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Synthesis of 5-benzylidene-3-(3-fluoro-4-yl-morpholin-4-yl-phenylimino)-thiazolidin-4-one derivatives catalyzed by [BmIm] OH and their anti-microbial activity

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Chinese Chemical Letters 2011年第8期22卷 883-886页

作者： Sudhakar G.Patil rahul r.bagul Mangesh S.Swami Nandini Kotharkar Kalpana Darade Organic Chemistry research Laboratory Maharashtra Udaygiri MahavidyalayUdgir 413517MaharashtraIndia G.H.raisoni Institute Interdisciplinary Sciences Wagholi Pune 411 001India

A series of novel 5-benzylidene-3-（3-fluoro-4-yl-morpholin-4-yl-phenylimino）thiazolidin-4-one derivatives were synthesized using[bmIm]OH as a catalyst and were tested for their antibacterial and antifungal *** compo... 详细信息

关键词： Basic ionic liquid [bmIm] OH Antimicrobials Anti-bacterial Anti-fungal Iminothizolidin-4-onc

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Dynamic role of myofibroblasts in oral lesions

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World Journal of Clinical Oncology 2015年第6期6卷 264-271页

作者： Neeta bagul Anjali Ganjre SN Goryawala rahul Kathariya Shrikant Dusane Department of Oral Pathology and Microbiology Dr.D.Y Patil Dental College and HospitalDr.D.Y Patil VidyapeethPune 411018India Department of Dentistry GMERS Medical College Department of Periodontology and Oral Implantology Dr. D.Y Patil Dental College and HospitalDr.D.Y Patil VidyapeethPune 411018India Department of Oral and Maxillofacial Surgery Sinhgad Dental College and Hospital

Fibroblasts are the most abundant cellular components of connective tissue. They possess phenotypical heterogenicity and may be present in the form of smooth muscle cells or myofibroblasts(MFs). MFs are spindle-shaped cells with stress fibres and welldeveloped fibronexus,and they display α-smooth muscle actin immunohistochemically and smoothmuscle myofilaments ultrastructurally. MFs play a crucial role in physiological and pathological processes. Derived from various sources,they play pivotal roles not only by synthesizing and producing extracellular matrix components,such as other connective tissue cells,but also are involved in force production. In the tissue remodelling phase of wound closure,integrinmediated interactions between MFs and type I collagen result in scar tissue formation. The tumour stroma in oral cancer actively recruits various cell types into the tumour mass,where they act as different sources of MFs. This article reviews the importance of MFs and its role in pathological processes such as wound healing,odontogenic cysts and tumours,salivary gland tumours,oral preneoplasia,and oral squamous cell carcinoma. research oriented on blocking the transdifferentiation of fibroblasts into MFs can facilitate the development of noninvasive therapeutic strategies for the treatment of fibrosis and/or cancer.

关键词： Myofibroblasts Neoplasm Fibroblasts Precancerous lesions Carcinoma-associated fibroblasts Precancerous conditions

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