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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon j.Brown rafael j.Yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Supercritical fluid technology as a sustainable alternative method for textile dyeing:An approach on waste,energy,and CO_(2)emission reduction

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j.urnal of Environmental Sciences 2024年第6期140卷 123-145页

作者： Carlos rafael Silva de Oliveira Patrícia Viera de Oliveira Leandro Pellenz Catia Rosana Lange de Aguiar Afonso Henrique da Silva j.nior Federal University of Santa Catarina Textile Engineering Department2514 João Pessoa St.BlumenauSC89036-004Brazil Federal University of Santa Catarina Chemical Engineering DepartmentS/n Biotério Central St.FlorianópolisSC88040-900Brazil

The clothing industry is considered one of the most polluting industries on the planet due to the high consumption of water,energy,chemicals/dyes,and high generation of solid waste and *** with environmental concerns,the textile ennoblement sector is the most critical of the textile production chain,especially the traditional dyeing *** an alternative to current problems,dyeing with supercritical CO_(2)(scCO_(2))has been presented as a clean and efficient process for a sustainable textile *** fluid dyeing(SFD)has shown a growing interest due to its significant impact on environmental preservation and social,economic,and financial *** main SFD benefits include economy and reuse of non-adsorbed dyes;reduction of process time and energy expenditure;capture of atmospheric CO_(2)(greenhouse gas);use and recycling of CO_(2)in SFD;generation of carbon credits;water-free process;effluent-free process;reduction of CO_(2)emission and auxiliary *** being still a non-scalable and evolving technology,SFD is the future of *** review presented a comprehensive overview of the environmental impacts caused by traditional processes and confronted the advantages of *** SFD technique was introduced,along with its latest advances and future *** and environmental gains were also discussed.

关键词： Textile industry Supercritical dyeing Sustainable processes Water free dyeing Energy saving Cleaner production

Biodiversity Assessment of Avifauna in the Forest Reservation of Aurora State College of Technology (ASCOT), Philippines

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Open j.urnal of Ecology 2024年第4期14卷 292-308页

作者： Afed S. Daiwey Heherson B. Ong Emerson V. Barcellano Edmundo C. Gumpal Michelle Ann M. Calubaquib rafael j. Padre School of Forestry and Environmental Sciences Aurora State College of Technology Baler Philippines College of Forestry and Environmental Science Isabela State University Cabagan Philippines College of Agriculture Isabela State University Cabagan Philippines College of Engineering Isabela State University Echague Philippines

The research study was conducted to assess and quantify the current status of avifauna biodiversity assets of Aurora State College of Technology’s Forest Reservation in Baler, Aurora, Philippines. Assessment of avifaunal diversity was undertaken by traversing the four established circular plots having a radius of 125 meters or 250 meters diameters each as permanent monitoring stations. Study revealed a total number of 151 Individual species, classified into 23 genera and 21 families. Eighteen of these species are endemic while the remaining five were fully migrated birds. All birds observed were classified as Least Concern (LC) species according to the International Union for Conservation of Nature’s Red List of Threatened Species and the updated list of the Birds of the World online. Its abundance, richness and diversity index were calculated using Shannon Diversity Index (H') while Pielou’s evenness (j.) for distribution of species. Forest reservation of ASCOT has more even (0.756 j.) and moderate diversity (2.812 H') observation on avifauna in general. However, this avian population evaluation was threatened into a verge of extinction due to natural and anthropological threats that causes forest deforestation. Such deforestation of habitat causes dwindling of wildlife territory leading to the scarcity of bird’s population. Thus, the assessment was conducted to aid ASCOT administration find significant plans to ensure sustainable conservation and protection of the remaining avifauna species in the reservation area.

关键词： Biodiversity Avifauna Abundance Species Richness Species Diversity

自发性脑出血治疗指南美国心脏协会／美国卒中协会对医疗卫生专业人员发布的指南

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国际脑血管病杂志 2010年第8期18卷 561-580页

作者： Lewis B. Morgenstem j. Claude Hemphill Ⅲ Craig Anderson Kyra Becker j.seph P. Broderick E. Sander Connolly j. Steven M. Greenberg j.mes N. Huang R. Loch Macdonald Steven R. Messe Pamela H. Mitchell Magdy Selim rafael j. tamargo 王玉洁(译) 王健(译) 刘相玉(译) 谢丽丽(译) 美国心脏协会卒中委员会和心血管护理委员会辽宁省人民医院神经内二科沈阳110016

目的本指南旨在为急性自发性脑出血的诊断和治疗提供最新的综合性推荐意见。方法通过Medline进行规范的文献检索，利用证据表合并资料。撰写委员会成员通过远程电信会议讨论根据资料得出的推荐意见。采用美国心脏协会卒中委员会的证据... 详细信息

目的本指南旨在为急性自发性脑出血的诊断和治疗提供最新的综合性推荐意见。方法通过Medline进行规范的文献检索，利用证据表合并资料。撰写委员会成员通过远程电信会议讨论根据资料得出的推荐意见。采用美国心脏协会卒中委员会的证据分级方案对推荐意见进行分级。由6位同行评议专家以及卒中委员会科学声明监督委员会和卒中委员会领导委员会成员对指南的草案进行发表前审阅。预期本指南在3年内完全更新。结果本文为脑出血患者的医疗诊治提供了循证指南。重点包括诊断、止血、血压管理、院内管理和护理、预防内科合并症、外科治疗、转归预测、康复、预防复发以及将来需要考虑的问题。结论脑出血是一种严重的疾病，早期积极救治可影响其转归。本指南为脑出血患者的目标导向治疗提供了一个框架。

关键词：美国心脏协会科学声明脑出血治疗诊断颅内压脑积水外科

Response to Commentary by Dr. Matthew j. Clarkson on

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j.urnal of Sport and Health Science 2024年第5期13卷 670-671页

作者： Hugo de Luca Corrêa Lysleine Alves Deus Dahan da Cunha Nascimento Nicholas Rolnick Rodrigo Vanerson Passos Neves Andrea Lucena Reis Thais Branquinho de Araúj. Carmen Tzanno-Martins Fernanda Silveira Tavares Luiz Sinésio Silva Neto Cláudio Avelino Rodrigues Santos Paolo Lucas Rodrigues-Silva Fernando Honorato Souza Vitória Marra da Motta Vilalva Mestrinho rafael Lavarini dos Santos Rosangela Vieira Andrade j.nato Prestes Thiago dos Santos Rosa Post-graduate Program of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil The Human Performance Mechanic Lehman CollegeNew YorkNY 10011USA Clinical Group Home Dialysis Center and RenalClass Sao Paulo 01239-040Brazil Department of Medicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of Medicine Federal University of TocantinsTocantins 77001-090Brazil Embrapa Genetic Resources and Biotechnology Brasılia 70770-917Brazil g Graduate Program of Genomic Sciences and Biotechnology Brasılia 71966-700Brazil

Dear editor:We sincerely thank Matthew *** for his insightful commentary1 on our recent publication in the j.urnal of Sport and Health Science.2 Clarkson's pioneering work in the development and application of blood flow restriction (BFR) exercise protocols has undeniably laid the groundwork for subsequent investigations in this field,including our own.(3-6)His commentary not only highlights the relevance and timeliness of our study but also offers valuable perspectives on refining safety considerations for intradialytic BFR exercise among hemodialysis patients.

关键词： patients application flow

On the Base Point Locus of Surface Parametrizations:Formulas and Consequences

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Communications in Mathematics and Statistics 2022年第4期10卷 757-783页

作者： David A.Cox Sonia Pérez-Díaz j.rafael Sendra Department of Mathematics and Statistics Amherst CollegeAmherstMA 01002USA Universidad de Alcalá Dpto.de Física y Matemáticas28871 MadridSpain

This paper shows that the multiplicity of the base point locus of a proj.ctive rational surface parametrization can be expressed as the degree of the content of a univariate *** a consequence,we get a new proof of the degree formula relating the degree of the surface,the degree of the parametrization,the base point multiplicity and the degree of the rational map induced by the *** addition,we extend both formulas to the case of dominant rational maps of the proj.ctive plane and describe how the base point loci of a parametrization and its reparametrizations are *** an application of these results,we explore how the degree of a surface reparametrization is affected by the presence of base points.

关键词： Base point Hilbert-Samuel multiplicity Surface parametrization Reparametrization Parametrization degree Surface degree

An Enhanced Physically Based Scour Model for Considering j.t Air Entrainment

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Engineering 2016年第3期2卷 294-301页

作者： rafael Duarte Antonio Pinheiro Anton j. Schleiss Laboratory of Hydraulic Constructions (LCH) fecole polytechniquefederale de Lausanne (EPFL) Lausanne CH-IOI5 Switzerland Civil Engineering Research and Innovation for Sustainability (CERIS) lnstituto Superior Tecnico Universidade de Lisboa Lisbon 1049-001 Portugal

Based on systematic experiments on the influence of air entrainment on rock block stability in plunge pools impacted by high-velocity j.ts,this study presents adaptations of a physically based scour *** modifications regarding j.t aeration are implemented in the Comprehensive Scour Model(CSM),allowing it to reproduce the physical-mechanical processes involved in scour formation concerning the three phases;namely,water,rock,and *** enhanced method considers the reduction of momentum of an aerated j.t as well as the decrease of energy dissipation in the j.t diffusive shear layer,both resulting from the entrainment of air *** ej.ction from the rock mass depends on a combination of the aerated time-averaged pressure coefficient and the modified maximum dynamic impulsion coefficient,which was found to be a constant value of 0.2 for high-velocity j.ts in deep *** modified model is applied to the case of the observed scour hole at the Kariba Dam,with good agreement.

关键词：冲刷模型空气夹带物理喷射高速射流块体稳定性冲击作用射流曝气

Sampling lattices in semi-grand canonical ensemble with autoregressive machine learning

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npj.Computational Materials 2022年第1期8卷 588-597页

作者： j.mes Damewood Daniel Schwalbe-Koda rafael Gómez-Bombarelli Department of Materials Science and Engineering Massachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA02319USA

Calculating thermodynamic potentials and observables efficiently and accurately is key for the application of statistical mechanics simulations to materials ***,naive Monte Carlo approaches,on which such calculations are often dependent,struggle to scale to complex materials in many state-of-the-art disciplines such as the design of high entropy alloys or multi-component *** address this issue,we adapt sampling tools built upon machine learning-based generative modeling to the materials space by transforming them into the semi-grand canonical ***,we show that the resulting models are transferable across wide ranges of thermodynamic conditions and can be implemented with any internal energy model U,allowing integration into many existing materials *** demonstrate the applicability of this approach to the simulation of benchmark systems (AgPd,CuAu) that exhibit diverse thermodynamic behavior in their phase ***,we discuss remaining challenges in model development and promising research directions for future improvements.

关键词： canonical thermodynamic directions

Boosting energy-storage capability in carbon-based supercapacitors using low-temperature water-in-salt electrolytes

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j.urnal of Energy Chemistry 2022年第7期31卷 521-530,I0013页

作者： j.ao Pedro A.Santos Manuel j.Pinzón érick A.Santos rafael Vicentini Cesar j.B.Pagan Leonardo M.Da Silva Hudson Zanin Brazilian Renewable Energies Center for Innovation on New EnergiesSchool of Electrical and Computer EngineeringUniversity of CampinasSao Paulo 13083-852Brazil Department of Semiconductors Instruments and PhotonicsSchool of Electrical and Computer EngineeringUniversity of CampinasSao Paulo 13083-852Brazil Laboratory of Fundamental and Applied Electrochemistry Department of ChemistryFederal University of Jequitinhonha e Mucuri’s ValleyMinas Gerais 39100-000Brazil

Supercapacitors(SCs) are high-power energy storage devices with ultra-fast charge/discharge *** using concentrated aqueous-based electrolytes can work at low temperatures due to their intrinsic properties, such as higher freezing point depression(FPD) and robustness. Besides the traditional organic-and aqueous-based(salt-in-water) electrolytes used in SCs, water-in-salt(WISE) sodium perchlorate electrolytes offer high FPD, non-flammability, and low-toxicity conditions, allowing the fabrication of safer, environmentally friendly, and more robust devices. For the first time, this work reports a comprehensive study regarding WISE system’s charge-storage capabilities and physicochemical properties under low-temperature conditions(T < 0 ℃) using mesoporous carbon-based electrodes. The effect of temperature reduction on the electrolyte viscosity and electrical properties was investigated using different techniques and the in-situ(or operando) Raman spectroscopy under dynamic polarization *** cell voltage, equivalent series resistance, and specific capacitance were investigated as a function of the temperature. The cell voltage(U) increased ~ 50%, while the specific capacitance decreased ~20%when the temperature was reduced from 25 ℃ to -10 ℃. As a result, the maximum specific energy(E = CU^(2)/2) increased ~ 100%. Therefore, low-temperature WISEs are promising candidates to improve the energy-storage characteristics in SCs.

关键词： Carbon supercapacitors Water-in-salt electrolytes Low-temperature charge-storage Specific energy improvement at low temperatures

A Technical Review of Hydro-Proj.ct Development in China

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Engineering 2016年第3期2卷 302-312页

作者： rafael Duarte António Pinheiro Anton j. Schleiss Laboratory of Hydraulic Constructions (LCH) école polytechnique fédérale de Lausanne (EPFL) Civil Engineering Research and Innovation for Sustainability (CERIS) Instituto Superior Técnico Universidade de Lisboa

This paper summarizes the development of hydro-proj.cts in China,blended with an international *** expounds maj.r technical progress toward ensuring the safe construction of high dams and river harnessing,and covers the theorization of uneven non-equilibrium sediment transport,inter-basin water diversion,giant hydro-generator units,pumped storage power stations,underground caverns,ecological protection,and so on.

关键词：中国水利工程技术综述水轮发电机组抽水蓄能电站不平衡输沙跨流域调水地下洞室群