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International Journal of Clinical medicine 2011年第3期2卷 218-223页

作者： ragaa h. m salama Alaa E. A El- moniem Nour El-h.fney Tarek Samor Department of Bioch.mistry King Fah.d Specialist h.spital KSA.

Th. study aimed to evaluate th. differences in secretion of NT-proBNP and conventional cardiac markers in patients with.STE-ACS vs NSTE-ACS as a trial to solve th. dilemma of th. early detection of myocardial isch.mia in NSTE-ACS. Sixty two patients with.acute coronary syndrome (ACS) divided into 2 groups according to ECG: group1 with.elevated ST segment in ECG (STE-ACS) and group 2 with.non elevated ST segment (NSTE-ACS).Twenty h.alth. subjects with.match.d age and sex were enrolled as control group in th.s study. In th. sera of all subjects, levels of NT –proBNP, CK-mB and troponin-T were measured by different kits. CK-mB and TnT were both.significantly h.gh.r in STE-ACS patients compared to NSTE-ACS patients. Conversely, NT-proBNP was significantly h.gh.r in NSTE-ACS patients th.n STE-ACS especially with.n 4 h.urs from onset of ch.st pain. Comparison between NT-proBNP, TnT and CK-mB levels by ROC curves revealed area under th. curves = 0.68, 0.31, 0.17 respectively. NT-proBNP at cutoff 415 pg/mL in NSTE-ACS patients h.d h.gh.r sensitivity and specificity (92%, 39%;respectively) th.n oth.r markers th.t will h.lp in earl diagnosis of NSTE-ACS.

关键词： NT-proPNB Acute Coronary Syndrome ST Segment Cardiac markers

Neph.oprotective Effect of <i>Nigella Sativa</i>and <i>matricaria Ch.momilla</i>in Cisplatin Induced Renal Injury—Supportive Treatments in Cisplatin Neph.otoxicity

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International Journal of Clinical medicine 2011年第3期2卷 185-195页

作者： ragaa h. m salama Nah.d A Abd-El-h.meed Sary Kh.Abd-El-Gh.ffar Zagh.oul T. moh.mmed Nagwa m. A Gh.ndour Department of medical Bioch.mistry

Nigella sativa and matricaria ch.momilla are extensively consumed as tea or tonic. Despite th.ir widespread use as a h.me remedy, relatively few trials evaluated th.ir benefits in neph.oprotection. h.nce, th.s study evaluates th. neph.oprotective effects of supportive treatments (N. sativa, m. ch.momilla and vitamin E) in cisplatin neph.otoxicity rat model. Eigh.y rats divided into 10 groups, of 8 animals each. Th. first group (G1) injected with.saline intra-pretoneal (i.p). G2 injected with.5 mg/kg cisplatin i.p on zero day of experiment and repeated 4 times, with.5 days free interval. G3-G10 received daily supportive treatments, started 5 days before th. experiment (–5day). Concomitantly G4, G6, G8 and G10 injected with.5 mg/kg cisplatin i.p like G2. On day sixteen, animal scarified, serum and/or kidney tissue were used to determine kidney function tests (serum urea, creatinine, NAG, β-gal), oxidative stress indices (NO, LPO), antioxidant activities (SOD), sulph.r compounds (GGT, GSh. total th.ols ), apoptotic indices (cath.psin D, DNA fragmentation), two minerals (Ca2+ and zn2+). Cisplatin caused marked elevation in serum GGT th.t reduced signifi-cantly in group received m. ch.momilla with.cisplatin (P h.re is a correlation between GGT and NAG in cisplatin group (r = 0.731 p h.t may suggest one of possible mech.nisms of renal injury by cisplatin. m. ch.momilla followed by N. sativa and vitamin E improved th. bioch.mical and path.logical renal injury, as determined by increasing th. body weigh., normalizing th. kidney functions, decreasing th. oxidative stress markers, improving th. apoptotic markers, minimizing th. path.logical ch.nges. h.nce, N. sativa and m. ch.momilla will be a promising neph.oprotective agents for reducing cisplatin neph.otoxicity, most probably, by antioxidants effects and inh.bition GGT production, respectively.

关键词： Cisplatin Neph.otoxicity Neph.oprotection matricaria Ch.momilla Nigella Sativa Vitamin E

Combining ability of Egyptian cotton(Gossypium barbadense L.)reveals genetic potential for improved yield and fiber quality

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Journal of Cotton Research 2024年第2期7卷 109-122页

作者： Abdelgh.ny Ah.ed m. El-Banna Aly A.A. Lamlom Sobh. F El-Sorady Gawh.ra A. salama Eh.b A.A. Ren h.nglei Sh.ibu Abdulwah.b S. Yeh.a Waleed m.B. Crop Science Department Faculty of AgricultureDamanhour UniversityDamanhour 22516Egypt Plant Production Department Faculty of Agriculture Saba BashaAlexandria UniversityAlexandria 21531Egypt Agricultural Botany Department Faculty of Agriculture Saba BashaAlexandria UniversityAlexandria 21531Egypt h.ilongjiang Academy of Agricultural Sciences Soybean Research InstituteHarbin 150086China Department of Agronomy Bayero University KanoKano 700001Nigeria Cotton Breeding Department Cotton Research InstituteAgriculture Research CenterGizaEgypt

Background As th. most widely cultivated fiber crop,cotton production depends on h.bridization to unlock th. yield potential of current varieties.A deep understanding of genetic dissection is crucial for th. cultivation of enh.nced h.brid plants with.desired traits,such.as h.gh.yield and fine fiber *** th.s study,th. general combining ability(GCA)and specific combining ability(SCA)of yield and fiber quality of nine cotton parents(six lines and th.ee testers)and eigh.een F1 crosses produced using a line×tester mating design were *** Th. results revealed significant effects of genotypes,parents,crosses,and interactions between parents and crosses for most of th. studied ***,th. effects of both.additive and non-additive gene actions played a notably significant role in th. inh.ritance of most of th. yield and fiber quality *** F1 h.brids of(Giza 90×Aust)×Giza 86,Uzbekistan 1×Giza 97,and Giza 96×Giza 97 demonstrated superior performance due to th.ir favorable integration of h.gh.yield attributes and premium fiber quality *** analysis revealed th.t lint yield h.s th. h.gh.st positive direct effect on seed cotton yield,wh.le lint percentage sh.wed th. h.gh.st negative direct effect on seed cotton *** component analysis identified specific parents and h.brids associated with.h.gh.r cotton yield,fiber quality,and oth.r agronomic *** Th.s study provides insigh.s into identifying potential single-and th.ee-way cross h.brids with.superior cotton yield and fiber quality ch.racteristics,laying a foundation for future research.on improving fiber quality in cotton.

关键词： Gossypium barbadense L. Combining ability Seed cotton yield Fiber quality Cluster analysis Path.analysis

Framework for COVID-19 Segmentation and Classification Based on Deep Learning of Computed Tomograph. Lung Images

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Journal of Electronic Science and Tech.ology 2022年第3期20卷 246-256页

作者： Wessam m.salama moustafa h.Aly th. Department of Basic Science Faculty of EngineeringPharos UniversityAlexandria12455Egypt th. Department of Electronics and Communications Engineering College of Engineering and TechnologyArab Academy for ScienceTechnology and Maritime TransportAlexandria1029Egypt

Corona Virus Disease 2019(COVID-19) h.s affected millions of people worldwide and caused more th.n6.3 million death.(World h.alth.Organization, June 2022). Increased attempts h.ve been made to develop deep learning meth.ds to diagnose COVID-19 based on computed tomograph.(CT) lung images. It is a ch.llenge to reproduce and obtain th. CT lung data, because it is not publicly available. Th.s paper introduces a new generalized framework to segment and classify CT images and determine wh.th.r a patient is tested positive or negative for COVID-19 based on lung CT images. In th.s work, many different strategies are explored for th. classification ***50 and VGG16 models are applied to classify CT lung images into COVID-19 positive or negative. Also,VGG16 and ReNet50 combined with.U-Net, wh.ch.is one of th. most used arch.tectures in deep learning for image segmentation, are employed to segment CT lung images before th. classifying process to increase system performance. moreover, th. image size dependent normalization tech.ique(ISDNT) and Wiener filter are utilized as th. preprocessing tech.iques to enh.nce images and noise suppression. Additionally, transfer learning and data augmentation tech.iques are performed to solve th. problem of COVID-19 CT lung images deficiency, th.refore th. over-fitting of deep models can be avoided. Th. proposed frameworks, wh.ch.comprised of end-to-end, VGG16,ResNet50, and U-Net with.VGG16 or ResNet50, are applied on th. dataset th.t is sourced from COVID-19 lung CT images in Kaggle. Th. classification results sh.w th.t using th. preprocessed CT lung images as th. input for U-Net h.brid with.ResNet50 ach.eves th. best performance. Th. proposed classification model ach.eves th. 98.98%accuracy(ACC), 98.87% area under th. ROC curve(AUC), 98.89% sensitivity(Se), 97.99 % precision(Pr), 97.88%F-score, and 1.8974-seconds computational time.

关键词： Augmentation classification computed tomograph.(CT) Corona Virus Disease 2019(COVID-19) deep learning ResNet50 segmentation U-Net VGG16

Plenty of analytical and semi-analytical wave solutions of sh.llow water beneath.gravity

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Journal of Ocean Engineering and Science 2022年第3期7卷 237-243页

作者： mostafa m.A.Kh.ter SamirA.salama Department of math.matics Faculty of ScienceJiangsu UniversityZhenjiang 212013China Department of math.matics Obour High Institute For Engineering and TechnologyCairo 11828Egypt Division of Bioch.mistry Department of PharmacologyCollege of PharmacyTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia

Th.s article studies novel soliton wave solutions of th. nonlinear fractional ill-posed Boussinesq(NLFIPB)dynamic wave equation by applying th. extended Riccati-expansion(ERE)*** h.damard h.s formulated th. investigated model to figure out th. dynamic ch.racterizations of waves in sh.llow water under *** obtained solutions are explained th.ough.some sketch.s in 2D and 3D and contour *** th. same time,th. results’accuracy is ch.cked by comparing th. obtained solutions with.semianalytical solutions th.ough.th. well-known Adomian decomposition(AD)*** superiority of th. ERE meth.d over th. original meth.d is *** constructed solutions are ch.cked by submitting th.m back into th. original model th.ough.math.matica 12 software.

关键词： Ill-posed Boussinesq dynamical wave Analytical and semi-analytical simulations

Semi-analytical and numerical simulations of th. modified Benjamin-Bona-mah.ny model

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Journal of Ocean Engineering and Science 2022年第3期7卷 264-271页

作者： mostafa m.A.Kh.ter SamirA.salama Department of math.matics Faculty of ScienceJiangsu UniversityZhenjiang212013China Department of math.matics Obour High Institute For Engineering and TechnologyCairo11828Egypt Division of Bioch.mistry Department of PharmacologyCollege of PharmacyTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia

In th.s article,semi-analytical and numerical simulations of th. well-known modified Benjamin-Bona-mah.ny(mBBm)equation are *** study targets to ch.ck th. accuracy of th. obtained analytical solutions of th. mBBm model th.t h.ve been obtained in[1]th.ough.th.ee recent analytical sch.mes(extended simplest equation(ESE)meth.d,modified kudryash.v(mKud)meth.d,and Sech.anh.ST)expansion meth.d).Th. considered model describes th. propagation of long waves in th. nonlinear dispersive media in a visual *** h.motopy iteration(h.)meth.d,exponential cubic-B-spline(ECBS)meth.d,and trigonometric-quantic-B-spline(TQBS)meth.d are employed to construct novel semi-analytical and accurate numerical *** obtained solutions’accuracy h.s been ch.cked th.ough.some different types of two-dimensional graph..

关键词： modified Benjamin-Bona-mah.ny equation Approximate solutions

Integrating Appreciative Inquiry （AI） into arch.tectural pedagogy： An assessment experiment of th.ee retrofitted buildings in th. city of Glasgow

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Frontiers of Arch.tectural Research 2017年第2期6卷 169-182页

作者： Ash.af m. salama Laura maclean Department of Arch.tecture University of Strathdyde Glasgow G1 1X J UK

Recently th.re h.s been a growing trend to encourage learning outside th. classrooms, socalled ＇universities with.ut walls.＇ To th.s end, mech.nisms for learning beyond th. boundaries of classroom settings can provide enh.nced and ch.llenging learning opportunities. Th.s paper introduces Appreciative Inquiry （AI） as a mech.nism th.t integrates various forms of inquiry into learning. AI is operationalized as a Walking Tour assessment project wh.ch.was introduced as part of th. class Cultural end Beh.viourel Fectors in Arch.tecture and Urbanism delivered at th. Department of Arch.tecture, University of Strath.lyde - Glasgow wh.re th.rty-two master of Arch.tecture students were enrolled. Th. Walking Tour assessment involved th. exploration of 6 factors th.t delineate key design ch.racteristics in th.ee retrofitted buildings in Glasgow： Th.atre Royal, Reid Building, and Th. Ligh.h.use. Working in groups, students assessed factors th.t included context, massing, interface, wayfinding, socio-spatial, and comfort. Findings reveal th.t students were able to focus on critical issues th.t go beyond th.se adopted in traditional teach.ng practices wh.le accentuating th. value of introducing AI and utilizing th. built environment as an educational medium. Conclusions are drawn to emph.size th. need for structured learning experiences th.t enable making judgments about building qualities wh.le effectively interrogating various ch.racteristics.

关键词： Arch.tectural pedagogy Appreciative Inquiry(AI) Experiential learning Inquiry-based learn-ing Assessment Glasgow

m2BPGi for assessing liver fibrosis in patients with.h.patitis C treated with.direct-acting antivirals

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World Journal of Gastroenterology 2020年第21期26卷 2864-2876页

作者： Sh.reen A Saleh.moh.med m salama marwan m Alh.sseini Gh.da A moh.med Gastroenterology and h.patology Unit Department of Internal MedicineFaculty of MedicineAin Shams UniversityCairo 11341Egypt

BACKGROUND Assessing liver fibrosis is important for predicting th. efficacy of direct-acting antivirals(DAAs)and patient ***-invasive tech.iques to assess liver fibrosis are becoming ***,serum mac-2 binding protein glycosylation isomer(m2BPGi)was identified as a non-invasive marker of liver *** To investigate th. diagnostic accuracy of m2BPGi in assessing liver fibrosis in patients with.ch.onic h.patitis C(Ch.)treated with.*** From December 2017 to August 2018,80 treatment-naive adult patients with.Ch. wh. were eligible for DAAs th.rapy were consecutively enrolled in th.s observational coh.rt *** 12 weeks,65 patients were treated with.sofosbuvir/daclatasvir,and 15 patients were treated with.sofosbuvir/daclatasvir and a weigh.-based dose of ribavirin at knowledge and tech.ology association for h.patitis C management clinic,Cairo,*** measured serum m2BPGi levels,PAPAS index,fibrosis-4(FIB-4)score and liver stiffness measurements(LSm)at baseline and 12 weeks after th. end of *** m2BPGi levels were measured using enzyme-linked immunosorbent *** All patients ach.eved sustained virologic response(SVR12)(100%).Serum m2BPGi levels,LSm,FIB-4 score and PAPAS index decreased significantly at SVR12(Pm m2BPGi levels correlated positively with.LSm at baseline and SVR12(Pmpared with.th. FIB-4 score and PAPAS index,m2BPGi was th. best marker to distinguish.patients with.grade F4 fibrosis(AUC=0.801,Ph.grade F2 from grade F0-1 fibrosis(AUC=0.713,P=0.012),patients with.grade F3-4 from grade F0-2 fibrosis(AUC=0.730,Ph.grade F2-4 from grade F0-1 fibrosis(AUC=0.763,Pm2BPGi h.d th. greatest AUCs for differentiating patients with.grade F4 fibrosis(AUC=0.844,Ph.grade F3 from grade F0-2 fibrosis(AUC=0.893,P=0.002),patients with.grade F3-4 from grade F0-2 fibrosis(AUC=0.891,Ph.grad

关键词： h.patitis C virus Liver fibrosis h.man mac-2 binding protein Antiviral agents Sustained virologic response Elastograph.

Rudists(Bivalvia) from a Cretaceous Platform in North.rn Egypt: Taxonomy and Paleobiogeograph.

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Acta Geologica Sinica(English.Edition) 2021年第6期95卷 1967-1983页

作者： Yasser salama Jamaan S.AJAREm Ah.ed A.ALLAm Ah.ed m.ALmALKI Geology Department Faculty of ScienceBeni-suef UniversityBeni-suef 65211Egypt Department of Zoology College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Department of Zoology Faculty of ScienceBeni-suef UniversityBeni-suef 65211Egypt

New well-preserved rudist materials come from th. Barremian–Turonian marine formations in th. Yelleg, minsh.rah. maaza, and Ragh.wi sections in North.Sinai, north.rn Egypt. Th.re, 17 discovered rudist species belonging to 13 genera and seven taxonomic families are described in detail as follows: Eoradiolites plicatus(Conrad), Eoradiolites liratus(Conrad), Praeradiolites ponsianus(d'Arch.ac), Arch.eoradiolites sp., Bournonia africana Douvillé, Bournonia fourtaui Douville, Biradiolites lombricalis(d'Orbigny), Biradiolites zumoffeni Douville, Radiolites lewyi lewyi Parnes, Radiolites sauvagesi(d'h.mbres-Firmas), Durania arnaudi(Ch.ffat), Toucasia carinata(math.ron), Toucasia sp., Neocaprina ragh.wiensis Steuber and Bach.ann, Sellaea sp., Ich.h.osarcolites sp. and h.roiopleura sp.. Th. Cenomanian deposits in th. north.rn Eastern desert of Egypt only contain E. liratus. Th. domination of th. Cenomanian rudist species in North.Sinai, h.wever, is attributed to ch.nges in th. platform, wh.ch.passes mainly from carbonate in th. north.to siliciclastics in th. south. Th. presence of h.riopleura sp. in th. late Barremian-early Aptian deposits is documented for th. first time, wh.ch.suggests th. expansion of taxa of th. genus h.riopleura Douville to North.Sinai during th.s interval. Th. age of th. rudist species is documented from th. late Barremian-Turonian formations, with.th.ir geograph.c distribution in th. mediterranean region considered..

关键词： invertebrate paleontology mollusks rudists Taxonomy Paleobiogeograph. Barremian–Turonian Egypt

Stevens-Joh.son syndrome complicating adalimumab th.rapy in Croh.'s disease

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World Journal of Gastroenterology 2009年第35期15卷 4449-4452页

作者： muna salama Ian Craig Lawrance Department of Gastroenterology Fremantle HospitalFremantle 6059WAAustralia Department of Gastroenterology Fremantle HospitalWAAustralia Centre for Inflammatory Bowel Diseases Fremantle HospitalWA Australia Department of medicine and Ph.rmacology University of Western AustraliaFremantle HospitalFremantle 6059WA Australia

Th. anti-tumor necrosis factor(TNF)αmedications demonstrate efficacy in th. induction of remission and its maintenance in numerous ch.onic inflammatory *** th. increasing number of patients receiving anti-TNFαagents,h.wever,less common adverse reactions will *** eruptions complicating treatment with.an anti-TNFαagent are not uncommon,occurring in around 20%of patients. Adalimumab,a fully h.manized antibody against TNFα, may be expected to cause minimal immune-mediated skin reactions compared to th. ch.meric monoclonal antibody,***,h.wever,report a case of Stevens-Joh.son syndrome th.t required h.spitalization and cessation of adalimumab in a patient with.Croh.’ s disease(CD).In th.s case report,a 29-year-old male with.colonic and perianal CD with.associated eryth.ma nodosum and large joint arth.opath. developed severe mucositis,periph.ral rash.and desquamation,fevers and respiratory symptoms concomitant with.a second dose of 40 mg adalimumab after a 2 mo break from adalimumab *** biopsies of th. abdominal wall confirmed eryth.ma multiforme and th. patient was on no oth.r drugs and infective etiologies were *** patient responded rapidly to IV h.drocortisone and was able to be commenced on infliximab with.ut recurrence of th. Stevens-Joh.son *** skin reactions h.ve now been described in th.ee of th. TNFαantagonists(infliximab,etanercept and adalimumab).Th.se reactions can be serious and prescribers need to be aware of th. potential mucocutaneous side effects of th.se agents,especially as Stevens-Joh.son syndrome is associated with.significant morbidity and mortality.

关键词： Stevens-Joh.son syndrome Croh.'sdisease Adalimumab Serious adverse effect