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Open Journal of Rheumatology and Autoimmune Diseases 2014年第4期4卷 207-211页

作者： Zavier Zomalheto raimi kpossou Anthelme Agbodande Jean-Paul Larbre Rheumatology Hospital Unit of National Hospital University Cotonou Benin

Aim: We report a rare case of gastric linitis plastica revealed by vertebral metastases without another digestive dissemination. Case presentation: The Benin native woman was hospitalized in rheumatology for inflammatory back pain without another signs. Rx ray showed vertebra metastasis. In the etiologic research, gastroscopy showed an infiltrating lesion of the antral area, indicating gastric linitis which was confirmed by biopsy. Short and medium-term evolution was favourable, characterized by a complete disappearance of the pains and a good physical condition. Conclusion: Vertebral metastases can reveal digestive cancer, although human gut is not among the most bone metastatic cancers.

关键词： Vertebral Metastasis Gastric Linitis Plastica Metastasis Gastric Cancer

Frequency and Etiology of Viral Arthropathies in West African Patients

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Open Journal of Rheumatology and Autoimmune Diseases 2017年第1期7卷 96-101页

作者： Zavier Zomalheto raimi kpossou Michée Assogba Anthelme K. Agbodande Marcelle Gounongbé Department of Rheumatology in the National Hospital University “Hubert Koutoukou Maga” of Cotonou Cotonou Benin Hepato-Gastroenterology Department in the National Hospital University “Hubert Maga Koutoukou” of Cotonou Cotonou Benin Department of Peadiatric of the National Hospital University “Hubert Maga Koutoukou” of Cotonou Cotonou Benin Department of Internal Medicine of the National Hospital University “Hubert Maga Koutoukou” of Cotonou Cotonou Benin

Aim: To determine the frequency and etiology of viral arthritis in West African patients at the National Hospital University Hubert Koutoukou Maga of Cotonou. Patients and Methods: It was a cross-sectional descriptive study carried out from January 2010 to July 2014 on patients received in rheumatology, hepato-gastroenterology, pediatric and internal medicine units. The selected patients had viral arthropathy. The diagnosis of viral arthritis was based on the presence of arthralgia or arthritis in the context of a viral infection. Patients with insufficiently explored records were excluded. Results: Among 4361 patients consulted, 49 (1.12%) had a viral arthropathy. The mean age of the patients was 49.13 ± 17.1 [15 - 68] years. The sex ratio was 0.58 (31 F/18 H). 38 patients were from Benin, 5 from Nigeria, 3 from Togo, 2 from Mali and 1 from Cote d’Ivoire. Joint symptoms were dominated by polyarthritis (n = 24 cases) and polyarthrlagias (n = 18 cases). Extra-articular signs present were dominated by fever (100%), skin signs (n = 37 cases), flu symptoms (n = 23 cases) and liver disorder (n = 19 cases). Viruses diagnosed were dominated by hepatitis B (n = 17), varicella-zona (n = 8) and HIV (n = 14). Conclusion: Viral arthropathy diagnosis is relatively common in West African patients especially with the HIV. This occurs as arthralgias or arthritis. The diagnosis is difficult in our working condition.

关键词： Arthropathy Viruses Hepatitis B HIV Africa

Effectiveness and Safety of Tenofovir Disoproxil Fumarate in Patients Treated for Hepatitis B in the National University Hospital of Cotonou

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Open Journal of Gastroenterology 2018年第6期8卷 213-222页

作者： Jean Sehonou Aboudou raimi kpossou Samuel Guido Comlan N’dehougbea Martin Sokpon Koffi Rodolph Vignon Jacques Vigan Department of Gastroenterology and Hepatology National University Hospital Center-Hubert Koutoukou Maga(CNHU-HKM)of CotonouCotonouBenin Department of Nephrology-Hemodialysis CNHU-HKM of CotonouCotonouBenin

Introduction: Viral hepatitis B (VHB) is a serious and global public health issue, particularly in sub-Saharan Africa where it is endemic. The objective of this work was to evaluate the effectiveness and safety of tenofovir disoproxil fumarate (TDF) in the treatment of chronic VHB in Cotonou. Methods: This was a descriptive cross-sectional study with a retrospective collection of data from January 1st, 2015 to December 31st, 2016 (24 months) and prospective from May to August 2017 (4 months). Chronic VHB patients treated with TDF for at least 6 months were included. The non-detectability of HBV DNA and the normalization of aminotransferases defined the virological and biochemical responses, respectively. The evaluation of the treatment response on liver fibrosis was done by using APRI score. Renal impairment was assessed by a reduction in glomerular filtration rate according to MDRD (Modifications of the Diet in Renal Disease) formula below 90 mL/min/1.73 m2. Results: In all, 42 patients treated with TDF were included. The average age was 46.7 ± 13.8 years. The study population was predominantly male with a sex ratio of 2.5. Among the 42 patients treated with TDF for an average of 60 weeks (24 to 96 weeks), 36 patients (85.7%) had a virological response;21 patients (50%) had a biochemical response. Virologic response was 70% at week 24 (W24), 92.6% at W48, 87.5% at W72 and 100% at W96 without significant difference between W24 and W48;between W48 and W72 then between W72 and W96. There was a regression of fibrosis and cirrhosis but not significantly. Renal involvement occurred in 3 out of 19 cases (15.8%) including a case of chronic end stage renal failure and 2 cases of mild chronic renal failure. Conclusion: The treatment with TDF is effective and globally safe in our patients with chronic viral hepatitis B in Cotonou.

关键词： Chronic Viral Hepatitis B Tenofovir Efficacy Safety Cotonou

Functional Constipation in the General Population in Cotonou:Prevalence and Associated Socio-Demographic Factors

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Open Journal of Gastroenterology 2018年第9期8卷 306-316页

作者： Jean Sehonou Aboudou raimi kpossou Comlan N’dehougbea Martin Sokpon Hugues Cataria Colette Azandjeme Koffi Rodolph Vignon Department of Gastroenterology and Hepatology National University Hospital Center-Hubert Koutoukou Maga(CNHU-HKM)CotonouBenin Regional Institute of Public Health(IRSP) OuidahBenin

Background: Constipation is considered rare in sub-Saharan Africa because of the high fiber content of the local diet. However, certain factors could intervene in this pathology. The purpose of this study was to assess the prevalence of constipation in the general population in Cotonou and to determine the associated socio-demographic factors. Methods: This was a cross-sectional descriptive and analytical study conducted from July to August 2017 in 7 districts of the township of Cotonou, according to a cluster sampling. We included anyone over the age of 15 living in the city of Cotonou for at least 6 months. Constipation was either self-reported or functional (meeting the Rome IV criteria). Results: A total of 1058 participants were included: 574 men (sex ratio of 1.2), mean age of 29 years [range 15 - 92]. Self-reported constipation was noted in 512 patients (48.5%). It was functional in 256 cases (24.2%). In the latter category, there was a predominance of women (138, 53.9%), of secondary education (46.5%), of self-employed professionals (50.4%), from the Ouémé-Plateau (41.8%). Were associated with the occurrence of functional constipation (univariate analysis), age ≥ 60 years (p = 0.049), female gender (p = 0.003), and subjects living alone (166, 64.8%) vs. those living in a relationship (90, 35.2%, p = 0.001). Conclusion: Constipation was not as rare in Cotonou. It was more common in women, subjects over 60 years old or living alone.

关键词： Constipation General Population Prevalence Associated Factors Cotonou

Treatment of Hepatitis C with Pegylated Interferon Alpha-2a and Ribavirin:Experience from Benin

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Open Journal of Gastroenterology 2018年第8期8卷 275-283页

作者： Aboudou raimi kpossou Jean Séhonou Gbénagnon Micael Geraud Adjigbe Rodolph Koffi Vignon Khadidjatou Sake Alassan Nicolas Kodjoh Department of Gastroenterology and Hepatology National University Hospital Center-Hubert Koutoukou Maga(CNHU-HKM)CotonouBenin Internal Medicine Unit University and Departmental Hospital of Borgou-AliboriParakouBenin Clinic Les Archanges Seme KpodjiBenin

Background: Viral hepatitis C (HCV) is common in Benin. Untreated, it can be complicated by cirrhosis and hepatocarcinoma, which are sources of death. The objectives of this work were twofold: 1) to evaluate the effectiveness and safety of treatment with classic dual interferon pegylated alpha-2a (IFN) and ribavirin therapy in Benin, and 2) to present problems related to financial accessibility to this treatment. Methods: This was a cross-sectional, descriptive and analytical study, with a retrospective collection of data from November 1, 2010 to December 31, 2015 and prospective collection from January 1, 2016 to July 31, 2016 (7 months). We included all patients treated with IFN + ribavirin for hepatitis C at CNHU/HKM. Sustained virological response (SVR) was defined as undetectable viral load C 6 months after stopping treatment. Safety was appreciated by the search for clinical and hematological adverse effects. Results: One hundred and six patients were followed for HCV, of whom 58 (54.7%) undergoing treatment (26 under standard dual therapy and 32 under direct-acting antivirals). Of the 26 patients under-conventional dual therapy, 12 (46.1%) were genotype 1, 13 (50%) genotype 2 and one (3.9%) genotype 4. In conventional dual therapy, SVR was achieved in 15 (57.7%) patients, including the genotype 4 patient, 4 out of 12 (33.3%) genotype 1 patients, and 10 out of 13 (76.9%) for genotype 2 patients. The most common side effects with this treatment were severe asthenia (23 cases), flu-like symptoms (22 cases), weight loss (21 cases) and neutropenia (22 cases), anemia and thrombocytopenia (20 of 26 cases). The overall cost of treatment per patient was 11,800,624 FCFA for genotypes 1 and 4;and 7,835,048 FCFA for genotype 2. Conclusion: The treatment of HCV with IFN + ribavirin in Benin is effective for genotype 2. But its adverse effects are manifold and its cost is high. The switch to direct-acting antivirals (more effective, better tolerated and less expensive) was

关键词： Hepatitis C Pegylated Interferon Alpha-2a Ribavirin Effectiveness Safety Cost

Haemorrhoidal Disease in Cotonou: Epidemiological, Clinical and Anuscopic Aspects

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Open Journal of Gastroenterology 2015年第7期5卷 77-82页

作者： Jean Sehonou Finangnon Armand Wanvoegbe Aboudou raimi kpossou Kouessi Anthelme Agbodande Roméo Dah-Bolinon Angèle Azon-Kouanou Marcel Zannou Fabien Houngbe Unit of Internal Medicine in the National Teaching Hospital“HKM” CotonouBenin Internal Medicine Unit Departmental Hospital of Oueme Plateau of Porto-NovoPorto-NovoBenin Unit of Hepato-Gastroenterology of the Hospital Menontin CotonouBenin

The haemorrhoidal disease is a very common disorder in proctology. It is favoured by many factors. Although benign, its treatment is difficult. Our aim is to study the epidemiological, clinical and anuscopic of haemorrhoidal disease. This was a cross sectional, descriptive and prospective study covering a three-month period from 06 January 2014 to 10 April 2014. It involved patients seen in gastroenterology consultation in internal medicine of the National Teaching Hospital of Cotonou and in the digestive diseases Unit of the Hospital of Menontin. We recorded 182 patients including 57 cases of haemorrhoidal disease, a prevalence of 31.3%. The sex ratio was 1.10. The average age was 43 years with extremes of 18 and 88 years. Anal events were dominated by rectal bleeding (54.4%) with a predominance of internal haemorrhoidal disease (87.7%). Stage 2 evolution of the disease was the most represented (65.4%). Haemorrhoidal disease is a common disorder seen mainly in actively producing people (young adult) with a male predominance.

关键词： Haemorrhoidal Disease Anal Event Cotonou

Contribution to the Study of Irritable Bowel Syndrome in Medical Students at the University of Parakou in Republic of Benin

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Open Journal of Gastroenterology 2023年第7期13卷 256-266页

作者： Khadidjatou Saké Aboudou raimi kpossou Adébayo Cossi Alassani Doriane Berline Magatsing Nzekou Serge Ade Angelo Cossi Attinsounon Comlan Albert Dovonou Stéphane Kofi-Mensa Savi de Tovè Jean Sehonou Department of Medicine and Medical Specialties Faculty of Medicine University of Parakou Parakou Republic of Benin Department of Medicine and Medical Specialties Faculty of Medicine University of Abomey-Calavi Abomey-Calavi Republic of Benin

Introduction: Irritable bowel syndrome is the most common functional gastrointestinal disorder. The objective of this work is to contribute to improving the medical follow-up of medical students at the University of Parakou through a study of irritable bowel syndrome. Study Methods: This was a descriptive and analytical cross-sectional study with prospective data collection. Data were collected from medical students from May 2018 to July 2018 using a pre-established questionnaire. Sampling was probabilistic using a two-stage survey. The diagnostic tools were: Rome IV criteria, Bristol scale and HAD (hospital anxiety and depression) scale. Data analysis was performed using Epi Info 7.***.3.14 software. CDC. Results: Thirty-two (7.55%) of the 424 students included had irritable bowel syndrome. Out of the 32 students with IBS, 24 (75%) were female. Their average age was 21.38 ± 2.39 years. For 24 students (75%), the symptoms occurred at the same time as exam preparation or the intense course period. Of the 32 students with IBS, 1 (3.12%) was regularly physically active. In this series, 8 students (28%) consulted a doctor for their symptoms. The factors associated with this syndrome were female sex (p = 0.022), sleep disorders (p = 0.008) and the presence of a doubtful depression (p = 0.021). Absenteeism due to irritable bowel syndrome was noted in 18 (56.25%) students. Conclusion: Irritable bowel syndrome is a common condition among medical students in Parakou. Support for better management of psychological disorders could improve the quality of life of these students.

关键词： Irritable Bowel Syndrome Medical Students Parakou Republic of Benin

Clinical and Etiological Profile of Ascites in the Departmental University Hospital of Porto-Novo

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Open Journal of Gastroenterology 2017年第7期7卷 197-205页

作者： Jean Sehonou Finangnon Armand Wanvoegbe Aboudou raimi kpossou Kouessi Anthelme Agbodande Josiane Dossou Angelo Attinsounon Adebayo Alassani Angèle Azon-Kouanou Albert Dovonou Marcel Zannou Fabien Houngbe Hepato-Gastroenterology Department HKM University HospitalCotonouBenin Internal Medicine Department Departmental University HospitalPorto-NovoBenin Internal Medicine Department HKM University HospitalCotonouBenin

Aim: To determine the frequency, the clinical and etiological aspects of ascites in the Internal Medicine Division of the University Hospital of Porto-Novo. Methods: It was a cross-sectional study with a descriptive focus covering the period from January 16 to August 31, 2015. It covered patients hospitalized for ascites in Internal Medicine Department at the Departmental University Hospital of Porto-Novo during the study period. Data were collected on a survey sheet and entered by Excel and analyzed with SPSS. The Chisquare test was used for statistical analysis and a significance threshold of 5% was retained. Results: Of the 511 hospitalized patients during the study period, 61 (11.9%) had ascites. The mean age was 49.6 ± 13.6 years with extremes of 19 years and 80 years. There was a male predominance with a sex ratio of 2.05. Ascites were often type III (34 patients, 55.7%), or type II (22 patients, 36.1%). The frequent signs were hepatomegaly (65.6%), splenomegaly (45.9%), pelvic limb edema (44.3%), and abdominal collateral venous circulation (39.3%). The macroscopic appearance of the ascites fluid was dominated by citrin yellow (82%), followed by hazy (11.5%). The hematic appearance was found in 6.5% of the cases. Hepatic cirrhosis was the most frequent etiology (34.4%) followed by overall heart failure (21.0%). Hepatocellular carcinoma was found in 16% of cases and nephrotic syndrome in 10% of cases. Conclusion: The etiological diversity of ascites, found in our study, imposes a careful clinical and paraclinical approach.

关键词： Ascites Etiology Porto-Novo Benin

Primary Duodenal Adenocarcinoma Revealed by Chronic Iron Deficiency Anemia:Diagnostic Difficulties in a Case Report in Internal Medicine CNHU HKM-COTONOU

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Open Journal of Internal Medicine 2015年第4期5卷 92-95页

作者： Angèle Azon-Kouanou Djimon Marcel Zannou Aboudou raimi kpossou Kouessi Anthelme Agbodande Roberto Dossou Torès Kouassi Prudencio Jean Sehonou Gaspard Gbessi Freddy Gnangnon Gabriel Ade Fabien Houngbe Internal Medicine and Medical Oncology Department National Teaching Hospital(NTH)Hubert Koudougou Maga(HKM)CotonouBenin Hepato-Gastroenterology Department National Teaching Hospital(NTH)Hubert Koudougou Maga(HKM)CotonouBenin Visceral surgery Department National Teaching Hospital(NTH)Hubert Koudougou Maga(HKM)CotonouBenin

The location of a primary duodenal adenocarcinoma is exceptional. Only few cases have been reported in the literature. We hereby report a case of primary adenocarcinoma of the duodenum with a 60 years old patient admitted because of chronic iron deficiency anemia. Endoscopic examination revealed a budding and ulcerated process in the second duodenum. The biopsy analysis showed primary adenocarcinoma. No other primary tumor was found. The staging directed showed cephalic pancreatic invasion. The patient died in the aftermath of a surgical management.

关键词： Chronic Iron Deficit Adenocarcinoma Duodenum Benin

Hepatitis D in Patients Infected with Hepatitis B Virus in Cotonou:Characteristics and Risk Factors

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Open Journal of Gastroenterology 2020年第2期10卷 31-44页

作者： Aboudou raimi kpossou Frédéric Sogbo Alexandra Marilyn Oloukèmi Zomahoun Khadidjatou Sake Alassan Rodolph Koffi Vignon Comlan N’déhougbèa Martin Sokpon Fadel Sourokou Jean Séhonou Nicolas Kodjoh Dissou Affolabi Faculty of Health Sciences University of Abomey-Calavi(UAC)Abomey-CalaviBenin National and University Hospital Hubert Koutoukou Maga(CNHU-HKM) CotonouBenin Department of Internal Medicine University and Departmental Hospital of BorgouParakouBenin International Clinic of Cotonou Aupiais CotonouBenin National Hepatitis Control Program Ministry of HealthCotonouBenin

Introduction: Hepatitis D virus (HDV) is a satellite virus of hepatitis B virus (HBV). The purpose of this work was to describe the epidemiological, clinical and biological characteristics of HBV/HDV co-infection and the factors associated with this co-infection in Cotonou. Methods: This was a cross-sectional, descriptive study with prospective data collection. It took place from June to October 2016 at CNHU/HKM and the Atinkanmey Polyclinic in Cotonou. Subjects over 15 years of age with HBsAg and untreated for hepatitis were included consecutively. Sociodemographic, clinical and biological characteristics were collected for each patient using only a standardized questionnaire. Then, a blood sample was taken for the determination of anti-HDV antibodies as well as the viral load of HBV. Results: A total of 156 subjects were included, predominantly male (sex-ratio = 2), and of median age 36 years. The majority were monogamous married (50%) or single (41.7%), and were from south of Benin (84.6%). Most subjects were asymptomatic (49.4%). The prevalence of total HDV antibodies was 3.9% (6/156). In subjects with total HDV antibodies, the prevalence of HDV IgM was 33.3%. Origin in northern Benin appears to be a risk factor for HDV infection (p = 0.042). Similarly, married subjects were statistically more infected with HDV than unmarried subjects (p = 0.002). Conclusion: The prevalence of HDV infection varies according to the origin of the patients and their marital status.

关键词： Viral Hepatitis B Viral Hepatitis D Prevalence Associated Factors