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Safety analysis of Sormeh underground mine to improve sublevel stoping stability

Deep Underground Science and Engineering 2023年第2期2卷 173-187页

作者： Mostafa Hosseini Amin Azhari rahman lotfi Alireza Baghbanan Department of Mining Engineering Isfahan University of TechnologyIsfahanIran

In underground mines,sublevel stoping is used among a variety of different methods for mining an orebody,which creates large underground *** this case,the stability of these openings is affected by a number of factors,including the geometrical characteristics of the rock and mining-induced *** this study,a sensitivity analysis was conducted with the numerical,squat pillar,and Mathews stability methods using the Taguchi technique to properly understand the influence of geometric parameters and stress on stope stability according to Sormeh underground mine *** results show a full factorial analysis is more reliable since stope stability is a complex ***,the numerical results indicate that overburden stress has the most impact on stope stability,followed by stope ***,the results obtained with Mathews and squat pillar methods show that stope height has the greatest impact,followed by overburden stress and *** appears that these methods overestimate the impact of stope ***,it is highly recommended that Mathews and squat pillar methods should not be used in high stope that is divided with several sill ***,Mathews method cannot accurately predict how the sill pillar impacts the stope *** addition,numerical analysis shows that all geometric parameters affect the roof safety factor,whereas the sill pillar has no significant influence on the safety factor of the hanging wall,which is primarily determined by the stope height–span ratio.

关键词： numerical method rib pillar stope stability sublevel stoping underground mining

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Simple and Efficient Synthesis of Novel Glycosyl Thiourea Derivatives Derived from Thiophene as Potential Antitumor Agents

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Journal of Chemistry and Chemical Engineering 2011年第1期5卷 73-81页

作者： Mohammed Mohsen Babatin lotfi Khezami Abdel-rahman Barakat Ahmed EI-Gazzar Department of Mathematics and Chemistry Faculty of Science Al-lmam Muhammad bin Saud Islamic University Riyadh 11623Kingdom of Saudi Arabia

The practical synthesis of pseudonucleosides incorporating thiourea derivative by coupling of monosaccharides (D-glucose and D-galactose) per-O-acetylated glycosyl isothiocyanates and different heterocyclic hydrazide derivatives is reported. The method involves the preparation of per-O-acetylated glycosyl isothiocyanates from per-O-acetylated sugars (two-step synthesis), which couple with heterocyclic hydrazides from amines to give thiourea-linked pseudonucleosides. All newly synthesized pseudo-nucleosides were assayed against human lung cancer-cell lines (PG) and human liver cancer-cell lines (BEL-7402) in vitro. The 6,6-dimethyl-benzothiophen-3-carbo-hydrazide-4-one pseudonucleosides showed moderate inhibition against these two cancer-cell lines with EC50 from 22.8 to 76.4 mM and from 54.9 to 82.4 mM, respectively. And the other compounds did not demonstrate any significant cytotoxicity even at concentrations up to 200 mM.

关键词：糖基异硫氰酸酯硫脲衍生物合成抗癌药物人肝癌细胞株噻吩肼衍生物乙酰化

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