AIm.To study if im.aired renal function is associated with increased risk of peri-infarct heart failure (HF) in patients with preserved ejection fraction (EF).m.THODS:Patients with occluded infarct-related arteries (I...
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AIm.To study if im.aired renal function is associated with increased risk of peri-infarct heart failure (HF) in patients with preserved ejection fraction (EF).m.THODS:Patients with occluded infarct-related arteries (IRAs) between 1 to 28 d after m.ocardial infarction (m.) were grouped into chronic kidney disease (CKD) stages based on estim.ted glom.rular filtration rate (eGFR).Rates of early post-m. HF were com.ared am.ng eGFR *** regression was used to explore independent predictors of ***:Reduced eGFR was present in 71.1% of 2160 patients,with significant renal im.airm.nt (eGFR m./m.n every 1.73 m.) in 14.8%.The prevalence of HF was higher with worsening renal function:15.5%,17.8% and 29.4% in patients with CKD stages 1,2 and 3 or 4,respectively (P m.ll absolute difference in m.an EF across eGFR groups:48.2 ± 10.0,47.9 ± 11.3 and 46.2 ± 12.1,respectively (P=0.02).The prevalence of HF was again higher with worsening renal function am.ng patients with preserved EF:10.1%,13.6% and 23.6% (P m.ng patients with depressed EF:27.1%,26.2% and 37.9% (P= 0.071).m.reover,eGFR was an independent correlate of HF in patients with preserved EF (P=0.003) but not in patients with depressed EF (P=0.181).CONCLUSION:A significant proportion of post-m. patients with occluded IRAs have im.aired renal *** renal function was associated with an increased rate of early post-m. HF,the association being strongest in patients with preserved *** findings have im.lications for m.nagem.nt of peri-infarct HF.
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