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Metabolic complications of hepatitis C virus infection

World Journal of Gastroenterology 2021年第13期27卷 1267-1282页

作者： rahul chaudhari Sherouk Fouda Ashik Sainu Joseph M Pappachan Department of Medicine Pennsylvania Hospital of the University of PennsylvaniaPennsylvaniaPA 19104United States School of Health and Biomedical Sciences RMIT UniversityMelbourne VIC 3000Australia Department of Gastroenterology and Hepatology Aster Oman HospitalAl GhubraMuscat OM 133Oman Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom

Hepatitis C virus(HCV) infection is a systemic disease that is implicated in multiple extrahepatic organ dysfunction contributing to its protean manifestations. HCV is associated with diverse extrahepatic disorders including atherosclerosis, glucose and lipid metabolic disturbances, alterations in the iron metabolic pathways, and lymphoproliferative diseases over and above the traditional liver manifestations of cirrhosis and hepatocellular carcinoma. The orchestration between HCV major proteins and the liver-muscle-adipose axis, poses a major burden on the global health of human body organs, if not adequately addressed. The close and inseparable associations between chronic HCV infection, metabolic disease, and cardiovascular disorders are specifically important considering the increasing prevalence of obesity and metabolic syndrome, and their economic burden to patients, the healthcare systems, and society. Cellular and molecular mechanisms governing the interplay of these organs and tissues in health and disease are therefore of significant interest. The coexistence of metabolic disorders and chronic hepatitis C infection also enhances the progression to liver fibrosis and hepatocellular carcinoma. The presence of metabolic disorders is believed to influence the chronicity and virulence of HCV leading to liver disease progression. This comprehensive review highlights current knowledge on the metabolic manifestations of hepatitis C and the potential pathways in which these metabolic changes can influence the natural history of the disease.

关键词： Chronic hepatitis C infection Insulin resistance Metabolic syndrome Cardiovascular diseases Fatty liver Diabetes mellitus

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Clinical implications of COVID-19 in patients with metabolicassociated fatty liver disease

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World Journal of Gastroenterology 2023年第3期29卷 487-502页

作者： Mohammad Sadiq Jeeyavudeen rahul chaudhari Joseph M Pappachan Sherouk Fouda Department of Endocrinology and Metabolism University Hospitals of EdinburghEdinburgh EH42XUUnited Kingdom Department of Gastroenterology Hepatology and NutritionVirginia Commonwealth UniversityRichmondVA 23298United States Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom School of Health and Biomedical Sciences RMIT UniversityMelbourne VICAustralia

People across the world are affected by the"coronavirus disease 2019(COVID-19)",brought on by the"SARS-CoV type-2 coronavirus".Due to its high incidence in individuals with diabetes,metabolic syndrome,and metabolic-associated fatty liver disease(MAFLD),COVID-19 has gained much *** metabolic syndrome's hepatic manifestation,MAFLD,carries a significant risk of *** link between the above two conditions has also drawn increasing consideration since MAFLD is intricately linked to the obesity *** of the metabolic syndrome,MAFLD may impact the severity of the viral infections,including COVID-19 or may even be a risk *** important question is whether the present COVID-19 pandemic has been fueled by the obesity and MAFLD *** liver markers are seen elevated in *** patients with associated comorbid conditions like obesity,cardiovascular disease,renal disease,malignancy,hypertension,and old age are prone to develop severe *** is an urgent need for more studies to determine the link between the two conditions and whether it might account for racial differences in the mortality and morbidity rates linked to *** role of innate and adaptive immunity alterations in MAFLD patients may influence the severity of *** review investigates the implications of COVID-19 on liver injury and disease severity and *** also addressed the severity of COVID-19 in patients with prior MAFLD and its potential implications and therapeutic administration in the clinical setting.

关键词： Metabolic-associated fatty liver disease COVID-19 Metabolic syndrome Non-alcoholic steatohepatitis Angiotensin converting enzyme 2

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变形机参数对PET变形丝性能的影响

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国际纺织导报 2022年第2期50卷 7-8,12页

作者： R.Turukmane S.Patil R.chaudhari 陈晶晶(译) 于俊荣(校) NMIMS MPSTME纺织功能中心(印度) 不详

聚酯纤维的结构性能优异,应用范围广泛。其性能主要取决于纱线类型、纤维根数、线密度和形状等。受加工过程中热箱温度和D/Y比的影响,这些工艺参数决定了纤维的变形程度。选用27.8 tex/48 F的预取向丝作为基础原料,在拉伸变形机上按标... 详细信息

聚酯纤维的结构性能优异,应用范围广泛。其性能主要取决于纱线类型、纤维根数、线密度和形状等。受加工过程中热箱温度和D/Y比的影响,这些工艺参数决定了纤维的变形程度。选用27.8 tex/48 F的预取向丝作为基础原料,在拉伸变形机上按标准和调整后的参数进行变形加工处理。通过系列试验研究了变形机参数对纤维线密度、强度和细丝断裂-紧点的影响。研究发现,加捻和解捻的巨大差异导致紧点数量增加;此外,随着热箱温度升高,纤维强度和卷曲收缩率增加,沸水收缩率则降低。

关键词：聚酯纤维(PET) 拉伸变形丝(DTY) 热箱温度

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