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Serum chromogranin-A in hepatocellular carcinoma: Diagnostic utility and limits

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World Journal of Gastroenterology 2005年第13期11卷 1987-1990页

作者： Aldo Spadaro Antonino Ajello Carmela Morace Agata Zirilli Graziella D'arrigo Carmelo Luigiano Francesco Martino Anna Bene Domenico Migliorato santi Turiano Oscar Ferraù Maria Antonietta Freni Dipartimento Clinico Sperimentale di Medicina e Farmacologia Dipartimento di Statistica Dipartimento di Scienze Radiologiche Unità Operativa di Gastroenterologia

AIM: The utility of serum alpha-fetoprotein (α-FP) for the detection of hepatocellular carcinoma (HCC) is *** serum levels of chromogranin-A (CgA) have recently been reported in HCC. Impaired hepatic, renal, and heart functions influence circulating CgA. The aim of this study was to assess sensitivity and specificity of serum CgA as a marker of HCC in patients with liver cirrhosis (LC).METHODS: Serum CgA levels were measured by RIA in 339 patients of which 54 HCC, 132 LC, 45 chronic hepatitis (CH), 27 chronic heart failure (CHF), 36 chronic renal failure (CRF), 45 chronic inflammatory bowel disease (IBD)as disease controls and in 75 healthy controls. Patients with liver disease or IBD and concomitant renal and/or heart failure were excluded. Pearson correlation, nonparametric combination test and confidence interval analysis were used for statistical ***: Serum CgA above normal values (100 ng/mL)were found in 83% of HCC patients, in 48% of LC patients,in 20% of CH patients, in 33% of IBD patients, in 92% of CRF patients, in 100% of CHF patients, and in none of the healthy controls. The mean CgA values in HCC (769±1 046), in LC (249±369), in CH (87±94), in CRF (1 390±1 401), in CHF (577±539), in IBD (146±287) were significantly higher than those in healthy controls (48±18).HCC patients had higher CgA values (P＜0.01) than LC,CH, and IBD patients but did not differ from those with CRF or CHF. The 95% CI for the mean (250-1 289 ng/mL)in HCC patients was selected as a CgA range and the lower value of such range was assumed as *** and specificity of CgA, calculated in relation to the cut-off in patients with cirrhosis and HCC, were respectively 61% (CI 48-73%) and 82% (CI 75-88%).Serum α-FP values were ＞200 ng/mL in 21% of the HCC patients and in none of the LC patients. No significant correlation was found between α-FP and CgA in patients with HCC and in patients with ***: When HCC is suspected and α-FP is norma

关键词：嗜铬粒蛋白-A 血清肝细胞癌诊断方法

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阿尔茨海默病进展过程中的内侧颞叶萎缩率

世界核心医学期刊文摘（神经病学分册） 2005年第7期1卷 37-38页

作者： Rusinek H. Endo Y. De santi S. 周永 Radiology NYUSM Bellevue Old C and D Bldg. 550 First Avenue New York NY 10016 United States Dr.

Objective: To establish the progression of brain atrophy rates in patients wit h a known date of onset of Alzheimer disease (AD).Methods: Each of 18 subjects h ad two high-resolution T1-weighted three-dimensional MRI examinations. The tw o MRIs were coregistered and the annual rate of brain tissue atrophy was derived both for the entire brain and regionally for the left and right medial temporal lobe (MTL). Time since onset (TSO) of AD, defined as the interval between the d ate of onset and the midpoint of MRI dates, ranged from -2.9 to 4.2 years. Resu lts:In patients with AD, TSO was a correlate of the atrophy rate for both the le ft MTL (R2 = 0.58, p = 0.001) and right MTL (R2 = 0.30, p = 0.03). When serial m easurements were applied to a control group of 21 cognitively normal elderly sub jects,MTL atrophy rate classified the group membership (AD vs normal cognition) with an accuracy of 92.3%. Conclusion:Increased annual atrophy rate in the medi al temporal lobe is a potential diagnostic marker of the progression of Alzheime r disease.

关键词：内侧颞叶萎缩阿尔茨海默病进展过程认知功能发病日期 cognition atrophy elderly 时间间隔 progression

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学校改造——曼谷大学学生休息厅

现代装饰 2012年第8期 86-95页

作者： Pitupong Chaowakul Suchart Ouypornchaisakul Nuntawat Tassanasangsoon Wattikon Kosolkit santi Sarasuphab Supanna Chanpensri Wison Tungthuny 何延庆 Supermachine Studio

关于现代的教育是不是应该停留在教室,抑或是走进图书馆、家庭、咖啡馆等,已经有过很多讨论。在互联网时代和社会网络化时期,知识已经变得触手可及,大学也正在适应这样的环境,走向崭新的发展阶段。曼谷大学学生休息厅（亦可称为想象休... 详细信息

关于现代的教育是不是应该停留在教室,抑或是走进图书馆、家庭、咖啡馆等,已经有过很多讨论。在互联网时代和社会网络化时期,知识已经变得触手可及,大学也正在适应这样的环境,走向崭新的发展阶段。曼谷大学学生休息厅（亦可称为想象休息室）正是适应这种趋势的试点项目。

关键词：休息厅大学学生曼谷改造学校互联网时代试点项目

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泥石流中石块尺寸与其流速间的关系

地基处理 2009年第2期20卷 63-70页

作者： Adam B. Prochaska Paul M. santi Jerry D. Higgins 秦鹏飞（译）韩同春（校） Relationships between size and velocity for particles within debris flows 不详

泥石流中砾石冲击力的估算对结构减灾设施的设计很重要。砾石冲击力公式对泥石流中的石块尺寸和速度非常敏感。目前的设计规范建议设计石块的尺寸等于流深，速度等于泥石流的流速。这篇论文运用录像分析软件考察了泥石流中不同尺寸石块... 详细信息

泥石流中砾石冲击力的估算对结构减灾设施的设计很重要。砾石冲击力公式对泥石流中的石块尺寸和速度非常敏感。目前的设计规范建议设计石块的尺寸等于流深，速度等于泥石流的流速。这篇论文运用录像分析软件考察了泥石流中不同尺寸石块的速度。泥石的速度大体上随尺寸的增大而减小，并发现其减小率取决于石块在泥石流中整合的能力。

关键词：泥石流砾石流速冲击力设计

Serum SCCA-IgM as a predictor of hepatocellular carcinoma in patients with liver cirrhosis

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Open Journal of Gastroenterology 2012年第2期2卷 56-61页

作者： Daniela Buccione Gianluca Fatti Andrea Gallotta Elisabetta Loggi Roberto Di Donato Lilia Testa Carlo Saitta Valentina santi Antonio Di Micoli Virginia Erroi Marta Frigerio Valentina Fazio Antonino Picciotto Alessandra Biasiolo Francoise Degos Patrizia Pontisso Giovanni Raimondo Franco Trevisani APHP Hopital Beaujon INSERM U 773 Clichy France Dipartimento di Medicina Clinica e Sperimentale “G. Patrassi” Università di Padova Padova Italia Dipartimento di Medicina Clinica Alma Mater Studiorum-Università di Bologna Bologna Italia Dipartimento di Medicina Interna Policlinico Universitario di Messina Messina Italia Dipartimento di Medicina Interna Università di Genova Genova Italia Xeptagen S.p.A. Venezia Italia

Aberrant Squamous Cell Carcinoma Antigen (SCCA) expression is an early hepatocarcinogenetic event and circulating SCCA-IgM complexes are elevated in most HCC patients. We evaluated whether serum SCCA-IgM levels can identify HCV +ve cirrhotic patients at low HCC risk. In this retrospective study we enrolled 29 cirrhotic patients in whom serum SCCA-IgM was measured 8 - 69 months (median 31) before HCC diagnosis, and 28 cirrhotic patients who remained HCC- free, with SCCA-IgM measured 15 - 68 months (median 48) before the study end. The best discriminating value of SCCA-IgM was calculated and tested in predicting HCC diagnosis within 12, 24 and 36 months. Sensitivity analysis, considering different HCC incidence, was conducted to identify the patient subgroup with an annual cancer risk below the threshold of a cost-effective semiannual surveillance with ultrasound. Cumulative HCC incidence at 12, 24 and 36 months was 7.0%, 15.7% and 26.3%, respectively. SCCA-IgM levels were higher in HCC than in cirrhotic patients [median: 381 (95% C.I.: 50 - 5289) vs. 100 (70 - 493) AU/mL, P = 0.005]. The SCCA-IgM value ≤ 200 AU/mL accurately identified patients at low risk of HCC development in the subsequent year (sensitivity 75%, specificity 62%, positive predictive value 13% and negative predictive value 97%). Considering an annual HCC incidence ≤ 3%, patients with SCCA-IgM ≤ 200 AU/mL (60% of the whole patients) had an HCC risk below the accepted threshold of a cost-effective surveillance (1.5%). In conclusion, provided that our provocative results are confirmed in larger studies, SCCA-IgM serum measurement could permit implementation of a two step (with different costs) surveillance: an initial serological surveillance, based on the annual monitoring of this biomarker, and the conventional surveillance by semiannual US when SCCA-IgM becomes >200 AU/mL. This could improve the cost/effectiveness of surveillance of HCV infected patients at risk of HCC.

关键词： SCCA-IgM HCC Risk Assessment Surveillance Cost/Effectiveness

科罗拉多危岩落石评估系统的修正和统计分析(二)

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四川建材 2011年第3期37卷 86-88页

作者： Paul M.santi Christopher P.Russell Jerry D.Higgins Jessica I.Spriet 李楚根中铁二院工程集团有限责任公司四川成都610031

（接上期）1.3.8不连续面：裂隙数目改良的RHRS系统加上了不连续面裂隙数目这一参数,用来反映破裂岩体中发生的渗透,冻楔作用以及化学风化的重要性（Senior,1999;Maerz et al.,2005;Romana,

关键词：评估系统统计分析危岩落石科罗拉多不连续面破裂岩体化学风化裂隙

科罗拉多危岩落石评估系统的修正和统计分析(一)

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四川建材 2011年第2期37卷 78-81,83页

作者： Paul M. santi Christopher P. Russell Jerry D. Higgins Jessica I. Spriet 李楚根（译）不详中铁二院工程集团有限责任公司四川成都610031

修正的科罗拉多危岩落石评估系统是通过加入一些新近的有助于危岩产生的地质和气象因素开发的。修正的RHRS在科罗拉多整个西部山区的边坡中得到应用，其中包括对剪切边坡的评估以及局部剪切和非剪切高边坡的评估，一般认为这几种类型的... 详细信息

修正的科罗拉多危岩落石评估系统是通过加入一些新近的有助于危岩产生的地质和气象因素开发的。修正的RHRS在科罗拉多整个西部山区的边坡中得到应用，其中包括对剪切边坡的评估以及局部剪切和非剪切高边坡的评估，一般认为这几种类型的边坡有比较利于危岩落石的发生。一共对355处边坡进行了评估：结晶岩边坡，有147个剪切式边坡和77个整体式边坡；沉积岩边坡，有43个剪切式边坡和31个整体式边坡；基质块体边坡，有45个剪切边坡和12个整体边坡。利用最小二乘回归分析，得到对总危险评分在统计学上有重要影响的参数。然后使用顺序逻辑回归对这些子集进行分析，再把这些参数划分等级，以确定哪个参数对总危险评分影响最大。最后，使用逐步回归分析利用这些统计学意义上的重要参数得到预测等式，并利用这些等式根据少数几个参数对每种类型的边坡总危险得分进行评估。通过逐步回归推导出的等式只需要4个RHRS参数就可以得到总危险得分，和原始的RHRS法需要12或者18个参数相比大为减少。这些参数的选取主要取决于边坡的类型，R^2值在68—82％之间。对一些情况，还可以使用更多参数的等式以及相应的更高的R2数值。通过分析等式能够区分出每种边坡类型中最重要和最不重要的参数。对所有边坡类型来说，发生特征和倾斜面很重要，而倾角、每年冻结／解冻等级、边坡水特征，以及不连续面的摩擦并不重要。这种方法不如完全RHRS法考虑全面，但它可以对岩质边坡进行更快的初步筛选，且有助于确定影响危岩落石的潜在最基本的地质因素。

关键词：落石风险边坡分级

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膀胱弥漫性节细胞神经瘤病和丛状神经纤维瘤

临床与实验病理学杂志 2009年第1期25卷 4-4页

作者： Scheithauer B W santi M Richter E R 李磊(摘译) 张仁亚(审校) 不详济宁医学院附属医院病理科济宁272029

儿童膀胱肿瘤最常见的是横纹肌肉瘤,其它膀胱肿瘤极其罕见,包括移行细胞乳头状瘤,乳头状癌,炎性肌纤维母细胞肿瘤和神经纤维瘤。膀胱孤立性神经纤维瘤是Ⅰ型神经纤维瘤病的早期表现,很少发生于20岁之前。作者报道了1例出现类似表现的6... 详细信息

儿童膀胱肿瘤最常见的是横纹肌肉瘤,其它膀胱肿瘤极其罕见,包括移行细胞乳头状瘤,乳头状癌,炎性肌纤维母细胞肿瘤和神经纤维瘤。膀胱孤立性神经纤维瘤是Ⅰ型神经纤维瘤病的早期表现,很少发生于20岁之前。作者报道了1例出现类似表现的6岁女性患者,并且发现其与膀胱弥漫性节细胞神经瘤病表现相同的丛状神经纤维瘤。作者描述了其临床表现、诊断经过和病理学特征。[第一段]

关键词：丛状神经纤维瘤节细胞神经瘤膀胱肿瘤弥漫性 Ⅰ型神经纤维瘤病横纹肌肉瘤母细胞肿瘤病理学特征

达比加群酯联合缬沙坦氨氯地平治疗高血压合并心房颤动的效果

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中国实用医刊 2021年第10期48卷 95-97页

作者：胡三提陈庆丽白志勇河南省郑州市第六人民医院急诊科 450000

目的:探讨达比加群酯联合缬沙坦氨氯地平治疗高血压合并心房颤动的效果。方法:抽取2018年10月至2020年10月郑州市第六人民医院收治的高血压合并心房颤动患者122例,根据治疗方案将其分为对照组与治疗组,每组61例。对照组口服缬沙坦氨氯... 详细信息

目的:探讨达比加群酯联合缬沙坦氨氯地平治疗高血压合并心房颤动的效果。方法:抽取2018年10月至2020年10月郑州市第六人民医院收治的高血压合并心房颤动患者122例,根据治疗方案将其分为对照组与治疗组,每组61例。对照组口服缬沙坦氨氯地平及华法林,治疗组口服缬沙坦氨氯地平及达比加群酯。回顾性比较两组治疗效果、凝血功能指标及复发情况。结果:治疗组临床有效率为90.16%(55/61),高于对照组的75.41%(46/61),P<0.05。治疗结束时,治疗组凝血酶原时间、国际标准化比值分别为(35.02±2.69)s、2.07±0.84,高于对照组的(30.27±3.19)s、2.44±0.61,P<0.05。随访1年,对照组心房颤动复发率为45.90%(28/61),高于治疗组的22.95%(14/61)。结论:达比加群酯联合缬沙坦氨氯地平治疗高血压和并心房颤动疗效确切,凝血功能明显改善,心房颤动复发率较低。

关键词：高血压心房颤动达比加群酯缬沙坦氨氯地平