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Melanocortin 3,5 receptors immunohistochemical expression in colonic mucosa of inflammatory bowel disease patients:A matter of disease activity?

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World Journal of Gastroenterology 2024年第9期30卷 1132-1142页

作者： Antonietta Gerarda Gravina Iacopo Panarese Maria Consiglia Trotta Michele D'Amico raffaele Pellegrino Franca Ferraraccio Marilena Galdiero Roberto Alfano Paolo Grieco Alessandro Federico Hepatogastroenterology Division Department of Precision MedicineUniversity of Campania Luigi VanvitelliNaples 80138Italy Pathology Division Department of Mental and Physical Health and Preventive MedicineUniversity of Campania Luigi VanvitelliNaples 80138Italy Department of Experimental Medicine Division of PharmacologyUniversity of Campania Luigi VanvitelliNaples 80138Italy Department of Advanced Medical and Surgical Sciences(DAMSS) University of Campania Luigi VanvitelliNaples 80138Italy Department of Pharmacy University of Naples Federico IINaples 80131Italy

BACKGROUND Melanocortin 3 and 5 receptors(i.e.,MC3R and MC5R)belong to the melanocortin ***,data regarding their role in inflammatory bowel diseases(IBD)are currently *** This study aims to ascertain their expression profiles in the colonic mucosa of Crohn’s disease(CD)and ulcerative colitis(UC),aligning them with IBD disease endoscopic and histologic *** Colonic mucosal biopsies from CD/UC patients were sampled,and immunohisto-chemical analyses were conducted to evaluate the expression of MC3R and *** sampling was performed on both traits with endoscopic scores(Mayo endoscopic score and CD endoscopic index of severity)consistent with inflamed mucosa and not consistent with disease activity(i.e.,normal appearing mucosa).RESULTS In both CD and UC inflamed mucosa,MC3R(CD:+7.7 fold vs normal mucosa,P<0.01;UC:+12 fold vs normal mucosa,P<0.01)and MC5R(CD:+5.5 fold vs normal mucosa,P<0.01;UC:+8.1 fold vs normal mucosa,P<0.01)were significantly more expressed compared to normal *** MC3R and MC5R are expressed in the colon of IBD ***,expression may differ according to disease endoscopic activity,with a higher degree of expression in the traits affected by disease activity in both CD and UC,suggesting a potential use of these receptors in IBD pharmacology.

关键词： Melanocortin 3 receptor Melanocortin 5 receptor Ulcerative colitis Crohn's disease Inflammatory bowel disease

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Automation 5.0: The Key to Systems Intelligence and Industry 5.0

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IEEE/CAA Journal of Automatica Sinica 2024年第8期11卷 1723-1727页

作者： Ljubo Vlacic Hailong Huang Mariagrazia Dotoli Yutong Wang Petros A.Ioannou Lili Fan Xingxia Wang raffaele Carli Chen Lv Lingxi Li Xiaoxiang Na Qing-Long Han Fei-Yue Wang Institute of Intelligent and Integrated Systems and the School of Engineering and Built Environment Griffith UniversityNathanQLD 4111Australia Department of Aeronautical and Aviation Engineering The Hong Kong Polytechnic UniversityHong KongChina Department of Electrical and Information Engineering Polytechnic of Bari70126 BariItaly State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing 100190and also with the Qingdao Academy of Intelligent IndustriesQingdao 266114China Department of Electrical Engineering-Systems University of Southern CaliforniaLos AngelesCA 90007 USA School of Automation Beijing Institute of TechnologyBeijing 100081China State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing 100190 School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049 Beijing Huairou Academy of Parallel Sensing Beijing 101499China School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore Department of Electrical and Computer Engineering Purdue School of Engineering and TechnologyIndiana University-Purdue University IndianapolisIndianapolisIN 46202 USA Department of Engineering University of CambridgeCB21TN CambridgeU.K. School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia State Key Laboratory for Management and Control of Complex Systems Chinese Academy of SciencesBeijing 100190 School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Dazhou Artificial Intelligence Institute Dazhouand the Faculty of Innovation EngineeringMacao University of Science and TechnologyMacao 999078China

AUTOMATION has come a long way since the early days of mechanization,i.e.,the process of working exclusively by hand or using animals to work with *** rise of steam engines and water wheels represented the first generation of industry,which is now called Industry Citation:***,***,***,***,***,***,***,***,***,***,***,Q.-***,and F.-***,“Automation 5.0:The key to systems intelligence and Industry 5.0,”IEEE/CAA ***,vol.11,no.8,pp.1723-1727,Aug.2024.

关键词： Automation machinery intelligence

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Corrigendum to ‘A novel STK11 gene mutation (c.388dupG,***130Glyfs∗33) in a Peutz-Jeghers family and evidence of higher gastric cancer susceptibility associated with alterations in STK11 region aa 107–170’ [Gene Dis (9) (2022) 288–291]

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Genes & Diseases 2024年第2期11卷 1082-1083页

作者： Giovanna Forte Filomena Cariola Katia De Marco Andrea Manghisi Filomena Anna Guglielmi raffaele Armentano Giuseppe Lippolis Pietro Giorgio Cristiano Simone Vittoria Disciglio Medical Genetics National Institute of Gastroenterology “S. de Bellis” Research Hospital Castellana Grotte Bari 70013 Italy Histopathology Unit National Institute of Gastroenterology “S. de Bellis” Research Hospital Castellana Grotte Bari 70013 Italy Department of General Surgery National Institute of Gastroenterology “S. de Bellis” Research Hospital Castellana Grotte Bari 70013 Italy Gastroenterology and Digestive Endoscopy Unit National Institute of Gastroenterology “S. de Bellis” Research Hospital Castellana Grotte Bari 70013 Italy Department of Biomedical Sciences and Human Oncology (DIMO) Medical Genetics University of Bari Aldo Moro Piazza Umberto I Bari 70124 Italy

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Acute recurrent pancreatitis:An autoimmune disease?

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World Journal of Gastroenterology 2008年第7期14卷 999-1006页

作者： raffaele Pezzilli Department of Internal Medicine and Gastroen-terology Sant'Orsola-Malpighi Hospital. Bologna 40138Italy

In this review article, we will briefly describe the main characteristics of autoimmune pancreatitis and then we will concentrate on our aim, namely, evaluating the clinical characteristics of patients having recurrence of pain from the disease. In fact, the open question is to evaluate the possible presence of autoimmune pancreatitis in patients with an undefined etiology of acute pancreatitis and for this reason we carried out a search in the literature in order to explore this issue. In cases of recurrent attacks of pain in patients with "idiopathic" pancreatitis, we need to keep in mind the possibility that our patients may have autoimmune pancreatitis. Even though the frequency of this disease seems to be quite low, we believe that in the future, by increasing our knowledge on the subject, we will be able to diagnose an ever-increasing number of patients having acute recurrence of pain from autoimmune pancreatitis.

关键词： Pancreatitis Autoimmune pancreatitis Diagnosis Therapy Outcome

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Enhanced motor cortex excitability after spinal cord injury

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Neural Regeneration Research 2015年第12期10卷 1943-1944页

作者： Nardone raffaele Department of Neurology Christian Doppler KlinikParacelsus Medical University Department of Neurology Franz Tappeiner Hospital Spinal Cord Injury and Tissue Regeneration Center Paracelsus Medical University

Transcranial magnetic stimulation（TMS）represents a useful non-invasive approach to studying cortical physiology,in addition to the descending motor pathways（Hallett,2000）,and may also be used to investigate the in... 详细信息

关键词： SCI MEP Enhanced motor cortex excitability after spinal cord injury

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Etiology of chronic pancreatitis:Has it changed in the last decade?

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World Journal of Gastroenterology 2009年第38期15卷 4737-4740页

作者： raffaele Pezzilli Department of Digestive Diseases and Internal Medicine Sant'Orsola-Malpighi Hospital

The evidence from recent surveys on chronic pancreatitis carried out around the world shows that alcohol remains the main factor associated with chronic pancreatitis, even if at a frequency lower than that reported previously. It has further conf irmed that heavy alcohol consumption and smoking are independent risk factors for chronic pancreatitis. Autoimmune pancreatitis accounts for 2%-4% of all forms of chronic pancreatitis, but this frequency will probably increase over the next few years. The rise in idiopathic chronic pancreatitis, especially in India, represents a black hole in recently published surveys. Despite the progress made so far regarding the possibility of establishing the hereditary forms of chronic pancreatitis and the recognition of autoimmune pancreatitis, it is possible that we are more inaccurate today than in the past in identifying the factors associated with chronic pancreatitis in our patients.

关键词： Cohort studies Combined modality therapy Data collection Genetics Pancreatitis Alcoholic Population

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A multi-class time-dependent model for the analysis of waiting phenomena at a motorway tollgate

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Journal of Traffic and Transportation Engineering(English Edition) 2021年第2期8卷 237-256页

作者： Andrea Pompigna raffaele Mauro Department of Civil Environmental and Mechanical EngineeringUniversity of TrentoTrento 38123Italy

The planning, design and operational management of motorway toll booths are of great interest in traffic engineering, as these facilities directly influence the quality of the service offered to users. This paper focuses on a time-dependent queue model based on the coordinates transformation criterion for operations assessment at a motorway tollgate. This model allows to face the whole spectrum of situations that may characterize a toll booth,some of which often fall outside the boundaries of the probabilistic theory for stationary *** paper proposes an M=G=1 multi-class queue model for the evaluation of evolutionary profiles of waiting times and queue lengths by closed-form equations. The results obtained for three numerical test cases show a good approximation level, compared with the mean values of queue parameters obtained reiterating a discrete-state simulation *** proposed time-dependent equations will be useful in technical cases, allowing to operate quickly and compactly even when probabilistic queue theory is not applicable or produce unrealistic results, and the burden of complexity of the simulation approach is not conveniently absorbable. The discussion highlights a significant flexibility of the model proposed in addressing situations with conventional vehicles, i.e., with total human control and proposes some considerations for application in future scenarios with the presence of connected vehicles(CVs).

关键词： Traffic engineering Time-dependent queue model Shared queue Coordinate transformation method Tollgate

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State of the art and computational aspects of time-dependent waiting models for non-signalised intersections

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第6期7卷 808-831页

作者： raffaele Mauro Andrea Pompigna Department of Civil Environmental and Mechanical EngineeringUniversity of TrentoTrento 38123Italy

Time-dependent models are of great importance in highway engineering as they are appropriate for evaluating waiting times and queue lengths at intersections,which are integral parts of various activities in planning,verification and decision support for *** reviewing the literature of the main time-dependent models based on the coordinate transformation method and a discussion about some computational issues in time-evolution profiles for non-signalised intersections,the paper identifies the requirements these models have to satisfy in order to be used as"basic"cases for analysing complex evolutionary ***"basic"cases are presented with their timedependent equations for vehicle waiting times and vehicle number;they have been completed and dimensionally homogenised in this *** they are recursive,these formulas can be applied for sequential intervals in the time domain in both vehicles and passenger car *** closed-form expressions for state variables show to be mutually equivalent in comparison with discrete event simulation models and imbedded Markov chain *** all the three models the paper presents a common deterministic simplification for average waiting time,with good approximation results in the tested *** proposed time-dependent formulas will contribute to a better adherence to the real phenomena,compared to the extremely simplified and unrealistic methods suggested by the international manuals for level of service *** proposed formulas will be useful for current applications and possible future development in order to meet the emerging needs of road and transport engineering.

关键词： Traffic engineering Priority system Non-signalised intersections Time-dependent queue model Shared queue delay Coordinate transformation method

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基于多源数据的北京通州区园林绿色废弃物处理站点最优配置

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中国城市林业 2024年第4期22卷 26-33页

作者：张澜卿冯飞江思敏张新娜李鹤菩邵卫才李亚齐 raffaele Lafortezza 北京林业大学林学院北京100083 北京市通州区园林绿化局北京101118 通州区园林绿化工程质量服务中心北京101100 意大利巴里大学土壤、植物和食品科学系意大利巴里70126

在推动生态文明建设的战略框架下,聚焦北京绿色生态大都市中园林绿色废弃物的综合管理体系构建,旨在通过合理规划其收集、高效处理、循环回收与资源化利用流程,实现园林废弃物处理站点设置科学化,促进城市绿色循环经济的可持续发展。文... 详细信息

在推动生态文明建设的战略框架下,聚焦北京绿色生态大都市中园林绿色废弃物的综合管理体系构建,旨在通过合理规划其收集、高效处理、循环回收与资源化利用流程,实现园林废弃物处理站点设置科学化,促进城市绿色循环经济的可持续发展。文章使用CASA模型得到通州区2022年的NPP分布,并换算成生物量和园林废弃物量;基于机器学习算法识别通州区5类植被分布;运用优化算法耦合GIS的空间分析技术,得到较优的三级园林废弃物处理点。结果表明:1)通州区的NPP高值区主要分布在东部,而通州区的东南部和东北部NPP呈现中低值;2)通州区落叶乔木产生的园林废弃物量最大,主要分布在通州西南部;3)科学设置的三级处理点可以最大化降低成本,提高园林废弃物处理效率。

关键词：园林绿色废弃物 CASA模型机器学习算法优化算法 GIS空间分析

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Decentralized Control for Residential Energy Management of a Smart Users' Microgrid with Renewable Energy Exchange

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IEEE/CAA Journal of Automatica Sinica 2019年第3期6卷 641-656页

作者： raffaele Carli Mariagrazia Dotoli IEEE the Department of Electrical and Information Engineering of the Polytechnic of Bari

This paper presents a decentralized control strategy for the scheduling of electrical energy activities of a microgrid composed of smart homes connected to a distributor and exchanging renewable energy produced by individually owned distributed energy resources. The scheduling problem is stated and solved with the aim of reducing the overall energy supply from the grid, by allowing users to exchange the surplus renewable energy and by optimally planning users' controllable loads. We assume that each smart home can both buy/sell energy from/to the grid taking into account time-varying non-linear pricing signals. Simultaneously, smart homes cooperate and may buy/sell locally harvested renewable energy from/to other smart homes. The resulting optimization problem is formulated as a non-convex non-linear programming problem with a coupling of decision variables in the constraints. The proposed solution is based on a novel heuristic iterative decentralized scheme algorithm that suitably extends the Alternating Direction Method of Multipliers to a non-convex and decentralized setting. We discuss the conditions that guarantee the convergence of the presented algorithm. Finally, the application of the proposed technique to a case study under several scenarios shows its effectiveness.

关键词： Alternating direction method of multipliers decentralized control energy management microgrid non-convex optimization renewable energy residential energy management smart homes

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