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Mathematical Translation of Metabolic Syndrome: Assessment of siMS Score for Metabolic Syndrome and Biochemical Risks

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Open Journal of Endocrine and Metabolic Diseases 2020年第7期10卷 95-106页

作者： Sikandar Hayat Khan Abdul Raheem Khan Asif Hashmat Roomana Anwar rahat shahid Tariq Chaudhry Department of Pathology PNS Hafeez Islamabad Pakistan Bedford Hospital NHS Bedford UK Department of Neurology Pak Emirates Military Hospital (PEMH) Rawalpindi Pakistan Department of Biochemistry Islamabad Medical & Dental College Islamabad Pakistan Department of Radiology PNS Hafeez Islamabad Pakistan PNS Hafeez Islamabad Pakistan

Background: Metabolic syndrome over decades has undergone multiple diagnostic criteria announced by National Cholesterol Education Program (NCEP), WHO, International Diabetic Federation (IDF) and certain regional criteria. Recently, Soldatovic et al. have provided a mathematical model for evaluating metabolic syndrome. We aimed to compare siMS score among subjects with and without metabolic syndrome and other biochemical risks including insulin resistance. Methods: The study was conducted at PNS HAFEEZ hospital from July-2017 to Jan-2019. A comparative cross-sectional analysis was carried out among 232 subjects to evaluate siMS score among metabolic syndrome and those without metabolic syndrome. Pearson’s correlation was performed for siMS score with other anthropometric and biochemical measures. Finally ROC curve analysis was performed to evaluate various biomarkers along with siMS score for diagnosis of metabolic syndrome. Results: Insulin resistance between subjects was higher among subjects with metabolic syndrome [Mean = 3.27 ± 4.45] than non-metabolic syndrome subjects [Mean = 2.10 ± 1.89] (p = 0.012). Differences in siMS score was higher in subjects with metabolic syndrome (Mean = 3.58 ± 0.725, N = 121) than subjects without metabolic syndrome (Mean = 2.83 ± 0.727, N = 108). AUC for various biochemical parameters was highest for sdLDL cholesterol and siMS score. Conclusion: siMS score has shown better performance than HOMAIR, sdLDL cholesterol, non-HDL cholesterol, HbA1c, and fasting plasma glucose in diagnosing metabolic syndrome.

关键词： siMS Score HOMA-IR Metabolic Syndrome Small Dense LDL-Cholesterol (sdLDL) Non-HDL Cholesterol HbA1c

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In vivo immunomodulatory profile of histamine receptors(H1,H2,H3 and H4):a comparative antagonists study

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Asian Pacific Journal of Tropical Medicine 2010年第6期3卷 465-470页

作者： Trivendra Tripathi Mohammad shahid Haris M Khan Aijaz Ahmed Khan Mashiatullah Siddiqui rahat Ali Khan Department of Biochemistry Faculty of MedicineJawaharlal Nehru Medical College & HospitalAligarh Muslim UniversityAligarh-202002U.P.India Department of Microbiology Faculty of MedicineJawaharlal Nehru Medical College & HospitalAligarh Muslim UniversityAligarh-202002U.P.India Department of Anatomy Faculty of MedicineJawaharlal Nehru Medical College & HospitalAligarh Muslim UniversityAligarh-202002U.P.India Department of Pharmacology Faculty of MedicineJawaharlal Nehru Medical College & HospitalAligarh Muslim UniversityAligarh-202002U.P.India

Objective:To delineate the comparative immunomodulatory roles of H1R-H4R in antibody generation profile in rabbit ***:The cohort comprised of eight groups containing 18(9 male and 9 female) rabbits in each ***Ⅰremained non-immunized and received only vehicle(sterile distilled water,1 mL/kg×b.i.d.) ***Ⅱreceived vehicle (1 mL/kg×b.i.d.) while GroupsⅢ-Ⅶ(drugs-treated) received subcutaneous histamine (100μg/kg×b.i.d.),and intramuscular H1R-antagonist(pheniramine,10 mg/kg×b.i.d.), H2R-antagonist(ranitidine,10 mg/kg×b.i.d.),H3R-antagonist(iodophenpropit,1μg/kg×b.i.d.) and H4R-antagonist(JNJ 7777120,10μg/kg×b.i.d.),and GroupⅧDMSO(1 mL/kg×b.i.d.),respectively for 10 days(starting from day 1).They were subsequendy immunized with intravenous injection of sheep red blood cells(SRBC) at day *** estimation of serum Igs,IgM and IgG were done by ELISA,and observed at day 0(pre-immunization),and 7,14,21,28 and 58(post-immunization).Results:It was shown that histamine and HRs-antagonists could influence a detectable antibody response to SRBC as early as day 7-post-immunization(post-Ⅰ), which lasted until day 58 post-Ⅰ.The results were found statistically significant(P<0.05,). Conclusions:This study suggests that histamine receptors play important roles in modulation of antibody generation in which H1R,H2R and H4R have immunosuppressive roles and conversely, H3R playes an immune enhancing *** findings of this study may have clinical significance and provide the baseline information for future study.

关键词： Histamine receptors Immunomodulation Humoral immune response H3R-antagonist H4R-antagonist

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Effects of histamine HlR-H4R-agonist on the airway epithelium of rabbits

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Asian Pacific Journal of Tropical Medicine 2010年第5期3卷 367-370页

作者： Naushad A Dilkash Trivendra Tripathi Aijaz Ahmed Khan Mohd shahid Haris M Khan Mashiatullah Siddiqui rahat Ali Khan Department of Anatomy Faculty of MedicineJawaharlal Nehru Medical College & HospitalAligarh Muslim University Department of Biochemistry Faculty of MedicineJawaharlal Nehru Medical College & HospitalAligarh Muslim University Department of Microbiology Faculty of MedicineJawaharlal Nehru Medical College & HospitalAligarh Muslim University Department of Pharmacology Faculty of MedicineJawaharlal Nehru Medical College & HospitalAligarh Muslim University

Objective:To explore the exact role of histamine receptors in respiratory ***: The cohort comprised of six groups(group I control and groupⅡ—Ⅳtreated) containing five rabbits in each ***-group received vehicle(sterile distilled water) and treated groups received subcutaneous histamine(100μg/kg,b.i.d.),and H1R-agonist(HTMT),H2R-agonist (amthamine),H3R-agonist(R-(-)-α-methylhistamine) and H4R-agonist(clobenpropit) each in a dose of 10μg/kg,*** 30 subsequent *** completion of treatment,animals were euthanized and perfused with 10% buffered *** tissue blocks of trachea and lungs were processed for paraffin *** were recorded in sample photomicrographs taken from 10μm *** and eosin stained ***:It was observed that trachea and bronchi from histamine,H1R and H4R groups had only patches of hyperplastic and hypertrophied epithelium and in general,cells in the affected region were taller heaped up. The bronchiolar epithelia from all treated groups showed hypertrophy and hyperplasia throughout with most of the cells having rounded profile and appeared to bud out from the basal cells. Conclusions:It is concluded that histamine receptors on induction via its specific agonist can induce hypertrophy,hyperplasia of respiratory tract epithelia suggesting its role akin to growth stimulating factor and warranting further long-term study.

关键词： Rabbit Airway epithelium Histamine receptors-agonist Hyperplasia Hypertrophy

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Modernity in tradition： Reflections on building design and technology in the Asian vernacular

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Frontiers of Architectural Research 2015年第1期4卷 46-55页

作者： Mamun Rashid Dilshad rahat Ara Department of Architectural Engineering (AE) University of Shauah PO BOX 27272 Sharjah United Arab Emirates Department of Architectural Engineering (AE) United Arab Emirates University (UAEU) PO BOX 15551 AlAin United Arab Emirates

Vernacular buildings across the globe provide instructive examples of sustainable solutions to building problems. Yet, these solutions are assumed to be inapplicable to modern buildings. Despite some views to the contrary, there continues to be a tendency to consider innovative building technology as the hallmark of modern architecture because tradition is commonly viewed as the antonym of modernity. The problem is addressed by practical exercises and fieldwork studies in the application of vernacular traditions to current problems. This study investigates some aspects of mainstream modernist design solutions and concepts inherent in the vernacular of Asia, particularly that of the Chittagong Hill Tracts （CHT）. This work hinges on such ideas and practices as ecological design, modular and incremental design, standardization, and flexible and temporal concepts in the design of spaces. The blurred edges between the traditional and modern technical aspects of building design, as addressed by both vernacular builders and modern architects, are explored.

关键词： Building technotogy Tradition-modernity Innovation Vernaculararchitecture

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Cloud authorization： exploring techniques and approach towards effective access control framework

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Frontiers of Computer Science 2015年第2期9卷 297-321页

作者： rahat MASOOD Muhammad Awais SHIBLI Yumna GHAZI Ayesha KANWAL Arshad ALI School of Electrical Engineering and Computer Science (SEECS) National University of Sciences and Technology (NUST) Islamabad - 44000 Pakistan

Despite the various attractive features that Cloud has to offer, the rate of Cloud migration is rather slow, pri- marily due to the serious security and privacy issues that exist in the paradigm. One of the main problems in this regard is that of authorization in the Cloud environment, which is the focus of our research. In this paper, we present a systematic analysis of the existing authorization solutions in Cloud and evaluate their effectiveness against well-established industrial standards that conform to the unique access control require- ments in the domain. Our analysis can benefit organizations by helping them decide the best authorization technique for deployment in Cloud; a case study along with simulation re- sults is also presented to illustrate the procedure of using our qualitative analysis for the selection of an appropriate tech- nique, as per Cloud consumer requirements. From the results of this evaluation, we derive the general shortcomings of the extant access control techniques that are keeping them from providing successful authorization and, therefore, widely adopted by the Cloud community. To that end, we enumer- ate the features an ideal access control mechanisms for the Cloud should have, and combine them to suggest the ultimate solution to this major security challenge - access control as a service （ACaaS） for the software as a service （SaaS） layer. We conclude that a meticulous research is needed to incorpo- rate the identified authorization features into a generic ACaaS framework that should be adequate for providing high level of extensibility and security by integrating multiple accesscontrol models.

关键词： authorization access control software as a ser-vice extensible access control markup language identity &access management cloud security

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Photosynthesis, Growth and Antioxidant Metabolism in Mustard (Brassica juncea L.) Cultivars Differing in Cadmium Tolerance

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Agricultural Sciences in China 2010年第4期9卷 519-527页

作者： Noushina Iqbal Asim Masood rahat Nazar Shabina Syeed Nafees A Khan Department of Botany Aligarh Muslim University

Two mustard （Brassica juncea L. Czern and Coss.） cultivars, Pusa Jai Kisan and SS2 differing in cadmium （Cd） tolerance were treated with 0, 25 and 50 umol L-1 Cd to study the physiological basis of difference in Cd tolerance. Cultivar SS2 （Cd sensitive） accumulated greater Cd in leaves than Pusa Jai Kisan （Cd tolerant）. Further, SS2 also exhibited higher contents of thiobarbituric acid reactive substances （TBARS） and H2O2 and electrolyte leakage. However, the activities of antioxidant enzymes, catalase （CAT）, ascorbate peroxidase （APX）, dehydroascorbate reduetase （DHAR）, and glutathione reductase （GR） were higher in Pusa Jai Kisan than those in SS2. Contrarily, the activity of superoxide dismutase （SOD） was higher in SS2 than that in Pusa Jai Kisan and was the greatest at 25 umol L-1 Cd. Treatment of 25 umol L-1 Cd induced the maximum activity of enzymes. However, the activity of GR increased up to 50 umol L-1 Cd in both the cultivars. The non-enzymatic antioxidants ascorbate （AsA） and glutathione （GSH） were higher in Pusa Jai Kisan than that in SS2, whereas dehydroascorbate （DHA） and oxidized glutathione （GSSG） were higher in SS2. Photosynthesis and growth were adversely and maximally decreased by 50 umol L-1 Cd treatment in both the cultivars, but SS2 exhibited greater reductions. The protection of photosynthesis and growth and lesser reduction in Pusa Jai Kisan were associated with its capacity to restrict accumulation of Cd in leaves resulting in lower level of TBARS and H2O2 and electrolyte leakage. Moreover, Pusa Jai Kisan exhibited efficient antioxidant metabolism for removal of Cd-induced reactive oxygen species.

关键词： antioxidant metabolism cadmium oxidative stress photosynthesis

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Multi-Channel NRZ/RZ-DPSK to CSRZ-DPSK Format Conversion Based on Nonlinear Polarization Rotation of SOA

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Chinese Physics Letters 2017年第10期34卷 34-38页

作者： Ya-Ya Mao Chong-Qing Wu Xin-Zhi Sheng Bo Liu rahat Ullah Feng Tian Institute of Optoelectronics Nanjing University of Information Science ＆ Technology Nanjing 210044 Key Lab of Luminescence and Optical Information Technology （Ministry of Education） School of Science Beijing Jiaotong University Beijing 100044

We present an all-optical nonreturn-to-zero/return-to-zero （NRZ/RZ） to carrier-suppressed return-to-zero （CSRZ） format conversion scheme for differential phase-shift keying （DPSK） signals. The conversion is based on nonlinear polarization rotation of a semiconductor optical amplifier （SOA）. The 4-channel NRZ-DPSK or RZ-DPSK signals at 10 Gb/s are simultaneously converted to the corresponding CSRZ-DPSK signals, with -0.8 and 1.4 dB average power penalties, respectively. Additionally, high quality format conversion performances are shown with the optical spectra and eye diagrams.

关键词： Semiconductor optical amplifiers

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A PHEMT Based Wideband LNA for Wireless Applications

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China Communications 2015年第10期12卷 108-116页

作者： Muhammad Saad Khan ZHANG Hongxin HE Pengfei Sulman Shahzad rahat Ullah School of Electronic Engineering Beijing University of Posts and Telecommunications(BUPT) Electrical Engineering Department University College of Engineering & TechnologyBahauddin Zakariya University Institute of Science and Technology for Opto-electronic Information Yantai University State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and Telecommunications

This work is about the development of a super low noise amplifier with minimum power consumption and high gain for several wireless *** amplifier operates at frequency bands of 0.9-2.4 GHz and can be used in many applications like Wireless local area network(WLAN),WiFi,Bluetooth,ZigBee and Global System for mobile communications(GSM).This new design can be employed for the IEEE 802.15.4 standard in industrial,scientific and medical(ISM) *** enhancement mode pseudomorphic high electron mobility transistor PHEMT is used here due to its high linearity,better performance and less noisy *** common source inductive degeneration method is employed here to enhance the gain of *** amplifier produces a gain of more than 17 dB and noise figure of about 0.5 *** lower values of S11 and S22 reflect the accuracy of impedance matching network placed at the input and output sides of *** Advance Design System(ADS) is used for the design and simulation *** the layout of design is developed on the FR4 substrate.

关键词： low noise amplifier phemt advanced design system wireless local area network global positioning system

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A mutation in the promoter of the yellow stripe-like transporter gene in cucumber results in a yellow cotyledon phenotype

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Journal of Integrative Agriculture 2024年第3期23卷 849-862页

作者： Jiawei Pan Jia Song rahat Sharif Xuewen Xu Shutong Li Xuehao Chen School of Horticulture and Landscape Architecture Yangzhou UniversityYangzhou 225009China Institute of Vegetables Tianjin Academy of Agricultural SciencesTianjin 300384China

Leaf color mutants in higher plants are considered to be ideal materials for studying the chlorophyll biosynthesis,photosynthesis mechanism and chloroplast ***,we identified a spontaneous mutant,yc412,in cultivated cucumber that exhibited yellow *** yellow-lethal mutant was diagnosed with an abnormal chloroplast ultrastructure,and reduced photosynthetic capacity and pigment *** bulked segregant analysis-based whole-genome sequencing and fine genetic mapping,we narrowed the yellow cotyledons (yc) locus to a 96.8 kb interval on chromosome *** resequencing and molecular cloning,we showed that Csyc is a potential candidate gene,which encodes a yellow stripe-like (YSL) *** T to C mutation in the promoter region of Csyc caused the yellow cotyledon phenotype in *** to YZU027A (WT),the expression of Csyc was significantly downregulated in the cotyledons of *** of Csyc in cucumber via virus-induced gene silencing resulted in chlorotic leaves,mainly by suppressing the chlorophyll ***,a comparative transcriptome analysis revealed that chloroplast-related genes and chlorophyll biosynthesis genes were significantly downregulated in yc412 *** results provide new insights into the molecular function of the YSL transporter in plant chloroplast development and chlorophyll synthesis.

关键词： cucumber yellow-lethal cotyledons chloroplast development yellow stripe-like transporter

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Pharmacotherapeutics and molecular docking studies of alphasynuclein modulators as promising therapeutics for Parkinson’s disease

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BIOCELL 2022年第12期46卷 2681-2694页

作者： rahat ALI AFTAB ALAM SATYENDRA K.RAJPUT RAZI AHMAD Department of Medical Elementology and Toxicology Jamia HamdardNew Delhi110062India Centre for Interdisciplinary Research in Basic Sciences Jamia Millia IslamiaNew Delhi110025India Department of Pharmaceutical Sciences Gurukul Kangri UniversityUttarakhand249404India Department of Pharmacology HIMSR Jamia HamdardNew Delhi110062India

Parkinson’s disease(PD)is an age-related neurodegenerative ailment that affects dopamine-producing neurons in a specific area of the brain called the substantia nigra of the ventral *** is clinically characterized by movement disorder and marked with unusual synaptic protein alpha-synuclein accumulation in the *** date,only a few Food and Drug Administration(FDA)approved drugs are available on the market for the treatment of ***,these drugs show parasympathomimetic related adverse events and remarkably higher toxicity;hence,it is important to find more efficacious molecules to treat *** our study,We chosen 22 natural compounds as inhibitors that potentially block the alpha-synuclein clump-the pathological hallmark of PD-and provide new avenues for its *** of these molecules exhibited good pharmacokinetic behaviors,making them decisively favorable drug candidates to cure *** docking studies were performed to investigate the binding interactions between natural compounds and alpha-synuclein as anti-Parkinson drug *** the examined compounds,curcumin and piperine emerged as promising phytochemicals with the highest binding affinity,key residual stable bindings and showed a good inhibitory ***,the present study indicates that curcumin and piperine hold the potential to be developed as treatment options against *** validations are needed for insights into their mechanism of action and potential clinical application.

关键词： Parkinson’s disease(PD) Alpha-synuclein Molecular docking and dynamics Anti-Parkinson drug Curcumin Piperine

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