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MicroRNA aberrations:An emerging field for gallbladdercancer management

World Journal of Gastroenterology 2016年第5期22卷 1787-1799页

作者： Vishal Chandra Jong Joo Kim Balraj Mittal rajani rai Department of Obstetrics and Gynecology Stephenson Cancer CenterUniversity of Oklahoma Health Sciences CenterOklahoma CityOK 73104United States Department of Biosciences Integral UniversityLucknow 226026(UP)India School of Biotechnology Yeungnam UniversityGyeongsan 712-749South Korea Department of Genetics Sanjay Gandhi Post Graduate Institute of Medical SciencesLucknow 226014India

Gallbladder cancer(GBC) is infrequent but most lethal biliary tract malignancy characterized by an advanced stage diagnosis and poor survival rates attributed to absence of specific symptoms and effective treatment options. These necessitate development of early prognostic/predictive markers and novel therapeutic interventions. Micro RNAs(mi RNAs) are small, noncoding RNA molecules that play a key role in tumor biology by functioning like tumor suppressor- or oncogenes and their aberrant expression are associated with the pathogenesis of several neoplasms with overwhelming clinical implications. Since mi RNA signature is tissue specific, here, we focused on current data concerning the mi RNAs abberations in GBC pathogenesis. In GBC, mi RNAs with tumor suppressor activity(mi R-135-5p, mi R-335, mi R-34 a, mi R-26 a, mi R-146b-5p, Mir-218-5p, mi R-1, mi R-145, mir-130a) were found downregulated, while those with oncogenic property(mi R-20 a, mi R-182, mir-155) were upregulated. The expression profile of mi RNAs was significantly associated with GBC prognosis and prediction, and forced over-expression/ inhibition of these mi RNAs was shown to affect tumor growth and development. Further, differential expression of mi RNAs in the blood samples of GBC patients suggest mi RNAs as promising noninvasive biomarker. Thus, mi RNAs represent potential candidate for GBC management, though many hurdles need to be overcome before mi RNAs therapy can be clinically applied to GBC prevention and treatment.

关键词： Gallbladder cancer MicroRNA Aberrations Tumor suppressor gene Oncogene Biomarker Therapy

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Expression profile of cholecystokinin type-A receptor in gallbladder cancer and gallstone disease

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Hepatobiliary & Pancreatic Diseases International 2011年第4期10卷 408-414页

作者： rajani rai Mallika Tewari Mohan Kumar Tej Bali Singh Hari S Shukla Department of Surgical Oncology the Institute of Medical SciencesBanaras Hindu UniversityVaranasi 221005 (UP)India Department of Pathology the Institute of Medical SciencesBanaras Hindu UniversityVaranasi 221005 (UP)India Department of Community Medicine the Institute of Medical SciencesBanaras Hindu UniversityVaranasi 221005 (UP)India

BACKGROUND:Regulatory peptide receptors have attracted the interest of oncologists as a new promising approach for cancer pathology,imaging and *** cholecystokinin (CCK) is a potent modulator of gallbladder contractility and plays a potential role in pancreatic carcinogenesis through CCK type-A receptor (CCKAR),its role in gallbladder cancer (GBC) is still unknown and immunohistochemical detection of CCKAR in the gallbladder has not yet been *** novel case-control study aimed to investigate the expression profile of CCKAR in GBC and gallstone disease (GSD).METHODS:This study included 162 samples of gallbladder:94 from GBC and 68 from *** of CCKAR was analyzed by immunohistochemistry and *** results were statistically correlated with disease history including age,sex,presence of gallstone,stage and ***:CCKAR was positive in 30/68 (44.1%) of GSD and 72/94 (76.6%) of GBC ***-one of the 72 (70.8%) CCKAR-positive GBC samples showed ***,consistent results also appeared in the immunoblotting ***:CCKAR expression was significantly increased in GBC compared to ***,CCKAR expression was associated with the degree of tumor differentiation,i.e.,less expression in poorly-differentiated ***,it has future prognostic and therapeutic implications in the management of GBC.

关键词： cholecystokinin cholecystokinin type-A receptor gallbladder cancer gallstone disease

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Reconfiguration of PV Arrays(T-C-T,B-L,H-C)Considering Wiring Resistance

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CSEE Journal of Power and Energy Systems 2022年第5期8卷 1408-1416页

作者： Kandipati rajani Tejavathu Rame Electrical and Electronics Engineering Department National Institute of Technology Andhra PradeshWest Godavari-534101India

Partial shadings on the photovoltaic(PV)array causes reduction in maximum power *** of PV arrays plays an important role in increasing the maximum power generation from PV array configurations under partial *** general,partial shadings on the PV arrays are concentrated on a group of ***,the distribution of shading over the array increases the maximum power *** paper uses a modified Sudoku pattern to increase the maximum power generation from the PV array *** PV array configurations are analyzed by considering column wiring resistance and cross ties *** modified Sudoku pattern is applied to Total-Cross-Tied(T-C-T),Bridge-Link(B-L)and Honey-Comb(H-C)configurations and their performances are analyzed under various shading patterns,such as short narrow,short wide,long narrow,long wide,middle and *** specifications,such as Global Maximum Power(GMP),Mismatch losses,Fill Factor,Efficiency are considered to see the efficacy of various PV array configurations and their *** the results,it can be concluded that reconfigured T-C-T PV array generates the highest GMP compared to other configurations under considered shading patterns.

关键词： Bridge-link efficiency fill factor global maximum power honey-comb photovoltaic array reconfiguration Sudoku Total-Cross-Tied

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OKRA (HIBISCUS ESCULENTUS) AND FENUGREEK (TRIGONELLA FOENUM GRACEUM) MUCILAGE:CHARACTERIZATION AND APPLICATION AS FLOCCULANTS FOR TEXTILE EFFLUENT TREATMENTS

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Chinese Journal of Polymer Science 2008年第6期26卷 679-687页

作者： rajani Srinivasan Anuradha Mishra Blackland Research and Extension Centre Texas A&M University System720East Blackland RoadTempleTX76502USA Department of Chemistry University Institute of Engineering and TechnologyCSJM UniversityKanpur-208 024India

The use of new food grade polysaccharides (mucilage) obtained from Hibiscus esculentus and Trigonella foenum graceum,commonly called Okra and Fenugreek,respectively,as flocculants was *** polysaccharides were used for removal of solids (suspended solids (SS) and total dissolved solids (TDS)) and dyes from real textile effluents and aqueous solutions of different class of synthetic *** of varying polysaccharide concentration,contact time and pH on removal of pollutant from the textile...

关键词： Fenugreek Okra Natural polysaccharides Flocculation Wastewater treatment Textile effluent Bridging Hibiscus esculentus Trigonella foenum graceum.

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Maximum Power Enhancement Under Partial Shadings Using a Modified Sudoku Reconfiguration

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CSEE Journal of Power and Energy Systems 2021年第6期7卷 1187-1201页

作者： Kandipati rajani Tejavathu Ramesh the Electrical Engineering Department National Institute of Technology Andhra PradeshWest Godavari-534101India

Partial shading is one of the important factors in reducing maximum power generation from PV(Photovoltaic)*** power generation can be improved by selecting a PV array through a Total-Cross-Tied(T-C-T)***,maximum power generated from T-C-T can still be improved by distribution of shading over various *** to distribution of shading,the current entering the node increases and results in improved maximum power *** can be done effectively by using Sudoku reconfiguration *** techniques are economical,since they don’t require any sensors and switching *** technique only changes the physical location of the PV panel but the electrical connection between the panels remains the *** paper proposes a Modified Sudoku reconfiguration pattern which enhances the maximum power from the T-C-T connected PV ***,the theoretical calculation of row current and power output have been done for existing and proposed topologies under various shading *** performance of the proposed pattern has been analyzed and compared using specifications,such as Global Maximum Power(GMP),Fill Factor(FF),mismatch losses,and *** the results,it can be concluded that the Modified Sudoku reconfiguration enhances the GMP under all shading conditions.

关键词： Efficiency fill factor global maximum power point mismatch losses partial shadings PV array reconfiguration shading patterns sudoku and total-cross-tied

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Bile acids and their effects on diabetes

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Frontiers of Medicine 2018年第6期12卷 608-623页

作者： Cynthia rajani Wei Jia University of Hawaii Cancer Center HonoluluHI 96813USA Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai 200233China

Diabetes is a widespread, rapidly increasing metabolic disease that is driven by hyperglycemia. Early glycemic control is of primary importance to avoid vascular complications including development of retinal disorders leading to blindness, end-stage renal disease, and accelerated atherosclerosis with a higher risk of myocardial infarction, stroke and limb amputations. Even after hyperglycemia has been brought under control, “metabolic memory,” a cluster of irreversible metabolic changes that allow diabetes to progress, may persist depending on the duration of hyperglycemia. Manipulation of bile acid (BA) receptors and the BA pool have been shown to be useful in establishing glycemic control in diabetes due to their ability to regulate energy metabolism by binding and activating nuclear transcription factors such as farnesoid X receptor (FXR) in liver and intestine as well as the G-protein coupled receptor, TGR5, in enteroendocrine cells and pancreatic β-cells. The downstream targets of BA activated FXR, FGF15/21, are also important for glucose/insulin homeostasis. In this review we will discuss the effect of BAs on glucose and lipid metabolism and explore recent research on establishing glycemic control in diabetes through the manipulation of BAs and their receptors in the liver, intestine and pancreas, alteration of the enterohepatic circulation, bariatric surgery and alignment of circadian rhythms.

关键词： bile acids metabolic memory diabetes circadian rhythm bariatric surgery

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A Novel Triple-tied-cross-linked PV Array Configuration with Reduced Number of Cross-ties to Extract Maximum Power Under Partial Shading Conditions

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CSEE Journal of Power and Energy Systems 2021年第3期7卷 567-581页

作者： Tejavathu Ramesh Kandipati rajani Anup Kumar Panda Department of Electrical Engineering National Institute of Technology RourkelaIndia Department of Electrical and Electronics Engineering National Institute of Technology Andhra PradeshIndia

Partial shadings cause output power reduction from Photovoltaic(PV)arrays due to mismatch *** selection of PV array configurations play a vital role in maximum power *** paper proposes a novel Triple-Tied-Cross-Linked(T-T-C-L)configuration to extract maximum power with a lesser number of cross ties than a Total-Cross-Tied(T-C-T)*** performance of the proposed T-T-C-L configuration has been compared with various conventional PV array configurations,such as Series(S),Parallel(P),Series-Parallel(S-P),Bridge-Link(B-L),Honey-Comb(H-C),and T-C-T under Partial Shading Conditions(PSCs)by considering the 9×9 PV *** PSCs considered are uneven row,column,diagonal,random,short&narrow,short&wide,long&narrow,long&wide shadings and uniform half module *** measures,such as open circuit voltage,short circuit current,maximum power,voltages and currents at maximum power,mismatch losses,fill factor and efficiency have been used for performance analysis of various *** the results,it can be concluded that the performance of the proposed T-T-C-L configuration is optimal compared to other configurations.

关键词： Efficiency fill factor maximum power point mismatch losses partial shading conditions PV array configurations triple-tied-cross-linked

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Latitudinal fluctuation in global concentration of CO2 and CH4 from shortwave infrared spectral observation by GOSAT during COVID-19

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International Journal of Digital Earth 2021年第12期14卷 1882-1896页

作者： Laxmi Kant Sharma rajani Kant Verma Department of Environmental Science School of Earth SciencesCentral University of RajasthanAjmerIndia

Various countries have rapidly implemented strict actions to slow the blowout of *** events were dis-regarded,and anthropogenic activities such as industrial and transport systems were at a *** countries were on lockdown,including the largest emitters of carbon *** to these lockdowns,anthropogenic activities have been reduced and reported that air quality improves at a regional scale in many countries,including ***,the current study using Greenhouse Gases Observing Satellite(GOSAT/IBUKI)datasets to monitor the fluctuation of the average global concentration of dry mole fractions of atmospheric Methane(CH_(4))and Carbon Dioxide(CO_(2))during these pandemic lockdowns from January to June *** emphasize no significant reduction in the average concentration of dry mole fractions of atmospheric CH_(4) over the globe,but a minor reduction was observed in global CO_(2) *** average concentration of both gases compares at each ten-degree *** study reveals that,against the regional breakdowns,these short time lockdowns are not enough to control the concentration of these greenhouse gases at a larger scale,such as 10°latitude and globally,except for a minor reduction in CO_(2) concentration.

关键词： Lockdown pandemic air quality greenhouse gas methane carbon dioxide

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Implications of multipurpose tree leaf application on wheat productivity in dry tropics

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Journal of Forestry Research 2013年第4期24卷 777-782页

作者： rajani Srivastava K.P.Singh Department of Botany Banaras Hindu University

Leaves of multipurpose tree species （those providing more than one function or product of human use） can serve as sources of fer- tilizer for nutrient supply, especially nitrogen （N）. In this study chopped leaves of tropical tree species （5 N-fixing species, 5 non-N-fixing species and combinations of 5 N-fixing with a non-N-fixing species） were in- corporated in soil to evaluate its effects on wheat biological productivity （including grain yield, GyIELD） under dryland conditions. High quality leaves of N-fixing tree species （e.g. Dalbergia sissoo, Cassia fistula and Prosopis cineraria） had lower carbon/nitrogen （C/N）, lignin/nitrogen （L^o/N）, polyphenol/nitrogen （PPt/N） and lignin＋polyphenol /nitrogen （L~＋PpL/N） ratios than low quality leaves of non-N-fixing species. Com- bination treatments had intermediate values of different parameters, Application of high quality leaves caused greater increases in wheat productivity and yield than other species.

关键词： multipurpose tree leaves chemical quality index grain yield,N-fixing species non-N fixing species Dryland agriculture

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PLANTAGO PSYLLIUM-GRAFTED-POLYACRYLONITRILE:SYNTHESIS,CHARACTERIZATION AND ITS USE FOR SOLID REMOVAL FROM SEWAGE WASTEWATER

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Chinese Journal of Polymer Science 2005年第1期23卷 113-118页

作者： Anuradha Mishra Alpa Yadav Monika Agarwal rajani Srinivasan Department of Chemistry Institute of Engineering and Technology.CSJM UniversityKanpur-208 024IndiaDepartment of ChemistryInstitute of Engineering and Technology.CSJM UniversityKanpur-208 024IndiaDepartment of ChemistryInstitute of Engineering and Technology.CSJM UniversityKanpur-208 024India

Plantago psyllium mucilage(PSY),an anionic natural polysaccharide consisting of pentosan and uronic acidobtained from the seeds of Plantago psyllium(Plantago family),was grafted with acrylonitrile(AN).Graft copolymers wereprepared by ceric ion initiated solution polymerization technique and were characterized by FT-IR spectroscopy,scanningelectron microscopy and differential scanning *** copolymers are good flocculating agents for removal ofsuspended(SS)and total dissolved solid(TDS)in sewage wastewater *** effects of copolymer dose,pH andcontact time on flocculation capacity of one selected copolymer sample were studied by jar test *** suitable pHrange for maximum solid removal was 7.0 to 9.2 and the optimum copolymer dose was 1.2 mg/*** overall process forsolid removal took 4 h.X-ray diffraction(XRD)patterns of grafted copolymer,PSY grafted polyacrylonitrile(PSY-g-PAN)and solid waste,before and after treatment are used to suggest the interaction of the solid waste with PSY-g-PAN copolymer.

关键词： Plantago psyllium-g-polyacrylonitrile(PSY-g-PAN) Flocculant X-ray Jar test Sewage wastewater.

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