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Neuroscience Bulletin 2024年第8期40卷 1093-1103页

作者： Yue Qiu Le Xie Xiaohui Wang Kai Xu Xue Bai sen Chen Yu Sun Department of Otorhinolaryngology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Otolaryngology Nanchang UniversityNanchang 330006China

GJB2 gene mutations are the most common causes of autosomal recessive non-syndromic hereditary *** individuals suffering from severe to profound GJB2-related deafness,cochlear implants have emerged as the sole remedy for auditory *** previous studies have highlighted the crucial role of preserving cochlear neural components in achieving favorable outcomes after cochlear ***,we generated a conditional knockout mouse model(Cx26-CKO)in which Cx26 was completely deleted in the cochlear supporting cells driven by the Sox2 *** Cx26-CKO mice showed severe hearing loss and massive loss of hair cells and Deiter’s cells,which represented the extreme form of human deafness caused by GJB2 gene *** addition,multiple pathological changes in the peripheral auditory nervous system were found,including abnormal innervation,demyelination,and degeneration of spiral ganglion neurons as well as disruption of heminodes in Cx26-CKO *** findings provide invaluable insights into the deafness mechanism and the treatment for severe deafness in Cx26-null mice.

关键词： Spiral ganglion neurons Gjb2 Heminode Hearing loss

An LSTM-based approach to detect transition to lean blowout in swirl-stabilized dump combustion systems

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Energy and AI 2024年第2期16卷 32-41页

作者： Tryambak Gangopadhyay Somnath De Qisai Liu Achintya Mukhopadhyay Swarnendu sen Soumik Sarkar Amazon Web Services AmazonSanta ClaraCAUSA Department of Aerospace Engineering Indian Institute of Technology MadrasChennaiIndia Department of Mechanical Engineering Iowa State UniversityAmesIAUSA Department of Mechanical Engineering Jadavpur UniversityKolkataIndia

Lean combustion is environment friendly with low NO_(x)emissions providing better fuel efficiency in a combustion ***,approaching towards lean combustion can make engines more susceptible to an undesirable phenomenon called lean blowout(LBO)that can cause flame extinction leading to sudden loss of *** the design stage,it is quite challenging for the scientists to accurately determine the optimal operating limits to avoid sudden LBO ***,it is crucial to develop accurate and computationally tractable frameworks for online LBO prediction in low NO_(x)emission *** the best of our knowledge,for the first time,we propose a deep learning approach to detect the transition to LBO in combustion *** this work,we utilize a laboratory-scale swirl-stabilized combustor to collect acoustic data for different *** each protocol,starting far from LBO,we gradually move towards the LBO regime,capturing a quasi-static time series dataset at different *** one of the protocols in our dataset as the reference protocol,we find a transition state metric for our trained deep learning model to detect the imminent LBO in other test *** find that our proposed approach is more precise and computationally faster than other baseline models to detect the transition to ***,we endorse this technique for monitoring the operation of lean combustion engines in real time.

关键词： Deep learning LSTM Detection of lean blowout Transition to LBO Confusion matrix

Microstructure and Mechanical Property of the Large Cross-Sectioned Mg-Gd-Y-Zn-Zr Alloy Produced by Small Extrusion Ratio

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Acta Metallurgica Sinica(English Letters) 2024年第6期37卷 999-1006页

作者： sen Wang Hucheng Pan Caixia Jiang Zhihao Zeng Zhen Pan Weineng Tang Chubin Yang Yuping Ren Gaowu Qin Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) College of Materials Science and EngineeringNortheastern UniversityShenyang110819China Mg and Mg Alloy Institute Technology CenterBaosteel Metal Co.LtdChina Baowu Steel GroupShanghai200940China Jiangxi Provincial Engineering Research Center for Magnesium Alloy Gannan Normal UniversityGanzhou341000China

In this work,the microstructure and mechanical properties of large cross-sectioned Mg-9Gd-3Y-1.2Zn-0.5Zr(VWZ931)samples produced by the small extrusion ratio has been *** as-extruded VWZ931 sample with diameter of~30 mm can exhibit the high yield strength(YS)of 339 MPa,ultimate tensile strength(UTS)of 387 MPa and elongation of 8.2%,*** peak-aged,the YS and UTS of the Mg samples were significantly increased to 435 MPa and 467 *** small extrusion ratio leads to the low fraction of dynamic recrystallized(DRX)grains in VWZ931 sample,and the texture hardening effect can be fully utilized to achieve high *** combined effect of precipitation strengthening due to the long-period stacking ordered phases and theβ′phase,grain boundary strengthening due to the fine DRX grains,heterogeneous deformation-induced strengthening caused by bimodal microstructure,can together contribute to the high strength of present Mg *** findings can shed light on designing other large-sized Mg wrought alloys with high mechanical performance.

关键词： Mg-RE alloy Mechanical property Bimodal grains Texture hardening

Microstructure and water-swelling mechanism of red-bed mudstone in the Xining region,Northeastern Tibetan Plateau

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2537-2551页

作者： Huan Guan Yong Ren Sixiang Ling Xiyong Wu Tao Yu Xian Li sen Wang Chunwei Sun School of Civil Engineering Southwest Jiaotong UniversityChengdu610031China Faculty of Geosciences and Engineering Southwest Jiaotong UniversityChengdu611756China Moe Key Laboratory of High-speed Railway Engineering Southwest Jiaotong UniversityChengdu610031China Guangzhou Metro Design and Research Institute Co Ltd. Guangzhou510010China Chengdu City Construction Investment Group Co Ltd. Chengdu610036China

This paper examines the effect of the microstructure and electrical conductivity(EC)on the swelling ratio and pressure in red-bed mudstone sampled from arid areas in the Xining region in the northeastern Tibetan Plateau.A series of laboratory tests,including swelling experiments,X-ray diffraction(XRD),and scanning electron microscope(SEM),was carried out for mechanical and microstructural *** coupled influence of the EC and microstructural parameters on the expansion ratio and pressure was investigated,and the weight coefficients were discussed by the entropy weight *** results revealed an increasing exponential trend in EC,and the maximum swelling speed occurred at an EC of approximately 10 μS/*** addition,a method for predicting the expansion potential is proposed based on the microstructure,and its reliability is verified by comparing with swelling experimental *** addition,according to the image analysis results,the ranges of the change in the clay minerals content(CMC),the fractal dimension(FD),the average diameter(AD)of pores,and the plane porosity(PP)are 23.75%-53%,1.08-1.17,7.53-22.45 mm,and 0.62%-1.25%,***,mudstone swelling is negatively correlated with the plane porosity,fractal dimension and average diameter and is linearly correlated with the clay mineral ***,the weight values prove that the microstructural characteristics,including FD,AD,and PP,are the main factors influencing the expansion properties of red-bed mudstones in the Xining *** on the combination of macro and micro-analyses,a quantitative analysis of the swelling process of mudstones can provide a better reference for understanding the mechanism of expansion behavior.

关键词： Mudstones Microstructure Swelling characteristics Electrical conductivity(EC) Scanning electron microscope Water-swelling

Universal and efficient hybrid modeling and direct slicing method for additive manufacturing processes

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Advances in Manufacturing 2024年第2期12卷 300-316页

作者： sen-Lin Wang Li-Chao Zhang Chao Cai Ming-Kai Tang Si Chen Jiang Huang Yu-Sheng Shi State Key Laboratory of Materials Processing and Die and Mould Technology Huazhong University of Science and TechnologyWuhan430074People’s Republic of China School of Machinery and Automation Wuhan University of Science and TechnologyWuhan430081People’s Republic of China

Model design and slicing contour generation in additive manufacturing(AM)data processing face challenges in terms of efficiency and scalability when stereolithography files generated by complex functionally graded structures have millions of *** paper proposes a hybrid modeling and direct slicing method for AM to efficiently construct and handle complex three-dimensional(3D)*** 3D solids,including conformal multigradient structures,were uniformly described using a small amount of data via signed distance *** hybrid representations were quickly discretized into numerous disordered directed lines using an improved marching squares *** establishing a directional HashMap to construct the topological relationship between lines,a connecting algorithm with linear time complexity is proposed to generate slicing contours for *** method replaces the mesh reconstruction and Boolean operation stages and can efficiently construct complex conformal gradient models of arbitrary topologies through hybrid ***,the time and memory consumption of direct slicing are much lower than those of previous methods when handling hybrid models with hundreds of millions of faces after mesh reconstruction.

关键词： Additive manufacturing(AM) Hybrid modeling Direct slicing Signed distance field

Dynamic gut microbiome-metabolome in cationic bovine serum albumin induced experimental immune-complex glomerulonephritis and effect of losartan and mycophenolate mofetil on microbiota modulation

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Journal of Pharmaceutical Analysis 2024年第4期14卷 562-577页

作者： Wenying Shi Zhaojun Li Weida Wang Xikun Liu Haijie Wu Xiaoguang Chen Xunrong Zhou sen Zhang State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100050China State Key Laboratory of Functions and Applications of Medicinal Plants College of PharmacyGuizhou Provincial Engineering Technology Research Center for Chemical Drug R&DGuizhou Medical UniversityGuiyang550004China Department of Medicine Solna Center for Molecular MedicineKarolinska University Hospital and Karolinska InstituteStockholm17176Sweden Department of Pharmacy The Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550001China

Dynamic changes in gut dysbiosis and metabolomic dysregulation are associated with immune-complex glomerulonephritis(ICGN).However,an in-depth study on this topic is currently ***,we report an ICGN model to address this *** was induced via the intravenous injection of cationized bovine serum albumin(c-BSA)into Sprague-Dawley(SD)rats for two weeks,after which mycophenolate mofetil(MMF)and losartan were administered *** and six weeks after ICGN establishment,fecal samples were collected and 16S ribosomal DNA(rDNA)sequencing and untargeted metabolomic were *** microbiota transplantation(FMT)was conducted to determine whether gut normali-zation caused by MMF and losartan contributed to their renal protective effects.A gradual decline in microbial diversity and richness was accompanied by a loss of renal *** 18 genera were found to have significantly different relative abundances between the early and later stages,and Marvinbryantia and Allobaculum were markedly upregulated in both *** metabolomics indicated that the tryptophan metabolism was enhanced in ICGN,characterized by the overproduction of indole and kynurenic acid,while the serotonin pathway was *** of losartan and MMF ameliorated microbial dysbiosis and reduced the accumulation of indoxyl conjugates in *** using feces from animals administered MMF and losartan improved gut dysbiosis by decreasing the Firmicutes/Bacteroidetes(F/B)ratio but did not improve renal *** findings indicate that ICGN induces serous gut dysbiosis,wherein an altered tryptophan metabolism may contribute to its *** and losartan significantly reversed the gut microbial and metabolomic dysbiosis,which partially contributed to their renoprotective effects.

关键词： Immune-complex glomerulonephritis Gut microbiome Metabolomics Fecal microbiota transplant Tryptophan metabolism

Mechanical responses of anchoring structure under triaxial cyclic loading

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 545-560页

作者： Peng Wang Nong Zhang Qun Wei Xingliang Xu Guangzhen Cui Aoran Li sen Yang Jiaguang Kan State Key Laboratory of Coal Resources and Safe Mining School of MinesChina University of Mining and TechnologyXuzhou221116China School of Civil Engineering Xuzhou University of TechnologyXuzhou221116China School of Mechanical Engineering Jiangsu University of TechnologyChangzhou213001China

Dynamic load on anchoring structures(AS)within deep roadways can result in cumulative damage and *** study develops an experimental device designed to test AS under triaxial *** device enables the investigation of the mechanical response,failure mode,instability assessment criteria,and anchorage effect of AS subjected to combined cyclic dynamic-static triaxial stress *** results show that the peak bearing strength is positively correlated with the anchoring matrix strength,anchorage length,and edgewise compressive *** bearing capacity decreases significantly when the anchorage direction is severely *** free face failure modes are typically transverse cracking,concave fracturing,V-shaped slipping and detachment,and spallation ***,when the anchoring matrix strength and the anchorage length decrease while the edgewise compressive strength,loading rate,and anchorage inclination angle increase,the failure intensity *** is determined by a negative tangent modulus of the displacement-strength curve or the continued deformation increase against the general downward *** cyclic loads,the driving force that breaks the rock mass along the normal vector and the rigidity of the AS are the two factors that determine roadway ***,a control measure for surrounding rock stability is proposed to reduce the internal driving force via a pressure relief method and improve the rigidity of the AS by full-length anchorage and grouting modification.

关键词： Triaxial stress Dynamic-static combination load Cyclic loading Anchoring structure(AS) Cumulative damage

Adhesion strength of tetrahydrofuran hydrates is dictated by substrate stiffness

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Petroleum Science 2024年第1期21卷 667-673页

作者： Yan-Wen Lin Tong Li Yi Zhang Wei-Wei Yan Xiao-Ming Chen Zhi-sen Zhang Jian-Yang Wu Department of Physics Research Institute for Biomimetics and Soft MatterJiujiang Research Institute and Fujian Provincial Key Laboratory for Soft Functional Materials ResearchXiamen UniversityXiamen361005FujianChina Key Laboratory of Marine Materials and Related Technologies Zhejiang Key Laboratory of Marine Materials and Protective TechnologiesNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo315201ZhejiangChina Key Laboratory of Icing and Anti/De-icing China Aerodynamics Research and Development CenterMianyang621000SichuanChina Micro-and Nano-technology Research Center State Key Laboratory for Manufacturing Systems EngineeringXi’an Jiaotong UniversityXi’an710049ShaanxiChina Electronic Materials Research Lab Key Laboratory of the Ministry of EducationXi’an Jiaotong UniversityXi’an710049ShaanxiChina NTNU Nanomechanical Lab Norwegian University of Science and Technology(NTNU)Trondheim7491Norway

Understanding the hydrate adhesion is important to tackling hydrate accretion in ***,the relationship between the Tetrahydrofuran(THF)hydrate adhesion strength(AS)and surface stiffness on elastic coatings is systemically examined by experimental shear force measurements and theoretical *** mechanical factor-elastic modulus of the coatings greatly dictates the hydrate AS,which is explained by the adhesion mechanics theory,beyond the usual factors such as wettability and structural ***,the hydrate AS increases with reducing the thickness of the elastic coatings,resulted from the decrease of the apparent surface elastic *** effect of critical thickness for the elastic materials with variable elastic modulus on the hydrate AS is also *** study provides deep perspectives on the regulation of the hydrate AS by the elastic modulus of elastic materials,which is of significance to design anti-hydrate surfaces for mitigation of hydrate accretion in petro-pipelines.

关键词： Hydrate Adhesion strength Elastic modulus Coatings

Ginsenoside Rg3 Promotes the Survival and Migration of Trophoblast Cells in a Rat Model of Gestational Hypertension by Regulating miR-100a/Insulin Growth Factor-2 Axis

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 65-74页

作者： Xiu-Mei Fan Li Yang Gang Zhao sen-Ye Huo Yan Gao Department of Obstetrics Xingtai Third HospitalXingtaiChina Department of Obstetrics Xingtai Maternal and Child Health Care HospitalXingtaiChina

Objective:Preeclampsia(PE)is a common complication during ***-100a is expressed in the placenta and regulates the survival and development of placental *** growth factor-2(IGF-2)may serve as its downstream *** study investigated the protective mechanisms of ginsenoside Rg3 against PE in rat *** and Methods:LPS-induced rat PE models were suitable for intravenous administration of the highly expressed miR-100a ginsenoside Rg3 lentiviral *** trophoblasts were cultured in vitro for JEG-3,and PE cell models were *** vivo effects on tumor growth and apoptosis were *** Rg3 was treated with different concentrations of shRNA,miR-100a analogs,inhibitors,or *** and the expression of autophagy-related proteins were *** activity and migration were determined using Cell Counting Kit-8 and Transwell *** drugs strongly inhibited trophoblasts under normal conditions with some synergy between ***-luciferase return assay confirmed the binding affinity of miR-100a for ***:In response to Rg3,autophagy and the expression of autophagy-related proteins LC3-I/II,Beclin1,and SQSTM1 were reduced in PE rat placental ***3 inhibited autophagy in JEG-3 cells and promoted JEG-3 survival and migration in a concentration-dependent ***-100a upregulated PE *** results suggested that autophagy was a vital signaling ***3 intervention inhibited miR-100a expression and miR-100a downregulated IGF-2 expression in placental tissues and promoted autophagy,thereby inhibiting JEG-3cell survival and *** rats,Rg3 inhibited PE development by regulating the activity of the miR-100a-IGF-2 signaling ***:Ginsenoside Rg3 positively regulates the miR-100a-IGF-2 axis and protects PE rats by inhibiting trophoblastic autophagy and promoting trophoblastic cell survival and migration.

关键词： Ginsenoside Rg3 inflammatory response miR-100a/insulin growth factor-2 axis preeclampsia pregnancy-induced hypertension

{1012}twin–twin intersection-induced lattice rotation and dynamic recrystallization in Mg–6Al–3Sn–2Zn alloy

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Journal of Magnesium and Alloys 2024年第4期12卷 1529-1539页

作者： Bin-Jiang Lv sen Wang Fu-Hao Gao Ning Cui Yi-Nan Li Tie-Wei Xu Feng Guo School of Mechanical and Automotive Engineering Qingdao University of Technology266520China Key Lab of industrial Fluid Energy Conservation and Pollution Control Qingdao University of Technology266520China

This study investigated the formation mechanism of new grains due to twin–twin intersections in a coarse-grained Mg–6Al–3Sn–2Zn alloy during different strain rates of an isothermal *** results of electron backscattered diffraction investigations showed that the activated twins were primarily{1012}tension twins,and 60°boundaries formed due to twin–twin intersections under different strain *** twin variants with 60°boundaries transformed into new grains through lattice rotations at a low strain rate(0.01 s^(−1)).At a high strain rate(10 s^(−1)),the regions surrounded by subgrain boundaries through high-density dislocation arrangement and the 60°boundaries transformed into new grains via dynamic recrystallization.

关键词： Mg alloy Twin-twin intersection Lattice rotation Dynamic recrystallization