检索结果-南通市图书馆

Olfactory receptors in neural regeneration in the central nervous system

Neural Regeneration Research 2025年第9期20卷 2480-2494页

作者： rafael Franco Claudia Garrigós Toni Capó Joan Serrano-Marín rafael rivas-santisteban Jaume Lillo Molecular Neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain CiberNed Network Center for Biomedical Research in Neurodegenerative Diseases Spanish National Health Institute Carlos ⅢMadridSpain School of Chemistry Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Physiology School of Pharmacy and Food SciencesUniversitat de BarcelonaBarcelonaSpain Laboratory of Computational Medicine Biostatistics UnitFaculty of MedicineAutonomous University of BarcelonaCampus BellaterraBarcelonaSpain

Olfactory receptors are crucial for detecting odors and play a vital role in our sense of smell,influencing behaviors from food choices to emotional *** receptors also contribute to our perception of flavor and have potential applications in medical diagnostics and environmental *** ability of the olfactory system to regenerate its sensory neurons provides a unique model to study neural regeneration,a phenomenon largely absent in the central nervous *** gained from how olfactory neurons continuously replace themselves and reestablish functional connections can provide strategies to promote similar regenerative processes in the central nervous system,where damage often results in permanent *** the molecular and cellular mechanisms underpinning olfactory neuron regeneration could pave the way for developing therapeutic approaches to treat spinal co rd injuries and neurodegenerative diseases like Alzheimer's *** ctory receptors are found in almost any cell of eve ry orga n/tissue of the mammalian *** ectopic expression provides insights into the chemical structures that can activate olfactory *** addition to odors,olfactory receptors in ectopic expression may respond to endogenous compounds and molecules produced by mucosal colonizing *** analysis of the function of olfactory receptors in ectopic expression provides valuable information on the signaling pathway engaged upon receptor activation and the receptor's role in proliferation and cell differentiation *** review explo res the ectopic expression of olfa ctory receptors and the role they may play in neural regeneration within the central nervous system,with particular attention to compounds that can activate these receptors to initiate regenerative *** suggests that olfactory receptors could serve as potential therapeutic targets for enhancing neural repair and recovery following central nervous syste

关键词： adenosine receptors adrenergic receptors ectopic expression G proteincoupled receptors glia neurons

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

腺苷受体是调节大脑内侧前额叶皮质星形胶质细胞大麻素1型(CB1)受体对突触可塑性作用的开关

引用

神经损伤与功能重建 2024年第4期19卷 250-250页

作者： Joana Gon?alves-Ribeiro Oksana K Savchak Sara Costa-Pinto Joana I Gomes rafael rivas-santisteban Alejandro Lillo Javier Sánchez Romero Ana M Sebasti?o Marta Navarrete Gemma Navarro rafael Franco Sandra H Vaz Instituto de Farmacologia e Neurociencias Faculdade de MedicinaUniversidade de Lisboa Instituto de Medicina Molecular Joao Lobo Antunes Faculdade de MedicinaUniversidade de Lisboa Department of Biochemistry and Physiology School of Pharmacy and Food ScienceUniversitat de Barcelona CiberNed Network Center for Neurodegenerative DiseasesNational Spanish Health Institute Carlos Ⅲ 5. Instituto CajalCSIC PhD Program in Neuroscience Universidad Autonoma de Madrid-Instituto Cajal Institut de Neurociencies Universitat de Barcelona Molecular Neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFaculty of Biology School of Chemistry Universitat de Barcelona

内侧前额叶皮质(mPFC)参与诸如工作记忆等认知功能。星形胶质细胞大麻素1型受体(CB1R)诱导细胞质内钙离子(Ca2+)浓度变化,对神经元功能产生影响。mPFC的星形胶质细胞也表达腺苷A1和A2A受体(A1R,A2AR),但目前尚不清楚这些细胞中的CB1R与... 详细信息

内侧前额叶皮质(mPFC)参与诸如工作记忆等认知功能。星形胶质细胞大麻素1型受体(CB1R)诱导细胞质内钙离子(Ca2+)浓度变化,对神经元功能产生影响。mPFC的星形胶质细胞也表达腺苷A1和A2A受体(A1R,A2AR),但目前尚不清楚这些细胞中的CB1R与腺苷受体之间的交流。我们在这里展示,通过CB1R-A2AR或CB1R-A1R异源二聚体,星形胶质细胞Ca2+信号传递发生了进一步的调节,最终影响mPFC突触可塑性。当A1R和A2AR被激活时,CB1R介导的Ca2+瞬变出现增加或减少,揭示了腺苷受体可能是星形胶质细胞CB1R的调节器。CB1R的激活导致mPFC的长时程增强(LTP)增强,受A1R控制,但不受A2AR控制。值得注意的是,在IP3R2KO小鼠中,由于没有显示出星形胶质细胞Ca2+水平升高,CB1R的激活减少了LTP,这种效果不受A1R或A2AR的调节。本研究表明,CB1R在mPFC LTP上具有稳态作用,受到A1R的控制,可能是由于这些受体在星形胶质细胞中的交流,最终改变了CB1R Ca2+信号传递。

关键词： CB1受体腺苷受体星形胶质细胞内侧前额叶皮质突触可塑性

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Deforestation and fragmentation trends of seasonal dry tropical forest in Ecuador: impact on conservation

引用

Forest Ecosystems 2021年第3期8卷 615-627页

作者： Carlos A.rivas JoséGuerrero-Casado rafael M.Navarro-Cerillo Instituto de Ciencias Básicas Universidad Técnica de ManabíPortoviejoManabíEcuador Department of Forest Engineering Laboratory of DendrochronologySilviculture and Global Change–DendrodatLab–ERSAFUniversity of CordobaCampus de RabanalesCrta.IVkm.396E-14071 CordobaSpain Departamento de Medicina Veterinaria Facultad de Ciencias VeterinariasUniversidad Técnica de ManabíPortoviejoManabíEcuador Department of Zoology University of CordobaCampus de Rabanales14071 CordobaSpain

Background:Fragmentation and deforestation are one of the greatest threats to forests,and these processes are of even more concern in the tropics,where the seasonal dry forest is possibly one of the most threatened ecosystems with the least remaining surface ***:The deforestation and fragmentation patterns that had occurred in Ecuadorian seasonal dry forests between 1990 and 2018 were verified,while geographic information systems and land cover shapes provided by the Ecuadorian Ministry of the Environment were employed to classify and evaluate three types of seasonal dry forests:deciduous,semi-deciduous,and *** study area was tessellated into 10 km2 hexagons,in which six fragmentation parameters were measured:number of patches,mean patch size,median patch size,total edge,edge density and reticular fragmentation index(RFI).The RFI was also measured both outside and inside protected natural areas(unprotected,national protected areas and protected forest).Moreover,the areas with the best and worst conservation status,connectivity and risk of disappearance values were identified by means of a Getis-Ord Gi*statistical ***:The deforestation of seasonal dry forests affected 27.04%of the original surface area still remaining in 1990,with an annual deforestation rate of−1.12%between 1990 and *** RFI has increased by 11.61%as a result of the fact that small fragments of forest have tended to disappear,while the large fragments have been fragmented into smaller *** semi-deciduous forest had the highest levels of fragmentation in *** three categories of protection had significantly different levels of fragmentation,with lower RFI values in national protected areas and greater values in protected ***:The seasonal dry forest is fragmenting,deforesting and disappearing in some *** increased protection and conservation of the Ecuadorian seasonal dry forest is,therefore,necessary owing to the fact that not all prot

关键词： Deciduous forest Semi-deciduous forest Remnant forest Patch isolation Habitat loss Protected areas

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Non-redundant Contribution of the Plastidial FAD8 ω-3 Desatumse to Glycerolipid Unsatumtion at Different Temperatures in Arabidopsis

引用

Molecular Plant 2015年第11期8卷 1599-1611页

作者： Angela Roman Maria L. Hernandez Angel Soria-Garcia Sara Lopez-Gomollon Beatriz Lagunas rafael Picorel Jose Manuel Martinez-rivas Miguel Alfonso Estacion Experimental de Aula Dei (EEAD-CSIC) Avda. Montanana 1005 50059 Zaragoza Spain Instituto de la Grasa (IG-CSIC) Campus Universidad Pablo de Olavide Building 46 Ctra. Utrera kin 1 41013 Seville Spain

Plastidial ω-3 desaturase FAD7 is a major contributor to trienoic fatty acid biosynthesis in the leaves of Arabidopsis plants. However, the precise contribution of the other plastidial ω-3 desaturase, FAD8, is poorly understood. Fatty acid and lipid analysis of several ω-3 desaturase mutants, including two insertion lines of AtFAD7 and AtFAD8, showed that FAD8 partially compensated the disruption of the AtFAD7 gene at 22℃, indicating that FAD8 was active at this growth temperature, contrasting to previous observations that circumscribed the FAD8 activity at low temperatures. Our data revealed that FAD8 had a higher selectivity for 18：2 acyl-lipid substrates and a higher preference for lipids other than galactolipids, particularly phosphatidylglycerol, at any of the temperatures studied. Differences in the mechanism controlling AtFAD7 and AtFAD8 gene expression at different temperatures were also detected. Confocal microscopy and biochemical analysis of FAD8-YFP over-expressing lines confirmed the chloroplast envelope localization of FAD8. Co-localization experiments suggested that FAD8 and FAD7 might be located in close vicinity in the envelope membrane. FAD8-YFP over-expressing lines showed a specific increase in 18：3 fatty acids at 22℃. Together, these results indicate that the function of both plastidial ω-3 desaturases is coordinated in a non-redundant manner.

关键词： Arabidopsis thaliana glycerolipid fatty acid FAD7 FAD8 plastid

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nanotechnology and Nanomedicine: A Promising Avenue for Lung Cancer Diagnosis and Therapy

引用

Engineering 2021年第11期7卷 1577-1585页

作者： Wei Yin Feng Pan Junjie Zhu Junwu Xu Diego Gonzalez-rivas Meinoshin Okumura Zhiyong Tang Yang Yang Key Laboratory of Oral Biomedical Engineering(Wuhan University) Ministry of EducationHospital of StomatologySchool of StomatologyWuhan UniversityWuhan 430079China Department of Biomedical Data Science Geisel School of MedicineDartmouth CollegeHanoverNH 03756USA Department of Thoracic Surgery Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghai 200433China Tus-Medical Health Technology Investment(Jiaxing)Co. Ltd.Jiaxing 314033China Minimally Invasive Thoracic Surgery Unit(UCTMI) Hospital San RafaelCoruña 15006Spain Osaka Toneyama Medical Center Osaka 560-8552Japan CAS Key Laboratory of Nanosystem and Hierarchical Fabrication National Center for Nanoscience and TechnologyBeijing 100190China

Lung cancer is a leading cause of cancer-related death worldwide,with a very poor overall five-year survival *** intrinsic limitations associated with the conventional diagnosis and therapeutic strategies used for lung cancer have motivated the development of nanotechnology and nanomedicine approaches,in order to improve early diagnosis rate and develop more effective and safer therapeutic options for lung *** nanomedicines aim to individualize drug delivery,diagnosis,and therapy by tailoring them to each patient’s unique physiology and pathological features—on both the genomic and proteomic levels—and have attracted widespread attention in this *** the successful application of nanomedicine techniques in lung cancer research,the clinical translation of nanomedicine approaches remains challenging due to the limited understanding of the interactions that occur between nanotechnology and biology,and the challenges posed by the toxicology,pharmacology,immunology,and largescale manufacturing of *** this review,we highlight the progress and opportunities associated with nanomedicine use for lung cancer treatment and discuss the prospects of this field,together with the challenges associated with clinical translation.

关键词： Nanomedicine Lung cancer Diagnosis Therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Serum levels of undercarboxylated osteocalcin are related to cardiovascular risk factors in patients with type 2 diabetes mellitus and healthy subjects

引用

World Journal of Diabetes 2017年第1期8卷 11-17页

作者： Sergio Sanchez-Enriquez Isabel Thalia Ballesteros-Gonzalez Josérafael Villafán-Bernal Sara Pascoe-Gonzalez Edgar Alfonso Rivera-Leon Blanca Estela Bastidas-Ramirez Jorge David rivas-Carrillo Juan Luis Alcala-Zermeno Juan Armendariz-Borunda Iris Monserrat Llamas-Covarrubias Abraham Zepeda-Moreno Biochemistry Laboratory Molecular Biology and Genomics Department University Center of Health Sciences University of Guadalajara Academic Group UDG-CA-533 Multidisciplinary Study of Chronic and Degenerative Diseases Molecular Biology and Genomics Department University Center of Health Sciences University of Guadalajara Departamento de Jóvenes Investigadores y Cátedras del Consejo Nacional de Ciencia y Tecnología (CONACYT) Departamento de Cirugía Centro Universitario de Ciencias de la Salud Universidad Autónoma de Aguascalientes Physiology Department University Center of Health Sciences University of Guadalajara Institute of Degenerative Chronic Diseases Molecular Biology and Genomics Department University Center of Health Sciences University of Guadalajara Molecular Biology and Genomics Department University Center of Health SciencesUniversity of Guadalajara Institute of Cancer Research in Child and Adolescent University Center of Health Sciences University of Guadalajara

AIM To determine a potential relationship between serum undercarboxylated(uc OC) concentration and cardiovascular risk factors in type 2 diabetes(T2D) patients and healthy subjects(HS).METHODS A cross-sectional study was conducted on 140 subjects classified into two groups, 70 with T2D and 70 HS. Medical history and physical examination with anthropometric measurements were obtained from all subjects. Body fat percentage was determined by bioelectrical impendency analysis. Serum uc OC concentration was determined by enzyme immunoassay,while serum levels of insulin and hsC RP were obtained using high sensitivity enzyme-linked immunosorbent assay. Insulin resistance was determined using the homeostasis model assessment-IR. Lipid profile [triglycerides,total cholesterol(TC), high-density lipoproteins(HDL-c),low density lipoproteins(LDL-c), very low-density lipoproteins] was determined by spectrophotometry and standard formulas when applicable. RESULTS The T2D patient group showed significantly higher values of waist circumference, waist-to-hip ratio, systolic blood pressure(SBP), diastolic blood pressure(DBP),current smoking, and alcohol use when compared to the HS group(P < 0.05). We observed a significantly lower serum ucO C concentration in T2D than in HS(1.5 ± 1.4vs 2.3 ± 1.8, P < 0.05). In the whole study population,ucO C concentration was inversely correlated with body mass index(BMI)(r =-0.236, P < 0.05), fasting plasma glucose(r =-0.283, P < 0.01) and HDL-c(r =-0.255,P < 0.05); and positively correlated with LDL-c/HDL-c ratio(r = 0.306, P < 0.05) and TC/HDL-c ratio(r =0.284, P < 0.05). In the T2D group, serum uc OC concentration was inversely correlated with BMI(r =-0.310, P < 0.05) and body-fat percentage(r =-0.311,P < 0.05), and positively correlated with DBP(r = 0.450,P < 0.01). In HS group a positive correlation between serum levels of uc OC and SBP(r = 0.277, P < 0.05)was observed. CONCLUSION Serum uc OC is a potential marker for cardiovascular risk in Mex

关键词： Bone Osteocalcin Glucose metabolism Diabetes Cardiovascular risk

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

引用

Cellular & Molecular Immunology 2021年第9期18卷 2128-2139页

作者： Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez E Clinical Unit of Infectious Diseases Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Department of Medical Biochemistry Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pneumology Service Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infectious Diseases Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain Group of Virology and Pathogenesis Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit of Infectious Diseases Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Institute of Biomedicine of Seville(IBiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Medico-Surgical Unit of Respiratory Diseases Virgen del Rocío University HospitalSevilleSpain Unit of Emergencies Virgen del Rocío University HospitalSevilleSpain Intensive Care Unit Virgen del Rocío University HospitalSevilleSpain Department of Medicine University of SevilleSevilleSpain Cardiology and Cardiovascular Surgery Unit Virgen del Rocío University HospitalSevilleSpain Rheumatology Unit Virgen del Rocío University HospitalSevilleSpain Internal Medicine Unit Virgen del Rocío University HospitalSevilleSpain Digestive and Hepatobiliary Unit Virgen del Rocío University HospitalSevilleSpain Neurology and Clinical Neurophysiology Unit Virgen del Rocío University HospitalSevilleSpain Endocrinology and Nutrition Unit Virgen del Rocío University HospitalSevilleSpain Urology and Nephrology Unit Virgen del Rocío University HospitalSevilleSpain Unit of Clinical Investigation and Clinical Trials Virgen del Rocío University HospitalSevilleSpain

Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity *** cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease *** this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory ***,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 ***,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were *** findings contribute to a better understanding of the immunological sequelae of COVID-19.

关键词： SARS-CoV-2 COVID-19 Dendritic cell Long-COVID

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：