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Chinese Journal of Natural Medicines 2017年第4期15卷 271-280页

作者： Saba Khanam Ambreen Fatima rahul smita jyoti Fahad Ali Falaq Naz Barkha Shakya Yasir Hasan Siddique Drosophila Transgenic Laboratory Section of GeneticsDepartment of ZoologyFaculty of Life SciencesAligarh Muslim UniversityAligarhUttar Pradesh 202002India

Capsaicin(trans-8-methyl-N-vanillyl-6-nonenamide) is the main component in hot peppers, including red chili peppers, alapenos, and habanero, belonging to the genus Capsicum. Capsaicin is a potent antioxidant that interferes with free radical activities. In the present study, the possible protective effect of capsaicin was studied against methyl methanesulphonate(MMS) induced toxicity in third instar larvae of transgenic Drosophila melanogaster(hsp70-lacZ)Bg^9. The third instar was allowed to feed on the diet having different doses of capsaicin and MMS separately and in combination. The results suggested that the exposure of third instar larvae to the diet having MMS alone showed significant hsp70 expression as well as tissue DNA and oxidative damage, whereas the larvae feed on the diet having MMS and capsaicin showed a decrease in the toxic effects for 48-h of exposure. In conclusion, capsaicin showed a dose-dependent decrease in the toxic effects induced by MMS in the third instar larvae of transgenic Drosophila melanogaster.

关键词： Capsaicin Methyl methanesulphonate Drosophila melanogaster Toxicity

Protective effect of Genistein against N-nitrosodiethylamine(NDEA)-induced hepatotoxicity in Swiss albino rats

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Journal of Pharmaceutical Analysis 2015年第1期5卷 51-57页

作者： Fahad Ali rahul Falaq Naz smita jyoti Yasir Hasan Siddique Section of Genetics Department of ZoologyFaculty of Life SciencesAligarh Muslim UniversityAligarhUttar Pradesh 202002India

In the present study,we studied the effect of Genistein against the hepatotoxicity induced by N-nitrosodiethylamine（NDEA）.NDEA is present in almost all kinds of food stuff and has been reported to be a *** male rats were exposed to NDEA（0.1 mg/mL） dissolved in drinking water separately and along with 25,50,100 mg/mL of Genistein for 21 *** activities of serum glutamic oxaloacetic transaminase（SGOT）,serum glutamic pyruvic transaminase（SGPT）.alkaline phosphatase（ALP） and lactate dehydrogenase（LDH） were measured in blood *** peroxidation,protein carbonyl content,micronucleus frequency and DNA damage（Comet assay） were performed on rat *** results of the study reveal that the treatment of NDEA along with Genistein showed a significant dose-dependent decrease in the levels of blood serum enzymes i.e.,SGOT,SGPT,ALP and LDH（P〈0.05）.The HE staining of histological sections of the liver also revealed a protective effect of Genistein.A significant dose-dependent reduction in the lipid peroxidation and protein carbonyl content was observed in rats exposed to NDEA（0.1 mg/mL） along with Genistein（P〈0.05）.The results obtained for the comet assay in rat hepatocytes showed a significant dose-dependent decrease in the mean tail length（P〈0.05）.Thus the present study supports the hepatoprotective role of Genistein.

关键词： Genistein N-nitrosodiethylamine Serum enzymes Antigenotoxic Hepatoprotective

Role of Ocimum sanctum leaf extract on dietary supplementation in the transgenic Drosophila model of Parkinson's disease

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Chinese Journal of Natural Medicines 2014年第10期12卷 777-781页

作者： Yasir Hasan Siddique Mohammad Faisal Falaq Naz smita jyoti rahul Drosophila Transgenic Laboratory Section of GeneticsDepartment of ZoologyFaculty of Life SciencesAligarh Muslim UniversityAligarhUttar PradeshIndia Forest Entomology Division Forest Research InstituteDehradun

AIM: To evaluate the effect of Ocimum sanctum leaf extract on the dietary supplementation in the transgenic Drosophila model of Parkinson's disease. METHOD: The effect of Ocimum sanctum leaf extract was studied on the transgenic Drosophila model of flies expressing normal human alpha synuclein(h-αs) in the neurons. O. sanctum extract at final concentrations of 0.042 8 × 10-4, 0.87 × 10-4, and 1.85 × 10-4 g·mL-1 of diet were established and the flies were allowed to feed for 21 days. The climbing assay and lipid peroxidation were taken as parameters for the study. RESULTS: The supplementation of O. sanctum extract showed a dose-dependent significant delay in the loss of climbing ability and reduction in oxidative stress in the brain of PD model flies. CONCLUSION: The results of the present study showed that the O. sanctum extract is potent in reducing the PD symptoms in transgenic Drosophila model.

关键词： Ocimum sanctum Parkinson's disease Drosophila model Climbing assay Lipid peroxidation

在不大不小的事物中寻找灵感孟买IronMan公寓

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室内设计与装修 2023年第6期 100-105页

作者： [印度]Lavanya Chopra smita Thomas rahul Naidu Rachita Murthy Ishita Sitwal(摄影) 秋落(编译) 不详 Multitude of Sins(MOS)

孟买被亲切地称为“梦想之城”。这座城市为居住在它怀抱中的人们播下了灵感的种子,无论他们停留的时间是长是短,这里都为他们敞开怀抱。这座城市和MOS很有缘,我们的第一个项目就在孟买完成。对于这座城市,我有着一种怀旧和似曾相识的... 详细信息

孟买被亲切地称为“梦想之城”。这座城市为居住在它怀抱中的人们播下了灵感的种子,无论他们停留的时间是长是短,这里都为他们敞开怀抱。这座城市和MOS很有缘,我们的第一个项目就在孟买完成。对于这座城市,我有着一种怀旧和似曾相识的感情。虽然“钢铁侠”(IronMan)的名字会把将人们的注意力推向漫威的电影,但我们依然觉得,用一个简单而有趣的名字去定义一个住宅很有必要。

关键词：孟买注意力似曾相识灵感

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罪恶之城班加罗尔Sin City办公室

室内设计与装修 2023年第6期 94-99页

作者： [印度]Lavanya Chopr smita Thomas Sachin Bhat rahul Naidu Basavaraj Ishita Sitwal(摄影) 许科(编译) 不详 Multitude of Sins(MOS)

总部位于班加罗尔的室内设计公司Multitude of Sins(MOS)的创始人兼首席设计师smita Thomas将自己的好奇心与兴趣表达在自家办公室的改造上。墙上的骷髅,穿着苏格兰短裙的忍者,还有带着“Slinky”气息的龙……这个称之为“罪恶之城”的... 详细信息

总部位于班加罗尔的室内设计公司Multitude of Sins(MOS)的创始人兼首席设计师smita Thomas将自己的好奇心与兴趣表达在自家办公室的改造上。墙上的骷髅,穿着苏格兰短裙的忍者,还有带着“Slinky”气息的龙……这个称之为“罪恶之城”的办公室确实新奇。“这间办公室的一切让你感到毛骨悚然吗?不,没有什么能让你感到害怕。”

关键词：班加罗尔首席设计师办公室苏格兰短裙好奇心