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A review of patent literature on the regulation of glucose metabolism by six phytocompounds in the management of diabetes mellitus and its complications

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Journal of Integrative Medicine 2023年第3期21卷 226-235页

作者： Anusree DasNandy rajashri virge Harsha V.Hegde Debprasad Chattopadhyay ICMR-National Institute of Traditional Medicine Belagavi 590010KarnatakaIndia

Diabetes mellitus is a chronic disease,typified by hyperglycemia resulting from failures in complex multifactorial metabolic functions,that requires life-long *** uncontrolled hyperglycemia leads to micro-and macro-vascular *** antidiabetic drugs are prescribed as the first-line treatment,many of them lose efficacy over time or have severe side *** is a lack of in-depth study on the patents filed concerning the use of natural compounds to manage ***,this patent analysis provides a comprehensive report on the antidiabetic therapeutic activity of 6 phytocompounds when taken alone or in *** patent databases were searched,and 17,649 patents filed between 2001 and 2021 were retrieved.0f these,139 patents for antidiabetic therapeutic aids that included berberine,curcumin,gingerol,gymnemic acid,gymnemagenin and mangiferin were *** results showed that these compounds alone or in combinations,targeting acetylcoenzyme A carboxylase 2,serine/threonine protein kinase,α-amylase,α-glucosidase,lipooxygenase,phosphorylase,peroxisome proliferator-activated receptor-γ(PPAR-γ),protein tyrosine phosphatase 1B,PPARγco-activator-1α,phosphoinositide 3-kinase and protein phosphatase 1 regulatory subunit 3C,could regulate glucose metabolism which are validated by pharmacological ***,or combination therapy,including different phytocompounds and plant extracts,has been studied extensively and found effective,whereas the efficacy of commercial drugs in combination with phytocompounds has not been studied in ***,gymnemic acid and mangiferin were found to be effective against diabetes-related complications.

关键词： Berberine Curcumin Gingerol Gymnemic acid Gymnemagenin Mangiferin Diabetes mellitus Patents

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