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Neural Regeneration Research 2021年第6期16卷 1150-1157页

作者： raheel khan Don Kulasiri Sandhya Samarasinghe Centre for Advanced Computational Solutions(C-fACS) Lincoln UniversityChristchurchNew Zealand Department of Molecular Biosciences Lincoln UniversityChristchurchNew Zealand

Protein phosphorylation and dephosphorylation are two essential and vital cellular mechanisms that regulate many receptors and enzymes through kinases and ***^2+- dependent kinases and phosphatases are responsible for controlling neuronal processing;balance is achieved through *** molecular mechanisms of learning and memory,kinases generally modulate positively while phosphatases modulate *** review outlines some of the critical physiological and structural aspects of kinases and phosphatases involved in maintaining postsynaptic structural *** also explores the link between neuronal disorders and the deregulation of phosphatases and kinases.

关键词： Alzheimer’s disease autism spectrum disorder CaMKII calcineurin longterm depression long-term potentiation protein kinase A protein phosphatase 1 protein dephosphorylation protein phosphorylation

A Framework for Enhancing Privacy and Anonymity in Blockchain-Enabled IoT Devices

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Computers, Materials & Continua 2024年第3期78卷 4263-4282页

作者： Muhammad Saad Muhammad raheel Bhutta Jongik Kim Tae-Sun Chung Department of Artificial Intelligence Ajou UniversitySuwon443-749Korea Department of Electrical and Computer Engineering University of Utah Asia CampusIncheon21985Korea Department of Artificial Intelligence Chungnam National UniversityDaejeon34134Korea

With the increase in IoT(Internet of Things)devices comes an inherent challenge of *** the world today,privacy is the prime concern of every *** one’s privacy and keeping anonymity throughout the system is a desired functionality that does not come without inevitable trade-offs like scalability and increased complexity and is always exceedingly difficult to *** challenge is keeping confidentiality and continuing to make the person innominate throughout the *** address this,we present our proposed architecture where we manage IoT devices using blockchain *** proposed architecture works on and off blockchain integrated with the closed-circuit television(CCTV)security camera fixed at the rental *** this framework,the CCTV security camera feed is redirected towards the owner and renter based on the smart contract *** entity(owner or renter)can see the CCTV security camera feed at one *** is no third-party dependence except for the CCTV security camera deployment *** contributions include the proposition of framework architecture,a novel smart contract algorithm,and the modification to the ring signatures leveraging an existing cryptographic *** are made based on different systems’security and key management *** an empirical study,our proposed algorithm performed better in key generation,proof generation,and verification *** comparing similar existing schemes,we have shown the proposed architectures’*** now,we have developed this system for a specific area in the real ***,this system is scalable and applicable to other areas like healthcare monitoring systems,which is part of our future work.

关键词： Privacy anonymity blockchain IoT smart contracts

Characteristics and trends of pediatric firepit burns: insights for prevention and safety

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World Journal of Pediatric Surgery 2024年第1期7卷 54-58页

作者： Maria Fazal Charbel Chidiac raheel Ahmad Oussama Issa Erica Hodgman Alejandro V Garcia Johns Hopkins School of Medicine BaltimoreMarylandUSA Department of Surgery Division of Pediatric SurgeryJohns Hopkins School of MedicineBaltimoreMarylandUSA Division of the Biological Sciences University of ChicagoChicagoIllinoisUSA School of Medicine American University of BeirutBeirutLebanon

Introduction As fire pits grow in popularity,so do the associated burn *** study examines pediatric fire pit burns characteristics to raise awareness and promote safety *** We conducted a retrospective review of pediatric patients(<21 years)with firepit burns at a tertiary care hospital from 2016 to *** Eighty-four patients were identified,of whom 70.2%were male,with a median age of 62 *** median percent total body surface area burned was 2%(interquartile range(IQR)=1-4).Thirty-five(41.7%)patients were admitted and 7(8.3%)underwent *** and trunk burns had the highest grafting rates(66%and 33%,respectively).The hands(41.7%)and the lower extremities(27.4%)were the most frequently burned body *** leading causes of burns were ashes/hot coals(34.5%),flames(31.0%),and direct contact(25.0%),often resulting from falling into the fire(59.5%)or running or playing in activities near it(26.2%).Thirty-five(41.7%)were admitted for inpatient management,while 49(58.3%)were treated as ***(13.2%)underwent at least one reconstructive surgery,7(8.4%)had at least one rehabilitation visit,and 65(77.4%)had follow-up clinic *** median length of stay was 2 days(IQR=1.0-3.5).The peak months for burns were from August through October(n=40,46.0%),with an increase observed from 10 cases in 2016to 20 cases in *** Given the significant proportion of firepit burns resulting from unsafe fire behaviors,it is crucial that caretakers are aware of proper firepit safety *** ofevidence Il.

关键词： burns admitted prevention

Trends in mortality among the geriatric population undergoing Surgical aortic valve replacement (SAVR) and potential racial disparities: a 20-year perspective via the National (Nationwide) Inpatient Sample

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Journal of Geriatric Cardiology 2024年第7期21卷 716-722页

作者： Nomesh Kumar Kamleshun Ramphul FNU Bawna Nitish Behary Paray Mansimran Si-ngh Dulay Jasninder Singh Dhaliwal Shruti Aggarwal Sebastian Mactaggart Suma Sri Chennapragada Shaheen Sombans Renuka Verma Hemamalini Sakthivel raheel Ahmed Department of Internal Medicine Detroit Medical Center Sinai Grace-Wayne State UniversityMichiganUSA In-dependent Researcher TrioletMauritius Independent researcher Farmington HillsMichiganUSA Royal Devon University Healthcare NHS Foundation Trust ExeterUnited Kingdom Royal Brompton Hospital part of Guy’s and St.Thomas’NHS Foundation TrustLondonUnited Kingdom Department of Internal Medicine University of Cali-forniaRiversideUSA Independent Researcher New DelhiIndia Northumbria Hospitals NHS Foundation Trust NewcastleUnited Kingdom Department of Internal Medicine Louisiana State UniversityShreveportUSA Sha-heen Sombans Independent ResearcherHyderabadIndia Department of Internal Medicine Kirk Kerkorian School of Medicine at UNLVLas VegasUSA One Brooklyn Health System/Interfaith Medical Ctr Program BrooklynNYUSA

Background Racial disparities in cardiovascular conditions are well *** similar race-based discrepancies in health outcomes also exist among elderly patients undergoing surgical aortic valve replacement(SAVR) for aortic stenosis remains *** We abstracted data from the National(Nationwide) Inpatient Sample over a 20-year period from 2001 to 2020 using specific ICD-9 and ICD-10 *** included patients aged ≥ 60 and ≤ 80 years with races recorded as White,African American,or Hispanic at the time of their hospitalization for *** analyzed and reported the baseline characteristics,risk-adjusted inhospital mortality,and complications stratified by *** Of 420,181 patients studied,90.0% identified as White,4.0% as African American and 6.0% as *** a decrease in overall in-hospital mortality rates from 3.8% between 2001-2005 to 1.8% between 2016-2020,African Americans had higher odds of all-cause in-hospital deaths compared to Whites(a OR = 1.390,P < 0.001).Additionally,they were more likely to experience cardiogenic shock(a OR = 1.241,P < 0.001) and acute kidney injury(a OR = 1.314,P < 0.001) as well as more likely to require organ support such as IABP use(a OR = 1.336,P < 0.001) or invasive mechanical ventilation(a OR = 1.342,P < 0.001).Interestingly,African Americans were less likely to report events of acute ischemic stroke compared to Whites(a OR = 0.852,P < 0.001).Conclusions Despite a reassuring reduction in overall in-hospital mortality rates of geriatric patients undergoing SAVR for aortic stenosis,racial disparities in health outcomes remain pervasive with minorities more likely to report higher in-hospital morbidity and mortality.

关键词： mortality likely spite

Left bundle branch pacing vs biventricular pacing in heart failure patients with left bundle branch block:A systematic review and meta-analysis

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World Journal of Cardiology 2024年第1期16卷 40-48页

作者： Farah Yasmin Abdul Moeed Rohan Kumar Ochani Hamna raheel Malik Ali Ehtsham Awan Ayesha Liaquat Arisha Saleem Muhammad Aamir Nael Hawwa Salim Surani Department of Internal Medicine Yale University School of MedicineNew HavenCT 06511United States Department of Medicine Dow University of Health ScienceKarachi 74200SindhPakistan Department of Medicine SUNNY Upstate Medical UniversitySyracuseNY 13210United States Department of Cardiovascular Medicine Lehigh Valley Heart and Vascular InstituteAllentownPA 18105United States Department of Medicine Cleveland ClinicClevelandOH 44195United States Department of Medicine&Pharmacology Texas A&M UniversityCollege StationTX 77843United States

BACKGROUND Left bundle branch pacing(LBBP)is a novel pacing modality of cardiac resynchronization therapy(CRT)that achieves more physiologic native ventricular activation than biventricular pacing(BiVP).AIM To explore the validity of electromechanical resynchronization,clinical and echocardiographic response of *** Systematic review and Meta-analysis were conducted in accordance with the standard guidelines as mentioned in detail in the methodology *** In our analysis,the success rate of LBBP-CRT was determined to be 91.1%.LBBP CRT significantly shortened QRS duration,with significant improvement in echocardiographic parameters,including left ventricular ejection fraction,left ventricular end-diastolic diameter and left ventricular end-systolic diameter in comparison with *** A significant reduction in New York Heart Association class and B-type natriuretic peptide levels was also observed in the LBBP-CRT group vs BiVP-CRT ***,the LBBP-CRT cohort had a reduced pacing threshold at follow-up as compared to BiVP-CRT.

关键词： Left bundle branch pacing Biventricular pacing QRS duration Left ventricular ejection fraction Heart failure

Early Detection of Diabetic Retinopathy Using Machine Intelligence throughDeep Transfer and Representational Learning

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Computers, Materials & Continua 2021年第2期66卷 1631-1645页

作者： Fouzia Nawaz Muhammad Ramzan Khalid Mehmood Hikmat Ullah khan Saleem Hayat khan Muhammad raheel Bhutta Department of Computer Science and Information Technology University of SargodhaSargodha40100Pakistan and School of Systems and TechnologyUniversity of Management and TechnologyLahore54782Pakistan Department of Computer Science COMSATS University IslamabadWah CampusIslamabadPakistan University Hospital Birmingham BirminghamUK Shifa International Hospital IslamabadPakistan Department of Computer Science and Engineering Sejong UniversitySeoulKorea

Diabetic retinopathy (DR) is a retinal disease that causes irreversible *** occurs due to the high blood sugar level of the patient, and it is clumsy tobe detected at an early stage as no early symptoms appear at the initial level. To preventblindness, early detection and regular treatment are needed. Automated detectionbased on machine intelligence may assist the ophthalmologist in examining thepatients’ condition more accurately and efficiently. The purpose of this study is toproduce an automated screening system for recognition and grading of diabetic retinopathyusing machine learning through deep transfer and representational *** artificial intelligence technique used is transfer learning on the deep neural network,Inception-v4. Two configuration variants of transfer learning are applied onInception-v4: Fine-tune mode and fixed feature extractor mode. Both configurationmodes have achieved decent accuracy values, but the fine-tuning method outperformsthe fixed feature extractor configuration mode. Fine-tune configuration modehas gained 96.6% accuracy in early detection of DR and 97.7% accuracy in gradingthe disease and has outperformed the state of the art methods in the relevant literature.

关键词： Diabetic retinopathy artificial intelligence automated screening system machine learning deep neural network transfer and representational learning

Low Impedance Fault Identification and Classification Based on Boltzmann Machine Learning for HVDC Transmission Systems

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Journal of Modern Power Systems and Clean Energy 2022年第2期10卷 440-449页

作者： raheel Muzzammel Ali Raza the Department of Electrical Engineering University of LahoreLahore 54000Pakistan

Identification and classification of DC faults are considered as fundamentals of DC grid protection.A sudden rise of DC fault current must be identified and classified to immediately operate the corresponding interrupting *** this paper,the Boltzmann machine learning(BML)approach is proposed for identification and classification of DC faults using travelling waves generated at fault point in voltage source converter based high-voltage direct current(VSC-HVDC)transmission *** unsupervised way of feature extraction is performed on the frequency spectrum of the travelling *** class logistic regression(BCLR)classifies the HVDC transmission system into faulty and healthy *** proposed technique reduces the time for fault identification and classification because of reduced tagged data with few ***,the faults near or at converter stations are readily identified and *** performance of the proposed technique is assessed via simulations developed in MATLAB/Simulink and tested for pre-fault and post-fault data both at VSC1 and VSC2,***,the proposed technique is supported by analyzing the root mean square error to show practicality and realization with reduced computations.

关键词： Binary class logistic regression(BCLR) Boltzmann machine learning(BML) DC grid protection fault identification and classification voltage source converter based high-voltage direct current(VSC-HVDC)transmission system

Adaptive Multi-Cost Routing Protocol to Enhance Lifetime for Wireless Body Area Network

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Computers, Materials & Continua 2022年第7期72卷 1089-1103页

作者： Muhammad Mateen Yaqoob Waqar Khurshid Leo Liu Syed Zulqarnain Arif Imran Ali khan Osman Khalid raheel Nawaz Department of Computer Science COMSATS University IslamabadAbbottabad Campus22060Pakistan Department of OTEHM Manchester Metropolitan UniversityManchesterUK

Wireless Body Area Network(WBAN)technologies are emerging with extensive applications in several *** is a fascinating domain of WBAN for smart monitoring of a patient’s *** important factor to consider in WBAN is a node’s *** the lifetime of nodes is critical to address many issues,such as utility and *** routing protocols have addressed the energy conservation problem but considered only a few parameters,thus affecting their ***,most of the existing schemes did not consider traffic prioritization which is critical in *** this paper,an adaptive multi-cost routing protocol is proposed with a multi-objective cost function considering minimum distance from sink,temperature of sensor nodes,priority of sensed data,and maximum residual energy on sensor *** performance of the proposed protocol is compared with the existing schemes for the parameters:network lifetime,stability period,throughput,energy consumption,and path *** is evident from the obtained results that the proposed protocol improves network lifetime and stability period by 30%and 15%,respectively,as well as outperforms the existing protocols in terms of throughput,energy consumption,and path loss.

关键词： Multi-cost routing protocol network lifetime wireless body area network adaptive routing residual energy clustering poisson distribution

An Open IoT Framework Based on Microservices Architecture

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China Communications 2017年第2期14卷 154-162页

作者： Long Sun Yan Li raheel Ahmed Memon College of Computer Science Sichuan University Chengdu 610064 China College of manufacturing Science and Engineering Sichuan University Chengdu 610064 China School of Computer Science University of Engineering Science and Technology Chengdu 610064 China Department of Computer Science Sukkur Institute of Business Administration Sukkur Sindh Pakistan

With the continuous development and evolvement of Internet of Things （IoT）, monolithic application becomes much larger in scale and even more complex in structure. This leads to poor scalability, extensibility and maintainability. In response to those challenges, microservice architecture has been introduced in the field of IoT application, due to its flexibility, lightweight and loose coupling. However, the existing loT framework of microservice mainly focus on a specific domain, therefore, this greatly limits its application. In this paper, we propose a general microservice system framework for the loT application, which is a better scalable, extendable and maintainable architecture. We introduce its system design and related microservices, and emphasize on core service and device communication from service layer to physical layer. It has better capacity to support interoperability and accommodate heterogeneous objects. In addition, this framework can easily achieve more application integration such as automation, intelligence, Geo service and Big Data.

关键词： Internet of things loT micro service software architecture

COVID-19:Effect on gastroenterology and hepatology service provision and training:Lessons learnt and planning for the future

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World Journal of Gastroenterology 2021年第44期27卷 7625-7648页

作者： Muhammad raheel Anjum Jodie Chalmers Rizwana Hamid Neil Rajoriya Department of Gastroenterology The Royal Wolverhampton NHS TrustWolverhampton WV100QPUnited Kingdom Department of Medicine Queen Elizabeth HospitalUniversity Hospitals Birmingham NHS Foundation TrustBirmingham B152WBUnited Kingdom Department of Gastroenterology Royal Alexandria HospitalPaisley PA29PJScotlandUnited Kingdom Queen Elizabeth Hospital University Hospitals Birmingham NHS Foundation TrustBirmingham B152WBUnited Kingdom Institute of Immunology and Immunotherapy University of BirminghamBirmingham B152TTUnited Kingdom

In late 2019,reports arose of a new respiratory disease in China,identified as a novel coronavirus,severe acute respiratory syndrome coronavirus *** World Health Organisation named the disease caused by the virus‘coronavirus disease 2019(COVID-19)’.It was declared a pandemic in early 2020,after the disease rapidly spread across the ***-19 has not only resulted in substantial morbidity and mortality but also significantly impacted healthcare service provision and training across all medical specialties with gastroenterology and Hepatology services being no ***,most,if not all‘nonurgent’services have been placed on hold during surges of *** a result there have been delayed diagnoses,procedures,and surgeries which will undoubtedly result in increased morbidity and *** services have been converted to remote consultations where possible in many *** have been redeployed to help care for COVID-19 patients in other settings,resulting in disruption to their training-particularly endoscopy and outpatient *** has led to significant anxiety amongst trainees,and risks prolongation of *** is of the utmost importance to develop strategies that continue to support COVID-19-related service provision,whilst also supporting existing and future gastroenterology and Hepatology services and *** to healthcare provision during the pandemic have generated new and improved frameworks of service and training delivery,which can be adopted in the post-COVID-19 world,leading to enhanced patient care.

关键词： COVID-19 Gastroenterology Hepatology Training Service provision