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Molecular Plant 2013年第1期6卷 235-238页

作者： Yariv Brotman Michael Normantovich Zachi Goldenberg Zvi Zvirin Irina Kovalski Nastacia Stovbun Tirza Doniger Anthony M. Bolqer Christelle Troadec Abdelhafid Bendahman~ RoniCohen Nurit Katzir Michel Pitrat Catherine Dogimont rafael peri-treves Mina and Everard Goodman Faculty of Life Sciences Bar-Ilan University Ramat-Gan 52900 Israel Max Planck institute of Molecular Plant Physiology 14476 Potsdam-Golm Germany Unite de Recherche en Genomique Veagetale INRA-UEVE-CNRS Evry France Department of Vegetable Research Agricultural Research Organization Newe Ya'ar Research Center PO Box 1021 Ramat Yishay 30095 Israel Unite de Genetique et Amelioration des Fruits et Legumes INRA UR1052 84143 Montfavet cedex France

Dear Editor, Potyviruses such as Papaya ring-spot virus （PRSV） cause important yield losses in cucurbits. Two distinct resistant alleles were identified in the Cucumis melo germplasm. Accession PI 414723 （Supplemental Table 1） possesses mono- genic resistance, controlled by the Prv2 allele, and reacts to PRSV by systemic necrotic lesions; plants with the PryI allele, described in cultivar WMR-29, remain symptomless （Pitrat and Lecoq, 1983）. Fusarium oxysporum f. sp. melonis （FUS） exclusively attacks melon, causing severe wilt. Monogenic dominant resistance was described against races O, 1, and 2. The Fore-2 gene, controlling resistance to races 0 and 1, was cloned by Joobeur et al. （2004）, and encodes a nucleotide bindina domain （NB）-Ieucine rich repeat （LRR） protein.

关键词： Muskmelon blight Ringspot virus R genes Control Papaya Resistance Construction Potato virus Y

Olfactory receptors in neural regeneration in the central nervous system

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Neural Regeneration Research 2025年第9期20卷 2480-2494页

作者： rafael Franco Claudia Garrigós Toni Capó Joan Serrano-Marín rafael Rivas-Santisteban Jaume Lillo Molecular Neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain CiberNed Network Center for Biomedical Research in Neurodegenerative Diseases Spanish National Health Institute Carlos ⅢMadridSpain School of Chemistry Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Physiology School of Pharmacy and Food SciencesUniversitat de BarcelonaBarcelonaSpain Laboratory of Computational Medicine Biostatistics UnitFaculty of MedicineAutonomous University of BarcelonaCampus BellaterraBarcelonaSpain

Olfactory receptors are crucial for detecting odors and play a vital role in our sense of smell,influencing behaviors from food choices to emotional *** receptors also contribute to our perception of flavor and have potential applications in medical diagnostics and environmental *** ability of the olfactory system to regenerate its sensory neurons provides a unique model to study neural regeneration,a phenomenon largely absent in the central nervous *** gained from how olfactory neurons continuously replace themselves and reestablish functional connections can provide strategies to promote similar regenerative processes in the central nervous system,where damage often results in permanent *** the molecular and cellular mechanisms underpinning olfactory neuron regeneration could pave the way for developing therapeutic approaches to treat spinal co rd injuries and neurodegenerative diseases like Alzheimer's *** ctory receptors are found in almost any cell of eve ry orga n/tissue of the mammalian *** ectopic expression provides insights into the chemical structures that can activate olfactory *** addition to odors,olfactory receptors in ectopic expression may respond to endogenous compounds and molecules produced by mucosal colonizing *** analysis of the function of olfactory receptors in ectopic expression provides valuable information on the signaling pathway engaged upon receptor activation and the receptor's role in proliferation and cell differentiation *** review explo res the ectopic expression of olfa ctory receptors and the role they may play in neural regeneration within the central nervous system,with particular attention to compounds that can activate these receptors to initiate regenerative *** suggests that olfactory receptors could serve as potential therapeutic targets for enhancing neural repair and recovery following central nervous syste

关键词： adenosine receptors adrenergic receptors ectopic expression G proteincoupled receptors glia neurons

Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

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Neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： rafael Lujan Alejandro Martín-Belmonte Sergi Ferré Francisco Ciruela Synaptic Structure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative Neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown rafael J.Yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

A numerical analysis to the non-linear fin problem

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第5期9卷 648-653页

作者： rafael CORTELL Department of Applied Physics Polytechnic University of Valencia 46022 Valencia Spain

In this paper a numerical analysis is carried out to obtain the temperature distribution within a single fin. It is assumed that the heat transfer coefficient depends on the temperature. The complete highly non-linear problem is solved numerically and the variations of both, dimensionless surface temperature and dimensionless surface temperature gradient as well as heat transfer characteristics with the governing non-dimensional parameters of the problem are graphed and tabulated.

关键词： Fins Ordinary differential equations (ODEs) Numerical solution Heat transfer

A Numerical Tackling on Sakiadis Flow with Thermal Radiation

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Chinese Physics Letters 2008年第4期25卷 1340-1342页

作者： rafael Cortell Department of Appfied Physics Polytechnic University of Valencia 46022 Valencia Spain

Momentum and energy laminar boundary layers of an incompressible fluid with thermal radiation about a moving plate in a quiescent ambient fluid are investigated numerically. Also, it has been underlined that the analy... 详细信息

关键词： BOUNDARY-LAYER EQUATIONS FINITE-DIFFERENCE METHOD POROUS VERTICAL PLATE NON-NEWTONIAN FLUID HEAT-TRANSFER VARIABLE VISCOSITY VISCOELASTIC FLUID MICROPOLAR FLUID BLASIUS EQUATION STRETCHING SHEET

Artificial neural network with a cross-validation approach to blast-induced ground vibration propagation modeling

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Underground Space 2021年第3期6卷 281-289页

作者： Gustavo Paneiro Manuel rafael DECivil/CERENA Tecnico LisboaULisboaPortugal Orica Mining Services Portugal Portugal

Given their technical and economic advantages,the application of explosive substances to rock mass excavation is widely ***,because of serious environmental restraints,there has been an increasing need to use complex tools to control environmental effects due to blast-induced ground *** the present study,an artificial neural network(ANN)with k-fold cross-validation was applied to a dataset containing 1114 observations that was obtained from published results;furthermore,quantitative and qualitative parameters were considered for ground vibration amplitude *** best ANN model obtained has a maximum coefficient of determination of 0.840 and a mean absolute error of 5.59 and it comprises 17 input parameters,12 neurons in a one-layer hidden layer,and a sigmoid transfer *** with the traditional models,the model obtained using the proposed methodology demonstrated better generalization ***,the proposed methodology offers an ANN model with higher prediction ability.

关键词： Rock blasting Excavation Ground vibrations Artificial neural network K-fold cross-validation Modeling

Proteomics and the genetics of sperm chromatin condensation

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Asian Journal of Andrology 2011年第1期13卷 24-30页

作者： rafael Oliva Judit Castillo Human Genetics Research Group IDI BAPS Department of Ciencias Fisiologicas I Faculty of Medicine University of Barcelona Barcelona 08036 Spain Biochemistry and Molecular Genetics Service Hospital Clinic i Provincial Barcelona 08036 Spain

Spermatogenesis involves extremely marked cellular, genetic and chromatin changes resulting in the generation of the highly specialized sperm cell. Proteomics allows the identification of the proteins that compose the spermatogenic cells and the study of their function. The recent developments in mass spectrometry （MS） have markedly increased the throughput to identify and to study the sperm proteins. Catalogs of thousands of testis and spermatozoan proteins in human and different model species are becoming available, setting up the basis for subsequent research, diagnostic applications and possibly the future development of specific treatments. The present review intends to summarize the key genetic and chromatin changes at the different stages of spermatogenesis and in the mature sperm cell and to comment on the presently available proteomic studies.

关键词： epigenetic imprinting protamine proteome spermatozoa

Envelopes of Commutative Rings

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Acta Mathematica Sinica,English Series 2012年第3期28卷 561-580页

作者： rafael PARRA Manuel SAORIN Departamento de Clculo. Escuela Bsica Facultad de Ingeniería Universidad de los Andes Departamento de Matemticas Universidad de Murcia

Given a significative class F of commutative rings, we study the precise conditions under which a commutative ring R has an S-envelope. A full answer is obtained when F is the class of fields, semisimple commutative rings or integral domains. When .F is the class of Noetherian rings, we give a full answer when the Krull dimension of R is zero and when the envelope is required to be epimorphic. The general problem is reduced to identifying the class of non-Noetherian rings having a monomorphic Noetherian envelope, which we conjecture is the empty class.

关键词： Noetherian ring envelope local ring artinian ring Krull dimension

Topical ocular administration of DPP-Ⅳ inhibitors:a new approach for treating diabetes-induced retinal neurodegeneration

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Neural Regeneration Research 2024年第4期19卷 713-714页

作者： rafael Simó Cristina Hernández Diabetes and Metabolism Research Unit Vall d’Hebron Research Institute(VHIR) Department of Medicine Autonomous University of Barcelona Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas(CIBERDEM) Instituto de Salud CarlosⅢ(ICSⅢ)

Retinal neurodegeneration plays a significant role in the pathogenesis of diabetic retinopathy(DR),the leading cause of preventable *** fact,the American Diabetes Association has defined DR as a highly specific neurovascular complication(Solomon et al.,2017).Therefore,it is no longer acceptable to consider DR as merely a microvascular *** this regard,the term diabetic retinal disease(DRD)has been proposed as a broader term comprising microangiopathy and ***,there are currently no treatments available that directly target the neurodegenerative changes of *** paper will give new insights into the translational research in this field with particular emphasis on glucagon-like peptide 1/dipeptidyl peptidase IV(GLP-1/DPP-IV)inhibitors.

关键词： neurodegeneration ocular insight