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Monitoring hepatitis C virus treatment rates in an Opioid Treatment Program:A longitudinal study

World Journal of Gastroenterology 2020年第38期26卷 5874-5883页

作者： Arantza sanvisens Inmaculada rivas Eva Faure néstor Espinach Anna Hernandez-Rubio Xavier Majó Joan Colom Robert Muga Department of Internal Medicine Hospital Universitari Germans Trias i PujolBadalona 08916Spain Mental Health and Addiction service Badalona Serveis Assistencials-BSABadalona 08911Spain Department of Internal Medicine Hospital Universitari Germans Trias i PujolUniversitat Autònoma de BarcelonaBadalona 08916Spain Program on HIV STIs and Viral Hepatitis-PCAVIHV Public Health Agency of CataloniaGeneralitat de CatalunyaBarcelona 08005Spain

BACKGROUnD Direct-acting antivirals(DAAs)are recommended for the treatment of hepatitis C virus(HCV)infection in patients treated with methadone or *** To assess HCV treatment rates in an Opioid Treatment Program(OTP).METHODs This longitudinal study included 501 patients(81.4%men,median age:45 years;interquartile range:39-50 years)enrolled in an OTP between October 2015 and september *** were followed until september *** on sociodemographics,substance use,HCV infection,human immunodeficiency virus(HIV)infection and laboratory parameters were collected at *** analyzed medical records to evaluate HCV ***-Meier methods and Cox regression models were used to analyze the DAA treatment uptake and to identify treatment *** Prevalence of HCV and HIV infection was 70%and 34%,*** anti-HCV-positive(n=336)patients,47.2%,41.3%,and 31.9%used alcohol,cannabis,and cocaine,***-RnA tests were positive in 233(69.3%)*** patients(8.3%)cleared the infection,and 59/308(19.1%)had received interferon-based treatment regimens before *** 249 patients eligible,111(44.6%)received *** rates significantly increased over time from 7.8/100 person-years(p-y)(95%CI:5.0-12.3)in 2015 to 18.9/100 p-y(95%CI:11.7-30.3)in *** a multivariate analysis,patients with HIV co-infection were twice as likely to receive DAAs(HR=1.94,95%CI:1.21-3.12)than patients with HCV *** drug use was an independent risk factor for not receiving treatment against infection(HR=0.48,95%CI:0.29-0.80).COnCLUsIOn HCV treatment is evolving in patients with HCV-HIV *** drug use while in an OTP might negatively impact the readiness to treat infection.

关键词： Direct-acting antiviral agents Opioid Treatment Program Opioid agonist therapy Hepatitis C virus infection Human immunodeficiency virus infection Drug use

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Performance evaluation of lateral canopy shakers with catch frame for continuous harvesting of oranges for juice industry

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International Journal of Agricultural and Biological Engineering 2020年第3期13卷 88-93,F0002页

作者： rafael R.sola-Guirado sergio Castro-Garcia Gregorio L.Blanco-Roldán Jesús A.Gil-Ribes Emilio J.González-sánchez Universidad de Córdoba Departamento de Ingeniería RuralE.T.S.I.Agronómica y de MontesCampus de RabanalesCtra.Nacional IV Km 396CordobaSpain

Citrus is mainly oriented to fresh consumption,and harvesting is usually performed ***,the high cost of harvesting and the low availability of labour can compromise the profitability of the crop when it is destined to juice *** development of citrus mechanical harvesting for industrial processing is conditioned to reach a high fruit removal efficiency,with a reduced damage to both fruit and *** current machines available are very large,requiring extensive plantations with long rows of trees to be *** this study,two lateral canopy shakers equipped with a catch frame were evaluated to harvest independently both sides of the hedge on intensive citrus plantations with the main objective of determining their performance and *** lateral canopy shakers tested were three tractor-drawn machines,one commercial machine and two *** tested machines reached a mean value of 78%of fruit ***,the prototypes,equipped with a catch frame,were able to recover a mean value of 70%of *** the results were promising,for achieving an efficient result,the application of this harvesting technology still requires a process of improvement,and the adaptation of both the machine and the *** machines should reduce the amount of post-harvest ground fruit(5.9%-10.4%).Tree damages generated by the contact of the catch frame with the trunk and the metal rods with main branches were the most ***,it is still necessary to increase the ground speed of the machinery and improving the design of the rods,regulating the rod penetrating deep in the canopy to improve the fruit recovery and limit the damage caused to the trees.

关键词： harvester mechanical harvesting fruit removal tree damage Citrus sinensis L.Osbeck

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A charged star with geometric Karmarkar condition

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Communications in Theoretical Physics 2023年第8期75卷 139-149页

作者： Gabino Estevez-Delgado Joaquin Estevez-Delgado rafael soto-Espitia Antonio Rendón Romero Jorge Mauricio Paulin-Fuentes Facultad de Químico Farmacobiología de la Universidad Michoacana de san nicolás de Hidalgo Facultad de Ciencias Físico Matemáticas de la Universidad Michoacana de san nicolás de Hidalgo Edificio BCiudad Universitaria Facultad de Ingeniería Civil de la Universidad Michoacana de san nicolás de Hidalgo Edificio A Ciudad Universitaria Facultad de Ingeniería Mecánica de la Universidad Michoacana de san nicolás de Hidalgo Edificio W Ciudad Universitaria División Académica de Ciencias Básicas de la Universidad Juárez Autónoma de Tabasco

In this paper,we analyse an analytical solution of the Einstein–Maxwell field equations that considers matter with anisotropic pressures in a static and spherically symmetric *** report the manner in which we obtained the solution,which is by means of the Karmarkar *** the model,we assume a state equation that describes the interaction of matter from quarks P=(c^(2)ρ-4B_(g))/3 and we consider the presence of electric charge,which can generate that the radial and tangential pressures are not *** a graphic manner,we analyse the physical properties of the model,taking as the observational data those of mass 1M⊙and radius7.69 km which were reported for the star Her *** charge values are found between 5.57×10^(18)C≤Q≤1.31×10^(20)C and the interval of the Bag constant Bg∈[118.7,122.13]MeV/fm^(3).Also,we show the stability of the configuration by means of the static stability criteria of Harrison–Zeldovich–novikov((?M)/?ρc>0),as well as in regards to infinitesimal radial adiabatic perturbation,since the adiabatic indexγ>3.3 which guarantees the stability of the solution.

关键词： general relativity exact solutions anisotropic fluid Karmarkar condition

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Identification of sUMO Targets by a novel Proteomic Approach in Plants

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Journal of Integrative Plant Biology 2013年第1期55卷 96-107页

作者： Gema López-Torrejón Davide Guerra rafael Catal Julio salinas Juan C. del Pozo Centro de Biotecnología y Genómica de Plantas (InIA-UPM) Campus de Montegancedo CRA-Genomics Research Centre (GPG) Centro de Investigaciones Biológicas (CsIC) Campus de la Ciudad Universitaria de Madrid

Post-translational modifications （PTMs） chemically and physically alter the properties of proteins, including their folding, subcellular localization, stability, activity, and consequently their function. In spite of their relevance, studies on PTMs in plants are still limited. small Ubiquitin-like Modifier （sUMO） modification regulates several biological processes by affecting protein-protein interactions, or changing the subcellular Iocalizations of the target proteins. Here, we describe a novel proteomic approach to identify sUMO targets that combines 2-D liquid chromatography, immunodetection, and mass spectrometry （Ms） analyses. We have applied this approach to identify nuclear sUMO targets in response to heat shock. Using a bacterial sUMOylation system, we validated that some of the targets identified here are, in fact, labeled with sUMO1. Interestingly, we found that GIGAnTEA （GI）, a photoperiodic-pathway protein, is modified with sUMO in response to heat shock both in vitro and in vivo.

关键词： Mass spectrometry plants post-translational modification proteomics sUMO.

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Machine learning in liver surgery:Benefits and pitfalls

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World Journal of Clinical Cases 2024年第12期12卷 2134-2137页

作者： rafael Calleja Manuel Durán María Dolores Ayllón Ruben Ciria Javier Briceño Hepatobiliary surgery and Liver Transplantation Unit Hospital Universitario Reina SofíaMaimonides Biomedical Research Institute of CordobaCórdoba 14004Spain

The application of machine learning(ML)algorithms in various fields of hepatology is an issue of ***,we must be cautious with the *** this letter,based on a published ML prediction model for acute kidney injury after liver surgery,we discuss some limitations of ML models and how they may be addressed in the *** the future faces significant challenges,it also holds a great potential.

关键词： Machine learning Liver surgery Artificial intelligence Random forest Prediction model

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Topical ocular administration of DPP-Ⅳ inhibitors:a new approach for treating diabetes-induced retinal neurodegeneration

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neural Regeneration Research 2024年第4期19卷 713-714页

作者： rafael simó Cristina Hernández Diabetes and Metabolism Research Unit Vall d’Hebron Research Institute(VHIR) Department of Medicine Autonomous University of Barcelona Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas(CIBERDEM) Instituto de Salud CarlosⅢ(ICSⅢ)

Retinal neurodegeneration plays a significant role in the pathogenesis of diabetic retinopathy(DR),the leading cause of preventable *** fact,the American Diabetes Association has defined DR as a highly specific neurovascular complication(solomon et al.,2017).Therefore,it is no longer acceptable to consider DR as merely a microvascular *** this regard,the term diabetic retinal disease(DRD)has been proposed as a broader term comprising microangiopathy and ***,there are currently no treatments available that directly target the neurodegenerative changes of *** paper will give new insights into the translational research in this field with particular emphasis on glucagon-like peptide 1/dipeptidyl peptidase IV(GLP-1/DPP-IV)inhibitors.

关键词： neurodegeneration ocular insight

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On the semiprimitivity and semiprimality Problems for Partial smash Products

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Algebra Colloquium 2018年第1期25卷 1-30页

作者： rafael Cavalheiro Alveri sant'Ana Instituto de Matemdtica Estatfstica e Fisica Universidade Federal do Rio Grande Brazil Instituto de Matemdtica Universidade Federal do Rio Grande do Sul Brazil

In this paper we discuss about the semiprimitivity and the semiprimality of partial smash products. Let H be a semisimple Hopf algebra over a field k and let A be a left partial H-module algebra. We study the H-prime and the H-Jacobson radicals of A and their relations with the prime and the Jacobson radicals of A#H, respectively. In particular, we prove that if A is H-semiprimitive, then A^fH is semiprimitive provided that all irreducible representations of A are finite-dimensional, or A is an affine PI-algebra over k and k is a perfect field, or A is locally finite. Moreover, we prove that A=#=H is semiprime provided that A is an H-semiprime PI-algebra, generalizing to the setting of partial actions the known results for global actions of Hopf algebras.

关键词： partial Hopf action partial smash product semiprimitivity semiprimality H-radical partial (A H)-module

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A simple and Efficient structural Topology Optimization Implementation Using Open-source software for All steps of the Algorithm:Modeling, sensitivity Analysis and Optimization

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Computer Modeling in Engineering & sciences 2023年第8期136卷 1371-1397页

作者： rafael Marin Ferro Renato Pavanello Coordination of Mechanical Engineering Federal Institute of Science and Technology of ES-IFESAracruz-ES29192-733Brazil Department of Computational Mechanics Faculty of Mechanical EngineeringUnicampCampinas-SP13083-860Brazil

This work analyzes the implementation of a continuous method of structural topology optimization(sTO)using open-source software for all stages of the topology optimization problem:modeling,sensitivity analysis and *** implementation involves three main components:numerical analysis using the Finite Element Method(FEM),sensitivity analysis using an Adjoint method and an optimization *** order to allow the automated numerical solution of Partial Differential Equations(PDEs)and perform a sensitivity analysis,FEniCs and Dolfin Adjoint software are used as tools,which are open-source *** the optimization process,Ipopt(Interior Point OPTimizer)is used,which is a software package for nonlinear optimization scale designed to find(local)solutions of mathematical optimization *** topological optimization method used is based on the sIMP-solid IsotropicMaterial with Penalization *** considered problem is the minimization of compliance/maximization of stiffness,considering the examples of recurrent structures in the literature in 2D and 3D.A density filtering algorithm based on Helmholtz formulation is *** complete code involves 51 lines of programming and is presented and commented in detail in this article.

关键词： structural topology optimization finite element method FEniCs Dolfin Adjoint

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Heterogeneous catalysis under flow for the 21st century fine chemical industry

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Green Energy & Environment 2021年第2期6卷 161-166页

作者： Rosaria Ciriminna Mario Pagliaro rafael Luque Istituto per Io studio dei Mate riali nanostnuturati CNRwia U.La Malfa 15390146PulemoItaly Deparamento de Quimica Orginica Univeridad de CordobaCampus de RabonalesEdificio Marie Curie(C-3)Cra Nnal IV-Akm 396Cordoba14014Spain Peoples Friendship University of Russia(RUDn Universiy) 6 Miklukho Maklaya St117198MoscowRussia

Due to metal leaching and poor catalyst stability, the chemical industry's fine chemical and pharmaceutical sectors have been historically reluctant to use supported transition metal catalysts to manufacture fine chemicals and active pharmaceutical ingredients. With the advent of new generation supported metal catalysts and flow chemistry, we argue in this study, this situation is poised to quickly change. Alongside heterogenized metal nanoparticles, both single-site molecular and single-atom catalyst will become ubiquitous. This study offers a critical outlook taking into account both technical and economic aspects.

关键词： Fine chemical Heterogeneous catalysis single atom catalysis Green chemistry Chemical industry

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Challenges and opportunities for modeling coupled human and natural systems

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national science Review 2023年第7期10卷 10-13页

作者： Yan Li shan sang safa Mote Jorge rivas Eugenia Kalnay state Key Laboratory of Earth surface Processes and Resources Ecology Beijing Normal University Institute of Land surface system and sustainable Development Faculty of Geographical Science Beijing Normal University Department of Atmospheric and Oceanic science University of Maryland Institute for Physical science and Technology University of Maryland

The Earth is a very large and complex system that consists of human and natural components interacting bidirectionally with each other,thus forming coupled human and natural systems (CHAns)[1].The increasing dominance of human impacts,especially after the 1950s [2],marked a new era for the Earth,the Anthropocene,which means humans have become the main drivers of the evolution of changes in the Earth ***,modeling CHAns is essential for understanding the emergent system properties of CHAns,predicting dynamics and feedbacks (*** shift,tipping point,and resilience),and informing governance of environmental systems to ensure a path toward sustainability [2,3].

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