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Corneal collagen cross-linking in patients with keratoconus from the Dresden protocol to customized solutions:theoretical basis

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 951-962页

作者： Ciro Caruso Luca D’Andrea Mario Troisi Michele Rinaldi raffaele Piscopo Salvatore Troisi Ciro Costagliola Corneal Transplant Center Pellegrini HospitalVia Portamedina alla Pignasecca 41Napoli 80127Italy Eye Clinic Department of NeurosciencesReproductive and Odontostomatological SciencesUniversity of Naples Federico IINaples 80131Italy Public Health Department University of Naples Federico IINaples 80131Italy Salerno Hospital University Ophthalmologic UnitBaronissiCampania 84131Italy

Keratoconus is an ectatic condition characterized by gradual corneal thinning,corneal protrusion,progressive irregular astigmatism,corneal fibrosis,and visual *** therapeutic options regarding improvement of visual function include glasses or soft contact lenses correction for initial stages,gas-permeable rigid contact lenses,scleral lenses,implantation of intrastromal corneal ring or corneal transplants for most advanced *** keratoconus cases showing disease progression corneal collagen crosslinking(CXL)has been proven to be an effective,minimally invasive and safe *** consists of a photochemical reaction of corneal collagen by riboflavin stimulation with ultraviolet A radiation,resulting in stromal crosslinks *** aim of this review is to carry out an examination of CXL methods based on theoretical basis and mathematical models,from the original Dresden protocol to the most recent developments in the technique,reporting the changes proposed in the last 15y and examining the advantages and disadvantages of the various treatment ***,the limits of non-standardized methods and the perspectives offered by a customization of the treatment are highlighted.

关键词： corneal collagen cross linking keratoconus custom fast protocol Dresden protocol lambert-beer law Bunsen-roscoe law

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Impaired diastolic function in nave untreated human immunodeficiency virus infected patients

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World Journal of Cardiology 2010年第4期2卷 98-103页

作者： Ugo Oliviero Giovanni Bonadies Giorgio Bosso Maria Foggia Valentina Apuzzi Mariarosaria Cotugno Antonio Valvano Enrico Leonardi Guglielmo Borgia Giuseppe Castello raffaele napoli Luigi Saccà Department of Inter-nal Medicine University Federico Ⅱ80131 NaplesItaly Department of Infectious Diseases University Federico Ⅱ80131 NaplesItaly National Cancer Institute G.Pascale Foundation80131 NaplesItaly

AIM:To evaluate cardiac function and structure in un-treated human immunodeficiency virus(HIV) patients without clinical evidence of cardiovascular ***:Fifty-three nave untreated HIV-infected patients and 56 healthy control subjects underwent clinical assessment,electrocardiography(ECG) and echocardiography,including tissue doppler ***,a set of laboratory parameters was obtained from all subjects,including HIV-RNA plasma levels,CD4 cell counts and tumor necrosis factor-α ***:The two groups showed normal ECG traces and no differences regarding systolic morphologic *** contrast,a higher prevalence of left ventricular diastolic dysfunction(abnormal relaxation or pseudonormal filling pattern) was found in the HIV patients(36% vs 9% in patients and controls,respec-tively,P <0.001).CONCLUSION:Subclinical cardiac abnormalities ap-pear in an early stage of the HIV infection,indepen-dent of antiretroviral *** data suggest that HIV per se plays a role in the genesis of diastolic dys-function.

关键词： Diastolic function Human immunodeficiency virus Naive subjects Cardiovascular risk factors

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Migraine attack restores the response of vascular smooth muscle cells to nitric oxide but not to norepinephrine

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World Journal of Cardiology 2013年第10期5卷 375-381页

作者： raffaele napoli Vincenzo Guardasole Emanuela Zarra An-tonietta De Sena Francesco Saccà Antonio Ruvolo Simona Grassi Speranza Giugliano Giovanna De Michele Antonio Cittadini Pietro Biagio Carrieri Luigi Saccà Department of Translational Medical Sciences Federico Ⅱ University School of Medicine Department of Neurology Federico Ⅱ University School of Medicine

AIM:To clarify whether the vasoconstrictory response is impaired and to study vascular function in patients with migraine during the headache ***:We studied vascular reactivity in the resistance arteries by using the forearm perfusion technique associated with *** measuredforearm blood flow by strain-gauge plethysmography during intra-brachial infusion of acetylcholine,sodium nitroprusside or norepinephrine in 11 controls and 13patients with migraine,11 of them(M) in the interval between the migraine attacks and 4 during a headache attack(MH).Written informed consent was obtained from patients and healthy controls,and the study was approved by the Ethics Committee of the University Federico Ⅱ.RESULTS:Compared to healthy control subjects,in patients with migraine studied during the interictal period,the vasodilating effect of acetylcholine,that acts through the stimulation of endothelial cells and the release of nitric oxide,was markedly reduced,but became normal during the headache attack(P0.05).CONCLUSION:In migrainers,the impaired relaxation of VSMCs is restored during the headache *** vasoconstrictory response is impaired and remains unchanged during the migraine attack.

关键词： Migraine Nitric oxide Endothelium Vascular smooth muscle cells

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An in-depth multi-technique characterization of rare earth carbonates-RE_(2)(CO_(3))_(3)·2H_(2)O-owning tengerite-type structure

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Journal of Rare Earths 2022年第8期40卷 1281-1290页

作者： Luca Spiridigliozzi Mauro Bortolotti Grazia Accardo Alessandro Vergara Domenico Frattini Claudio Ferone raffaele Cioffi Gianfranco Dell'Agli Department of Civil and Mechanical Engineering University of Cassino and Southern LazioVia G.Di Biasio 4303043Cassino(FR)Italy Department of Industrial Engineering University of TrentoVia Sommarive 938123TrentoItaly Center of Hydrogen-Fuel Cell Research Korea Institute of Science and TechnologyHwarang-ro 14-gilSeongbuk-guSeoul136-791Republic of Korea Centre for Cooperative Research on Alternative Energies(CIC EnergiGUNE) Basque Research and Technology Alliance(BRTA)Alava Technology ParkCalle Albert Einstein 4801510Vitoria-GasteizSpain Department of Chemical Sciences University of Napoli“Federico II”Via Cintia80126NapoliItaly Graduate School of Energy and Environment Seoul National University of Science and TechnologyGongneung-ro 232Nowon-guRepublic of Korea Department of Engineering University of Napoli“Parthenope”Centro DirezionaleIsola C480143Napoli(NA)Italy INSTM-National Interuniversity Consortium of Materials Science and Technology

The present study has been conducted to contribute,once and for all,filling the lack of structural information for the whole class of rare earth(RE)carbonates owning the tengerite-(Y)structure.A complete structural characterization,carried out by Rietveld refinement of X-ray powder diffraction(XRD)data,was comparatively performed for the first time on several hydrated RE carbonates,having the general chemical formula RE_(2)(CO_(3))_(3)·χH_(2)O,RE=Y,Gd,Tb,Dy,Ho and *** samples share the same space group and lattice parameters similar to tengerite-(Y);the structures are also closely related,consisting in all cases of a three-dimensional framework of nine-fold coordinated RE atom polyhedral,linked together by carbonate *** addition to relatively minor changes in fractional coordinates of atom sites and corresponding interatomic distances,the only perceivable difference lies in the lattice parameters affected by the ionic radius of RE^(3+).However,in the case of Er,which has the lowest cationic radius among the analyzed RE,the stabilization of tengerite structure is at its limit condition,because the carbonate groups are heavily ***,FT-IR and Raman spectra confirm the main structural features obtained by Rietveld *** observed morphology of the various samples is almost the same,being characterized by the presence of bidimensional rod-like particles grouped in agglomerates,typical of tengerite crystals,thus indicating that the crystallization mechanism occurring during the hydrothermal synthesis is the same,irrespective of the involved RE cation.

关键词： Rare Earth carbonates Tengerite Structural refinement Hydrothermal treatment

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Approximate Dynamic Programming for Stochastic Resource Allocation Problems

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IEEE/CAA Journal of Automatica Sinica 2020年第4期7卷 975-990页

作者： Ali Forootani raffaele Iervolino Massimo Tipaldi Joshua Neilson the Hamilton Institute Maynooth UniversityCo.Kildare W23 F2K8Ireland the Department of Electrical Engineering and Information Technology University of NaplesNapoli 80125Italy the Department of Engineering University of SannioBenevento 82100Italy

A stochastic resource allocation model, based on the principles of Markov decision processes(MDPs), is proposed in this paper. In particular, a general-purpose framework is developed, which takes into account resource requests for both instant and future needs. The considered framework can handle two types of reservations(i.e., specified and unspecified time interval reservation requests), and implement an overbooking business strategy to further increase business revenues. The resulting dynamic pricing problems can be regarded as sequential decision-making problems under uncertainty, which is solved by means of stochastic dynamic programming(DP) based algorithms. In this regard, Bellman’s backward principle of optimality is exploited in order to provide all the implementation mechanisms for the proposed reservation pricing algorithm. The curse of dimensionality, as the inevitable issue of the DP both for instant resource requests and future resource reservations,occurs. In particular, an approximate dynamic programming(ADP) technique based on linear function approximations is applied to solve such scalability issues. Several examples are provided to show the effectiveness of the proposed approach.

关键词： Approximate dynamic programming(ADP) dynamic programming(DP) Markov decision processes(MDPs) resource allocation problem

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Massive bleeding from gastric submucosal arterial collaterals secondary to splenic artery thrombosis: A case report

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World Journal of Gastroenterology 2022年第37期28卷 5506-5514页

作者： Alberto Martino Marco Di Serafino Francesco Paolo Zito Franco Maglione raffaele Bennato Luigi Orsini Alessandro Iacobelli Raffaella Niola Luigia Romano Giovanni Lombardi Department of Gastroenterology and Digestive Endoscopy AORN“Antonio Cardarelli”Napoli 80131Italy Department of General and Emergency Radiology AORN“Antonio Cardarelli”Napoli 80131Italy Department of Radiology Sanatrix ClinicNapoli 80127Italy Department of Pathology AORN“Antonio Cardarelli”Napoli 80131Italy Department of Interventional Radiology AORN“Antonio Cardarelli”Napoli 80131Italy

BACKGROUND Gastric submucosal arterial collaterals(GSAC)secondary to splenic artery occlusion is an extraordinary rare and potentially life-threatening cause of acute upper gastrointestinal ***,we report a case of massive bleeding from GSAC successfully treated by means of a multidisciplinary minimally invasive *** SUMMARY A 60-year-old non-cirrhotic gentleman with a history of arterial hypertension was admitted due to *** esophagogastroduodenoscopy revealed pulsating and tortuous varicose shaped submucosal vessels in the gastric fundus along with a small erosion overlying one of the *** order to characterize the fundic lesion,pre-operative emergent computed tomography-angiography was performed showing splenic artery thrombosis(SAT)and tortuous arterial structures arising from the left gastric artery and the left gastroepiploic artery in the gastric *** was successfully treated by means of a minimally invasive step-up approach consisting in endoscopic clipping followed by transcatheter arterial embolization(TAE).CONCLUSION This was a previously unreported case of bleeding GSAC secondary to SAT successfully managed by means of a multidisciplinary minimally invasive approach consisting in endoscopic clipping for the luminal bleeding control followed by elective TAE for the definitive treatment.

关键词： Upper gastrointestinal bleeding Non variceal upper gastrointestinal bleeding Acute upper gastrointestinal bleeding Gastric submucosal arterial collaterals Splenic artery thrombosis Case report

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A Model of a Quantum Particle in a Quantum Environment: A Numerical Study

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Communications in Computational Physics 2015年第6期18卷 247-262页

作者： raffaele Carlone Rodolfo Figari Claudia Negulescu Universita Federico II di napoli Dipartimento di Matematica e Applicazioni“R.Caccioppoli”MSA I-80126 NapoliItaly Universita Federico II di napoli Dipartimento di Fisica e INFN Sezione di NapoliMSA I-80126 NapoliItaly Universite de Toulouse&CNRS UPSInstitut de Mathematiques de Toulouse UMR 5219F-31062 ToulouseFrance

We define and investigate,via numerical analysis,a one dimensional toymodel of a cloud *** energetic quantum particle,whose initial state is a superposition of two identical wave packets with opposite average momentum,interacts during its evolution and exchanges(small amounts of)energy with an array of localized *** by the interaction with the environment,the initial superposition state turns into an incoherent sum of two states describing the following situation:or the particle is going to the left and a large number of spins on the left side changed their states,or the same is happening on the right *** evolution is reminiscent of what happens in a cloud chamber where a quantum particle,emitted as a spherical wave by a radioactive source,marks its passage inside a supersaturated vapour-chamber in the form of a sequence of small liquid bubbles arranging themselves around a pssible classical trajectory of the particle.

关键词： Schrodinger equation quantum particle+environment model multi-channel point interactions Wilson cloud chamber trace formation decoherence numerical discretization

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Concentrated suspensions of Brownian beads in water: dynamic heterogeneities through a simple experimental technique

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Science China(Physics,Mechanics & Astronomy) 2019年第10期62卷 33-44页

作者： raffaele Pastore Marco Caggioni Domenico Larobina Luigi Santamaria Amato Francesco Greco Department of Chemical Materials and Production EngineeringUniversity of Naples FedericoⅡNapoli 80125Italy Corporate Engineering The Procter&Gamble CompanyCincinnatiWest Chester OH 45069USA Institute for Polymers Composites and BiomaterialsNational Research Council of ItalyNapoli 80055Italy ASI Agenzia Spaziale ItalianaCentro di Geodesia SpazialeMatera 75100Italy

Concentrated suspensions of Brownian hard-spheres in water are an epitome for understanding the glassy dynamics of both soft materials and supercooled molecular *** an experimental point of view,such systems are especially suited to perform particle tracking easily,and,therefore,are a benchmark for novel optical techniques,applicable when primary particles cannot be *** variance analysis(DVA)is one such novel technique that simplifies significantly the characterization of structural relaxation prcKesses of soft glassy materials,since it is directly applicable to digital image sequences of the *** succeeds in monitoring not only the average dynamics,but also its spatio-temporal fluctuations,known as dynamic *** this work,we study the dynamics of dense suspensions of Brownian beads in water,imaged through digital video-microscopy,by using both DVA and single-particle *** focus on two commonly used signatures of dynamic heterogeneities:the dynamic susceptibility,^,and the non-Gaussian parameter,a *** direct comparison of these two quantities,we are able to highlight similarities and *** do confirm th aχ4 andα2 provide qualitatively similar information,but we find quantitative discrepancies in the scalings of characteristic time and length scale on approaching the glass transition.

关键词： glass transition structural relaxation dynamic heterogeneities colloidal glasses

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Unilateral post-chemotherapy robot-assisted retroperitoneal lymph node dissection in Stage II non-seminomatous germ cell tumor:A tertiary care experience

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Asian Journal of Urology 2023年第4期10卷 440-445页

作者： Dario Franzese Antonio Tufano Alessandro Izzo raffaele Muscariello Giovanni Grimaldi Giuseppe Quarto Luigi Castaldo Sabrina Rossetti Savio Domenico Pandolfo Sonia Desicato Paola Del Prete Matteo Ferro Sandro Pignata Sisto Perdonà Department of Urology National Cancer InstitutePascale FoundationNaplesItaly Urology Unit Department of Maternal-Child and Urological Sciences“Sapienza”UniversityRomeItaly Department of Neurosciences Science of Reproduction and OdontostomatologyUniversity of Naples Federico IINaplesItaly Scientific Directorate Istituto Nazionale Tumori di NapoliIRCCS“G.Pascale”NaplesItaly Division of Urology European Institute of Oncology(IEO)IRCCSMilanItaly Division of Medical Oncology Department of Uro-Gynaecological OncologyIstituto Nazionale per lo Studio e la Cura dei Tumori“Fondazione G.Pascale”IRCCSNaplesItaly

Objective Post-chemotherapy retroperitoneal lymph node dissection(PC-RPLND)represents an integral component of the management of patients with non-seminomatous germ cell tumor(NSGCT).Modified templates have been proposed to minimize the surgical morbidity of the ***,the implementation of robotic surgery in this setting has been *** report our experience with unilateral post-chemotherapy robot-assisted retroperitoneal lymph node dissection(PC-rRPLND)for clinical Stages IIA and IIB *** A retrospective single institution review was performed including 33 patients undergoing PC-rRPLND for Stages IIA and IIB NSGCTs between January 2015 and February *** orchiectomy,patients were scheduled for chemotherapy with three cycles of *** with a residual tumor of<5 cm and an ipsilateral metastatic disease on pre-and post-chemotherapy CT scans were eligible for a unilateral template in absence of rising tumor *** statistics were provided for demographics,clinical characteristics,intraoperative and postoperative ***,oncological,and functional outcomes were *** Overall,7(21.2%)patients exhibited necrosis or fibrosis;14(42.4%)had mature teratoma;and 12(36.4%)had viable tumor at final *** median lymph node size at surgery was 25(interquartile range[IQR]21-36)*** operative time was 180(IQR 165-215)min and no major postoperative complications were *** ejaculation was preserved in 75.8%of *** follow-up was 26(IQR 19-30)months and a total of three recurrences were *** PC-rRPLND is a reliable and technically reproducible procedure with safe oncological outcomes and acceptable postoperative ejaculatory function in well selected patients with NSGCTs.

关键词： Testis tumor Robot-assisted retroperitoneal lymph node dissection Retroperitoneal lymph node dissection Non-seminomatous germ cell tumor Unilateral dissection Modified template Post-chemotherapy

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Intra-hepatic and extra-hepatic cholangiocarcinoma:New insight into epidemiology and risk factors

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World Journal of Gastrointestinal Oncology 2010年第11期2卷 407-416页

作者： Vincenzo Cardinale Rossella Semeraro Alessia Torrice Manuela Gatto Cristina napoli Maria Consiglia Bragazzi raffaele Gentile Domenico Alvaro Dipartimento di Scienze e Biotecnologie Medico-Chirurgiche Sapienza University of Rome00185 RomeItaly

Cholangiocarcinoma(CCA) is a malignant tumour that arises from biliary epithelium at any portion of the biliary *** is currently classified as intra-hepatic or extra-hepatic CCA(EH-CCA).Recent evidences suggest that intra-hepatic CCA(IH-CCA) and EH-CCA are biologically different cancers,giving further support to a number of recent epidemiological studies showing large differences in terms of incidence,mortality and risk *** purpose of this manuscript is to review recent literature dealing with the descriptive epidemiology and risk factors of CCA with a special effort to compare IH-with EH-CCA.

关键词： Liver flukes Viral hepatitis Liver stem cells Peribiliary glands Epidemiology Extra-hepatic cholangiocarcinoma Risk factors Primary sclerosing cholangitis Intra-hepatic cholangiocarcinoma Liver cirrhosis

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