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Spectral Gap of the Largest Eigenvalue of the Normalized Graph Laplacian

Communications in Mathematics and Statistics 2022年第3期10卷 371-381页

作者： Jürgen Jost raffaella mulas Florentin Münch Max Planck Institute for Mathematics in the Sciences LeipzigGermany

We offer a new method for proving that the maxima eigenvalue of the normalized graph Laplacian of a graph with n vertices is at least n+1/n−1 provided the graph is not complete and that equality is attained if and only if the complement graph is a single edge or a complete bipartite graph with both parts of size n−1/2.With the same method,we also prove a new lower bound to the largest eigenvalue in terms of the minimum vertex degree,provided this is at most n−1/2.

关键词： Spectral graph theory Normalized Laplacian Largest eigenvalue Sharp bounds

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地震光和地震地面加速度之间的时间差相关性

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Applied Geophysics 2021年第1期18卷 9-16,128页

作者： Juan Antonio Lira Maurizio mulas Facultad de Ciencias Físicas Universidad Nacional Mayor de San MarcosLima 1Peru Sección Física Departamento Académico de CienciasPontificia Universidad Católica del PerúLima 32Peru Escuela Superior Politécnica del Litoral ESPOLFacultad de Ingeniería en Ciencias de la TierraCampus Gustavo Galindo Km 30.5 Vía PerimetralP.O.Box 09-01-5863

虽然自古以来就知道地震光,但直到60年代,才拍摄下第一张地震光照片。在2007年在秘鲁发生地震期间,录下了第一部地震光录像。同样,在2016年瓜多尔地震和2017年墨西哥地震期间,记录了两部地震光电影。这些电影记录,无论是客观还是信息内... 详细信息

虽然自古以来就知道地震光,但直到60年代,才拍摄下第一张地震光照片。在2007年在秘鲁发生地震期间,录下了第一部地震光录像。同样,在2016年瓜多尔地震和2017年墨西哥地震期间,记录了两部地震光电影。这些电影记录,无论是客观还是信息内容,都有助于研究地震光。已经提出了几种解释地震光的因果机制:压电性、氡放射、流体扩散、摩擦汽化、正极洞穴和偶极电流等等。在这项工作中,我们发现了地震光和地震地面加速度之间的时间差相关性,并使用地震数据和地震光的胶片记录来解释其起源。在讨论部分,建议岩石破裂在某种程度上表现为通过感应产生静电的地震光。我们建立了一个新的感应模型,可以用于解释EQL的形成,即使地壳具有大电阻率层。该模型还解释了地震光的形成,而不需要地球表面或大气中的特殊条件。更好地理解地震光的生成过程可以提高我们对地震活动的理解,并有助于预测地震。

关键词：时差相关性地震光地震地面加速度岩石破裂

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The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13

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Cellular & Molecular Immunology 2021年第6期18卷 1512-1527页

作者： Floriana mulas Xu Wang Shanshan Song Gopala Nishanth Wenjing Yi Anna Brunn Pia-Katharina Larsen Berend Isermann Ulrich Kalinke Antonio Barragan Michael Naumann Martina Deckert Dirk Schlüter Institute of Medical Microbiology and Hospital Hygiene Otto-von-Guericke University Magdeburg39120MagdeburgGermany Institute of Medical Microbiology and Hospital Epidemiology Hannover Medical School30625HannoverGermany Chemical Biology Research Center School of Pharmaceutical SciencesWenzhou Medical University325035WenzhouChina Department of Neuropathology Faculty of Medicine and University Hospital CologneUniversity of Cologne50931CologneGermany Institute for Experimental Infection Research TWINCORE Centre for Experimental and Clinical Infection Researcha joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research30625HannoverGermany Institute for Clinical Chemistry and Pathobiochemistry Otto-von-Guericke University Magdeburg39120MagdeburgGermany Cluster of Excellence-Resolving Infection Susceptibility(RESIST) Hannover Medical School30625HannoverGermany Department of Molecular Biosciences Stockholm University10691StockholmSweden Institute for Experimental Internal Medicine Otto-von-Guericke University Magdeburg39120MagdeburgGermany

Dendritic cells(DCs)are indispensable for defense against pathogens but may also contribute to immunopathology.Activation of DCs upon the sensing of pathogens by Toll-like receptors(TLRs)is largely mediated by pattern recognition receptor/nuclear factor-κB(NF-κB)signaling and depends on the appropriate ubiquitination of the respective signaling molecules.However,the ubiquitinating and deubiquitinating enzymes involved and their interactions are only incompletely understood.Here,we reveal that the deubiquitinase OTU domain,ubiquitin aldehyde binding 1(OTUB1)is upregulated in DCs upon murine Toxoplasma gondii infection and lipopolysaccharide challenge.Stimulation of DCs with the TLR11/12 ligand T.gondii profilin and the TLR4 ligand lipopolysaccharide induced an increase in NF-κB activation in OTUB1-competent cells,resulting in elevated interleukin-6(IL-6),IL-12,and tumor necrosis factor(TNF)production,which was also observed upon the specific stimulation of TLR2,TLR3,TLR7,and TLR9.Mechanistically,OTUB1 promoted NF-κB activity in DCs by K48-linked deubiquitination and stabilization of the E2-conjugating enzyme UBC13,resulting in increased K63-linked ubiquitination of IRAK1(IL-1 receptor-associated kinase 1)and TRAF6(TNF receptor-associated factor 6).Consequently,DC-specific deletion of OTUB1 impaired the production of cytokines,in particular IL-12,by DCs over the first 2 days of T.gondii infection,resulting in the diminished production of protective interferon-γ(IFN-γ)by natural killer cells,impaired control of parasite replication,and,finally,death from chronic T.encephalitis,all of which could be prevented by low-dose IL-12 treatment in the first 3 days of infection.In contrast,impaired OTUB1-deficient DC activation and cytokine production by OTUB1-deficient DCs protected mice from lipopolysaccharide-induced immunopathology.Collectively,these findings identify OTUB1 as a potent novel regulator of DCs during infectious and inflammatory diseases.

关键词： OTUB1 dendritic cell signal transduction ubiquitination innate immunity

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A New Volumetric Parameter for a Comparative Finite-Element Analysis of a Six- or Four-Implant Mandibular Total-Arch Rehabilitation

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Open Journal of Stomatology 2016年第1期6卷 12-21页

作者： Alfredo Natali Enrico Bertocchi Andrea Baldini Giuseppe Antonio mulas Matteo Martinolli Bortolini Sergio DDS Teacher at the PhD “Enzo Ferrari” in Industrial and Environmental Engineering University of Modena and Reggio Emilia Modena Italy Department of Engineering “Enzo Ferrari” University of Modena and Reggio Emilia Modena Italy Tecnopolo di Mirandola Science and Technology Park for Medicine Mirandola Italy School of High Mechanics and Automotive Design & Technology Department of Mechanical and Civil Engineering University of Modena and Reggio Emilia Modena Italy Department of Surgery Medicine Dentistry and Morphologic Science with Interests in Transplant Oncologic and Regenerative Medicine University of Modena and Reggio Emilia Modena Italy

In a full-arch implant rehabilitation ad modum Branemark, the distribution of stress and strain in mandibular bone is influenced by the type, number and position of implants used. In particular, the biomechanical behaviour of the bone structure after complete osseointegration depends on the load transferred to the bone by each fixture. In this study, a finite-element analysis of two models was performed. Models of an all-on-four configuration and a six-implant configuration were compared in a worst-case scenario. A new V parameter is presented to aid the quantitative and comparative analysis of the all-on-four and six-implant configurations. The influence of orthotropy was also investigated, and a geometric change in the all-on-four configuration is presented.

关键词： Finite-Element Analysis Oral Implants All-on-Four Configuration Six-Implant Configuration Bone Mechanics Comparative Analysis

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