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Liver transplantation:Fifty years of experience

World Journal of Gastroenterology 2014年第18期20卷 5363-5374页

作者： Alice Tung Wan Song Vivian Iida Avelino-Silva rafael Antonio Arruda pecora Vincenzo Pugliese Luiz Augusto Carneiro D'Albuquerque Edson Abdala Liver and Digestive Organ Transplantation Unit Gastroenterology DepartmentUniversity of Sao Paulo Medical SchoolSao Paulo 05403-900Brazil Infectious Diseases Department University of Sao Paulo Medical SchoolSao Paulo 05403-900Brazil Hepatitis Research Laboratory Infectious Diseases DepartmentUniversity of Sao Paulo Medical SchoolSao Paulo 05403-000Brazil

Since 1963,when the first human liver transplantation(LT)was performed by Thomas Starzl,the world has witnessed 50 years of development in surgical techniques,immunosuppression,organ allocation,donor selection,and the indications and contraindications for *** has led to the mainstream,wellestablished procedure that has saved innumerable lives ***,there are hundreds of liver transplant centres in over 80 *** review aims to describe the main aspects of LT regarding the progressive changes that have occurred over the *** herein review historical aspects since the first experimental studies and the first attempts at human *** also provide an overview of immunosuppressive agents and their potential side effects,the evolution of the indications and contraindications of LT,the evolution of survival according to different time periods,and the evolution of methods of organ allocation.

关键词： Liver transplantation History Survival Indications Organ allocation

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Extended criteria brain-dead organ donors:Prevalence and impact on the utilisation of livers for transplantation in Brazil

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World Journal of Hepatology 2023年第2期15卷 255-264页

作者： Victoria S Braga Amanda P C S Boteon Heloisa B Paglione rafael a a pecora Yuri L Boteon Faculdade Israelita de Ciências da Saúde Albert Einstein Hospital Israelita Albert EinsteinSão Paulo 05652-900Brazil Transplant Centre Hospital Israelita Albert EinsteinSão Paulo 05652-900Brazil

BACKGROUND Despite its association with higher postoperative morbidity and mortality,the use of extended criteria donor(ECD)livers for transplantation has increased globally due to the high demand for the *** To investigate the prevalence of ECD in donation after brain death(DBD)and its impact on organ acceptance for *** Retrospective analysis of DBD organ offers for liver transplantation between 2017 and 2020 in a high-volume transplant *** incidence of the Eurotransplant risk factors to define an ECD(ET-ECD)among DBD donors and the likelihood of organ acceptance over the years were *** relationship between organ refusal for transplantation,the occurrence,and the number of ET-ECD was assessed by simple and multiple logistic regression *** A total of 1619 organ donors were *** these,78.31%(n=1268)had at least one ET-ECD *** was an increase in the acceptance of ECD DBD organs for transplantation(1 criterion:from 23.40%to 31.60%;2 criteria:from 13.10%to 27.70%;3 criteria:From 6.30%to 13.60%).For each addition of one ETECD variable,the estimated chance of organ refusal was 64.4%higher(OR 1.644,95%CI 1.469-1.839,P165 mmol/L(P=0.310),all ET-ECD criteria increased the estimated chance of organ refusal for *** A high prevalence of ECD DBD was *** the increase in their utilisation,the presence and the number of extended donor criteria were associated with an increased likelihood of their refusal for transplantation.

关键词： Liver transplantation Extended criteria donors Donation after brain death Organ donation

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