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neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown rafael J.Yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for inherited neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMn1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMn2,which can produce low levels(approximately 10%)of the full-length functional SMn protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMn2 copy number is used as a proxy for the prediction of disease severity,with higher SMn2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMn2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMn2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

imaging the Architecture of Mineral Systems and the Pathways of Ore-forming Fluids across Mongolia with Magnetotellurics

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Acta Geologica Sinica(English Edition) 2024年第S1期 11-13页

作者： Matthew J.COMEAU rafael RiGAUD Erdenechimeg BATMAGnAi Shoovdor TSEREnDUG Sodnomsambuu DEMBEREL Michael BECKEn Alexey KUVSHinOV Department of Geoscience & Engineering Delft University of Technology institute of Geophysics ETH institute of Astronomy and Geophysics Mongolian Academy of Sciences institut für Geophysik Universit?t Münster

in the framework of a mineral system approach, a combination of components is required to develop a mineral system. This includes the whole-lithosphere architecture, which controls the transport of ore-forming fluids, and favorable tectonic and geodynamic processes, occurring at various spatial and temporal scales, that influence the genesis and evolution of ore-forming fluids(Huston et al., 2016; Groves et al., 2018; Davies et al., 2020). Knowledge of the deep structural framework can advance the understanding of the development of a mineral system and the emplacement of mineral deposits. Deep geophysical exploration carried out with this aim is increasingly important for targeting new ore deposits in unexplored and underexplored regions(Dentith et al., 2018; Dentith, 2019).

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Liver transplantation as an alternative for the treatment of perihilar cholangiocarcinoma: A critical review

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Hepatobiliary & Pancreatic Diseases international 2024年第2期23卷 139-145页

作者： Wellington Andraus Francisco Tustumi Alexandre Chagas Santana rafael Soares nunes Pinheiro Daniel Reis Waisberg Liliana Ducatti Lopes Rubens Macedo Arantes Vinicius Rocha Santos Rodrigo Bronze de Martino Luiz Augusto Carneiro D’Albuquerque Department of Gastroenterology Transplantation UnitUniversidade de São PauloSão PauloBrazil

Background:Perihilar cholangiocarcinoma(phCCC)is a dismal *** is no consensus regard-ing the best treatment for patients with unresectable *** present review aimed to gather the current pieces of evidence for liver transplantation and liver resection as a treatment for phCCC and to build better guidance for clinical *** sources:The search was conducted in PubMed,Embase,Cochrane,and *** related references were searched *** criteria were:reports in English or Portuguese literature that a)patients with confirmed diagnosis of phCCC;b)patients treated with a curative intent;c)patients with the outcomes of liver resection and liver *** reports,reviews,letters,editorials,conference abstracts and papers with full-text unavailability were excluded from the ***:Most of the current literature is based on observational retrospective studies with low grades of *** resection has better long-term outcomes than systemic chemotherapy or palliation ther-apy and liver transplantation is a good alternative for selected patients with unresectable *** candidates for resection or transplantation should be medically fit and free of intrahepatic or extrahep-atic *** a general rule,patients presenting with a tumor having a longitudinal size>3 cm or extending below the cystic duct,lymph node disease,confirmed extrahepatic dissemination;intraoper-atively diagnosed metastatic disease;a history of other malignancies within the last five years,and did not complete chemoradiation regimen and were medically unfit should not be considered for *** of these criteria should be individually *** transplantation or resection should only be considered in highly experienced hepatobiliary centers,and any decision-making must be based on a multidisciplinary ***:phCCC is a complex condition with high *** therapies,including hepatec-tomy and liv

关键词： Liver transplantation Cholangiocarcinoma Liver neoplasms

ProTSA: A Testing Process for Automotive Software Domain

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Journal of Software Engineering and Applications 2024年第7期17卷 571-615页

作者： Renato rafael Arcanjo Luiz Eduardo Galvão Martins Dirceu Lavoiser Fernandes Graci Department of inovation and Science Federal University of Sao Paulo (UNIFESP) Sao Jose dos Campos Brazil Department of Automotive Electronics Faculty of Technology of Sao Paulo (Fatec) Santo Andre Brazil

This study evaluates the development of a testing process for the automotive software domain, highlighting challenges stemming from the absence of adequate processes. The research demonstrates the application of Design Science Research methodology in developing, an automotive software testing process—ProTSA, using six functional testing modules. Additionally, the study evaluates the benefits of implementing ProTSA in a specific Original Equipment Manufacturer (OEM) using an experimental single-case approach with industry professionals’ participation through a survey. The study concludes that combining testing techniques with effective communication and alignment is crucial for enhancing software quality. Furthermore, survey data indicates that implementing ProTSA leads to productivity gains by initiating tests early, resulting in time savings in the testing program and increased productivity for the testing team. Future work will explore implementing ProTSA in cybersecurity, over-the-air software updates, and autonomous vehicle testing processes. .

关键词： Verification and Validation Automotive Software Automotive Systems

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利用掺杂层研究磁化靶中的能斯特效应

强激光与粒子束 2024年第9期36卷 169-174页

作者：陈诗佳张华周沧涛卓红斌吴福源 rafael Ramis 深圳大学应用技术学院广东深圳518060 深圳技术大学深圳市超强激光与先进材料技术重点实验室超强激光应用技术研究中心工程物理学院广东深圳518118 上海交通大学物理与天文学院上海200240 马德里理工大学航空航天学院马德里E-28040

双层磁化套筒靶在内层采用高原子序数(Z)材料,减少了因能斯特效应导致的磁通损失并降低点火要求,为磁化靶聚变提供了一种备选方案。然而,添加高Z材料也可能增加由于物质混合而产生的辐射损失。通过在金属套筒中使用带有塑料掺杂的锗作为... 详细信息

双层磁化套筒靶在内层采用高原子序数(Z)材料,减少了因能斯特效应导致的磁通损失并降低点火要求,为磁化靶聚变提供了一种备选方案。然而,添加高Z材料也可能增加由于物质混合而产生的辐射损失。通过在金属套筒中使用带有塑料掺杂的锗作为高Z替代物,初步分析了磁场能斯特输运和物质混合对磁化套筒惯性聚变的影响。与单层套筒相比,双层套筒靶展示出温度和磁通的显著增加,从而使聚变产额提高了154%。将碳氢掺杂剂添加到最内层的锗中,模拟了物质混合对聚变产额的影响。研究结果表明,锗与CH混合,保持较低的混合比例,能够显著提高聚变产额。

关键词：双层套筒磁化靶聚变能斯特效应掺杂物质混合

impact of data balancing a multiclass dataset before the creation of association rules to study bacterial vaginosis

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intelligent Medicine 2024年第3期4卷 188-199页

作者： Freddy de la Cruz-Ruiz Juana Canul-Reich rafael Rivera-López Erick de la Cruz-Hernández Academic Division of Science and Technology of the information Juárez Autonomous University of TabascoLa Esmeralda DistrictTabascoMexico Department of Systems National Technological Institute of MexicoTechnological Institute of VeracruzVeracruzMexico Multidisciplinary Academic Division of Comalcalco Juárez Autonomous University of TabascoTabascoMexico

Background Bacterial vaginosis is a polymicrobial syndrome in which the homeostasis exerted by the Latobacillus species that protect the vaginal mucosa has been *** study explored the data balancing process with the intention of improving the quality of association *** article aimed to balance the unbalanced multiclass dataset to improve association rule *** A dataset with 201 observations and 58 variables was analyzed.A preconstructed dataset was *** authors collected the data between August 2016 and October 2018 in Tabasco,*** study population comprised sexually active women ages 18 to 50 who underwent gynecological inspection at the infectious and metabolic diseases research laboratory at the Universidad Juarez Autonoma de *** determine the best κ-value,the random-forest algorithm was used and the balancing was performed with the synthetic minority over-sampling technique(SMOTE),random over-sampling examples(ROSE),and adaptive syntetic sampling approach for imbalanced learning(ADASYn)*** Apriori algorithm created the rules and to select rules with statistical significance,the ***(),***(),and ***()functions and quality metric Fisher’s exact tes were *** biological validation was carried out by the expert(bacteriologist).Results The ADASYn algorithm at K=9 the out of the bag(OOB)error was zero,this was the best𝐾-*** the balancing process the ADASYn algorithm show best the *** the dataset balanced with ADASYn,the apriori algorithm created the association rules and the selection with the quality metric Fisher’s exact test,and the biological validation reported 13 ***-bacteria Atopobium vaginae,Gardnerella vaginalis,Megasphaera filotipo 1,Mycoplasma hominis and Ureaplasma parvum were detected by the apriori algorithm from the balanced *** Balancing may improve the creation of association rules to efficiently model the bacteria that cause bac

关键词： Bacterial vaginosis Data balancing Random forest Synthetic minority over-sampling technique

impact Containment Barriers with Geotextile Tubes

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Journal of Geoscience and Environment Protection 2024年第5期12卷 325-344页

作者： Flávio da Silva Ornelas Luís Fernando Martins Ribeiro rafael Cerqueira Silva instituto Federal de Educaç &#227o Ci&#234ncia e Tecnologia&#8212IFTO Palmas Brasil Departamento de Engenharia Civil e Ambiental Programa de p&#243s gradua&#231&#227o em Geotecnia Universidade de Bras&#237lia&#8212UnB/Campus Universit&#225rio Darcy Ribeiro Bras&#237lia Brasil

Recently, tragic tailings dam collapses in Brazil have caused deaths and major destruction and the need to develop technologies capable of preventing damage to people and the environment. Brazilian tailings dams are in a situation of uncertainty due to new legislation that even requires decommissioning, an activity that involves many problems and where the risk of failure is the main one. An impact containment structure downstream of these dams can be effective and geotextile tubes, in a new approach, have emerged as an option with advantages in terms of execution, costs and safety. The technology is versatile and can bring many benefits such as the reuse of tailings or filling with low-energy or reused materials. in this research, geotextile tubes were tested as free containment barriers, experiencing impacts in reduced models. The safety factor for the stability of the structure was constructed using an equation which is the ratio between the self-weight of the barrier structure and its coefficient of static friction and the impact pressure, where the data showed an adequate correlation which suggests the viability of mitigating risks.

关键词： Geotextile Tube Debris Flow Barriers impact Mining

Typhoon-and pollution-driven enhancement of reactive bromine in the mid-latitude marine boundary layer

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national Science Review 2024年第4期11卷 93-101页

作者： Shanshan Wang Qinyi Li Ruifeng Zhang Anoop Sharad Mahajan Swaleha inamdar nuria Benavent Sanbao Zhang Ruibin Xue Jian Zhu Chenji Jin Yan Zhang Xiao Fu Alba Badia rafael P.Fernandez Carlos A.Cuevas Tao Wang Bin Zhou Alfonso Saiz-Lopez Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3) Department of Environmental Science and Engineering Fudan University institute of Eco-Chongming(iEC) Department of Atmospheric Chemistry and Climate Institute of Physical Chemistry Blas CabreraCSIC Department of Civil and Environmental Engineering The Hong Kong Polytechnic University Environment Research institute Shandong University Centre for Climate Change Research Indian Institute of Tropical MeteorologyMinistry of Earth Sciences Department of Chemistry University of Colorado Boulder institute of Environment and Ecology Tsinghua Shenzhen International Graduate SchoolTsinghua University Sostenipra Research Group Institute of Environmental Science and Technology(ICTA)Universitat Autonoma de Barcelona(UAB) institute for interdisciplinary Science (iCB) National Research Council (CONICET)

Tropospheric reactive bromine is important for atmospheric chemistry,regional air pollution,and global *** studies have reported measurements of atmospheric reactive bromine species in different environments,and proposed their main sources,***-salt aerosol（SSA）,oceanic biogenic activity,polar snow/ice,and *** and other strong cyclonic activities（***） induce abrupt changes in different earth system processes,causing widespread destructive ***,the role of typhoons in regulating reactive bromine abundance and sources remains ***,we report field observations of bromine oxide（BrO）,a critical indicator of reactive bromine,on the Huaniao island（Hni）in the East China Sea in July *** observed high levels of BrO below 500 m with a daytime average of9.7±4.2 pptv and a peak value of ～26 pptv under the influence of a *** field measurements,supported by model simulations,suggest that the typhoon-induced drastic increase in wind speed amplifies the emission of SSA,significantly enhancing the activation of reactive bromine from SSA *** also detected enhanced BrO mixing ratios under high nOxconditions（ppbv level） suggesting a potential pollution-induced mechanism of bromine release from *** elevated levels of atmospheric bromine noticeably increase ozone destruction by as much as ～40% across the East China *** the high frequency of cyclonic activity in the northern hemisphere,reactive bromine chemistry is expected to play a more important role than previously thought in affecting coastal air quality and atmospheric oxidation *** suggest that models need to consider the hitherto overlooked typhoon-and pollution-mediated increase in reactive bromine levels when assessing the synergic effects of cyclonic activities on the earth system.

关键词： reactive bromine atmospheric chemistry marine boundary layer atmospheric oxidation capacity marine emission

护理干预促进慢性呼吸困难患者自我管理的研究进展:整合性综述

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international Journal of nursing Sciences 2024年第2期11卷 241-257,I0003页

作者： Helga rafael Henriques Andreia Correia Tatiana Santos Jose Faria Diana Sousa Joana Portela Joana Teixeira nursing School of Lisbon LisbonPortugal CiDnUR-nursing Research Innovation and Development Centre of LisbonLisbonPortugal Unidade de Hemodi-alise de Torres Vedras-nephrocare Torres VedrasPortugal Unidade de Cuidados Continuados na AMETiC Torres VedrasPortugal Unidade Local de Saúde Sao Jose Cardiology DepartmentLisbonPortugal Unidade Local de Saúde da Arrabida General Surgery DepartmentSetúbalPortugal

目的旨在通过系统综述,确定针对复杂慢性病患者增强自我管理的干预措施,以改善慢性呼吸困难,为护理人员促进该类人群的自我管理提供依据。方法2023年12月,系统检索Medline、Scopus、Web of Science、CinAHL、Cochrane图书馆和乔安娜布... 详细信息

目的旨在通过系统综述,确定针对复杂慢性病患者增强自我管理的干预措施,以改善慢性呼吸困难,为护理人员促进该类人群的自我管理提供依据。方法2023年12月,系统检索Medline、Scopus、Web of Science、CinAHL、Cochrane图书馆和乔安娜布里格斯研究所(Joanna Briggs institute,JBi)循证实践数据库。对纳入研究进行数据提取和综合,研究人员采用Rayyan文献管理软件筛选标题及摘要,并依据JBi研究质量评估工具进行方法学质量评估。结果共纳入18项研究。这些研究探讨了针对慢性呼吸困难的各种干预措施,包括药物干预(氧气疗法和吸入疗法)和非药物方法(教育计划、呼吸练习、液体摄入管理、身体感知技术、同伴支持、情商培训和网络应用程序的使用)。这些干预措施减轻了患者情绪困扰,可以使患者在自我管理方面变得独立自主。结论促进复杂慢性病患者对慢性呼吸困难的自我管理需要采取综合方法,但目前研究中没有充分考虑到针对患者行为改变的干预措施,需要进一步开展相关研究完善干预措施。

关键词：慢性疾病呼吸困难护理病人自我管理

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棒与星系整体恒星形成性质关系的统计研究

天文学进展 2024年第1期42卷 115-127页

作者：穆子豪沈世银 rafael S.de Souza Ana L.Chies-Santos 中国科学院上海天文台星系宇宙学重点实验室上海200030 中国科学院大学北京100049 星系和宇宙学半解析研究重点实验室上海200034 赫特福德大学天体物理研究中心英国哈特菲尔德学院巷AL109AB 南里奥格兰德州联邦大学科学研究所巴西阿雷格里港9500

盘状星系中的棒结构特征与星系自身所处环境及整体恒星形成特征之间存在复杂的相互关系。利用细致的星系形态特征测量计划Galaxy Zoo DECaLS中的数据构建了一组目前最大的具有同样恒星质量分布的强棒、弱棒和无棒星系样本。通过引入星... 详细信息

盘状星系中的棒结构特征与星系自身所处环境及整体恒星形成特征之间存在复杂的相互关系。利用细致的星系形态特征测量计划Galaxy Zoo DECaLS中的数据构建了一组目前最大的具有同样恒星质量分布的强棒、弱棒和无棒星系样本。通过引入星系所处暗晕质量及相空间特征来控制星系所处的环境效应之后,进一步对比研究强棒、弱棒和无棒星系的恒星形成特征。研究表明,有棒星系中的恒星形成熄灭的比例系统地高于无棒星系,且强棒的效应更为明显。但是,对于仍处于恒星形成主序上的星系来说,强棒、弱棒和无棒星系的恒星形成特征并没有显著差别。以上结果表明,星系中的棒特征在其存在的时标中可能使部分星系迅速地从恒星形成转入熄灭状态。

关键词：棒旋星系恒星形成环境