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Quantitative Assessment of Liver Fibrosis by elastography in Patients with Chronic Liver Disease: A Cross-Sectional Study in Lomé (Togo)

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Open Journal of Radiology 2024年第2期14卷 42-54页

作者： Massaga Dagbe Bidamin N’timon Sonia Ekembe rafiou el-hadji yakoubou Pihou Gbande Lantam Sonhaye Lama Kegdigoma Agoda-Koussema Komlanvi Victor Adjenou Department of Radiology and Medical Imaging Kara University Hospital Kara Kara Togo Department of Radiology and Medical Imaging Lom University Hospital Lome Togo Department of Hpato-gastroenterology Kara University Hospital Kara Togo Department of Radiology and Medical Imaging Sokod Regional Hospital Sokode Togo Department of Internal Medicine Kara University Hospital Kara Togo

Aim: To describe the two-dimensional elastographic profile according to the Shearwave (2D-SWE) technique in patients with chronic liver disease in Lom. Materials and method: Cross-sectional, descriptive study conducted over seven month at the Autel delie Clinic in Lom, from January to August 2022, on adult patients with chronic liver disease who underwent abdominal ultrasound coupled with two-dimensional elastography. Results: The sample size was 54 patients. The mean age of the patients was 33 12 years, with extremes of 18 and 66 years. Patients aged 30 years or less accounted for 48.1% (n = 26). All patients (n = 54) had at least one transaminase assay with a mean of 69.3 78.3 IU/l (AST) and 59.3 82.8 IU/l (ALT). There was no statistically significant association between the biological parameters and the presence of fibrosis. Viral liver disease was the main cause, accounting for 81.5% (n = 44) of cases, with no significant association with the degree of fibrosis. Ultrasound revealed a dysmorphic liver (57.4%;n = 31) and portal hypertension (18.5%, n = 10). Fibrosis stages F1, F2 and F4 accounted for (48.1%, n = 26), (24.1%, n = 13) and (13%, n = 7) of cases respectively. Liver dysmorphia was significantly associated with the presence of fibrosis (p = 0.012) and portal hypertension was significantly associated with the degree of fibrosis (p = 0.0063). Conclusion: Assessment of liver fibrosis in patients with chronic liver disease using 2D-SWE elastography is essential for patient follow-up.

关键词： Hepatic Fibrosis 2D-SWE elastography Chronic Liver Disease Lomé

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Patients’ Lived Experience and Injuries Observed during Upper Digestive Endoscopy at KARA Teaching Hospital (Togo)

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Open Journal of Gastroenterology 2021年第12期11卷 285-294页

作者： Oumboma Bouglouga rafiou el-hadji yakoubou Laté Mawuli Lawson-Ananissoh Aklesso Bagny Datouda Redah Department of Hepatology and Gastroenterology CHU-KARA Kara Togo Department of Hepatology and Gastroenterology CHU-CAMPUS Lomé Togo

Background: Endoscopy remains the most performant medical exam exploring the upper digestive tract;but depending on patients, its tolerance is variable. Objective: This study aimed at describing the experience and evaluating the tolerance, acceptability and injuries observed during upper gastrointestinal endoscopy. Methods: This is a prospective and descriptive study carried out from April to July 2017 in the digestive endoscopy unit of the Kara teaching hospital (Togo). The gastroscopy was performed by the same operator (Hepatogastroenteroloogist). The premedication was done with direct intravenous injection of 10 mg of Metoclopramide hydrochloride and viscous Lidocaine oral gel. Previously, essential information about the examination course was given to patients after obtaining their verbal consent. Patients’ impressions of the experience, tolerance and acceptability were collected on a survey sheet, before and after the examination. Results: One hundred and eleven patients were included, 62 women and 49 men. The average age was 45.9 years (15 - 88 years), and the sex ratio (F/M) was 1.2. Most of the patients (89.2%) were experiencing the gastroscopy for the first time, and the main reason was epigastralgia in 55%. The examination duration was good at 88.3% and tolerance was good at 72.1%. Tingling, irritation, pain or sore throat feelings were noted in 13.5%. Pati

关键词： Upper Digestive Endoscopy Experience Tolerance Acceptability Injuries Togo

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Characteristics and Prognosis of Patients with Hepatocellular Carcinoma at Campus Teaching Hospital of Lome

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Open Journal of Gastroenterology 2019年第11期9卷 203-210页

作者： Aklesso Bagny Late Mawuli Lawson-Ananissoh Oumboma Bouglouga Lidawu Kogoe rafiou el hadji-yakoubou Debohoma Redah Datouda Redah Hepatology and Gastroenterology Department of Campus Teaching Hospital of Lome Lome Togo Gastroenterology Unit of Teaching Hospital of Kara Kara Togo

Background: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world, as well as in Togo, where it is a major public health problem. HCC is the third most common cause of death from cancer. Chronic infection with HBV and HCV is the most important cause of HCC. Objective: To determine the epidemiological, diagnostic and evolutionary aspects of HCC in the hepatology and gastroenterology department of Campus Teaching Hospital of Lomé. Patients and method: Descriptive and analytical study, conducted from January 1, 2013 to December 31, 2017, on all patients admitted in the hepatology and gastroenterology department of Campus Teaching Hospital of Lome for hepatocellular carcinoma. The statistical analysis was done using Stata 13 software. The significance threshold was used for p Findings: A total of 250 patients were retained. Hospital prevalence was 6.1%. There was a male predominance with a sex ratio of 2.84. The average age was 47.15 ± 13.85 (extreme: 20 - 85 years). The average duration of symptoms was 67.08 ± 82.59 days. Pain in the right hypochondrium was the most common reason for consultation (64.6%). The average AFP value was 24,062 ± 33,318 ng/ml. Ultrasound found more than two nodules in 74.75% of cases and a portal thrombosis in 64.97% of cases. The main etiologies found were chronic hepatitis B (55%) and C (8%) virus infections. The majority (89.20%) of patients were in the BCLC D stage. Survival at 6 months was 45%. Factors associated with death were: chronic ethylism (OR = 16.87, p = 0.002), jaundice (OR = 341.57, p = 0.004), rupture of esophageal varices (OR = 42.45, p = 0.008) and a BCLC D score (OR = 9.82, p = 0.041). Conclusion: Young adults were the most affected by HCC, whose etiologies are dominated in our context by hepatitis B and C viruses. The majority of our patients consulted late and was found at the terminal stage of the disease, limiting any therapeutic possibility. In this situation, the best attitude remains

关键词： Hepatocellular Carcinoma Diagnosis Survival Togo

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Effectiveness of Treatment of Chronic Viral Hepatitis C by Direct-Acting Antivirals in Togo

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Open Journal of Gastroenterology 2019年第7期9卷 125-133页

作者： Laté Mawuli Lawson-Ananissoh Aklesso Bagny Oumboma Bouglouga Laconi Kaaga rafiou el-hadji yakoubou Lidaw Kogoe Datouda Redah Hepatogastroenterology Unit University Hospital Campus Lomé Togo Hepatogastroenterology Unit University Hospital of Kara Kara Togo

Background: Viral hepatitis C is the second leading cause of hepatocellular carcinoma after hepatitis B in Africa and Togo in particular. The advent of direct acting antivirals has revolutionized the care and prognosis of patients infected with hepatitis C virus (HCV). Objective: To evaluate the sustained virological response (SVR) 12 weeks after oral treatment without interferon in HCV infected patients with genotypes 1 and 2. Patients and Method: Descriptive and analytical study based on the retrospective collection of data in the hepatogastroenterology unit of the University Hospital Campus of Lome (Togo) from July 11, 2016 to April 22, 2018. All patients who had a chronic viral hepatitis C with viral replication, naive, regardless of the genotype, regardless of the degree of liver fibrosis, and who had completed their treatment with direct-acting antivirals were included. Results: We recruited 84 patients, 60 of whom were infected with HCV genotype 2 (71.43%) and 24 with HCV genotype 1 (28.57%). There were 58 men and 26 women (sex ratio: 0.45). In HCV genotype 1 patients, the median age was 54.29 years and Sofosbuvir/Ledipasvir was the most used combination (62.50%). In HCV genotype 2 patients, the median age was 54.5 years and Sofosbuvir associated with Ribavirin was the most used treatment (81.66%). The virological response at the end of treatment was 100% (genotype 1) and 93.30% (genotype 2). The SVR 12 was 100% (genotype 1) and 91.70% (genotype 2). Five patients were in treatment failure (genotype 2). Conclusion: Direct-acting antivirals were effective in our patients. The rate of sustained virological response was above 90%.

关键词： Viral Hepatitis C Direct-Acting Antivirals Sustained Virological Response Togo

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Hematological Profile of Anemia in Hospitalized Cirrhotics in the Hepato-Gastroenterology Unit of the University Hospital Campus of Lome (Togo)

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Open Journal of Gastroenterology 2021年第10期11卷 194-202页

作者： Laté Mawuli Lawson-Ananissoh Lidawu Roland-Moïse Kogoe Venceslas Debehoma Redah Oumboma Bouglouga rafiou el-hadji yakoubou Laconi Kaaga Aklesso Bagny Hepatogastroenterology Unit University Hospital Campus Lomé Togo Hepatogastroenterology Unit University Hospital of Kara Kara Togo

Background: Anemia is multifactorial and very frequently observed in the evolution of cirrhosis. Only biological investigations can clarify its mechanisms. Objective: To determine the frequency of anemia in cirrhosis patients and to identify the different types of anemia encountered. Patients and Methods: Descriptive and analytical study based on the retrospective collection of data was carried out over 12 months in the hepato-gastroenterology unit of the University Hospital Campus of Lome (Togo). This study included hospitalized cirrhotic patients with a complete medical file including a blood count and presenting anemia. Results: During the study period, we collected 253 cases of cirrhosis, of which 153 patients had anemia (60.5%);there was a male predominance of 73.2%. The mean age was 51 ± 13 years. The B viral origin of cirrhosis was the most common (60.1%). Oedemato-ascitic decompensation (82.4%) and hepatocellular carcinoma (34%) were the main complications

关键词： Anemia Blood Count Cirrhosis Hepatitis B Virus Togo

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Interest of Serum-Ascites Albumin Concentration Gradient in the Diagnosis of Portal Hypertension in Cirrhotic Patients

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Open Journal of Gastroenterology 2019年第1期9卷 13-21页

作者： Laté Mawuli Lawson-Ananissoh Aklesso Bagny Oumboma Bouglouga Ismael Mahaman Salissou Ganbobo rafiou el-hadji yakoubou Lidawu Kogoe Laconi Kaaga Datouda Redah Hepatogastroenterology Unit University Hospital Campus Lome Togo Hepatogastroenterology Unit University Hospital of Kara Kara Togo

Objective: To find a more accessible and less restrictive mean such as serum-ascites albumin gradient (SAAG) to predict esophageal varices (EV) in cirrhotics with ascit. Patients and methods: Descriptive and analytical studies based on the retrospective collection of data on 125 patients’ records in the hepatogastroenterology unit of the University Hospital Campus of Lome (Togo) from January 1, 2008 to March 31, 2018 were included. Cirrhotic patients aged 15 years and older had performed cytochemical analysis of ascites fluid and upper gastrointestinal fibroscopy and had a protidogram. Statistical analysis was done by R Studio Software 3.4.2. Results: The mean age was 48.70 years;there was a male predominance (70.40%) with a sex ratio of 2.38. Protein levels in ascitic fluid was Conclusion: Our study noted that at an upper threshold of 1.10 g/dl, the SAAG significantly predicted the presence of EV.

关键词： Esophageal Varices Serum-Ascit Albumin Gradient Cirrhosis Togo

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