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Lafoensia pacari alleviates intestinal damage by modulating cyclooxygenase-2:In silico and in vivo evaluation in a colitis model

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World Journal of Gastroenterology 2023年第17期29卷 2628-2641页

作者： Gabrielle Caroline Peiter Thayene Kamyli Moesch Queiroz Edson luiz Michalkiewicz Jr Raphael Henrique Chappuis Jennefer Sousa Luz luiz Henrique Casagrande Piovezani Cleison Ferreira Silva Matheus Nozomi Tsutumi Augusto Fernandes Chaves rafael messias luiz Cinthia Façanha Wendel Ana Carla Zarpelon-Schutz Kádima Nayara Teixeira Programa Multicêntrico de Pós-graduação em Biquímica e Biologia Molecular-Setor Palotina Universidade Federal do ParanáPalotina 85.950-000ParanáBrazil Programa de Pós-graduação em Biotecnologia-Setor Palotina Universidade Federal do ParanáPalotina 85.950-000ParanáBrazil Campus Toledo Universidade Federal do ParanáToledo 85.919-899ParanáBrazil

BACKGROUND Inflammatory bowel diseases(IBD)are a worldwide health problem and mainly affect young people,consequently affecting the *** treatments are often associated with side effects,and new therapeutic options are *** centuries,plants have represented important substrates in the field of drug *** pacari(***)is a plant whose pharmaceutical potential has been described,and may have biological activity relevant to the treatment of IBD *** To investigate the activity of keto-alcoholic extracts of *** with respect to ameliorating the inflammatory and nociceptive symptoms of acute experimental colitis in *** Keto-alcoholic extracts of *** leaves and bark were administered to male andfemale Swiss mice weighing 25 g to 30 g(n=8 male mice and n=8 female mice).The effect of these extracts was observed in an acetic acid-induced acute experimental model of colitis with regard to antinociception/analgesia and inflammatory tissue *** macroscopic indices included the Wallace score and the colon weight obtained using a precision *** hyperalgesia was determined using an electronic *** related to overt pain was determined by quantifying the number of writhing instances within 20 min of administration of acetic *** docking was performed using human and murine cyclooxygenase-2(COX-2)with 3 flavonoids(ellagic acid,kaempferol,and quercetin)on the AutoDock Vina *** of variance followed by Tukey’s posttest was used with P<0.05 indicating *** In this murine model of colitis,administration of extracts from *** ameliorated acetic acidinduced writhing and colitis-associated inflammatory *** improvements may be attributable to the reduction in edema,inflammation(e.g.,ulcers,hyperemia,and bowel wall damage),and the intensity of abdominal *** keto-alcoholic extracts of *** leaves and bark administered at a

关键词： Antinociceptive activity Anti-inflammatory activity Cyclooxygenase-2 Flavonoids Inflammatory bowel disease Lafoensia pacari

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Multidimensional Projections for Visual Analysis of Social Networks

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Journal of Computer Science & Technology 2012年第4期27卷 791-810页

作者： rafael messias Martins Gabriel Faria Andery Henry Heberle Fernando Vieira Paulovich Alneu de Andrade Lopes Helio Pedrini Rosane Minghim Institute of Mathematics and Computer Science University of Sao PauloSao Carlos 13566-590Brazil CPM Braxis Capgemini Sao Paulo 04543-900Brazil Institute of Computing University of CampinasCampinas-SP 13083-852Brazil

Visual analysis of social networks is usually based on graph drawing algorithms and tools. However, social networks are a special kind of graph in the sense that interpretation of displayed relationships is heavily dependent on context. Context, in its turn, is given by attributes associated with graph elements, such as individual nodes, edges, and groups of edges, as well as by the nature of the connections between individuals. In most systems, attributes of individuals and communities are not taken into consideration during graph layout, except to derive weights for force-based placement strategies. This paper proposes a set of novel tools for displaying and exploring social networks based on attribute and connectivity mappings. These properties are employed to layout nodes on the plane via multidimensional projection techniques. For the attribute mapping, we show that node proximity in the layout corresponds to similarity in atgribute, leading to easiness in locating similar groups of nodes. The projection based on connectivity yields an initial placement that forgoes force-based or graph analysis algorithm, reaching a meaningful layout in one pass. When a force algorithm is then applied to this initial mapping, the final layout presents better properties than conventional force-based approaches. Numerical evaluations show a number of advantages of pre-mapping points via projections. User evaluation demonstrates that these tools promote ease of manipulation as well as fast identification of concepts and associations which cannot be easily expressed by conventional graph visualization alone. In order to allow better space usage for complex networks, a graph mapping on the surface of a sphere is also implemented.

关键词： social network visual exploration multidimensional visualization

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Morphological and molecular diversity of arbuscular mycorrhizal fungi in revegetated iron-mining site has the same magnitude of adjacent pristine ecosystems

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Journal of Environmental Sciences 2018年第5期30卷 330-343页

作者： Caroline Krug Vieira Matheus Nicoletti Marascalchi Arthur Vinicius Rodrigues rafael Dutra de Armas Sidney luiz Stürmer Universidade Regional de Blumenau(FURB) Programa de Pos-Graduacao em Engenharia Ambiental89030-903 BlumenauSCBrazil Universidade Regional de Blumenau(FURB) Departamento de Ciencias Naturais(DCN)89030-903 BlumenauSCBrazil Uniuersidade Regional de Blumenau(FURB) Programaa de Pos-Graduacao em Engenharia Florestal89030-903 BlumenauSCBrazil Centro Universitario-Catolica de Santa Catarina 89203-005 JoinvilleSCBrazil

Arbuscular mycorrhizal fungi（AMF） are important during revegetation of mining sites, but few studies compared AMF community in revegetated sites with pristine adjacent ecosystems. The aim of this study was to assess AMF species richness in a revegetated iron-mining site and adjacent ecosystems and to relate AMF occurrence to soil chemical parameters. Soil samples were collected in dry and rainy seasons in a revegetated iron-mining site（RA） and compared with pristine ecosystems of forest（FL）, canga（NG）,and Cerrado（CE）. AMF species were identified by spore morphology from field and trap cultures and by LSU r DNA sequencing using Illumina. A total of 62 AMF species were recovered, pertaining to 18 genera and nine families of Glomeromycota. The largest number of species and families were detected in RA, and Acaulospora mellea and Glomus sp1 were the most frequent species. Species belonging to Glomeraceae and Acaulosporaceae accounted for 42%–48% of total species richness. Total number of spores and mycorrhizal inoculum potential tended to be higher in the dry than in the rainy season, except in RA. Sequences of uncultured Glomerales were dominant in all sites and seasons and five species were detected exclusively by DNA-based identification. Redundancy analysis evidenced soil p H,organic matter, aluminum, and iron as main factors influencing AMF presence. In conclusion, revegetation of the iron-mining site seems to be effective in maintaining a diverse AMF community and different approaches are complementary to reveal AMF species, despite the larger number of species being identified by traditional identification of field spores.

关键词： Community structure Glomeromycota Illumina LSU rDNA Spore morphology Taxonomic distinctness index

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Successful liver allograft inflow reconstruction with the right gastroepiploic vein

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Hepatobiliary & Pancreatic Diseases International 2016年第1期15卷 106-110页

作者： rafael S Pinheiro Ruy J Cruz Jr Lucas S Nacif Matheus F Vane luiz AC D'Albuquerque Liver Transplant Division Department of GastroenterologyUniversity of S?o Paulo School of Medicine Department of Anesthesiology University of S?o Paulo School of Medicine

Portal vein thrombosis is a common complica- tion in cirrhotic patients. When portal vein thrombectomy is not a suitable option, a large collateral vessel can be used for allograft venous inflow reconstruction. We describe an unusu- al case of successful portal revascularization using the right gastroepiploic vein. The patient underwent a cadaveric or- thotropic liver transplantation with end-to-end anastomosis of the portal vein to the right gastroepiploic vein. Six months after liver transplantation the patient is well with good liver function. The use of the right gastroepiploic vein for allograft venous reconstruction is feasible and safe, with a great advan- tage of avoiding the need of venous jump graft.

关键词： liver transplantation vascular grafting portal vein, cavernous transformation of varicose veins hypertension, portal

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Object-based image analysis supported by data mining to discriminate large areas of soybean

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International Journal of Digital Earth 2019年第3期12卷 270-292页

作者： Carlos Antonio da Silva Junior Marcos rafael Nanni José Francisco de Oliveira-Júnior Everson Cezar Paulo Eduardo Teodoro rafael Coll Delgado Luciano Shozo Shiratsuchi Muhammad Shakir Marcelo luiz Chicati Geotechnology Applied in Agriculture and Forest(GAAF) State University of Mato Grosso(UNEMAT)Alta FlorestaMato GrossoBrazil Department of Agronomy(DAG/PGA) State University of Maringá(UEM)MaringáParanáBrazil Institute of Atmospheric Sciences(ICAT) Federal University of Alagoas(UFAL)MaceióAlagoasBrazil Federal University of Mato Grosso do Sul(UFMS) Chapadão do SulMato Grosso do SulBrazil Department of Environmental Sciences(DCA) Forestry Institute(IF)Federal Rural University of Rio de Janeiro(UFRRJ)SeropédicaRio de JaneiroBrazil AgCenter Louisiana State University(LSU)Baton RougeLAUSA Institute of Space Technology Islamabad Pakistan IslamabadPakistan

This research aimed to analyze the possibility to estimate and automatically map large areas of soybean cultivation through the use of MODIS(Moderate-Resolution Imaging Spectroradiometer)*** major techniques were used:GEOgraphic-Object-Based Image Analysis(GEOBIA)and Data Mining(DM).In order to obtain the images,the segmentation algorithm implemented by Definiens Developer was used.A decision tree(DT)was created from a training set previously ***-series of images from the MODIS sensor aboard the Terra satellite were acquired in order to represent the wide variation of the vegetation pattern along the soybean crop *** time-series data were used only for the CEI ***,to compare the results obtained from GEOBIA,the slicing technique was used at the CEI *** the training,the DT was applied to the vegetation indices generating the thematic map of the spatial distribution of *** accordance with the error matrix and kappa parameter analysis,tests for statistical significance were *** indicate that the classification achieved by Kappa coefficients is *** short,the obtained results proved that combining vegetation indices and time-series data using GEOBIA return promising results for mapping soybean plantation on a regional scale.

关键词： GEOBIA time-series vegetation indices MODIS vegetation dynamics

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Liver transplantation:Fifty years of experience

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World Journal of Gastroenterology 2014年第18期20卷 5363-5374页

作者： Alice Tung Wan Song Vivian Iida Avelino-Silva rafael Antonio Arruda Pecora Vincenzo Pugliese luiz Augusto Carneiro D'Albuquerque Edson Abdala Liver and Digestive Organ Transplantation Unit Gastroenterology DepartmentUniversity of Sao Paulo Medical SchoolSao Paulo 05403-900Brazil Infectious Diseases Department University of Sao Paulo Medical SchoolSao Paulo 05403-900Brazil Hepatitis Research Laboratory Infectious Diseases DepartmentUniversity of Sao Paulo Medical SchoolSao Paulo 05403-000Brazil

Since 1963,when the first human liver transplantation(LT)was performed by Thomas Starzl,the world has witnessed 50 years of development in surgical techniques,immunosuppression,organ allocation,donor selection,and the indications and contraindications for *** has led to the mainstream,wellestablished procedure that has saved innumerable lives ***,there are hundreds of liver transplant centres in over 80 *** review aims to describe the main aspects of LT regarding the progressive changes that have occurred over the *** herein review historical aspects since the first experimental studies and the first attempts at human *** also provide an overview of immunosuppressive agents and their potential side effects,the evolution of the indications and contraindications of LT,the evolution of survival according to different time periods,and the evolution of methods of organ allocation.

关键词： Liver transplantation History Survival Indications Organ allocation

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Pentoxifylline enhances the protective effects of hypertonic saline solution on liver ischemia reperfusion injury through inhibition of oxidative stress

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Hepatobiliary & Pancreatic Diseases International 2015年第2期14卷 194-200页

作者： Vinicius Rocha-Santos Estela RR Figueira Joel A Rocha-Filho Ana MM Coelho rafael Soraes Pinheiro Telesforo Bacchella Marcel CC Machado luiz AC D'Albuquerque Department of Gastroenterology Laboratory of Medical Investigations LIM37 Discipline of Liver and Gastrointestinal Transplantation Hospital das Clinicas University of Sao Paulo School of Medicine Discipline of Anesthesiology Hospital das Clinicas University of Sao Paulo School of Medicine Department of Gastroenterology Laboratory of Medical Investigations LIM37 Discipline of Liver and Gastrointestina Hospital das Clinicas University of Sao Paulo School of Medicinel Transplantation

BACKGROUND：Liver ischemia reperfusion（IR）injury triggers a systemic inflammatory response and is the main cause of organ dysfunction and adverse postoperative outcomes after liver ***（PTX）and hypertonic saline solution（HTS）have been identified to have beneficial effects against IR *** study aimed to investigate if the addition of PTX to HTS is superior to HTS alone for the prevention of liver IR ***： Male Wistar rats were allocated into three groups. Control rats underwent 60 minutes of partial liver ischemia, HTS rats were treated with 0.4 mL/kg of intravenous 7.5% NaCl 15 minutes before reperfusion, and HPTX group were treated with 7.5% NaC1 plus 25 mg/kg of PTX 15 minutes before reperfusion. Samples were collected after reperfusion for determination of ALT, AST, TNF-α, IL-6, IL-10, mitochondrial respiration, lipid peroxidation, pulmonary permeability and myeloperoxidase. RESULTS： HPTX significantly decreased TNF-α 30 minutes after reperfusion. HPTX and HTS significantly decreased ALT,AST, IL-6, mitochondrial dysfunction and pulmonary myelo- peroxidase 4 hours after reperfusion. Compared with HTS only, HPTX significantly decreased hepatic oxidative stress 4 hours after reperfusion and pulmonary permeability 4 and 12 hours after reperfusion. CONCLUSION： This study showed that PTX added the beneficial effects of HTS on liver IR injury through decreases of hepatic oxidative stress and pulmonary permeability.

关键词： pentoxifylline hypertonic saline solution hepatic oxidative stress ischemia reperfusion injury pulmonary permeability

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Formation of TiO_(2) Nanotube Layer by Anodization of Titanium in Ethylene Glycol-H_(2)O Electrolyte

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Journal of Surface Engineered Materials and Advanced Technology 2014年第3期4卷 123-130页

作者： Alain Robin Michele Bernardes de Almeida Ribeiro Jorge luiz Rosa Roberto Zenhei Nakazato messias Borges Silva Escola de Engenharia de Lorena Universidade de Sao PauloLorenaBrazil Faculdade de Engenharia de Guaratingueta Universidade Estadual PaulistaGuaratinguetaBrazil

In orthopaedics and orthodontics, the growth of nanotubes of titanium oxide on titanium implants is a promising route for improving the osseointegration. Among the fabrication routes to produce nanotubes, anodization was generally preferred due to its simplicity and low cost. TiO2 nanotubes are formed by the simultaneous anodic reaction and chemical dissolution due to the fluoride species present in the anodization bath. In this work, the formation of TiO2 nanotubes was studied in stirred ethylene glycol-H2O electrolyte (90 - 10 v/v) containing NH4F at room temperature. In order to study the effect of NH4F concentration, voltage and anodization time, and to reduce the number of experiments, a design of experiments (DOE) based on a 2k factorial design with four replicates at the center point was used. The analysis of variance (ANOVA) was used to evaluate the effects of the factors of control and their interactions on the percentage of the titanium surface coated by nanotubes. The dimensions of nanotubes (length and diameter) were also evaluated using field emission gun scanning electron microscopy. The cristallinity and phase composition of the oxide layers was investigated by X-ray diffractometry. The electrochemical behavior of as-received and anodized titanium specimens was studied in Ringer’s solution. The statistical analysis showed that fluoride concentration is the most significant factor. The best condition according to the response surface analysis is the center point (1% NH4F, 20 V, 2 h). The nanotubular oxide layers presented an amorphous structure. Electrochemical tests showed that TiO2 nanotubes coated titanium is less corrosion resistant than as-received titanium.

关键词： Nanotubes Titanium Anodization Implants

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Structural Optimization of a Composite Plate Subjected to a Small Mass Impact

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材料科学与工程（中英文B版） 2011年第4期1卷 536-550页

作者： rafael Thiago luiz Ferreira Mauricio Vicente Donadon Jose Antonio Hemandes ITA-Instituto Tecnol6gico de Aeronautica Sao Jose dos Campos 12228-900 Sao Paulo Brasil

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Liver transplantation as an alternative for the treatment of perihilar cholangiocarcinoma: A critical review

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 139-145页

作者： Wellington Andraus Francisco Tustumi Alexandre Chagas Santana rafael Soares Nunes Pinheiro Daniel Reis Waisberg Liliana Ducatti Lopes Rubens Macedo Arantes Vinicius Rocha Santos Rodrigo Bronze de Martino luiz Augusto Carneiro D’Albuquerque Department of Gastroenterology Transplantation UnitUniversidade de São PauloSão PauloBrazil

Background:Perihilar cholangiocarcinoma(phCCC)is a dismal *** is no consensus regard-ing the best treatment for patients with unresectable *** present review aimed to gather the current pieces of evidence for liver transplantation and liver resection as a treatment for phCCC and to build better guidance for clinical *** sources:The search was conducted in PubMed,Embase,Cochrane,and *** related references were searched *** criteria were:reports in English or Portuguese literature that a)patients with confirmed diagnosis of phCCC;b)patients treated with a curative intent;c)patients with the outcomes of liver resection and liver *** reports,reviews,letters,editorials,conference abstracts and papers with full-text unavailability were excluded from the ***:Most of the current literature is based on observational retrospective studies with low grades of *** resection has better long-term outcomes than systemic chemotherapy or palliation ther-apy and liver transplantation is a good alternative for selected patients with unresectable *** candidates for resection or transplantation should be medically fit and free of intrahepatic or extrahep-atic *** a general rule,patients presenting with a tumor having a longitudinal size>3 cm or extending below the cystic duct,lymph node disease,confirmed extrahepatic dissemination;intraoper-atively diagnosed metastatic disease;a history of other malignancies within the last five years,and did not complete chemoradiation regimen and were medically unfit should not be considered for *** of these criteria should be individually *** transplantation or resection should only be considered in highly experienced hepatobiliary centers,and any decision-making must be based on a multidisciplinary ***:phCCC is a complex condition with high *** therapies,including hepatec-tomy and liv

关键词： Liver transplantation Cholangiocarcinoma Liver neoplasms

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