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Laparoscopic resection for hepatocellular carcinoma: eastern and western experiences

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Chinese Journal of Cancer Research 2014年第3期26卷 234-236页

作者： Paulo Herman Fabricio ferreira coelho Liver Surgery Unit Department of GastroenterologyUniversity of Sao Paulo Medical School

Hepatocellular carcinoma （HCC） is the most common primary liver cancer （1）. The incidence is rising in the last decades due to many factors, especially hepatitis C, alcoholic liver disease and non-alcoholic steatohepatitis. Moreover, the introduction of screening programs in patients with chronic liver disease has led to an increase in HCC diagnosis （1,2）. In the western world, 80% to 90% of HCC eases occur in patients with liver cirrhosis （3） while this proportion is lower in some regions in Asia and sub-Saharian Africa, where hepatitis B remains as an important etiologic factor for chronic liver disease （2,4）. In 1990, the annual world frequency of HCC was 437,000 cases/year （1）, and in 2012 the number reached 782,200 cases/year being responsible for 746,000 deaths （5）. Nowadays, HCC represents the 6th most frequent neoplastic disease in the world and the 3rd in mortality （5）.

关键词： HCC eastern and western experiences Laparoscopic resection for hepatocellular carcinoma

Novel preoperative strategies to improve hepatocellular carcinoma resectability

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Hepatobiliary Surgery and Nutrition 2023年第1期12卷 140-141页

作者： Francisco Tustumi Fabricio ferreira coelho Paulo Herman Department of Gastroenterology Universidade de São PauloSao PauloBrazil Department of Surgery Hospital Israelita Albert EinsteinSao PauloBrazil

Peng et al.(1)performed a pretty interesting article,reporting the proposal of a new strategy to improve resectability for hepatocellular carcinoma(HCC).Their findings are *** strategies to improve liver resection are methods for promoting future liver remnant(FLR)growth in a timely manner before cancer *** main strategies are portal vein embolization(PVE)and associating liver partition and portal vein ligation for staged hepatectomy(ALPPS).

关键词： hepatocellular liver

Totally intracorporeal robot-assisted urinary diversion for bladder cancer(Part 1).Review and detailed characterization of ileal conduit and modified Indiana pouch

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Asian Journal of Urology 2021年第1期8卷 50-62页

作者： Hugo Otaola-Arca rafael coelho Vipul R.Patel Marcelo Orvieto Department of Urology Clı´nica AlemanaSantiagoChile School of Medicine Clı´nica Alemana-Universidad del DesarrolloSantiagoChile Universidade de Sa˜o Paulo Instituto do Caˆncer do Estado de Sa˜o Paulo Brazil Department of Urology AdventHealth Global Robotics InstituteCelebrationFLUnited States

Objective:To review the most used robot-assisted cutaneous urinary diversion(CUD)after radical cystectomy for bladder cancer and create a unified compendium of the different alternatives,including new consistent images Methods:A non-systematic review of the literature with the keywords“bladder cancer”,“cutaneous urinary diversion”,and“radical cystectomy”was ***:Twenty-four studies of intracorporeal ileal conduit(ICIC)and two of intracorporeal Indiana pouch(ICIP)were included in the *** ICIC,the patients’age ranged from 60 to 76 *** operative time to perform a urinary diversion ranged from 60 to 133 *** total estimated blood loss ranged from 200 to 1117 *** rate of positive surgical margins ranged from 0%to 14.3%.Early minor and major complication rates ranged from 0%to 71.4%and from 0%to 53.4%,*** minor and major complication rates ranged from 0%to 66%and from 0%to 32%,*** ICIP data are limited to one case report and one clinical ***:The most frequent type of CUD is *** studies comparing the performance of the different types of CUD,the performance in an intra-or extracorporeal manner,or the performance of a CUD versus orthotopic ileal neobladder are lacking in the *** this day,there are not enough quality data to determine the supremacy of one *** manuscript represents a compendium of the most used CUD with detailed descriptions of the technical aspects,operative and perioperative outcomes,and new consistent images for each technique.

关键词： Bladder cancer Ileal conduit Indiana pouch Intracorporeal urinary diversion Robot-assisted radical cystectomy Surgical technique

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The CASTOR-K Code,Recent Developments and Applications

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Plasma Science and Technology 2015年第2期17卷 89-96页

作者： F.NABAIS D.BORBA R.coelho A.FIGUEIREDO J.ferreira N.LOUREIRO P.RODRIGUES Associao EURATOM/IST Instituto de Plasmas e Fuso Nuclear-Instituto Superior TcnicoUniversidade de Lisboa

The CASTOR-K code is a hybrid magnetohydrodynamic （MHD）-drift kinetic code developed for the study of MHD modes in the presence of energetic ion populations. It allows a fast assessment of the linear stability of the modes, as well as an accurate calculation of damping due to thermal species （Landau damping）. These capabilities make the code an invaluable tool for parametric studies and data analysis. In recent years, CASTOR-K has been mostly used to analyze JET data, including the identification of mechanisms involved in the expulsion of energetic ions from the plasma. However, in order to prepare the code to be used for a wider range of tokamaks including ITER, the code is being subject to a series of important improvements. These improvements aim not only to introduce new physics in the code but also to make it capable of exchanging data with other codes through its integration in modelling infrastructures. In this paper a description of the CASTOR-K code is presented, as well as a summary of the most important results obtained with this code and a description of the new improvements being implemented.

关键词： controlled fusion tokamaks plasma instabilities magnetohydrodynamics(MHD) Alfven waves energetic particles

Duodenal stenting for malignant gastric outlet obstruction:Prospective study

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World Journal of Gastroenterology 2012年第9期18卷 938-943页

作者： Eduardo Guimaräes Hourneaux Moura Flávio coelho ferreira Spencer Cheng Diogo Turiani Hourneaux Moura Paulo Sakai Bruno Zilberstain Gastrointestinal Endoscopy Unit University of Sao Paulo Department of Gastroenterology University of Sao Paulo

AIM： To evaluate the results of duodenal stenting for palliation of gastroduodenal malignant obstruction by using a gastric outlet obstruction score （GOOS）.

关键词： Enteral stenting Gastric outlet obstructionscoring system Gastroduodenal malignancy Self-expan-dable metal stent

Repeat hepatectomy for recurrent colorectal liver metastases:A comparative analysis of short-and long-term results

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 162-167页

作者： Paulo Figueiredo Costa Fabricio ferreira coelho Vagner Birk Jeismann Jaime Arthur Pirola Kruger Gilton Marques Fonseca Ivan Cecconello Paulo Herman Digestive Surgery Brazilian College of Digestive Surgery(Colégio Brasileiro de Cirurgia Digestiva-CBCD) São PauloBrazil Digestive Surgery Division Department of GastroenterologyUniversity of São Paulo School of MedicineSão PauloBrazil Instituto do Câncer do Estado de São Paulo(ICESP) São PauloBrazil

Background: Liver recurrence after resection of colorectal liver metastases(CRLM) is frequent. Repeat hepatectomy has been shown to have satisfactory perioperative results. However, the long-term outcomes and the benefts for patients with early recurrence have not been clarifed. The aim of this study was to compare the short-and long-term outcomes of patients undergoing single hepatectomy and repeat hepatectomy for CRLM. Additionally, the oncological outcomes of patients with early( ≤ 6 months) and late recurrence who underwent repeat hepatectomy were compared. Methods: Consecutive adult patients undergoing hepatectomy for CRLM between June 20 0 0 and February 2020 were included and divided into two groups: single hepatectomy and repeat hepatectomy. Results: A total of 709 patients were included: 649 in the single hepatectomy group and 60 in the repeat hepatectomy group. Patients in the repeat hepatectomy group underwent more cycles of preoperative chemotherapy [4(3-6) vs. 3(2-4), P = 0.003]. Patients in the single hepatectomy group more frequently underwent major hepatectomies(34.5% vs. 16.7%, P = 0.004) and had a greater number of lesions resected(2.9 ± 3.6 vs. 1.9 ± 1.8, P = 0.011). There was no increase in operative time, estimated blood loss, length of hospital stay, complications, or mortality in the repeat hepatectomy group. There were no differences in overall survival( P = 0.626) and disease-free survival( P = 0.579) between the two groups. Similarly, for patients underwent repeat hepatectomy, no difference was observed between the early and late recurrence groups in terms of overall survival( P = 0.771) or disease-free survival( P = 0.350). Conclusions: Repeat hepatectomy is feasible and safe, with similar short-and long-term outcomes when compared to single hepatectomy. Surgical treatment of early liver recurrence offers similar oncological outcomes to those obtained for late recurrence.

关键词： Colorectal cancer Metastasis Hepatectomy Postoperative complications Survival analysis

High-resolution multi-scale air pollution system:Evaluation of modelling performance and emission control strategies

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Journal of Environmental Sciences 2024年第3期137卷 65-81页

作者： Diogo Lopes Joana ferreira Sandra rafael Ka In Hoi Xin Li Yuan Liu Ka-Veng Yuen Kai Meng Mok Ana Isabel Miranda Department of Environment and Planning&CESAM University of AveiroAveiroPortugal Department of Civil&Environmental Engineering Faculty of Science and TechnologyUniversity of MacaoMacao SARChina

A high percentage of the world's population lives in areas where air pollutant concentrations exceed the World Health Organization *** work aims to develop and test,a high-resolution multi-scale air pollution modelling system by integrating a set of adequate *** system is able to provide detailed air pollutant concentrations in urban areas and support air quality management strategies through a better identification of different atmospheric *** also allows furthering the design and assessment of air pollution control measures for a specific *** evaluate its performance and suitability,the system was applied to the Macao Special Administrative Region(SAR),China,one of the most densely populated areas on earth,during a winter period when this area is affected by high levels of Particulate Matter(PM).Although the developed system tends to underestimate the PM concentrations,it revealed a good performance in reproducing the temporal and spatial air pollution *** exceedances of the Chinese air quality standards were calculated and high population exposure to PM pollution was *** tested urban atmospheric emission reduction scenarios have shown air quality improvements,indicating that emission reduction measures at urban level should focus on the domestic ***,it is crucial to implement joint pollution prevention strategies with neighbouring regions to improve the air quality in Macao *** approach developed in this work can support policymakers in defining new strategies to reduce atmospheric pollution in urban areas.

关键词： Urban areas High-resolution emission inventory Particulate matter Population exposure

Splenic artery ligature associated with endoscopic banding for schistosomal portal hypertension

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World Journal of Gastroenterology 2014年第44期20卷 16734-16738页

作者： Renata Potonyacz Colaneri Fabrício ferreira coelho Roberto de Cleva Marcos Vinícius Perini Paulo Herman Department of Gastroenterology University of S?o Paulo Medical School

AIM: To propose a less invasive surgical treatment for schistosomal portal hypertension.

关键词： Endoscopic banding Esophageal varices Portal hypertension Schistosomiasis Variceal bleeding

Surgical treatment of fibrolamellar hepatocellular carcinoma:an underestimated malignant tumor?

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Hepatobiliary & Pancreatic Diseases International 2014年第6期13卷 618-621页

作者： Paulo Herman Aline Lopes Chagas Marcos Vinicius Perini Fabricio ferreira coelho Gilton Marques Fonseca Venancio Avancini ferreira Alves Flair José Carrilho Ivan Cecconello Digestive Surgery Division Department of GastroenterologyUniversity of Sao Paulo School of MedicineAvenida Doutor Enéas de Carvalho Aguiar255Instituto Central9°andarSala 9074CEP:05403-900Cerqueira Cesar-Sao PauloSPBrazil Digestive Surgery Division Department of GastroenterologyUniversity of Sao Paulo School of MedicineAvenida Doutor Enéas de Carvalho Aguiar255Instituto Central9°andarSala 9074CEP:05403-900Cerqueira Cesar-Sao PauloSPBrazil Department of Pathology University of Sao Paulo School of MedicineAvenida Doutor Enéas de Carvalho Aguiar255Instituto Central9°andarSala 9074CEP:05403-900Cerqueira Cesar-Sao PauloSPBrazil Digestive Surgery Division Department of GastroenterologyUniversity of Sao Paulo School of MedicineAvenida Doutor Enéas de Carvalho Aguiar255Instituto Central9°andarSala 9074CEP:05403-900Cerqueira Cesar-Sao PauloSPBrazil

BACKGROUND： Fibrolamellar hepatocellular carcinoma （FLHCC） is a rare disease with an indolent behavior. Its prognosis is better than that of patients with hepatocellular carcinoma. The authors present their experience with resection of FLHCC. METHODS： Twenty-one patients with FLHCC were treated at our institution between 1990 and 2012. Of these patients, 14 were subjected to resection of the tumor. Patient demographics, medical history, results of imaging studies and laboratory tests, surgical data, and pathologic findings were evaluated. RESULTS： The median age of the patients at the diagnosis of the tumor was 20 years and 14 patients were female. None of the patients had tumor-associated chronic liver disease or cirrhosis. The mean tumor size was 12.8 cm （range 6-19） and 18 patients had a single liver nodule. Fourteen patients were subjected to hepatectomy and six of them had lymph node metastases resected. Pathologic evaluation revealed that 5 （35.7%） patients had major vascular invasion. Tumor recurrence was seen in 8 patients （66.7%）, during a follow-up. The median survival time for patients who were subjected to resection was 36 months. The 5-year overall survival rate and disease free survival rate were 28.0% and 8.5%, respectively. Univariate analysis showed that vascular invasion was the only variable associated with the disease free survival ***： Despite an aggressive treatment, patients with FLHCC presented unexpected low survival rates. It seems that an underestimated malignant behavior is attributed to this disease, and that the forms of adjuvant treatment should be urgently evaluated.

关键词： fibrolamellar hepatocellular carcinoma hepatectomy hepatocellular carcinoma lymph node excision survival