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Journal of Metallic Material Research 2019年第2期2卷 1-8页

作者： rafael fernandez-fuentes Americo Scotti Amado Cruz-Crespo Roberto Silva Gonzalez rafael Ariza Nelson Guedes de Alcantara Universidad Central Marta Abreu de Las Villas–UCLV Cuba Universidade Federal de Uberlandia–UFU Brazil Universidade Federal de Sao Carlos-UFSCar Brazil University of West Department of Engineering ScienceTrollhattanSweden

The objective of this work was to study the effect of the heat treatment and further operation aging on the stereological parameters(size,quantity and volume fraction)of precipitates within ferrite grains of a creep-resistant 1.25Cr0.5Mo steel after long-term *** heat treatment was similar to the treatment that is carried out in industrial steam pipelines after welding(post weld heat treatment-PWHT)during installation and/or *** operation aging corresponds to a subsequent long in-service operation after *** determine the stereological parameters,SEM digital images were taken from samples of this material after conditions of in-service-aged(after long-term operation),in-service-aged and heat-treated(simulating repairing)and in-service-aged,heat-treated and in-laboratory aged(simulating subsequent long-term operation after repairing).The results indicate that the changes in the stereological parameters of the precipitates within ferrite grains after PWHT is associated with the coarsening process of the within-ferrite-grain precipitates as well as stabilizing the microstructure,since the material aging after PWHT of an in-serviced aged material would not change the stereological parameters.

关键词： Creep-resistant 1.25Cr0.5Mo Steel Repairing PWHT Precipitation coarsening

Telomeric DNA breaks in human induced pluripotent stem cells trigger ATR-mediated arrest and telomerase-independent telomere damage repair

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Journal of Molecular Cell Biology 2024年第3期16卷 46-60页

作者： Katrina N.Estep John W.Tobias rafael J.fernandez Brinley M.Beveridge F.Brad Johnson Department of Pathology and Laboratory Medicine University of PennsylvaniaPhiladelphiaPA 19104USA Quantiative Biosciences Merck&Co.Inc.West PointPA 19486USA Penn Genomic Analysis Core University of PennsylvaniaPhiladelphiaPA 19104USA

Although mechanisms of telomere protection are well-defined in differentiated cells,how stem cells sense and respond to telomere dysfunction,in particular telomeric double-strand breaks(DSBs),is poorly ***,we report the DNA damage signaling,cell cycle,and transcriptome changes in human induced pluripotent stem cells(iPSCs)in response to telomere-internal *** engineer human iPSCs with an inducible TRF1-FokI fusion protein to acutely induce DSBs at *** this model,we demonstrate that TRF1-FokI DSBs activate an ATR-dependent DNA damage response,which leads to p53-independent cell cycle arrest in *** CRISPR–Cas9 to cripple the catalytic domain of telomerase reverse transcriptase,we show that telomerase is largely dispensable for survival and lengthening of TRF1-FokI-cleaved telomeres,which instead are effectively repaired by robust homologous recombination(HR).In contrast to HR-based telomere maintenance in mouse embryonic stem cells,where HR causes ZSCAN4-dependent extension of telomeres beyond their initial lengths,HR-based repair of telomeric breaks is sufficient to maintain iPSC telomeres at a normal length,which is compatible with sustained survival of the cells over several days of TRF1-FokI *** findings suggest a previously unappreciated role for HR in telomere maintenance in telomerase-positive iPSCs and reveal distinct iPSC-specific responses to targeted telomeric DNA damage.

关键词： telomeres telomerase alternative lengthening of telomeres pluripotent stem cells DNA damage double-strand breaks

Typhoon-and pollution-driven enhancement of reactive bromine in the mid-latitude marine boundary layer

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National Science Review 2024年第4期11卷 93-101页

作者： Shanshan Wang Qinyi Li Ruifeng Zhang Anoop Sharad Mahajan Swaleha Inamdar Nuria Benavent Sanbao Zhang Ruibin Xue Jian Zhu Chenji Jin Yan Zhang Xiao Fu Alba Badia rafael P.fernandez Carlos A.Cuevas Tao Wang Bin Zhou Alfonso Saiz-Lopez Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3) Department of Environmental Science and Engineering Fudan University Institute of Eco-Chongming(IEC) Department of Atmospheric Chemistry and Climate Institute of Physical Chemistry Blas CabreraCSIC Department of Civil and Environmental Engineering The Hong Kong Polytechnic University Environment Research Institute Shandong University Centre for Climate Change Research Indian Institute of Tropical MeteorologyMinistry of Earth Sciences Department of Chemistry University of Colorado Boulder Institute of Environment and Ecology Tsinghua Shenzhen International Graduate SchoolTsinghua University Sostenipra Research Group Institute of Environmental Science and Technology(ICTA)Universitat Autonoma de Barcelona(UAB) Institute for Interdisciplinary Science (ICB) National Research Council (CONICET)

Tropospheric reactive bromine is important for atmospheric chemistry,regional air pollution,and global *** studies have reported measurements of atmospheric reactive bromine species in different environments,and proposed their main sources,***-salt aerosol（SSA）,oceanic biogenic activity,polar snow/ice,and *** and other strong cyclonic activities（***） induce abrupt changes in different earth system processes,causing widespread destructive ***,the role of typhoons in regulating reactive bromine abundance and sources remains ***,we report field observations of bromine oxide（BrO）,a critical indicator of reactive bromine,on the Huaniao Island（HNI）in the East China Sea in July *** observed high levels of BrO below 500 m with a daytime average of9.7±4.2 pptv and a peak value of ～26 pptv under the influence of a *** field measurements,supported by model simulations,suggest that the typhoon-induced drastic increase in wind speed amplifies the emission of SSA,significantly enhancing the activation of reactive bromine from SSA *** also detected enhanced BrO mixing ratios under high NOxconditions（ppbv level） suggesting a potential pollution-induced mechanism of bromine release from *** elevated levels of atmospheric bromine noticeably increase ozone destruction by as much as ～40% across the East China *** the high frequency of cyclonic activity in the northern hemisphere,reactive bromine chemistry is expected to play a more important role than previously thought in affecting coastal air quality and atmospheric oxidation *** suggest that models need to consider the hitherto overlooked typhoon-and pollution-mediated increase in reactive bromine levels when assessing the synergic effects of cyclonic activities on the earth system.

关键词： reactive bromine atmospheric chemistry marine boundary layer atmospheric oxidation capacity marine emission

Subaxial cervical spine injury classification system: is it most appropriate for classifying cervical injury?

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Neural Regeneration Research 2015年第9期10卷 1416-1417页

作者： rafael Martínez-Pérez Francisco fuentes Víctor S.Alemany Division of Neurosurgery Department of Clinical Neurological Sciences University of Western Ontario Department of Neurology Hospital Rafael Méndez School of Medicine Universidad Complutense

The cervical spine injury represents a potential devastating disease with 6% associated in-hospital mortality （lain et al., 2015）. Neurological deterioration ranging from complete spinal cord injury （SCI） to incomplete SCI or single radiculopathy are potential consequences of the blunt trauma over this region. The subaxial cervical spine accounts the vast majority of cervical injuries, making up two thirds of all cervical fractures （Alday, 1996）. Few classifications （Holdsworth, 1970; White et al., 1975; Mien et al., 1982; Denis, 1984; Vaccaro et al., 2007） have been proposed to describe injuries of the cervical spine for several reasons. First, to delineate the best treatment in each case; second, to determinate an accurate neurological prognosis, and third, to establish a standard way to communicate and describe specific characteristics of cervical injuries patterns. Classical systems are primarily descriptive and no single system has gained widespread use, largely because of restrictions in clinical relevance and its complexity.

关键词： is it most appropriate for classifying cervical injury SLIC Subaxial cervical spine injury classification system

Human immunodeficiency virus type-1 induces a regulatory B cell-like phenotype in vitro

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Cellular & Molecular Immunology 2018年第10期15卷 917-933页

作者： Jacobo Lopez-Abente Adrián Prieto-Sanchez Maria-Ángeles Muñoz-fernandez rafael Correa-Rocha Marjorie Pion Laboratorio de Inmuno-Regulación Immunology DepartmentPabellón de Medicina y Cirugía ExperimentalHospital General Universitario Gregorio MarañónInstituto de Investigación Sanitaria Gregorio Marañón(IiSGM)Calle Máiquez9Madrid 28009Spain Laboratorio de Inmuno-Biología Molecular Immunology DepartmentHospital General Universitario Gregorio MarañónInstituto de Investigación Sanitaria Gregorio Marañón(IiSGM)C/Dr.Esquerdo 46Madrid 28007Spain Networking Research Center on Bioengineering Biomaterials and Nanomedicine(CIBER-BBN)C/Monforte de Lemos 3-5Pabellón 11Madrid 28029Spain

Individuals infected with human immunodeficiency virus type-1(HIV-1)usually show a general dysregulation and hyper-activation of the immune system.A direct influence of HIV-1 particles on B-cell phenotypes and functions has been previously ***,the consequences of B-cell dysregulation are still poorly *** evaluated the phenotypic changes in primary B cells after direct contact with HIV-1 particles in comparison with different types of *** functionality of treated B cells was challenged in co-culture experiments with autologous CD4+and CD8+T *** demonstrated that HIV-1 induces a phenotypic change in B cells towards a regulatory B-cell phenotype,showing a higher level of IL-10,TGF-β1,EBI3 or IL-12(p35)mRNA expression and acquiring an immunosuppressive *** acquisition of a Breg phenotype was confirmed by co-culture experiments where HIVtreated B cells reduced the proliferation and the TNFαproduction of CD4+or CD8+T *** suppressive ability of HIV-treated B cells was dependent on cell-to-cell contact between these B cells and effector *** our knowledge,these data provide the first evidence that HIV-1 can directly induce a regulatory B cell-like immunosuppressive phenotype,which could have the ability to impair specific immune *** dysregulation could constitute one of the mechanisms underlying unsuccessful efforts to develop an efficient vaccine against HIV-1.

关键词： HIV-1 immune hyper-activation regulatory B cells

Benefits of Biochars and NPK Fertilizers for Soil Quality and Growth of Cowpea (Vigna unguiculata L. Walp.) in an Acid Arenosol

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Pedosphere 2019年第3期29卷 311-333页

作者： Rogerio Borguete Alves rafael Maria Luisa fernandez-MARCOS Stefania COCCO Maria Letizia RUELLO Flavio FORNASIER Giuseppe CORTI Department of Rural Engineering Faculty of Agronomy and Forestry Engineering Universidade Eduardo Mondlane Maputo 257 (Mozambique) Department of Agriculture Food and Environmental Sciences Univ er sit a Politecnica delle Marche Ancona 60131 (Italy) Department of Soil Science and Agricultural Chemistry Universidad de Santiago de Compostela Lugo 27002 (Spain) Department of Materials Environmental Sciences and Urban Planning Universita Politecnica delle Marche Ancona 60131 (Italy) Centro di Ricerca Viticoltura ed Enologia Gorizia 34170 (Italy) Instituto de Biodiv ersidade Agraria e Desenvolvimento Rural Universidad de Santiago de Compostela Lugo 27002 (Spain)

Fertilization is required for optimum plant growth, particularly in unfertile soils, while optimizing nutrient use effciency is an alternative to reduce inorganic fertilizer needs and reduce environmental problems caused by nutrient leaching. This study investigated soil properties and cowpea yield responses to biochars(BCs) made from different feedstocks, baby corn peel biochar(BC1), branches of mango tree biochar(BC2), and rice husk biochar(BC3), applied in combination with nitrogen-phosphorus-potassium(NPK) *** experiment was conducted in a greenhouse, using an acid sandy soil(Arenosol) that was submitted for 70 d to the following eight treatments: i) control;ii) full dose of NPK(a commercial compound fertilizer(12-24-12 of N-P2O5-K2O)+ urea(46% N));iii) BC1+ half dose of NPK;iv) BC1 + full dose of NPK;v) BC2 + half dose of NPK;vi) BC2 + full dose of NPK;vii) BC3 + half dose of NPK;and viii) BC3 + full dose of NPK. All biochars were applied at a rate of 0.9%(weight/weight), and each type of biochar was combined with half and full doses of NPK fertilizers. Soil pH increased significantly(P < 0.05) in treatments with BC1 and BC2,while cation exchange capacity(CEC) and available P were higher in the treatments with BC1;BC1 and BC2 also induced higher activity of enzymes related to the P cycle and higher cowpea yield. Similar soil properties and cowpea yield parameters were obtained with the full and half doses of NPK fertilizers for each type of biochar used. In conclusion, biochars in the combination with NPK fertilizers improved soil chemistry and enzymatic activities, allowing reduced fertilizer application and food production costs in the acid soil studied.

关键词： acid soil nutrient use effciency organic amendment plant growth potential enzyme activity soil fertility soil pH

HLA B27 as Predisposition Factor to Suffer Age Related Macular Degeneration

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Cellular & Molecular Immunology 2009年第4期6卷 303-307页

作者： Enrique Villegas Becerril rafael Gonzalez fernandez Luis Perula Torres Manuel Santos Lacomba Jose Maria Gallardo Galera Hospital Universitario Reina Sofia Cordoba Spain Faculty of Medicine University of Cordoba Spain Hospital Universitario Reina Sofia C/Conchita Cintron n 4 Atico 2 CP 14011

To research whether specific alleles HLA class Ⅰ （HLA-A and HLA-B） and class Ⅱ （HLA-DR） are risk factors for the development of exudative type of Age Related Macular Degeneration（ARMD）, HLA antigens are expressed both in normal and affected eyes with ARMD. We designed a prospective case-controlled study. We recruited 75 patients with choroidal neovascuiarization predominantly classic or occult, secondary to ARMD, and treated with photodynamic therapy. Two hundred and fifty patients over 55 years old, without ophthalmologic pathology who went to hospital for an analytical routine check were used as control. The analysis of the data shows a significant difference between two groups. Allele HLA-B27 correlated positively with ARMD （p 〈 0.0113）. However, we didn＇t find alleles negatively associated. Thus HLA-B27 is an allele predisposed to suffer ARMD.

关键词： HLA alleles ARMD HLA B27 patient with ARMD

Direct observation of the CO_(2) formation and C–H consumption of carbon electrode in an aqueous neutral electrolyte supercapacitor by in-situ FTIR and Raman

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Journal of Energy Chemistry 2022年第8期31卷 488-496,I0013页

作者： Murilo M.Amaral Victor Y.Yukuhiro rafael Vicentini Alfredo C.Peterlevitz Leonardo M.Da Silva Pablo fernandez Hudson Zanin Advanced Energy Storage Division State University of Campinas13083-852Av.Albert Einsten 400CampinasSPBrazil Chemistry Institute State University of Campinas13083-970Josue de Castro StreetCampinasSPBrazil Department of Chemistry Laboratory of Fundamental and Applied ElectrochemistryFederal University of Jequitinhonha and Mucuri’s ValleyRodovia MGT 367km 5835000Alto da Jacuba39100-000DiamantinaMGBrazil Center for Innovation on New Energies University of Campinas13083-841 CampinasSão PauloBrazil

Electrical double-layer capacitors(EDLCs)consist of energy storage devices that present high-power and moderate energy *** electrolyte and electrode physicochemical properties are crucial for improving their overall energy storage ***,the stability of the EDLCs’materials is the primary focus of this *** energy storage depends on the specific capacitance,and also on the square of the maximum capacitive cell voltage(UMCV).Thus,electrodes with high specific surface area(SSA)and electrolytes with excellent electrochemical stability are commonly reported in the *** electrolytes are safer and green devices compared to other organic-based *** the other hand,their UMCVis reduced compared to other electrolytes(e.g.,organic-based and ionic liquids).In this sense,spanning the UMCVfor aqueous-based electrolytes is a’hot topic’***,the lack of protocols to establish reliable UMCVvalues has culminated in the publishing of several conflicting ***,we confirm that multiwalled carbon nanotubes(MWCNTs)housed in cells degrade and produce CO_(2) under abusive polarisation *** is probed by employing electrochemical techniques,in-situ FTIR and in-situ Raman *** these considerations,the current study uses spectro-electrochemical techniques to support the correct determination of the electrode and electrolyte stability conditions as a function of the operating electrochemical parameters.

关键词： Electrode and electrolyte stabilities In-situ FTIR CO_(2)formation Carbon degradation Supercapacitor Aqueous electrolytes Carbon nanotubes

Antioxidant effects of D-004, a lipid extract from the Roystonea regia fruit, on the plasma of healthy men

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Asian Journal of Andrology 2009年第3期11卷 385-392页

作者： Emesto Lopez Vivian Molina Jose Illnait Ambar Oyarzfibal Lilia C. Femandez Rosa Mas rafael Gamez Julio C. fernandez Sonia Jimenez Meilis Mesa Ivon Hollands Sarahi Mendoza Medical Surgical Research Centre Havana 6990 Cuba Centre of Natural Products from the National Centre for Scientific Research Havana 6880 Cuba

The aim of thisstudy was to conduct a randomized, double-blind and placebo-controlled study to investigate the effects of D-004, a lipid extract of the Roystonea regia fruit that prevents testosterone- and phenylepinephrine- induced prostate hyperplasia in rodents, on plasma oxidative markers in healthy men. We enrolled male volunteers （20-55 years） in good health and without lower urinary tract symptoms. Thirty-four eligible participants were randomized to placebo or D-004 （320 mg） capsules administered daily for 6 weeks. An interim check-up and a final visit were conducted after 3 and 6 weeks of therapy, respectively. Physical examinations were performed at each visit, and laboratory tests were performed at baseline and at treatment completion. Oxidative variables included plasma malondialdehyde （MDA）, total hydroxyperoxides （TOH）, sulphydryl （SH） groups and total antioxidant status （TAS）. We assessed treatment compliance and addressed adverse experiences （AEs） at weeks 3 and 6. At week 6, with D-004, the mean reductions of plasma MDA （26.7%）, TOH （18.8%） and SH groups （31.6%）, and the mean increase of TAS （35.3%） were significantly different from those of placebo （P 〈 0.001 for plasma TAS, P 〈 0.0001 for all other comparisons）. D-004 did not differ from the placebo in safety indicators. There were two withdrawals （both in the D-004 group）, with one due to dyspepsia （the only AE during the trial）. In conclusion, D-004 displayed antioxidant effects on plasma oxidative markers in healthy men, which was consistent with findings from laboratory experimental studies.

关键词： antioxidant benign prostate hyperplasia D-004 lipid peroxidation Roystonea regia

A charged star with geometric Karmarkar condition

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Communications in Theoretical Physics 2023年第8期75卷 139-149页

作者： Gabino Estevez-Delgado Joaquin Estevez-Delgado rafael Soto-Espitia Antonio Rendón Romero Jorge Mauricio Paulin-fuentes Facultad de Químico Farmacobiología de la Universidad Michoacana de San Nicolás de Hidalgo Facultad de Ciencias Físico Matemáticas de la Universidad Michoacana de San Nicolás de Hidalgo Edificio BCiudad Universitaria Facultad de Ingeniería Civil de la Universidad Michoacana de San Nicolás de Hidalgo Edificio A Ciudad Universitaria Facultad de Ingeniería Mecánica de la Universidad Michoacana de San Nicolás de Hidalgo Edificio W Ciudad Universitaria División Académica de Ciencias Básicas de la Universidad Juárez Autónoma de Tabasco

In this paper,we analyse an analytical solution of the Einstein–Maxwell field equations that considers matter with anisotropic pressures in a static and spherically symmetric *** report the manner in which we obtained the solution,which is by means of the Karmarkar *** the model,we assume a state equation that describes the interaction of matter from quarks P=(c^(2)ρ-4B_(g))/3 and we consider the presence of electric charge,which can generate that the radial and tangential pressures are not *** a graphic manner,we analyse the physical properties of the model,taking as the observational data those of mass 1M⊙and radius7.69 km which were reported for the star Her *** charge values are found between 5.57×10^(18)C≤Q≤1.31×10^(20)C and the interval of the Bag constant Bg∈[118.7,122.13]MeV/fm^(3).Also,we show the stability of the configuration by means of the static stability criteria of Harrison–Zeldovich–Novikov((?M)/?ρc>0),as well as in regards to infinitesimal radial adiabatic perturbation,since the adiabatic indexγ>3.3 which guarantees the stability of the solution.

关键词： general relativity exact solutions anisotropic fluid Karmarkar condition