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Risk of gastrointestinal cancer in a symptomatic cohort after a complete colonoscopy:Role of faecal immunochemical test

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World Journal of Gastroenterology 2020年第1期26卷 70-85页

作者： noel Pin-Vieito maría J Iglesias David Remedios Lorena Rodríguez-Alonso Francisco Rodriguez-moranta VictoriaÁlvarez-sánchez Fernando Fernández-Bañares Jaume Boadas Eva martínez-Bauer rafael Campo Luis Bujanda Ángel Ferrandez Virginia Piñol Daniel Rodríguez-Alcalde Jordi Guardiola Joaquín Cubiella Gastroenterology Department Complexo Hospitalario Universitario de OurenseCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBERehd)Ourense 32005Spain Department of Gastroenterology and Hepatology University Hospital of Bellvitge-IDIBELLL'Hospitalet de LlobregatBarcelona 08907Spain.Ciber de Epidemiología y Salud Pública(CIBERESP)Spain Gastroenterology Department Complejo Hospitalario de PontevedraPontevedra 36001Spain Gastroenterology Department Hospital Universitari Mútua de TerrassaCIBERehdTerrassa 08221Spain Gastroenterology Department Consorci Sanitari de TerrassaTerrassa 08221Spain Gastroenterology Department Hospital de SabadellCorporacióSanitària Donostia Hospital Biodonostia InstituteUniversity of the Basque Country UPV/EHUCIBERehdSan Sebastian 20010Spain servicio de Aparato Digestivo Hospital Clínico UniversitarioIIS AragónUniversity of ZaragozaCIBERehdZaragoza 50009Spain Gastroenterology Department Hospital Dr.Josep TruetaGirona 17007Spain Digestive Disease section Hospital Universitario de MóstolesMadrid 28935Spain

BACKGROUnD Faecal immunochemical test(FIT)has been recommended to assess symptomatic patients for colorectal cancer(CRC)***,some conditions could theoretically favour blood originating in proximal areas of the gastrointestinal tract passing through the colon unmetabolized.A positive FIT result could be related to other gastrointestinal cancers(GIC).AIm To assess the risk of GIC detection and related death in FIT-positive symptomatic patients(threshold 10μg Hb/g faeces)without *** Post hoc cohort analysis performed within two prospective diagnostic test studies evaluating the diagnostic accuracy of different FIT analytical systems for CRC and significant colonic lesion *** patients with gastrointestinal symptoms referred consecutively for colonoscopy from primary and secondary healthcare,underwent a quantitative FIT before undergoing a complete *** without CRC were divided into two groups(positive and negative FIT)using the threshold of 10μg Hb/g of faeces and data from follow-up were retrieved from electronic medical records of the public hospitals involved in the *** determined the cumulative risk of GIC,CRC and upper *** rate(HR)was calculated adjusted by age,sex and presence of significant colonic *** We included 2709 patients without CRC and a complete baseline colonoscopy,730(26.9%)with FIT≥10μgr Hb/*** a mean time of 45.5±20.0 mo,a GIC was detected in 57(2.1%)patients:An upper GIC in 35(1.3%)and a CRC in 14(0.5%).Thirty-six patients(1.3%)died due to GIC:22(0.8%)due to an upper GIC and 9(0.3%)due to ***-positive subjects showed a higher CRC risk(HR 3.8,95%CI:1.2-11.9)with no differences in GIC(HR 1.5,95%CI:0.8-2.7)or upper GIC risk(HR 1.0,95%CI:0.5-2.2).Patients with a positive FIT had only an increased risk of CRC-related death(HR 10.8,95%CI:2.1-57.1)and GIC-related death(HR 2.2,95%CI:1.1-4.3),with no differences in upper GIC-related death(HR 1.4,95%CI:0.6-3.3).An

关键词： Colonoscopy Colorectal cancer Faecal immunochemical test Gastric cancer Gastroesophageal cancer Gastrointestinal cancer symptoms

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multiplexed detection and differentiation of bacterial enzymes and bacteria by color-encoded sensor hydrogels

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Bioactive materials 2021年第12期6卷 4286-4300页

作者： Zhiyuan Jia mareike müller Tony Le gall martijn Riool max müller sebastian A.J.Zaat Tristan montier Holger schönherr Physical Chemistry I&Research Center of micro and nanochemistry and Engineering(Cμ) Department of Chemistry and BiologyUniversity of SiegenAdolf-Reichwein-Straße 257076SiegenGermany Univ Brest INSERMEFSUMR 1078 GGFBF-29200BrestFrance Department of medical microbiology and Infection Prevention Amsterdam institute for Infection and ImmunityAmsterdam UMCUniversity of AmsterdamMeibergdreef 91105AZAmsterdamthe Netherlands CHRU de Brest Service degenetique medicale et de biologie de la reproductionCentre de Réference des Maladies Rares《Maladies neuromusculaires》F-29200BrestFrance

We report on the fabrication and characterization of color-encoded chitosan hydrogels for the rapid,sensitive and specific detection of bacterial enzymes as well as the selective detection of a set of tested bacteria through characteristic enzyme *** patterned sensor hydrogels are functionalized with three different colorimetric enzyme substrates affording the multiplexed detection and differentiation ofα-glucosidase,β-galactosidase andβ-*** limits of detection of the hydrogels for an observation time of 60 min using a conventional microplate reader correspond to concentrations of 0.2,3.4 and 4.5 nm of these enzymes,*** on their different enzyme expression patterns,staphylococcus aureus strain Rn4220,methicillin-resistant ***(mRsA)strain n315,both producingα-glucosidase,but notβ-glucuronidase andβ-galactosidase,Escherichia coli strain DH5α,producingβ-glucuronidase andα-glucosidase,but notβ-galactosidase,and the enterohemorrhagic ***(EHEC)strain E32511,producingβ-galactosidase,but none of the other two enzymes,can be reliably and rapidly distinguished from each *** results confirm the applicability of enzyme sensing hydrogels for the detection and discrimination of specific enzymes to facilitate differentiation of bacterial *** hydrogels thus possess the potential to be further refined as detection units of a multiplexed format to identify certain bacteria for future application in point-of-care microbiological diagnostics in food safety and medical settings.

关键词： multiplexed biosensors Bacteria detection Bacterial enzyme Reporter hydrogels Colorimetric substrates

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Altered Liver Gene Expression Due to Hypertension and Age in Rats

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Journal of Biosciences and medicines 2023年第8期11卷 82-94页

作者： maría Dolores Ronquillo-sánchez Jorge Ramírez-salcedo Itzell Alejandrina gallardo-Ortíz rafael Villalobos-molina Unidad de Biomedicina Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México Tlalnepantla México Departamento de Biología Celular y del Desarrollo Instituto de Fisiología Celular Universidad Nacional Autónoma de México Ciudad de México México Carrera de Enfermería Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México Tlalnepantla México

Hypertension and metabolic syndrome, both of which increase with age, are multifactorial disorders. Their etiology is complex, making it challenging to isolate involved genes. This study aimed to characterize the hepatic gene expression in spontaneously hypertensive rats (sHR) at different ages. Blood pressure in sHR was determined by tail-cuff method at one and three months of age. Hepatic RnA was isolated and gene expression was compared using microarrays. Comparison between sHR and normotensive rats revealed significant variation in gene expression: 98 genes were upregulated and 122 were downregulated in sHR;while 88 genes were upregulated and 139 genes were downregulated in age-matched normotensive rats. Furthermore, within the sHR group, 110 genes were found to be upregulated and 168 genes downregulated across different ages. Analyses via the Gene Ontology, and Kyoto Encyclopedia of Genes and Genomes pathways revealed that several genes are potentially implicated in both, hypertension and metabolic syndrome. The results suggest that sHR display variations in gene expression due to aging, and when compared to normotensive rats. These variations could contribute to the development of hypertension and metabolic syndrome. microarray studies involving older rats are necessary to further validate these findings.

关键词： Hypertension metabolic syndrome Gene Expression sHR microarray

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Three-dimensional mapping and comparative analysis of the distal human corpus cavernosum and the inflatable penile prosthesis

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Asian Journal of Andrology 2013年第4期15卷 567-570,I0012页

作者： Tariq s Hakky Daniel Ferguson Philippe E spiess Paul Bradley Tom FLue rafael E Carrion Department of Urology University of South Florida Tampa General Circle Tampa FL 33602 USA 23D3solutions Burnaby BCV5J 5M8 Canada and Department of Urology University of Southern California San Francisco 400 Parnassus Ave San Francisco CA 94143 USA

The intricate anatomy of the corpus cavernosum in both the flaccid and tumescent state has not been fully elucidated. We report our experience using a three-dimensional （3D） scanner to reconstruct cadaveric casts and compare them with 3D images of two prototypes of penile prosthesis. Two different models of the Titan Coloplast inflatable penile prosthesis were analyzed using a 3D scanner. The first was the standard model and the second was a newer model with a rounder silicone tip. Two cadaveric phalluses were harvested using smooth-Cast 300Q polyurethane molding. The molds were excised and scanned along side the penile prosthesis. 3D scans were completed and analyzed using Leios mesh software, and GOm Inspect software. The 3D scans demonstrated the mean human corporal radii 2 mm from the distal tip to be 36.51 mm （36.01-37.0 mm）, which is an obtuse angle. The standard Titan penile prosthesis spherical radius at the same level was 202.52 mm, while the new silicone tip prosthesis had a radius of 139.33 mm. 3D mapping further demonstrated the trajectory of the cavernosa appeared curvilinear and the distal ends appeared blunt. The use of cadaveric cavernosal molds in combination with the 3D scanner allowed us to accurately image the corpus cavernosum for the first time. Our findings suggest that anatomically accurate corporal tips appear to be relatively blunt and that the new Titan silicone tip penile prosthesis more closely resembles the human corporal tip.

关键词： corpus cavernosum penile prosthesis three-dimensional analysis

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Epstein-Barr virus is related with 5-aminosalicylic acid, tonsillectomy, and CD19^+ cells in Crohn's disease

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World Journal of Gastroenterology 2015年第15期21卷 4666-4672页

作者： Juan C Andreu-Ballester rafael Gil-Borrás Carlos García-Ballesteros Ignacio Catalán-serra Victoria Amigo Virgina Fernández-Fígares Carmen Cuéllar Research Department Arnau de Vilanova Hospital Digestive Department Arnau de Vilanova Hospital Hematology Department Arnau de Vilanova Hospital Department of Parasitology Faculty of Pharmacy Complutense University

AIm: To study anti-Epstein-Barr virus(EBV) Ig G antibodies in Crohn′s disease in relation to treatment, immune cells, and prior tonsillectomy/***: This study included 36 CD patients and 36 healthy individuals(controls), and evaluated different clinical scenarios(new patient, remission and active disease), previous mucosa-associated lymphoid tissue removal(tonsillectomy and appendectomy) and therapeutic regimens(5-aminosalicylic acid, azathioprine, anti-tumor necrosis factor, antibiotics, and corticosteroids). T and B cells subsets in peripheral blood were analyzed by flow cytometry(markers included: CD45, CD4, CD8, CD3, CD19, CD56, CD2, CD3, TCRαβ and TCRγδ) to relate with the levels of anti-EBV Ig G antibodies, determined by enzyme-linked immunosorbent ***: The lowest anti-EBV Ig G levels were observed in the group of patients that were not in a specific treatment(95.4 ± 53.9 U/m L vs 131.5 ± 46.2 U/m L, P = 0.038). The patients that were treated with 5-aminosalicylic acid showed the highest anti-EBV Ig G values(144.3 U/m L vs 102.6 U/m L, P = 0.045). CD19+ cells had the largest decrease in the group of CD patients that received treatment(138.6 vs 223.9; P = 0.022). The analysis of anti-EBV Ig G with respect to the presence or absence of tonsillectomy showed the highest values in the tonsillectomy group of CD patients(169.2 ± 20.7 U/m L vs 106.1 ± 50.3 U/m L, P = 0.002). However, in the group of healthy controls, no differences were seen between those who had been tonsillectomized and subjects who had not been operated on(134.0 ± 52.5 U/m L vs 127.7 ± 48.1 U/m L, P = 0.523).COnCLUsIOn: High anti-EBV Ig G levels in CD are associated with 5-aminosalicylic acid treatment, tonsillectomy, and decrease of CD19+ cells.

关键词： B cells Crohn's disease Epstein-Barr virus Tonsillectomy 5-aminosalicylic acid

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Quercetin prevents spinal motor neuron degeneration induced by chronic excitotoxic stimulus by a sirtuin 1-dependent mechanism

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Translational neurodegeneration 2017年第1期6卷 310-323页

作者： rafael Lazo-Gomez Ricardo Tapia División de neurociencias Instituto de Fisiología CelularUniversidad Nacional Autónoma de MéxicoCircuito exterior s/nCiudad UniversitariaCoyoacán04510 Ciudad de MéxicoMexico

Background:Excitotoxicity is a mechanism of foremost importance in the selective motor neuron degeneration characteristic of motor neuron *** therapeutic strategies are an unmet need for these ***,such as quercetin and resveratrol,are plant-derived compounds that activate sirtuins(sIRTs)and have shown promising results in some models of neuronal death,although their effects have been scarcely tested in models of motor neuron ***:In this work we investigated the effects of quercetin and resveratrol in an in vivo model of excitotoxic motor neuron death induced by the chronic infusion ofα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid(AmPA)into the rat spinal cord *** and resveratrol were co-infused with AmPA and motor behavior and muscle strength were assessed daily for up to ten ***,animals were fixed and lumbar spinal cord tissue was analyzed by histological and immunocytological ***:We found that the chronic infusion of AmPA[1 mm]caused a progressive motor neuron degeneration,accompanied by astrogliosis and microgliosis,and motor deficits and paralysis of the rear *** infusion ameliorated AmPA-induced paralysis,rescued motor neurons,and prevented both astrogliosis and microgliosis,and these protective effects were prevented by EX527,a very selective sIRT1 *** contrast,neither resveratrol nor EX527 alone improved motor behavior deficits or reduced motor neuron degeneration,albeit both reduced ***:These results suggest that quercetin exerts its beneficial effects through a sIRT1-mediated mechanism,and thus sIRT1 plays an important role in excitotoxic neurodegeneration and therefore its pharmacological modulation might provide opportunities for therapy in motor neuron disorders.

关键词： motor neuron disorder Quercetin Resveratrol sirtuin Excitotoxicity

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Challenges at the early stages of the environmental licensing procedure and potential contributions from geomorphology

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Geoscience Frontiers 2021年第6期12卷 36-45页

作者： Cristina I.Pereira Celene B.milanes rafael sarda Benjamin Cuker Camilo m.Botero Coastal systems Research Group Playas Corporation Ltda.BogotáColombia Corporación para el Desarrollo sostenible del Urabá–CORPOURABA Barrio ManzanaresCl.92No 98-39ApartadóColombia Civil and Environmental Department Universidad de la CostaBarranquillaColombia Centro de Estudios Avanzados de Blanes Consejo Superior de Investigaciones CientíficasCEAB-CSICSpain Department of marine and Environmental science Hampton UniversityHamptonVA 23668USA University sergio Arboleda School of LawSanta MartaColombia

Defining impact significance is the main technical task that influences decision-making during the Environmental Licensing Procedure(ELP).The ELP begins with screening to determine potentially significant impacts of the proposed *** then follows to address any interventions deemed worthy of attention in the production of an Environmental Impact Assessment(EIA).This will include consideration of relevant landforms and geomorphological ***,preliminary assessments of environmental impacts often lack the scientific robustness to procure substantive and transactive *** review presents an examination of the established practices of screening and scoping while highlighting the foremost challenges to improve the technical grounds of the *** analysis of screening and scoping practices stresses the need for novel methods that ensure the sequential reasoning between their criteria while improving the preliminary evaluation of impact *** the inherent subjectivity of discretionary judgment requires scientific methodologies that acknowledge the interaction between the natural system and human interventions,which has been addressed by geomorphological *** knowledge consolidated in this review opens the gate to explore the compatibility between the United nations strategy of Ecosystem Approach(EA)with the ELP through a novel geomorphological interpretation of the ***,this diagnosis demonstrate that screening and scoping practices would benefit from reliable methods that balance the precautionary principle with the efficient character required in the ELP.

关键词： EIA effectiveness screening and scoping practices Landforms Geomorphological processes Ecosystem approach

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Hydrodynamic study of Lake Enriquillo in Dominican Republic

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Journal of Geoscience and Environment Protection 2017年第5期5卷 115-124页

作者： A. Delanoy Ramón rafael méndez-Tejeda Facultad de Ciencias Instituto de Física Universidad Autónoma de Santo Domingo Santo Domingo Dominican Republic Laboratorio de Ciencias Atmosféricas Departamento de Ciencias Naturales Universidad de Puerto Rico en Carolina Carolina Puerto Rico

This study presents an analysis of the hydrochemical characteristics of Lake Enriquillo in the southwestern region of the Dominican Republic. This lake is hypersaline and endorheic. The climatology of the region is influenced by the Caribbean Regulator Climate Centers (CRCCs). Due to the endorheic nature of the basin, evaporation plays an extremely important role in its dynamics [1]. During the study period, in november 2002, the water level of Lake Enriquillo was 42 m below sea level (BLs), and the salinity level was 104.2‰. By 2014, the water level of the lake rose to 29 m below sea level, and the salinity decreased to 23.4‰, as a result of the high cyclonic activity in the Caribbean region.

关键词： Hydrochemical Parameter Endorheic Lake Hypersaline Lake Enriquillo

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Direct observation of the CO_(2) formation and C–H consumption of carbon electrode in an aqueous neutral electrolyte supercapacitor by in-situ FTIR and Raman

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Journal of Energy Chemistry 2022年第8期31卷 488-496,I0013页

作者： murilo m.Amaral Victor Y.Yukuhiro rafael Vicentini Alfredo C.Peterlevitz Leonardo m.Da silva Pablo Fernandez Hudson Zanin Advanced Energy storage Division State University of Campinas13083-852Av.Albert Einsten 400CampinasSPBrazil Chemistry Institute State University of Campinas13083-970Josue de Castro StreetCampinasSPBrazil Department of Chemistry Laboratory of Fundamental and Applied ElectrochemistryFederal University of Jequitinhonha and Mucuri’s ValleyRodovia MGT 367km 5835000Alto da Jacuba39100-000DiamantinaMGBrazil Center for Innovation on new Energies University of Campinas13083-841 CampinasSão PauloBrazil

Electrical double-layer capacitors(EDLCs)consist of energy storage devices that present high-power and moderate energy *** electrolyte and electrode physicochemical properties are crucial for improving their overall energy storage ***,the stability of the EDLCs’materials is the primary focus of this *** energy storage depends on the specific capacitance,and also on the square of the maximum capacitive cell voltage(UmCV).Thus,electrodes with high specific surface area(ssA)and electrolytes with excellent electrochemical stability are commonly reported in the *** electrolytes are safer and green devices compared to other organic-based *** the other hand,their UmCVis reduced compared to other electrolytes(e.g.,organic-based and ionic liquids).In this sense,spanning the UmCVfor aqueous-based electrolytes is a’hot topic’***,the lack of protocols to establish reliable UmCVvalues has culminated in the publishing of several conflicting ***,we confirm that multiwalled carbon nanotubes(mWCnTs)housed in cells degrade and produce CO_(2) under abusive polarisation *** is probed by employing electrochemical techniques,in-situ FTIR and in-situ Raman *** these considerations,the current study uses spectro-electrochemical techniques to support the correct determination of the electrode and electrolyte stability conditions as a function of the operating electrochemical parameters.

关键词： Electrode and electrolyte stabilities In-situ FTIR CO_(2)formation Carbon degradation supercapacitor Aqueous electrolytes Carbon nanotubes

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Influence of Rare-Earth substitution for Iron in FeCrmoCB Bulk metallic Glasses

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Chinese Physics Letters 2010年第7期27卷 192-194页

作者： Abderrezak Bouchareb Badis Bendjemil rafael Piccin marcello Baricco Dipartimento di Chimica I.F.m/nIs/CnIsm/InsTm Universita di Torino Via Giuria 9 10125 Torino Italy Laboratoire d'Etude et la Recherche de l'Etat Condensd (LEREC) University of Badji Mokhtar P.O. Box 12 23000 Annaba Algeria University of Guelma P.O. Box 12 24000 Guelma Algeria

The effects of rare earth addition on the glass forming ability of Fe50-xCr15mo14C15B6mx （x =0, 2 and m=Y, Gd） bulks and ribbons are studied. The thermal and structural properties of the samples are measured by a combination of differential scanning calorimetry （DsC）, x-ray diffraction and scanning electron microscopy. Chemical compositions are checked by energy dispersive spectroscopy analysis. The copper mold casting technique leads to a fully amorphous structure up to 2mm only for compositions containing Y or Gd. In the case of ribbons, a fully amorphous phase is observed for all the compositions. The roles of Y and Gd are discussed on the basis of melting behavior analyzed by high-temperature DsC. such elements act as oxygen scavengers, avoiding heterogeneous nucleation.

关键词： RARE earths sUBsTITUTIOn reactions mETALLIC glasses IROn compounds ADDITIOn reactions mETALWORK X-ray diffraction

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