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Best therapy for the easiest to treat hepatitis C virus genotype 1binfected patients

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World Journal of Gastroenterology 2022年第45期28卷 6380-6396页

作者： Dorota Zarębska-Michaluk Michal Brzdęk Jerzy Jaroszewicz Magdalena Tudrujek-Zdunek Beata Lorenc Jakub Klapaczyński Włodzimierz Mazur Adam Kazek Marek Sitko Hanna Berak Justyna Janocha-Litwin Dorota Dybowska Łukasz Supronowicz rafal Krygier Jolanta Citko Anna Piekarska Robert Flisiak Department of Infectious Diseases Jan Kochanowski UniversityKielce 25-317Poland Department of Infectious Diseases and Hepatology Medical University of SilesiaKatowice 40-055Poland Department of Infectious Diseases Medical University of LublinLublin 20-059Poland Pomeranian Center of Infectious Diseases Medical University GdańskGdańsk 80-214Poland Department of Internal Medicine and Hepatology Central Clinical Hospital of the Ministry of Internal Affairs and AdministrationWarszawa 00-241Poland Clinical Department of Infectious Diseases Medical University of SilesiaChorzów 41-500Poland ID Clinic Mysłowice 41-400Poland Department of Infectious and Tropical Diseases Jagiellonian UniversityKraków 31-088Poland Hospital for Infectious Diseases Hospital for Infectious DiseasesWarszawa 02-091Poland Department of Infectious Diseases and Hepatology Medical University WrocławWrocław 50-367Poland Department of Infectious Diseases and Hepatology Faculty of MedicineNicolaus Copernicus UniversityBydgoszcz 85-030Poland Department of Infectious Diseases and Hepatology Medical University of BiałystokBiałystok 15-089Poland Infectious Diseases and Hepatology Outpatient Clinic Gemini NZOZŻychlin 62-571Poland Medical Practice of Infections Regional HospitalOlsztyn 10-561Poland Department of Infectious Diseases and Hepatology Medical UniversityŁódźŁódź90-419Poland

BACKGROUND The revolution in treatment of patients with chronic hepatitis C virus(HCV)infection dates back to the introduction of direct-acting antivirals(DAAs).The increase in efficacy was most pronounced in patients infected with genotype(GT)1b,as this was the most poorly responsive population to treatment during the interferon *** To identify the most effective interferon-free therapy for GT1b-infected patients and to determine positive and negative predictors of virological *** This real-world retrospective analysis included patients chronically infected with GT1b HCV whose data were obtained from the multicenter observational EpiTer-2 *** effectiveness was evaluated for each therapeutic regimen as the percentage of sustained virological responses(SVR).Assessment of the safety was based on the evaluation of the course of therapy,the occurrence of adverse events including serious ones,deaths during treatment and in the post 12-wk follow-up *** The studied population consisted of 11385 patients with a mean age of 53±14.8 years and a female predominance(53.4%).The majority of them were treatment-naïve(74.6%)and patients with cirrhosis accounted for 24.3%.Of the DAA regimens used,76.9%were GT-specific with ombitasvir/paritaprevir/ritonavir+dasabuvir±ribavirin being the most used option(32.4%).A total of 10903 patients responded to treatment resulting in a 98.1%in the per-protocol analysis after excluding 273 patients without SVR *** effectiveness of all regimens exceeded 90%and the highest SVR of 98.9%was achieved in patients treated with a combination of glecaprevir/*** regression analyses showed that the virologic response was independently associated with female sex[odds ratio(OR)=1.67],absence of decompensated cirrhosis at baseline(OR=2.42)and higher baseline platelets(OR=1.004 per 1000/μL increase),while the presence of human immunodeficiency virus(HIV)coinfection significantly decreased the odds

关键词： Hepatitis C Genotype 1b Direct-acting antivirals Pangenotypic Genotype-specific Sustained virologic response

From the stomach to other organs:Helicobacter pylori and the liver

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World Journal of Hepatology 2015年第18期7卷 2136-2146页

作者： Marek Waluga Michal Kukla Michal Zorniak Agata Bacik rafal Kotulski School of Medicine in Katowice Medical University of SilesiaDepartment of Gastroenterology and Hepatology Municipal Hospital

Many recent studies have examined the importance of Helicobacter pylori(H. pylori) infection in the pathogenesis of the diseases outside the stomach and explored the significance of this bacterium in the pathogenesis of some metabolic and cardiovascular diseases. Recent studies have provided evidence that H. pylori is also involved in the pathogenesis of some liver diseases. Many observations have proved that H. pylori infection is important in the development of insulin resistance, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, liver fibrosis and cirrhosis. The worsening of liver inflammation of different origins also occurs during H. pylori infection. Some studies have indicated that H. pylori infection induces autoimmunological diseases in the liver and biliary tract. The potential significance of this bacterium in carcinogenesis is unclear, but it is within the scope of interest of many studies. The proposed mechanisms through which H. pylori impacts the development of hepatobiliary diseases are complex and ambiguous. The importance of other Helicobacter species in the development of hepatobiliary diseases is also considered because they could lead to the development of inflammatory, fibrotic and necrotic injuries of the liver and, consequently, to hepatocellular carcinoma. However, many contrary viewpoints indicate that some evidence is not convincing, and further studies of the subject are needed. This review presents the current knowledge about the importance of H. pylori in the pathogenesis of liver and in biliary diseases.

关键词： Helicobacter pylori Non-alcoholic fatty liver dise

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CPU缓存污染攻击SMM内存？

黑客防线 2009年第6期 39-42页

作者： rafal Wojtczuk Joanna Rutkowska Fahrenheit（译）

系统管理模式（SMM）是x86／x86—64体系结构下特权最多的一种CPU操作模式．我们可以将其想象为“Ring2”。在该模式上运行的代码甚至比硬件监视器（hypervisors）的特权还要多，而大家通常认为后者是具有Ring1级权限。

关键词：缓存污染 SMM SMI

Isolated right posterior bile duct injury following cholecystectomy:Report of two cases

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World Journal of Gastroenterology 2013年第36期19卷 6118-6121页

作者： Maciej Wojcicki Waldemar Patkowski Tomasz Chmurowicz Andrzej Bialek Anna Wiechowska-Kozlowska rafal Stankiewicz Piotr Milkiewicz Marek Krawczyk Department of General Transplant and Liver Surgery Medical University of Warsaw Department of General Surgery and Transplantation District Hospital Department of Gastroenterology Pomeranian Medical University Department of Endoscopy MSW Hospital Liver Research Laboratories Pomeranian Medical University

Anatomic variations of the right biliary system are one of the most common risk factors for sectoral bile duct injury(BDI)during *** right posterior BDI may in particular be a challenge for both diagnosis and *** we describe two cases of isolated right posterior sectoral BDI that took place during laparoscopic *** effective external biliary drainage from the liver hilum in both cases,there was a persistent biliary leak observed which was not visible on endoscopic *** evaluation of images from both endoscopic and magnetic resonance cholangiograms revealed the diagnosis of an isolated right posterior sectoral *** were treated with a delayed bisegmental(segments 6 and 7)liver resection and a Roux-en-Y hepaticojejunostomy respectively with good outcomes at 24 and 4 mo of *** paper discusses strategies for prevention of such injuries along with the diagnostic and therapeutic challenges it offers.

关键词： Cholecystectomy Bile duct injury Sectoral bile duct Hepaticojejunostomy Liver resection

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棉织物用乙二醛加水解淀粉的免烫整理

国外纺织技术（化纤．染整．环境保护分册） 1993年第4期 28-32页

作者： R.rafal 沈煜如

引言棉织物用 N-羟甲基整理剂的化学整理赋予织物免烫性.从工艺和经济观点两者来看,N-羟甲基整理剂是生产免烫棉织品最适合的整理剂。然而,在加工过程中以及贮存时从整理的织物中释放的游离甲醛现在在服装卫生学上已被提出作为一个重要... 详细信息

引言棉织物用 N-羟甲基整理剂的化学整理赋予织物免烫性.从工艺和经济观点两者来看,N-羟甲基整理剂是生产免烫棉织品最适合的整理剂。然而,在加工过程中以及贮存时从整理的织物中释放的游离甲醛现在在服装卫生学上已被提出作为一个重要问题。由于这个原因。

关键词：棉织物乙二醛水解淀粉免烫整理

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涂热解石墨改善炭和陶瓷材料的性质

炭素技术 1989年第4期8卷 23-24页

作者： rafal Wlodarski Andrzej Nowicki Lidia Pekalska 刘旭东

用不同的方法,在某一材料上涂以另一种较适当的材料(或涂以与其组成相同但结构不同的材料)来改善这种材料的性质,在60年代人们就进行了这项研究。那些研究的目的是为了获得更好表面性质的材料,以减少它们产品的造价,或者是为了获得用传... 详细信息

用不同的方法,在某一材料上涂以另一种较适当的材料(或涂以与其组成相同但结构不同的材料)来改善这种材料的性质,在60年代人们就进行了这项研究。那些研究的目的是为了获得更好表面性质的材料,以减少它们产品的造价,或者是为了获得用传统方法生产造价非常昂贵,甚至是不可能的形状复杂的零部件。本研究是关于将炭或石墨材料(也有陶瓷材料,特别是烧结氧化铝)。涂以热解石墨或热解炭以改进其性质的工艺过程。在波兰,有关这一方面的最初的研究是由***,***和R.

关键词：陶瓷材料烧结氧化铝热解石墨热解炭工艺过程石墨涂层无机杂质高纯石墨碳化铝耐热冲击

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波兰第三共和国新近历史的研究状况

学术研究 2010年第3期 102-110页

作者：拉非尔.斯托比斯基陈茂华波兰罗兹大学历史研究所华东大学人文学院历史研究所

20世纪80年代,波兰史学界围绕当代史展开了激烈的争论,并出现了两种新近历史形象的对立,即"正式历史"与未经过审查出版的"对立性历史"。新近历史焦点在于确认主体——历史学家——与他的研究客体相比较,在时间上靠近被讨论或者被记录下... 详细信息

20世纪80年代,波兰史学界围绕当代史展开了激烈的争论,并出现了两种新近历史形象的对立,即"正式历史"与未经过审查出版的"对立性历史"。新近历史焦点在于确认主体——历史学家——与他的研究客体相比较,在时间上靠近被讨论或者被记录下来的事件,在时间线上不可能有一个固定点,它随流逝的时间及可延伸的历史情景而"行进"。波兰对新近历史新形象的讨论无疑是更完整的波兰历史研究的一部分。这些讨论的参照点既有与我们有关过去知识的新形式相关的争论及其在美国和西欧学术中呈现的社会地位,也有在其他后共产党国家致力于历史形象的全国性争论。

关键词：波兰第三共和国新近历史正式历史对立性历史

Multimodal epidermal devices for hydration monitoring

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Microsystems & Nanoengineering 2017年第1期3卷 267-277页

作者： Siddharth Krishnan Yunzhou Shi R.Chad Webb Yinji Ma Philippe Bastien Kaitlyn E.Crawford Ao Wang Xue Feng Megan Manco Jonas Kurniawan Edward Tir Yonggang Huang Guive Balooch rafal M.Pielak John A.Rogers Department of Materials Science and Engineering Frederick Seitz Materials Research LaboratoryUniversity of Illinois at Urbana-ChampaignUrbanaIL 61801USA Department of Materials Science and Engineering Northwestern UniversityEvanstonIL 60208USA L’Oreal Tech Incubator California Research Center953 Indiana StreetSan FranciscoCA 94107USA Department of Civil and Environmental Engineering Mechanical EngineeringMaterials Science and EngineeringNorthwestern UniversityEvanstonIL 60208USA L’Oréal Research and Innovation 1 Avenue Eugène SchullerAulnay sous Bois 93601France Department of Engineering Mechanics Center for Mechanics and MaterialsTsinghua UniversityBeijing 100084China L’Oréal Early Clinical 133 Terminal AvenueClarkNJ 07066USA Departments of Materials Science and Engineering Biomedical EngineeringChemistryMechanical EngineeringElectrical Engineering and Computer Scienceand Neurological SurgeryCenter for Bio-Integrated ElectronicsSimpson Querrey Institute for Nano/biotechnologyNorthwestern UniversityEvanstonIL 60208USA

Precise,quantitative in vivo monitoring of hydration levels in the near surface regions of the skin can be useful in preventing skinbased pathologies,and regulating external *** we introduce multimodal sensors with important capabilities in this context,rendered in soft,ultrathin,‘skin-like’formats with numerous advantages over alternative technologies,including the ability to establish intimate,conformal contact without applied pressure,and to provide spatiotemporally resolved data on both electrical and thermal transport properties from sensitive regions of the *** in vitro studies and computational models establish the underlying measurement principles and associated approaches for determination of temperature,thermal conductivity,thermal diffusivity,volumetric heat capacity,and electrical impedance using simple analysis *** studies on 20 patients subjected to a variety of external stimuli validate the device operation and allow quantitative comparisons of measurement capabilities to those of existing state-of-the-art tools.

关键词： epidermal electronics hydration monitoring thermal characterization

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深圳蛇口汇港中心中国深圳

世界建筑导报 2019年第4期34卷 79-83页

作者： Cynthia Liau rafal Kapusta Lintang Wuriantari Darmaganda Mark Mancenido Olivia Wong Fabian Ong Paula Zheng Arnold Galang Natasha Hill 不详

这是一组建筑面积约七万平方米的商业综合体和交通枢纽项目,由一个110米高、27层的办公塔楼和5个通过景观露台连接的独栋商业组成,创造了该地区第一个独特的开放式的商业和具有活力的目的性消费场所。然而这个项目的雄心并非商业本身—... 详细信息

这是一组建筑面积约七万平方米的商业综合体和交通枢纽项目,由一个110米高、27层的办公塔楼和5个通过景观露台连接的独栋商业组成,创造了该地区第一个独特的开放式的商业和具有活力的目的性消费场所。然而这个项目的雄心并非商业本身——它同时建设在公交站点和"海上世界"地铁站口之上,成为蛇口区域新的交通枢纽——也是中等规模的TOD开发典范。SPARK的设计策略在建筑、景观、室内三个方面呈现出高度的一致性:那就是层叠的山体景观。

关键词：蛇口商业综合体深圳中国交通枢纽建筑面积 SPARK 公交站点