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Thiazolidinedione treatment inhibits bile duct proliferation and fibrosis in a rat model of chronic cholestasis

World Journal of Gastroenterology 2005年第32期11卷 4931-4938页

作者： Fabio Marra raffaella defranco Gaia Robino Erica Novo Eva Efsen Sabrina Pastacaldi Elena Zamara Alessandro Vercelli Benedetta Lottini Carlo Spirli Mario Strazzabosco Massimo Pinzani Maurizio Parola Dipartimento di Medicina Interna and Center for ResearchTransfer and High Education ‘DENOTHE'University of FlorenceItaly Dipartimento di Medicina e Oncologia SperimentaleUniversity of Turin Italy Benedetta LottiniMassimo Pinzani Dipartimento di Medicina Interna and Center for ResearchTransferand High Education ‘DENOTHE'University of FlorenceItaly Dipartimento di AnatomiaFarmacologia e Medicina Legale University of TurinItaly Istituto Veneto di Medicina MolecolarePadua Italy

AIM: To investigate the effects of troglitazone (TGZ), an anti-diabetic drug which activates peroxisome proliferatoractivated receptor-γ (PPAR-γ), for liver tissue repair, and the development of ductular reaction, following common bile duct ligation (BDL) in rats.METHODS: Rats were supplemented with TGZ (0.2% w/w in the pelleted food) for 1 wk before BDL or sham operation.Animals were killed at 1, 2, or 4 wk after surgery.RESULTS: The development of liver fibrosis was reduced in rats receiving TGZ, as indicated by significant decreases of procollagen type Ⅰ gene expression and liver hydroxyproline levels. Accumulation of α-smooth-muscle actin (SMA)-expressing cells surrounding newly formed bile ducts following BDL, as well as total hepatic levels of SMA were partially inhibited by TGZ treatment, indicating the presence of a reduced number and/or activation of hepatic stellate cells (HSC) and myofibroblasts. Development of the ductular reaction was inhibited by TGZ, as indicated by histochemical evaluation and hepatic activity of γ-glutamyltransferase (GGT).CONCLUSION: Treatment with thiazolidinedione reduces ductular proliferation and fibrosis in a model of chronic cholestasis, and suggests that limiting cholangiocyte proliferation may contribute to the lower development of scarring in this system.

关键词：胆管增生胆管纤维化小鼠动物实验慢性胆汁郁积治疗方法

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酒宴管理 1

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2006年

作者：（美）德弗兰克（Agnes defranco）（美）阿博特（JeAnna Abbott）王向宁

清华经营:本书介绍了美国酒宴服务业在产品、服务和管理方面的经验和特色，阐述了对酒宴服务的认识和理解，并详细论述了酒宴服务的实际管理知识和操作技巧以及需要注意的事项。

ISBN: (数字)7302125155

ISBN: (纸本)7302125155

关键词：商业管理宴会

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T.B细胞间的复杂联系

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青海医学院学报 1992年第3期13卷 198-199页

作者： AnthonyL.defranco 耿排力

免疫应答的中心环节是辅助性T细胞与B细胞间由抗原特异性反应所引起彼此活化的过程。分子水平的研究表明,细胞表面的蛋白质参与这种细胞间的“对话”,并揭示了这种“对话”

关键词： T细胞 B细胞免疫应答

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Stresses Analysis on a Rail Part

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Journal of Civil Engineering and Architecture 2013年第8期7卷 964-972页

作者： Cassio Eduardo Lima de Paiva Jose Lulz Antunes de Oliveira e Sousa Luiz Carlos de Almeida Paulo RobertoAguiar Luiz Femando de Melo Correia Juliana Silva Watanabe Rodrigo Moreira de Carvalho Creso defranco Peixoto Denis Palomo Paschoalin Geotecnical and Ttransportation Department & Department of Structure School of Civil Engineering University of CampinasCampinas 13083-852 Brazil Ignatian Educational Foundation S6o Bernardo do Campo 09850-901 Brazil VALE S A. Belo Horizonte 30140-001 Brazil

The EFVM (Vitoria Minas Railroad) is one of the main railways in Brazil. It transports freight trains of ore, 220 wagons each. These wagons have 2 boogies of 2 axles each and 32 metric tons on metre gauge. Elastic strains were measured on a special part of this railway due to these trains. The main load to evaluate stresses and strains was a G 16 Locomotive, a C-C kind from Vale, a Brazilian Company. The measurements were obtained by dynamic deflectometer installed on a main line of this railway, near Ipatinga, a city from Minas Gerais, one of Brazil states. This track was equipped to obtain stresses under an equal repeated static load. A simulation of the stresses was made under critical strain by Ferrovia 1.0 software. It was also made an evaluation of unequal results from neighbor sleepers taking in comparison two equipped parts of this railway, one with compacted ballast and no compaction to the other. The results were strain limited, avoiding breakage or damage to the studied rails. This work analyses these measurements focusing on the improvement of track quality.

关键词：应力分析铁路应变测量部件货运列车维多利亚弯沉测量临界应变

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血糖与急性冠脉综合征患者远期死亡风险间关系

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心血管病学进展 2007年第3期28卷 507-507页

作者： Bhadnraju S Ray KK defranco AC 袁志敏（摘译）刘运德（校）不详四川省第五人民医院成都市第三人民医院

罹患急性冠脉综合征(ACS)时常伴有高血糖症;已证实其高水平血糖与ACS患者院内近期死亡危险增加有关。现就ACS患者所伴有的血糖升高与其远期死亡风险间关系进行分析。[第一段]

关键词：急性冠脉综合征高血糖症死亡风险死亡危险血糖升高 ACS

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