of less than 100 kHz using dual OFCs with tailored spectral phase,line spacing,and bandwidth.

关键词： pump optical fiber

Impacts of PI3k/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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Neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-Núñez maría Fernanda González Ana maría Avalos Lisette Leyton Cellular Communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3k)/protein kinase B(AkT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3k/AkT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3k/AkT/connexin 43,and Notch/PI3k/AkT *** targeting the inactivation of the PI3k/AkT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3k/AkT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90)