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Changes in biochemical constituents and induction of early sprouting by triadimefon treatment in white yam(Dioscorea rotundata Poir.) tubers during storage

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第4期8卷 283-288页

作者： JALEEL Cheruth Abdul GOPI Ragupathi MANIVANNAN Paramasivam KISHOREKUMAR Ashok GOMATHINAYAGAM Muthiah panneerselvam rajaram Stress Physiology Lab Department of BotanyAnnamalai UniversityAnnamalainagar 608 002Tamil NaduIndia

The ability of triadimefon （TDM）, a triazolic fungicide, to alter the biochemical constituents and thereby minimizing the days required for sprouting in white yam （Dioscorea rotundata Poir.） tubers during storage under （30±2） ℃ in the dark, was studied. TDM at 20 mg/L was given to tubers by dipping the tubers in treatment solution containing 20 mg/L TDM on 10, 25 and 40 d after storage （DAS）. Starch, sugars, protein, amino acid contents as well as protease and a-amylase activities were estimated on 15, 30 and 45 DAS from two physiological regions viz., apical and basal regions of the tubers. In normal conditions （control） sprouting occurred on 70 to 80 DAS. The starch content decreased, while protein, amino acid, sugar contents and protease and a-amylase activities were increased due to TDM treatment and led to early sprouting.

关键词： Biochemical constituents Enzyme activities Dioscorea rotundata Sprouting Storage Triadimefon (TDM)

抗氧化剂和吲哚生物碱在粉红色和白色长春花植株不同部位中的分布(英文)

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中国药理学与毒理学杂志 2007年第6期21卷 487-494页

作者： Cheruth Abdul JALEEL rajaram panneerselvam Stress Physiology Lab Department of BotanyAnnamalai University Annamalainagar 608002Tamil Nadu India Stress Physiology Lab Department of BotanyAnnamalai UniversityAnnamalainagar 608002Tamil Nadu India

目的研究抗氧化剂和吲哚生物碱在2种长春花(粉红色和白色)植株不同部位的分布。方法通过检测无酶活性的抗氧化分子含量和抗氧化酶活性测定抗氧化能力。无酶活性的抗氧化分子包括抗坏血酸、α-生育酚和还原型谷胱甘肽。抗氧化酶包括超氧... 详细信息

目的研究抗氧化剂和吲哚生物碱在2种长春花(粉红色和白色)植株不同部位的分布。方法通过检测无酶活性的抗氧化分子含量和抗氧化酶活性测定抗氧化能力。无酶活性的抗氧化分子包括抗坏血酸、α-生育酚和还原型谷胱甘肽。抗氧化酶包括超氧化物歧化酶、抗坏血酸过氧化物酶、过氧化氢酶、过氧化物酶和多酚氧化酶。所用样品为从田间收集到的植株的根、茎、叶、花和豆荚。结果与其他部位比较,根和茎中抗氧化剂的含量较高,花和豆荚中含量最低。粉红色长春花中抗氧化剂和生物碱含量较高。叶中抗氧化酶的活性较高,但吲哚生物碱的含量在粉红色长春花的根中较高。结论对于抗氧化剂和生物碱含量而言,粉红色长春花更适合培养。

关键词：长春花医学,草药抗氧化剂吲哚生物碱类

Preliminary study on the antimicrobial activity of Enicostemma littorale using different solvents

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Asian Pacific Journal of Tropical Medicine 2012年第7期5卷 552-555页

作者： Pitchamuthu Abirami Muthiah Gomathinayagam rajaram panneerselvam Plant Growth Regulation Lab Department of BotanyAnnamalai UniversityAnnamalainagarTamilnaduIndia

Objective:To study the antimicrobial activity of Enicostemma littorale(***) using different ***:Chloroform,methanol and acetone extracts of different parts of ***(leaf,stem and root) were evaluated for antimicrobial activity using disc diffusion method against some gram-negative species such as Escherichia coli,Klebsiella pnemoniae, Pseudomonas aeruginosa,Salmonella typhi and gram-positive species Staphylococcus aureus, Bacillus cereus,Bacillus subtilis and two fugal species viz.,Aspergillus fumigates and Aspergillus ***:The chloroform extracts showed the highest antibacterial *** leaf, stem and root extracts,the stem extracts showed maximum antibacterial *** of the used extracts had no significant antifungal activity against Aspergillus fumigates and Aspergillus *** chloroform stem extract showed highest activity(about 20 mm inhibition zone) against Bacillus subtilis(at 500 tng/mL) followed by the methanolic stem extract which showed highest activity against the same *** lowest antibacterial activity was observed by the acetone leaf extract(about 8 mm inhibition zone) against Escherichia ***:The findings of the study indicate littorale could also be a new source for antibiotics discovery.

关键词： Antimicrobial activity Enicostemma littorale Extracts Medicinal plants

Elevated Liver Enzymes along with Comorbidity Is a High Risk Factor for COVID-19 Mortality:A South Indian Study on 1,512 Patients

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Journal of Clinical and Translational Hepatology 2022年第1期10卷 120-127页

作者： Narayanasamy Krishnasamy Karthick Rajendran Parimita Barua Arunkumar Ramachandran Priyadarshini panneerselvam Muthukumaran rajaram Institute of Hepatobiliary Sciences Madras Medical College and Rajiv Gandhi Government General HospitalChennaiTamil NaduIndia Multidisciplinary Research Unit(MRU) Madras Medical CollegeChennaiTamil NaduIndia

Background and Aims:Liver enzyme abnormalities in coronavirus 2019(COVID-19)are being addressed in the *** predictive risk of elevated liver enzymes has not been established for COVID-19 *** this study,we hypothesized that elevated liver enzymes at ad-mission can predict the outcome of COVID-19 disease with other known indicators,such as ***:This retrospective study included all the consecutive hos-pitalized patients with confirmed COVID-19 disease from March 4th to May 31st,*** study was conducted in Rajiv Gandhi Government General Hospital,Chennai,Ta-mil Nadu,*** assessed demography,clinical vari-ables,COVID-19 severity,laboratory parameters,and ***:We included 1,512 patients,and median age was 47 years(interquartile range:34-60)with 36.9%being *** enzyme level(aspartate aminotrans-ferase and/or alanine aminotransferase)was elevated in 450/1,512(29.76%)*** was present in 713/1,512(47.16%)*** with liver enzymes’elevation and presence of comorbidity were older,more frequently hospitalized in ICU and had more severe symp-toms of COVID-19 at the time of *** of liver enzymes’elevation with comorbidity was a high risk factor for death(OR:5.314,95%CI:2.278-12.393),as compared to patients with presence of comorbidity(OR:4.096,95%CI:1.833-9.157).Conclusions:Comorbid-ity combined with liver enzymes’elevation at presentation independently increased the risk of death in COVID-19 by at least 5-fold.

关键词： COVID-19 SARS-CoV-2 Liver enzyme Comorbidity Aspartate aminotransferase Alanine aminotransferase

Indolin-2-Ones in Clinical Trials as Potential Kinase Inhibitors: A Review

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Pharmacology & Pharmacy 2012年第1期3卷 62-71页

作者： Chinnasamy rajaram Prakash panneerselvam Theivendren Sundararajan Raja 不详

The kinases have been intensely studied because of their involvement in regulating essential cellular activation of signaling cascades in response to extracellular and intracellular stimuli to control cell growth, proliferation, and survival. Recent cancer genomic sequencing studies have revealed that many more kinases contribute to tumor genesis and are potential targets for inhibitor drug development intervention. Herein we review recent results that have helped to unravel the indolin-2-ones underlying the confiicting roles of the kinase inhibition regulation. This review focuses on the potential of kinases as a chemotherapeutic target in cancer treatment and highlights important recent advances in the development of indolin-2-ones as kinase inhibitors.

关键词： Isatin Enzyme Inhibition Anticancer

Indolin-2-Ones in Clinical Trials as Potential Kinase Inhibitors: A Review

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