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In flue nee of microwave drying and con venti onal drying methods on the mechanical properties of naproxen sodium drug tablets

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Particuology 2020年第6期18卷 30-40页

作者： Maha Al-Ali rajarathinam parthasarathy Chemical and Environmental Engineering School of EngineeringRM1T UniversityMelbourneVictoria 3001Australia

Tablets are one of the most comm only used solid dosage forms taken by *** preparati on of high-quality tablets requires an understanding of the preparation process and elucidation of how the physical and mechanical properties change as a function of the preparation *** work aims to investigate the impact of microwave irradiation drying and conventional drying methods(including freeze,convective and vacuum drying)on the hardness,tensile strength and friability of tablets made from a multi-component formulation containing naproxen sodium,microcrystalline cellulose,and *** results show that tablets subjected to microwave drying had the secondhighest tensile strength and hardness of 1.296 MPa and 67 N,*** tablets subjected to vacuum drying had the lowest tensile strength and hardness of 1.21 MPa and 64 N,*** friability index values for the tablets derived from the microwave and freeze-drying methods werel%.Microwave drying was observed to be an efficient method to produce naproxen sodium-containing tablets with satisfactory mechanical *** findings confirm that the drying method plays an essential role in the improvement or degradation of the mechanical properties of tablets.

关键词： Microwave drying Naproxen sodium Hardness Friability Tensile strength

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Comparative analyses/evaluation of the textural properties of naproxen sodium tablets and powders prepared using microwave and other drying techniques

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Particuology 2020年第3期18卷 197-204页

作者： Maha Al-Ali Selvakannan Periasamy rajarathinam parthasarathy Chemical and Environmental Engineering School of EngineeringRMIT UniversityMelbourneVictoria 3000Australia Applied Chemistry School of ScienceRMIT UniversityMelbourneVictoria 3000Australia

The properties of oral tablets are normally related to the properties of the powders they *** of oral tablets is important for the development of tablets with rapid and safe release of the active *** this study,a new formulation of naproxen sodium was prepared and dried using microwave drying (MWD) and the following conventional drying techniques:freeze-drying (FD),vacuum drying (VD),and convective drying (CD).The reference drug powder (RDP) and dry granules MWG,CDG,VDG,and FDG,which were dried using MWD,CD,VD,and FD,respectively were compressed to form tablets labeled RF-TAB,MW-TAB,CD-TAB,VD-TAB,and FD-TAB,*** dry granules and prepared tablets were characterized using Fourier transform infrared spectrometry,scanning electron microscopy,and X-ray *** study aimed to explore the correlation between the textural characteristics of the tablets and their respective powders for different drying *** the morphologies of the dry particles were irregular,the prepared tablets were smooth and flat with few *** increased the amorphous nature of the granules but decreased their *** crystallinities of all tablets,except those prepared by VD,decreased after *** summary,the characteristics of the prepared tablets were acquired from their respective powders.

关键词： Naproxen sodium Microwave drying Tablet Texture Crystallinity

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