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儿童哮喘的诊断和治疗：PRACTALL共识报告（续完）

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中华临床免疫和变态反应杂志 2009年第4期3卷 303-315页

作者： L.B.Bacharier A.Boner K.-h.Carlsen P.A.Eigenmann T.Frischer M.G(o)tz P.J.helms J.hunt A.Liu N.Papadopoulos T.Platts-Mills P.Pohunek F.E.R.Simons E.Valovirta U.Wahn J.Wildhaber 青曼丽 The European Pediatric Asthma Group 中国医学科学院北京协和医学院北京协和医院变态反应科

哮喘管理应该包括全面的治疗计划，包括避免气传变应原及刺激性诱因（如有可能），恰当的药物治疗及对患儿、家长和看护人员的哮喘教育。对有些患者，变应原特异性免疫治疗可能是有益的。

关键词：儿童哮喘治疗计划特异性免疫治疗气传变应原诊断药物治疗哮喘教育刺激性

Multi-UAV Cooperative hunting in Cluttered Environments Considering Downwash E®ects

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Guidance, Navigation and Control 2023年第1期3卷 61-84页

作者： Shichen Fan hugh h.-T.Liu Institute for Aerospace Studies University of Toronto 4925 Du®erin Street North YorkOntarioCanada M3H 5T6

This paper presents a novel solution to the three-dimensional (3D) cooperative hunting ofmultiple drones that deals with surrounding a target simultaneously while navigating aroundobstacles in the cluttered dynamic 3D environment. Meanwhile, drones avoid the air°owdownwash force created by the spinning propellers on unmanned aerial vehicles (UAVs) andtheir e®ect on the other UAVs. This solution consists of a 3D Simultaneous Encirclementstrategy, the cooperative hunting objective with a novel revised particle swarm optimization(PSO*) path planning algorithm, a °ocking theory-inspired obstacle avoidance algorithm, and acascade PI controller. Simulation results with varying conditions were carried out to validatethe e®ectiveness of the proposed solution by successfully taking care of the downwash e®ects,and having multiple hunter UAVs hunt and encircle a moving or stationary target in a dynamicor static obstacle-rich cluttered environment.

关键词： Cooperative hunting downwash e®ect UAS.

新研究确定了与肝病和脂肪代谢有关的肝细胞突变

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中西医结合肝病杂志 2021年第11期31卷 1011-1011页

作者： Stanley W. K. Ng Foad J. Rouhani Simon F. Brunner Natalia Brzozowska Federico Abascal Luiza Moore Lia Chappell Daniel Leongamornlert Aleksandra Ivovic Philip Robinson Timothy Butler Mathijs A. Sanders Nicholas Williams Tim h. h. Coorens Jon Teague Keiran Raine Adam P. Butler Yvette hooks Beverley Wilson Natalie birtchnell Michael R. Stratton Iñigo Martincorena raheleh Rahbari Peter J. Campbell Foad J. Rouhani & huw Naylor Sarah J. Aitken & Matthew hoare Sarah J. Aitken & Susan E. Davies Sarah J. Aitken Ming Yang Efterpi Nikitopoulou Christian Frezza Matthew hoare Cancer Genome Project Wellcome Sanger Institute Hinxton UK Department of hematology Erasmus University Medical Center Rotterdam The Netherlands Stem Cell Institute University of Cambridge Cambridge UK Department of Surgery Addenbrooke’s Hospital Cambridge UK CRUK Cambridge Institute Cambridge UK Department of Pathology Addenbrooke’s Hospital Cambridge UK MRC Toxicology Unit University of Cambridge Cambridge UK MRC Cancer Unit University of Cambridge Cambridge UK Department of Medicine University of Cambridge Addenbrooke’s Hospital Cambridge UK

一项来自英国韦尔科姆基金会桑格研究所和剑桥大学等研究机构的研究人员的新研究分析了来自34例患者肝脏样本的1590个基因组,包括健康对照、酒精相关肝病和非酒精性脂肪肝疾病患者的肝脏样本,结果发现ACVR2A、TNRC6B、NEAT1、FOXO1和GP... 详细信息

一项来自英国韦尔科姆基金会桑格研究所和剑桥大学等研究机构的研究人员的新研究分析了来自34例患者肝脏样本的1590个基因组,包括健康对照、酒精相关肝病和非酒精性脂肪肝疾病患者的肝脏样本,结果发现ACVR2A、TNRC6B、NEAT1、FOXO1和GPAM 五个基因在肝病患者的肝细胞中发生了突变,过程如图a所示。而其中的FOXO1、CIDEB、GPAM三个基因是对肝细胞如何代谢脂肪和对胰岛素作出反应有直接影响的基因。

关键词： FOXO1 肝病患者细胞突变肝细胞脂肪代谢胰岛素 GPA 剑桥大学

A history of high-power laser research and development in the United Kingdom

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high Power Laser Science and Engineering 2021年第2期9卷 41-126页

作者： Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.hall David C.hanna Wayne harris David I.hillier Christopher J.hooker Simon M.hooker Nicholas hopps Janet hull David hunt Dino A.Jaroszynski Mark Kempenaars helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff h.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem h.rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone AWE Aldermaston ReadingUK Oxford Centre for high Energy Density Science Department of PhysicsClarendon LaboratoryUniversity of OxfordOxfordUK Centre for Intertial Fusion Studies Blackett LaboratoryImperial College LondonLondonUK Formerly of Electrox LetchworthUK Formerly of Central Laser Facility Rutherford LaboratoryDidcotUK Formerly of Ferranti Defence Systems LincolnUK Leonardo EdinburghUK Retired AWEReadingUK Formerly of AWE ReadingUK Formerly of Laser Lines Ltd BanburyUK Formerly of Optilas Ltd Milton KeynesUK Retired Pro-Lite TechnologyCranfieldUK Specialised Imaging Ltd PitstoneUK Central Laser Facility STFC Rutherford Appleton LaboratoryDidcotUK Magna-Power Electronics Ltd ReadingUK DeBe Lasers Needham Laser TechnologiesWhitchurchUK Blackett Laboratory Imperial College LondonLondonUK SPIE Europe CardiffUK Professor Emeritus(Physics) University of HullKingston upon HullUK Kentech Instruments Ltd WallingfordUK Department of Physics Clarendon LaboratoryUniversity of OxfordOxfordUK Professor Emeritus Department of PhysicsUniversity of StrathclydeGlasgowUK Department of Physics Durham UniversityDurhamUK Professor Emeritus(Photonics) Heriot-Watt UniversityEdinburghUK Professor Emeritus University of SouthamptonSouthamptonUK Optical Surfaces Ltd KenleyUK JEh Lasers Ltd RugbyUK Scottish Universities Physics Alliance Department of PhysicsUniversity of StrathclydeGlasgowUK ITER Organization Saint-Paul-lez-DuranceFrance Manx Precision Optics Ltd BallasallaUK Laser Lines Ltd BanburyUK Elliot Scientific Ltd MetroTest Scientific GroupHarpendenUK Centre for Plasma Physics Queen’s University BelfastBelfastUK Retired Founderand former MDRofin-Sinar UK LtdHullUK heraeus Noblelight Ltd CambridgeUK Mirli Books ChelmsfordUK M Squared Lasers Ltd GlasgowUK University of hertfordshire HatfieldUK E&EO UK Ltd Barton-upon-HumberUK Department of Physics University of YorkYorkUK IC Optical Systems Ltd BeckenhamUK Laser Micromachining Ltd St AsaphUK MBDA UK Ltd Brist

The first demonstration of laser action in ruby was made in 1960 by *** of hughes Research Laboratories,*** laboratories worldwide began the search for lasers using different materials,operating at different *** the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of *** historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years.

关键词： high-power lasers history United Kingdom

动脉瘤性蛛网膜下腔出血处理指南美国心脏协会卒中委员会特别写作组给医疗专业人员的声明

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国际脑血管病杂志 2009年第4期17卷 248-278页

作者： Joshua B. Bederson E. Sander Connolly h. hunt Batjer Ralph G. Dacey Jacques E. Dion Michael N. Diringer John E. Duldner Robert E. harbaugh Aman B. Patel Robert h. Rosenwasser 高翔(译) 李洛(译) 李海峰(译) 不详青岛大学医学院附属医院神经内科 266003 青岛大学医学院附属医院神经外科 266003

蛛网膜下腔出血（subarachnoid hemorrhage，SAh）是一种常见病，常常导致严重后果，约占全部卒中病例的5％，在美国每年有多达3万人罹患该病。美国心脏协会（American heart Association，AhA）曾发表过“动脉瘤性SAh处理指南”。此后... 详细信息

蛛网膜下腔出血（subarachnoid hemorrhage，SAh）是一种常见病，常常导致严重后果，约占全部卒中病例的5％，在美国每年有多达3万人罹患该病。美国心脏协会（American heart Association，AhA）曾发表过“动脉瘤性SAh处理指南”。此后，在血管内技术、诊断方法以及手术和围手术期管理方面已取得了显著进展。尽管如此，SAh患者的预后依然较差，基于人群研究报告的病死率高达45％，并且存活者会遗留严重残疾。一些多中心前瞻性随机试验和前瞻性队列分析已对SAh的治疗方案产生影响。然而，

关键词：动脉瘤性SAh 蛛网膜下腔出血美国心脏协会出血处理医疗专业指南卒中 hemorrhage

对老年性黄斑变性患者佩戴棱镜后矫正作用进行判定的随机对照试验

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世界核心医学期刊文摘（眼科学分册） 2005年第12期1卷 23-24页

作者： Smith h.J Dickinson C.M Cacho I 王文军 Arthritis Research Centre Robert Jones and Agnes Hunt Orthopaedic Hospital Gobowen Nr Oswestry SY10 7AG United Kingdom.Dr

Objective: To determine the effectiveness of prism spectacles in people with age-related macular degeneration by relocating the retinal image. Methods: We implemented a randomized, placebo-controlled, double-masked trial. Participantswith agerelated macular degeneration received a standard low-vision assessment and the prescription of conventional low-vision aids 6 weeks before the study intervention. Participants were randomized to receive 1 of the following, including the optimal refractive correction: (1) custom, incorporating bilateral prisms to match participants’ preferred power and base direction; (2) standard, incorporating standard bilateral prisms (6 prism diopters Δ base up for logMAR [logarithm of the minimum angle of resolution]visual acuity (VA) of 0.48- 1.00 and 10Δ base up for logMAR VA of 1.02- 1.68); or (3) placebo, consisting of spectacles matched in weight and thickness to prism spectacles but without prism. Main Outcome Measures: Outcomes measured binocularly at baseline and 3- month follow-up included distance logMAR VA, reading speed, critical print size, visual functioning questionnaires, and observed visual task performance. Scores on the 25- item National Eye Institute Visual Functioning Questionnaire and the Melbourne Low-Vision ADL (Activities of Daily Living) Index were converted to linear estimates usingRasch analysis. The Manchester Low Vision Questionnaire was used to collect descriptive data. Results: A total of 225 participants completed the trial (median age, 81 years). We found no significant effect of treatment group on any of the outcome measures, includingVA, the primary outcome (adjusted for baseline) (P=.63). Participants’ responses to the Manchester Low Vision Questionnaire suggested that the prism spectacles added to their problems. Conclusions: Prism spectacles are no more effective than conventional spectacles for peoplewith age-relatedmacular degeneration.

关键词：老年性黄斑变性随机对照试验三棱镜屈光度低视力眼镜处方视功能矫正效果屈光矫正安慰剂对照双盲试验

抗菌药物实验治疗模型——III.开放性创伤感染模型和药物疗效的观察

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微生物学报 1964年第1期 113-118页

作者：刘文富黄雄阎桂华唐冀雪中国医学科学院药物研究所药理学系

研究药物的局部杭感染作用需要有合用的动物模型进行实验。曾有很多学者报导了用不同动物和不同感染方法的实验桔果。Morgenroth等、hunt、Grunberg等、Schnitzer,和刘文富等曾采用了小白鼠腹部皮内感染的方法,认为可用于测定药物的局... 详细信息

研究药物的局部杭感染作用需要有合用的动物模型进行实验。曾有很多学者报导了用不同动物和不同感染方法的实验桔果。Morgenroth等、hunt、Grunberg等、Schnitzer,和刘文富等曾采用了小白鼠腹部皮内感染的方法,认为可用于测定药物的局部抗感染作用和作用机制的研究。刘文富等在Selbie等的工作基础上用小白鼠后肢肌肉内感染的方法,观察药物的局部抗菌作用。hartmann用家兔皮内注入葡萄球菌和药物混悬液的方法观察了磺胺呲啶钠和磺胺噻唑的抗菌作用。Collier等建立了豚鼠皮内感

关键词：金黄色葡萄球菌大鼠药物疗效 III 金霉素氯四环素治疗模型杆菌抗菌药物伤口愈合菌数蛇床子油油膏炎症反应西林清洁处理开放性

伴面神经麻痹的Tolosa-hunt综合征患者的Mri表现

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世界核心医学期刊文摘（神经病学分册） 2006年第9期2卷 53-54页

作者： Kang h. Park K. - J. Son S. 袁海峰(译) 不详 Gyeongsang Institute of health Sciences Department of Neurology Gyeongsang National University College of Medicine 90 Chiram-dong Jinju 660-702South Koreat

A 44-year-old woman developed a severe right frontotemporal headache, retro-orbital pain, and, later, diplopia owing to right sixth nerve palsy. The brain Mri demonstrated strong enhancement of the right cavernous sinus. The sixth nerve palsy and headache improved with steroid therapy after 6 weeks. At that time, she suffered right peripheral facial nerve palsy. Enhancement of the distal canalicular and labyrinthic segment of the right facial nerve was found on contrast-enhanced Mri. To our knowledge, this is a very rare case of Tolosa-hunt syndrome with facial nerve palsy, with simultaneous enhancement of the cavernous sinus and facial nerve on contrast-enhanced Mri.

关键词： Tolosa-hunt综合征周围性面神经麻痹 Mri表现外展神经麻痹增强Mri 头痛症状女性患者眼眶后部

对2129名挪威青年男女青春期早期性成熟与青春期晚期吸烟酗酒状况的前瞻性研究

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世界核心医学期刊文摘（儿科学分册） 2006年第A3期2卷 51-52页

作者： Bratberg G.h. Nilsen T.I.L. holmen T.L. Vatten L.J. 虎小毅 Faculty of Medicine HUNT Research Centre Norwegian University of Science and Technology Verdal Norway

Early sexual maturation has been associated with higher involvement in risk behaviour during early and mid-adolescence. In a prospective study of 2,129 girls and boys, we investigated whether the timing of sexual maturation was associated with cigarette smoking and alcohol drinking in late adolescence and whether this relation differed between boys and girls. Nine hundred and eighty boys and 1,149 girls, who participated in a cross-sectional study in middle school, were included in a follow-up study in high school 4 years later. Self-rating of pubertal status, as registered at baseline in middle school, was used to indicate the timing of sexual maturation. Age-adjusted odds ratios (ORs) with 95% confidence intervals (CIs), estimated by logistic regression, were used to assess the association between sexual maturation and alcohol drinking and daily smoking at follow-up. We found that girls who had matured early (OR 1.7, CI 1.2-2.4) or late (OR, 1.5, CI, 1.1-2.2) were both more likely to report more advanced drinking in late adolescence than were girls who were on time. Boys who had matured late were less likely (OR 0.5, CI 0.3-0.8) than boys who were on time to engage in advanced drinking. In general, daily smoking was more common among girls than boys, and more common among girls who had matured early (OR 1.5, CI 1.1-2.2) than among girls who were on time. Adjustment for social factors, e.g. parental education and marital status and parental drinking and smoking habits, did not substantially influence these results. We concluded that, for girls, but not for boys, early sexual maturation was associated with more advanced drinking and higher frequency of smoking in late adolescence. In boys, late sexual maturation was associated with reduced risk of advanced drinking.

关键词：性成熟青年男女青春晚期性早熟横断面调查比值比犯罪倾向逻辑回归分析反映性随访研究