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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： sharon j.Brown rafael j.Yáñez-Muñoz Heidi R.Fuller school of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

spinal muscular atrophy(sMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of sMA was understood in 1995 when loss or impairment of the survival motor neuron 1(sMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,sMN2,which can produce low levels(approximately 10%)of the full-length functional sMN protein,has led to the generation of sMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,sMN2 copy number is used as a proxy for the prediction of disease severity,with higher sMN2 copy number typically being associated with reduced severity of sMA,although this relationship is not absolute:some individuals with low sMN2 copy number have less severe sMA phenotypes and vice ***,the etiology of sMA is further complicated by other factors,such as non-typical nucleotide variants and sMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

supercritical fluid technology as a sustainable alternative method for textile dyeing:An approach on waste,energy,and CO_(2)emission reduction

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journal of Environmental sciences 2024年第6期140卷 123-145页

作者： Carlos rafael silva de oliveira Patrícia Viera de oliveira Leandro Pellenz Catia Rosana Lange de Aguiar Afonso Henrique da silva júnior Federal University of santa Catarina Textile Engineering Department2514 João Pessoa St.BlumenauSC89036-004Brazil Federal University of santa Catarina Chemical Engineering DepartmentS/n Biotério Central St.FlorianópolisSC88040-900Brazil

The clothing industry is considered one of the most polluting industries on the planet due to the high consumption of water,energy,chemicals/dyes,and high generation of solid waste and *** with environmental concerns,the textile ennoblement sector is the most critical of the textile production chain,especially the traditional dyeing *** an alternative to current problems,dyeing with supercritical CO_(2)(scCO_(2))has been presented as a clean and efficient process for a sustainable textile *** fluid dyeing(sFD)has shown a growing interest due to its significant impact on environmental preservation and social,economic,and financial *** main sFD benefits include economy and reuse of non-adsorbed dyes;reduction of process time and energy expenditure;capture of atmospheric CO_(2)(greenhouse gas);use and recycling of CO_(2)in sFD;generation of carbon credits;water-free process;effluent-free process;reduction of CO_(2)emission and auxiliary *** being still a non-scalable and evolving technology,sFD is the future of *** review presented a comprehensive overview of the environmental impacts caused by traditional processes and confronted the advantages of *** sFD technique was introduced,along with its latest advances and future *** and environmental gains were also discussed.

关键词： Textile industry supercritical dyeing sustainable processes Water free dyeing Energy saving Cleaner production

Multiple ecological strategies explain the distribution of exotic and native C_(4) grasses in heterogeneous early successional sites in Hawai’i

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journal of Plant Ecology 2017年第3期10卷 426-439页

作者： rafael de oliveira Xavier Carla M.D’Antonio Ecology and Conservation Lab Department of HydrobiologyFederal University of São CarlosWashington Luís Highwaykm 235São CarlosSão Paulo 13565-905Brazil Environmental studies Program 4312-L Bren University of CaliforniaSanta BarbaraCA 93106USA

Aims Biotic homogenization results in novel communities contain-ing multiple exotic *** attributes that contribute to the dominance of invaders and increase invasibility of communities have been identified,but rarely have factors governing the domi-nance of co-occurring invaders been *** we assess the presence and performance of five exotic and one native C_(4) grass species across local(microsite)and more broad-scale variation in fire history,soil age,altitude and *** ask whether species show preferences for the same conditions,whether all are constrained by poor soil development,and how their performance changes when alone versus *** addition to providing information useful to managers who want to control some of these species,such information can help to predict how distributions might change with climate change Methods We measured percent cover and plant height of each grass species in 64 plots in each of 15 sites,located in young volcanic substrates across environmental gradients in Hawai’i Volcanoes National Park,Hawai’i,*** varied in fire history and soil age,across altitu-dinal and precipitation *** estimated microsite heteroge-neity by measuring rock cover and soil depth,where each species was present and in plots as a *** analyzed effects of pos-sible controlling variables using chi-square tests and Generalized Additive Mixed *** Findings Two species(schizachyrium condensatum and Hyparrhenia rufa)were absent in shallow soil,restricted to more mesic sites and showed increasing performance with soil *** contrast,two other species(Andropogon virginicus and Melinis repens)tended to occur in shal-low soil with high rock cover across a wide range of *** addi-tional species(Melinis minutiflora)was weakly affected by soil depth and was the dominant at higher elevation(more mesic)and on burned sites,especially in old *** species was largely absent from lower elevation si

关键词： elevation gradient fire invasive species Melinis minutiflora soil depth

decontamination of mobile phones and electronic devices for health care professionals using a chlorhexidine/carbomer 940■gel

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Frontiers of Chemical science and Engineering 2019年第1期13卷 192-198页

作者： rafael Muniz de oliveira Nereida Mello da Rosa Gioppo jancineide oliveirade Carvalho Francilio Carvalho oliveira Thomas jay Webster Fernanda Roberta Marciano Anderson oliveira Lobo University Hospital of the West of Parana State University of West of Parana Cascavel PR Brazil University Center for Health. Humanities and Technology of Piaui (UNINOVAFAPI). Piaui Brazil science and Technology Institute Brasil University Itaquera SP Brazil Nanomedicine Laboratory Department of Chemical Engineering Northeastern University MA 02115 USA Materials science and Engineering graduation program Technology Center Federal University of Piaui. PI Brazil

Though they reduce microorganism growth, current hospital disinfectants also damage many of today’s modern electronic devices such as tablets and smartphones. Herein, the efficacy of a new chlorhexidine digluconate gel (CDG) was tested as a disinfectant for mobile and electronic devices in a clinical environment. specifically, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and methicillin resistant staphylococcus aureus were used to infect the screen of eight smartphones. The CDG was prepared at concentrations of 2%, 4% and 6%, and tested on paper disks infected with these bacteria before being tested on the smartphones. The devices were disinfected with the CDG gel (4%) at two times: immediately and after 5 min of the bacterial contamination. In all cases, the CDG gel eliminated 100% of gram-positive and gram-negative microorganisms compared to the control (without any agent). In addition, the gel did not damage the smartphones. Therefore, our study suggests that the CDG gel may be applied to disinfect a wide range of electronic devices for health care professionals in the hospital environment.

关键词： smartphones disinfection clinical environment chlorhexidine bacteria

Molecule-based kinetic modeling by Monte Carlo methods for heavy petroleum conversion

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science China Chemistry 2013年第11期56卷 1608-1622页

作者： de oliveira Luís Pereira VERsTRAETE jan j. KOLB Max IFP Energies nouvelles Rond-point de l'échangeur de Solaize-BP 369360 SolaizeFrance Laboratoire de Chimie cole Normale Supérieure69364 Lyon Cedex 07France

A methodology for kinetic modeling of conversion processes is *** proposed approach allows to overcome the lack of molecular detail of the petroleum fractions and to simulate the reactions of the process by means of a two-step *** the first step,a synthetic mixture of molecules representing the feedstock is generated via a molecular reconstruction method,termed sR-REM molecular *** the second step,a kinetic Monte Carlo method,termed stochastic simulation algorithm(ssA),is used to simulate the effect of the conversion reactions on the mixture of *** resulting methodology is applied to the Athabasca vacuum residue *** adequate molecular representation of the vacuum residue is obtained using the sR-REM *** reaction simulations present a good agreement with the laboratory data for Athabasca vacuum residue *** addition,the proposed methodology provides the molecular detail of the vacuum residue conversion throughout the reactions simulations.

关键词： Monte-Carlo molecular reconstruction kinetic modeling stochastic simulation algorithm vacuum residue hydrocracking

Inductive Model Generation for Text Classification Using a Bipartite Heterogeneous Network

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journal of Computer science & Technology 2014年第3期29卷 361-375页

作者： rafael Geraldeli Rossi Alneu de Andrade Lopes Thiago de Paulo Faleiros solange oliveira Rezende Institute of Mathematics and Computer science University of So PauloSo CarlosBrasil

Algorithms for numeric data classification have been applied for text classification. Usually the vector space model is used to represent text collections. The characteristics of this representation such as sparsity and high dimensionality sometimes impair the quality of general-purpose classifiers. Networks can be used to represent text collections, avoiding the high sparsity and allowing to model relationships among different objects that compose a text collection. such network- based representations can improve the quality of the classification results. One of the simplest ways to represent textual collections by a network is through a bipartite heterogeneous network, which is composed of objects that represent the documents connected to objects that represent the terms. Heterogeneous bipartite networks do not require computation of similarities or relations among the objects and can be used to model any type of text collection. Due to the advantages of representing text collections through bipartite heterogeneous networks, in this article we present a text classifier which builds a classification model using the structure of a bipartite heterogeneous network. such an algorithm, referred to as IMBHN （Inductive Model Based on Bipartite Heterogeneous Network）, induces a classification model assigning weights to objects that represent the terms for each class of the text collection. An empirical evaluation using a large amount of text collections from different domains shows that the proposed IMBHN algorithm produces significantly better results than k-NN, C4.5, sVM, and Naive Bayes algorithms.

关键词： heterogeneous network text classification inductive model generation

susceptibility of Large Wind Power Plants to Voltage Disturbances-Recommendations to stakeholders

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journal of Modern Power systems and Clean Energy 2022年第2期10卷 416-429页

作者： Roger Alves de oliveira Math H.j.Bollen the Electric Power Engineering Group Lulea University of TechnologySkellefteaSweden

sufficient fault ride-through(FRT)of large wind power plants(WPPs)is essential for the operation security of transmission *** majority of studies on FRT do not include all disturbances originating in the transmission system or the disturbances irrelevant to the operation *** on the knowledge of power quality,this paper provides a guide to stakeholders in different aspects of FRT for wind turbines(WTs)and *** paper details the characteristics of the most common disturbances originated in the transmission system,how they propagate to the WT terminals,and how they impact the dynamic behavior of a large *** paper shows that the details of the voltage disturbances,not only in the transmission system,but also at the WT terminals,should be taken into ***,a detailed representation or characterization of voltage dips is important for FRT studies,despite that the simplified models used in the literature are *** paper strongly recommends that distinct events and additional characteristics such as the phase-angle jump and oscillations in the transition segments should be considered in FRT analysis.

关键词： Wind power generation wind farm power quality fault ride-through(FRT) low voltage ride-through(LVRT)

Partition coefficient prediction of Baker's yeast invertase in aqueous two phase systems using hybrid group method data handling neural network

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Chinese journal of Chemical Engineering 2017年第5期25卷 652-657页

作者： Carlos Eduardo de Araújo Padilha sérgio Dantas de oliveira júnior Domingos Fabiano de santana souza jackson Araújo de oliveira Gorete Ribeiro de Macedo Everaldo silvino dos santos Laboratory of Biochemical Engineering Chemical Engineering DepartmentFederal University of Rio Grande do Norte (UFRN)

A hybrid GMDH neural network model has been developed in order to predict the partition coefficients of invertase from Baker's yeast. ATPs experiments were carried out changing the molar average mass of PEG(1500–6000 Da), p H(4.0–7.0), percentage of PEG(10.0–20.0 w/w), percentage of MgsO_4(8.0–16.0 w/w), percentage of the cell homogenate(10.0–20.0 w/w) and the percentage of MnsO_4(0–5.0 w/w) added as cosolute. The network evaluation was carried out comparing the partition coefficients obtained from the hybrid GMDH neural network with the experimental data using different statistical metrics. The hybrid GMDH neural network model showed better fitting(AARD = 32.752%) as well as good generalization capacity of the partition coefficients of the ATPs than the original GMDH network approach and a BPANN model. Therefore hybrid GMDH neural network model appears as a powerful tool for predicting partition coefficients during downstream processing of biomolecules.

关键词： Partitioning Invertase Aqueous Two Phase system GMDH Neural network

Resveratrol attenuates metabolic,sperm,and testicular changes in adult Wistar rats fed a diet rich in lipids and simple carbohydrates

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Asian journal of Andrology 2019年第2期21卷 201-207页

作者： Fabiana A de oliveira Waldemar s Costa Francisco j B sampaio Bianca M Gregorio Urogenital Research Unit Biomedical CenterState University of Rio de JaneiroRio de Janeiro 20551-030Brazil

High-fat diets affect male reproduction and sexual ***,we evaluated the effects of prolonged resveratrol administration on the metabolic,sperm,and testicular parameters of rats fed a cafeteria *** Wistar rats were divided at weaning into control(Cv n=20)and cafeteria(CAF,n=16)*** 3 months,half of them were given daily supplementations of resveratrol(C-R,n=10;CAF-R,n=8)at a dosage of 30 mg kg-1 body mass for 2 *** were killed at 5 months of age,and blood,spermatozoa,and testes were collected for further *** were analyzed by one-way ANOVA,and Ps considered statistically *** CAF diet promoted hyperglycemia(Psveratrol reversed this condition(Psperm viability and motility,while resveratrol improved these parameters(Fsticular morphology,the height of the seminiferous epithelium was reduced in the CAF group compared with that of the C group(P=0.0007).spermatogenic cell proliferation was also reduced in the CAF group compared with that of the C ***,the CAF-R showed an increase in cell proliferation rate compared with that of the untreated CAF group(P=0.0024).Although it did not modify body mass,the consumption of a CAF diet promoted hyperglycemia,adverse testicular morphology remodeling,and abnormal sperm,which were attenuated by treatment with resveratrol,thus suggesting a protective effect of this antioxidant on spermatogenesis.

关键词： cafeteria diet morphology resveratrol spermatozoa testicle

Protein profile of leprosy patients with plantar ulcers from the Eastern Amazon region

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Infectious Diseases of Poverty 2017年第1期6卷 947-954页

作者： Marineia Porto de oliveira jorge Rodrigues de sousa rafael silva de Araujo Tinara Leila de sousa Aarao juarez Antonio simoes Quaresma Nucleo de Medicina Tropical Universidade Federal do ParaAv.Generalissimo Deodoro 92UmarizalBelemPara 66055240Brazil Centro de Ciencias Biologicas e da saude Universidade do Estado do ParaBelemParaBrazil

Background:studies investigating the nutritional status of patients with leprosy and plantar ulcers are ***,the objective of this study was to describe the protein profile of leprosy patients with plantar ulcers from the Eastern Amazon ***:A case record form was created for 75 patients with leprosy(31 with plantar ulcers and 44 without plantar ulcers)with the following data:sociodemographic characteristics,clinical form of leprosy,presence or absence of plantar ulcers,and nutritional assessment using anthropometry consisting of the measurement of body mass index,arm circumference,arm muscle circumference,and triceps *** of blood albumin,transferrin,and C-reactive protein(CRP)were also *** regarding protein intake were obtained using a Food Frequency ***:Plantar ulcers occurred more frequently in male patients(67.7%),patients aged 40-49 years(mean±sD:47.3±8.0 years),and patients receiving 300 or 600 UsD(71.0%).The mean weight and height of patients were 71.6±11.4 kg and 1.62±0.1 m,*** levels of CRP were detected in 51.6%of leprosy patients with plantar ulcers and only 9.1%of patients without plantar ulcers(Pdepletion of transferrin was observed in 14.3%of patients with paucibacillary leprosy and 44.3%of patients with multibacillary leprosy(P=0.0447).Most patients had normal levels of serum albumin(74.2%with plantar ulcers and 77.3%without plantar ulcers).Conclusions:Most leprosy patients with plantar ulcers have normal levels of serum albumin and transferrin and high CRP levels,which indicates the presence of an inflammatory *** findings suggest the need to monitor patients with leprosy to prevent the occurrence of plantar ulcers and to provide adequate treatment for patients with existing plantar ulcers.

关键词： Leprosy Plantar ulcer Nutritional status Anthropometric assessment Albumin Transferrin C-reactive protein