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Laparoscopic sleeve gastrectomy for morbid obesity

World Journal of Gastroenterology 2008年第6期14卷 821-827页

作者： Antonio Iannelli raffaella dainese Thierry Piche Enrico Facchiano Jean Gugenheim Service de Chirurgie Digestive et Centre de Transplantation Hépatique. Ple Digestif du CHU de Nice Université de Nice-Sophia-Antipolis Faculté de Médecine Nice F-06107 France raffaella dainese Thierry Piche Gastroenterology Department and Functional Unit Ple Digestif du CHU de Nice Centre Hospitalier Universitaire de Nice Ple Digestif Nice F-06202 France

The incidence of obesity is steadily rising, and it has been estimated that 40% of the US population will be obese by the year 2025 if the current trend continues. In recent years there has been renewed interest in the surgical treatment of morbid obesity in concomitance with the epidemic of obesity. Bariatric surgery proved effective in providing weight loss of large magnitude, correction of comorbidities and excellent short-term and long-term outcomes, decreasing overall mortality and providing a marked survival advantage. The Laparoscopic Sleeve Gastrectomy (LSG) has increased in popularity and is currently very "trendy" among laparoscopic surgeons involved in bariatric surgery. As LSG proved to be effective in achieving considerable weight loss in the short-term, it has been proposed by some as a sole bariatric procedure. This editorial focuses on the particular advantages of LSG in the treatment of morbid obesity.

关键词： Obesity Bbariatric surgery Sleeve gastrectomy Ghrelin Weight loss

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Long-term results of subtotal colectomy with cecorectal anastomosis for isolated colonic inertia

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World Journal of Gastroenterology 2007年第18期13卷 2590-2595页

作者： Antonio Iannelli Thierry Piche raffaella dainese Pascal Fabiani Albert Tran Jean Mouiel Jean Gugenheim Service de Chirurgie Digestive-Université de Nice-Sophia-Antipolis Faculté de Médecine Nice F-06107 France & Centre Hospitalier Universitaire de Nice Ple Digestif Nice F-06107 France Service de Gastroentérologie-Université de Nice-Sophia-Antipolis Faculté de Médecine Nice F-06107 France & Centre Hospitalier Universitaire de Nice Ple Digestif Nice F-06107 France Inserm U526 Nice F-06107 France Service de Gastroentérologie-Université de Nice-Sophia-Antipolis Faculté de Médecine Nice F-06107 France & Centre Hospitalier Universitaire de Nice Ple Digestif Nice F-06107 France

AIM： To evaluate the results of sub total colectomy withI cecorectal anastomosis （STC-CRA） for isolated colonicinertia （CI）. METHODS： Fourteen patients （mean age 57.5±16.5 year） underwent surgery for isolated CI between January 1986 and December 2002. The mean frequency of bowel motions with the aid of laxatives was 1.2±0.6 per week. All subjects underwent colonoscopy, anorectal manometry, cinedefaecography and colonic transit time （CTF）. CI was defined as diffuse markers delay on CTF without evidence of pelvic floor dysfunction. All patients underwent STC-CRA. Long-term follow-up was obtained prospectively by clinical visits between October 2005 and February 2006 at a mean of 10.5 ＋ 3.6 years （range 5-16 years） during which we considered the number of stool emissions, the presence of abdominal pain or digitations, the use of pain killers, laxatives and/or fibers. Patients were also asked if they were satisfied with the surgery. RESULTS： There was no postoperative mortality Postoperative complications occurred in 21.4% （3/14）. At the end of follow-up, bowel frequency was significantly （P〈0.05）increased to a mean of 4.8±7.5 per day （range 1-30）. One patient reported disabling diarrhea. Two patients used laxatives less than three times per month without complaining of what they called constipation Overall, 78.5% of patients would have chosen surgery again if necessary. CONCLUSION： STC-CRA is feasible and safe in patients with CI achieving 79% of success at a mean follow-up of 10.5 years. A prospective controlled evaluation is warranted to verify the advantages of this surgical approach in patients with CI.

关键词： Constipation Colonic inertia Surgery Subtotal colectomy Cecorectal anastomosis

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Multispecies probiotic protects gut barrier function in experimental models

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World Journal of Gastroenterology 2014年第22期20卷 6832-6843页

作者： Mylene Nébot-Vivinus Cherryl Harkat Hanene Bzioueche Christel Cartier raffaella Plichon-dainese Lara Moussa Helene Eutamene Dorsa Pishvaie Sophie Holowacz Christian Seyrig Thierry Piche Vassilia Theodorou Department of Immunology Pole of BiologyCHU de Nice06103 NiceFrance Hanene Bzioueche Raffaella Neuro-Gastroenterology and Nutrition Group Toxalim UMR 1331 INRA/INPT/UPSF-31027 ToulouseFrance EA 6302 "Tolérance immunitaire" Université de Nice Sophia Antipolis06103 NiceFrance Department of Gastroenterology CHU de Nice06103 NiceFrance Groupe PiLeJe 37 Quai de Grenelle75015 Paris Cedex 15France

AIM: To investigate the effect of the probiotic combination Lactibiane Tolerance® (LT) on epithelial barrier function in vitro and in vivo.

关键词： Irritable bowel syndrome Probiotic Intestinal epithelial barrier permeability Hypersensitivity

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FOLFIRI3-aflibercept in previously treated patients with metastatic colorectal cancer

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World Journal of Clinical Oncology 2018年第5期9卷 110-118页

作者： CANDice Carola Fran?ois Ghiringhelli Stefano Kim Thierry ANDré Juliette Barlet Le?la Bengrine-Lefevre Hélène Marijon Marie-Line Garcia-Larnicol Christophe Borg Linda dainese Nils Steuer Hubert Richa Magdalena Benetkiewicz Annette K Larsen Aimery de Gramont Benoist Chibaudel Department of Medical Oncology Franco-British Institute Department of Medical Oncology Centre George Fran?ois Leclerc Department of Medical Oncology CHU Besan?on Department of Medical Oncology Saint-Antoine Hospital and Sorbonne Universités UMPC Department of Anatomy-Pathology Paris Pathology Institute Department of Gastrointestinal Surgery Franco-British Institute Fondation ARCAD Cancer Biology and Therapeutics Centre de Recherche Saint-Antoine INSERM U938 Faculté de Médecine Sorbonne Université

AIM To evaluate the efficacy and safety of the modified FOLFIRI3-aflibercept as second-line therapy in patients with metastatic colorectal *** This is a retrospective multicenter cohort, evaluating the efficacy and safety of the association of aflibercept with FOLFIRI3(day 1: aflibercept 4 mg/kg, folinic acid 400 mg/m^2, irinotecan 90 mg/m^2, 5-fluorouracil infusion 2400 mg/m^2 per 46 h; day 3: irinotecan 90 mg/m^2) in patients with previously treated metastatic colorectal cancer. The primary endpoint was overall response rate(ORR). Secondary endpoints were disease control rate(DCR), progression-free survival(PFS), overall survival(OS), and *** Among 74 patients treated in four French centers, nine were excluded due to prior use of aflibercept(n = 3), more than one prior treatment line in irinotecanna?ve patients(n = 3), and inadequate liver function(n = 3). In the "irinotecan-na?ve" patients(n = 30), ORR was 43.3% and DCR was 76.7%. Median PFS and OS were 11.3 mo(95%CI: 6.1-29.0) and 17.0 mo(95%CI: 13.0-17.3), respectively. The most common(> 5%) grade 3-4 adverse events were diarrhea(37.9%), neutropenia(14.3%), stomatitis and anemia(10.4%), and hypertension(6.7%). In the "pre-exposed irinotecan" patients(n = 35), 20(57.1%) received ≥ 2 prior lines of treatment. ORR was 34.3% and DCR was 60.0%. Median PFS and OS were 5.7 mo(95%CI: 3.9-10.4) and 14.3 mo(95%CI: 12.8-19.5), *** Minimally modified FOLFIRI has improvement dramatically the FOLFIRI3-aflibercept efficacy, whatever prior use of irinotecan. A prospective randomized trial is warranted to compare FOLFIRI-aflibercept to FOLFIRI3-aflibercept.

关键词： Chemotherapy Irinotecan Aflibercept Second-line Colorectal cancer

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