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Texosome-based drug delivery system for cancer therapy: from past to present

Cancer Biology & Medicine 2015年第3期12卷 150-162页

作者： Hamideh Mahmoodzadeh Hosseini raheleh halabian Mohsen Amin Abbas Ali Imani Fooladi Applied Microbiology Research Center Baqiyatallah University of Medical Sciences Department of Drug and Food Control Faculty of Pharmacy Tehran University of Medical Sciences

Rising worldwide cancer incidence and resistance to current anti-cancer drugs necessitate the need for new pharmaceutical compounds and drug delivery system. Malfunction of the immune system, particularly in the tumor microenvironment, causes tumor growth and enhances tumor progression. Thus, cancer immunotherapy can be an appropriate approach to provoke the systemic immune system to combat tumor expansion. Texosomesj which are endogenous nanovesicles released by all tumor cells, contribute to cell-cell communication and modify the phenotypic features of recipient cells due to the texosomes＇ ability to transport biological components. For this reason, texosome-based delivery system can be a valuable strategy for therapeutic purposes. To improve the pharmaceutical behavior of this system and to facilitate its use in medical applications, biotechnology approaches and mimetic techniques have been utilized. In this review, we present the development history oftexosome-based delivery systems and discuss the advantages and disadvantages of each system.

关键词： Cancer therapy texosome mimetic tumor microenvironment immunotherapy

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Ocular tuberculosis associated with Epstein-Barr virus myelitis: A case report

Infectious Medicine

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Infectious Medicine 2024年第3期3卷 73-77页

作者： Fakhri Alahyari raheleh halabian Javad Hosseini Nejad Neuroscience Research Center Baqiyatallah University of Medical SciencesTehran14359-44711Iran Applied Microbiology Research Center Systems Biology and Poisonings InstituteBaqiyatallah University of Medical SciencesTehran14359-44711Iran

Ocular tuberculosis(OTB)is a chronic eye infection caused by Mycobacterium *** cases of myelitis are associated with Epstein-Barr virus(EBV),with 1-5%of EBV infections leading to neurologic *** describe a 34-year-old Iranian woman with OTB and EBV *** initial success with anti-TB agents,the disease progressed,necessitating *** tuberculosis was detected by a tuberculin coagulation test,and EBV was confirmed via polymerase chain *** showed plaques in the spinal cord and *** patient was treated with anti-TB and antiretroviral *** TB in the differential diagnosis of EBV myelitis is crucial.

关键词： Epstein-Barr virus Mycobacterial infection Myelitis Ocular tuberculosis

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