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Psychosocial Experience of Parents of Children, Adolescents and Young Adults with Type 1 Diabetes in Brazzaville

Health 2022年第6期14卷 617-628页

作者： Nestor Ghislain Andzouana Mbamognoua Rockiath Adou Osseni Farel Elilie Mawa Ongoth raissa laure mayanda ohouna Evariste Bouenizabila Aymande Okoumou Moko Henri Germain Monabeka Department of Metabolic and Endocrine Diseases Brazzaville University Hospital Brazzaville Republic of Congo Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of Congo

Type 1 diabetes is one of the main chronics pathologies in children. Efficient care requires a good knowledge of the disease by the parents, and an exploration of psychosocial experience of the parents, who are on the front lines of the support. Objectives: Assess the impact of parents’ level of knowledge, from their psychosocial experience and from the quality of life on the glycemic control of children, adolescents and young adults with type 1 (DT1) diabetes in Brazzaville. Patients and Methods: This was an analytical cross-sectional study with prospective data collection during 7 months at Brazzaville University Hospital CHU, involving 103 parents. We studied socio-demographic variables, the balance of children’s diabetes by glycated hemoglobin, parents’ knowledge of diabetes by questionnaire “Michigan Diabetes Research and Training Center’s Revised Diabetes Knowledge Test”. The assessment of anxiety and depression through the “Hospital Anxiety and Depression” (HAD) score. Parental stress was assessed by the “Pediatric Inventory for Parents” (PIP). Results: We reported certain anxiety symptomatology in 60 parents (58.3%). Certain depression was reported in 63 parents (61.2%), and a lesser degree of parental distress. These psychosocial disorders in the parents did not influence the glycemic balance of the children. Low socio-economic level of the family (p = 0.001), poor knowledge about diabetes (p = 0.046) and poorer quality of life (p Conclusion: Psychosocial disorders were well observed in parents of DT1 children.

关键词： Knowledge Quality of Life Psychosocial Experience Parents Type 1 Diabetes

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Hyperhomocysteinemia: Risk Factors and Faster Onset of Degenerative Complications of Type 2 Diabetes in Brazzaville

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Journal of Diabetes Mellitus 2023年第3期13卷 257-267页

作者： Ikia Monde Valsy Russelh Evariste Bouenizabila Farel Elilie Mawa Ongoth raissa laure mayanda ohouna Aymande Okoumou-Moko Paulin Kibeke Ghislain Loubano-Voumbi Luc Magloire Boumba Anicet Wilson Fabrice Ondongo Mayindou Kimbangu Archimède Gotran Tienelle Freiss Mabiala Wann Koumou Onanga Thierry Raoul Ngombea Benjamin Longo Mbenza Edouard Ngou Milama Christian Andres Etienne Mokondjimobe Henri Germain Monabeka Biochemistry Laboratory Department University Hospital Center Brazzaville Republic of the Congo Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of the Congo Department of Metabolic and Endocrine Diseases University Hospital Brazzaville Republic of the Congo Pointe-Noire Research Area National Institute for Research in Health Sciences Pointe-Noire Republic of the Congo Department of Statistics Health Information and Epidemiological Surveillance Departmental Directorate of Health Care and Services Brazzaville Republic of the Congo Department of Public Health LOMO Research University Kinshasa Democratic Republic of the Congo Faculty of Medicine University of Health Sciences Libreville Gabon Department of Biochemistry and Molecular Biology Tours Regional University Hospital Tours France

Background: Type 2 diabetes (T2D) remains a major global public health problem. This complex metabolic disorder can lead to various complications, including cardiovascular diseases (leading cause of death) in T2D. Among the biochemical markers associated with increased risk for cardiovascular disease, homocysteine is currently one of the predictive markers under evaluation. We investigate the link between hyperhomocysteinemia and diabetes complications in DT2 population in Brazzaville. Methodology: We conducted a cross-sectional analytical study, from October to December 2022. One hundred and fifty participants were included, 100 patients T2D (34 with complications, 33 with comorbidities, 33 without), and 50 patients controls. Sociodemographic and clinical characteristics were collected. Homocysteine (Hcy) serum levels were measured using Sandwich ELISA method. Results: Study population was composed of 50% males and 50% females with sex ratio of 1;mean age was 52.2 ± 10.8 years (30 - 83). The prevalence of hyperhomocysteinemia (HHcy) was 36% (20% moderate Hcy, 15% intermediate and 1% severe). Mean Hcy concentration was 31.9 μmol/l (18 - 103). Age, gender and physical inactivity were strongly correlated to Hcy (OR of 3.5;9.4 and 3 respectively). Multivariate analysis showed that HHcy was a risk accelerator for degenerative complications (stroke: OR = 6.2;ischemic heart disease: 4.9;neuropathy: 9.2;retinopathy: 4.5 and peripheral arterial disease: 4.9). Conclusion: These findings suggest that hyperhomocysteinemia can be considered as a predictive marker to be taken into account in targeting cardiovascular risk in Congolese subjects with T2D.

关键词： Hyperhomocysteinemia Patients with T2D Risk Factor Acceleration Factor Degenerative Complications Congo

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Factors Associated with Mortality in Diabetic Patients with End-Stage Renal Failure Starting Emergency Hemodialysis

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Open Journal of Nephrology 2024年第1期14卷 17-24页

作者： Gaël Honal Mahoungou Daniel Tony Eyeni Sinomono Farel Elilié Mawa Ongoth Éric Ngandzali-Ngabé Nestor Andzouana raissa laure mayanda Aymande Okoumou-Moko Francky Ambounou Précieux Ngoma Berline Ndinga Héléna Botokoto Bothard Hardy Ibovi Richard Loumingou Department of Nephrology University Hospital of Brazzaville Brazzaville Congo Faculty of Health Sciences University Marien Ngouabi Brazzaville Congo Department of Metabolic Diseases University Hospital of Brazzaville Brazzaville Congo

Background: Diabetic nephropathy is the leading cause of end-stage chronic kidney disease with poor prognosis in resource-limited settings. This study aimed to determine factors associated with mortality in patients starting dialysis treatment for end-stage chronic renal disease in an emergency context. Patients and Methods: This was a retrospective study from January 2020 to December 2022 at CHU-B. Data from 79 diabetic patients requiring emergency dialysis were compared with those of 79 non-diabetic patients with an end-stage renal disease requiring emergency dialysis. Data were collected from the Nephrology Department registry. We studied their initial clinical and biological profiles and factors related to mortality. Results: Out of 545 compiled records, 79 diabetic chronic kidney disease patients needing dialysis were included (group 1). A control group of 79 non-diabetic chronic kidney disease patients requiring emergency dialysis was also included (group 2). The average age of patients was 53.5 ± 17 years, and the duration of diabetes at dialysis initiation was 14.8 ± 4.3 years. Twenty-three percent were hypertensive. Fifty-two percent of patients experienced intra-dialytic hypotension. Death occurred in 22% of patients. Results show that age (adjusted OR 1.955;CI: 1.025 - 1.086;p-value: Conclusion: Emergency dialysis in diabetics is associated with unfavorable outcomes in terms of mortality. Despite follow-up, renal involvement remains poorly explored, emphasizing the need for physician awareness.

关键词： Diabetic Nephropathy Emergency Dialysis Republic of the Congo

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Hyperhomocysteinemia: Risk Factors and Faster Onset of Degenerative Complications of Type 2 Diabetes in Brazzaville

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Journal of Diabetes Mellitus（糖尿病） 2023年第3期

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Factors Associated with Mortality in Diabetic Patients with End-Stage Renal Failure Starting Emergency Hemodialysis

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Open Journal of Nephrology（肾脏病） 2024年第1期 17页

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