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Instance Segmentation of Characters recognized in Palmyrene Aramaic Inscriptions

Computer Modeling in engineering & Sciences 2024年第9期140卷 2869-2889页

作者： Adéla Hamplová Alexey Lyavdansky tomášNovák Ondrej Svojše David Franc Arnošt Veselý Czech University of Life Sciences in Prague(CULS) Faculty of Economics and ManagementDepartment of Information EngineeringPrague16500Czech Republic National research University Higher School of economics(HSe) Faculty of HumanitiesInstitute for Oriental and Classical StudiesMoscow101000The Russian Federation

this study presents a single-class and multi-class instance segmentation approach applied to ancient Palmyrene inscriptions,employing two state-of-the-art deep learning algorithms,namely YOLOv8 and Roboflow *** goal is to contribute to the preservation and understanding of historical texts,showcasing the potential of modern deep learning methods in archaeological *** research culminates in several key findings and scientific *** comprehensively compare the performance of YOLOv8 and Roboflow 3.0 in the context of Palmyrene character segmentation—this comparative analysis mainly focuses on the strengths and weaknesses of each algorithm in this *** also created and annotated an extensive dataset of Palmyrene inscriptions,a crucial resource for further research in the *** dataset serves for training and evaluating the segmentation *** employ comparative evaluation metrics to quantitatively assess the segmentation results,ensuring the reliability and reproducibility of our findings and we present custom visualization tools for predicted segmentation *** study advances the state of the art in semi-automatic reading of Palmyrene inscriptions and establishes a benchmark for future *** availability of the Palmyrene dataset and the insights into algorithm performance contribute to the broader understanding of historical text analysis.

关键词： Optical character recognition instance segmentation Palmyrene ancient languages computer vision

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energy exchange between charged relativistic fluids in f(t) gravity

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Communications in theoretical Physics 2024年第10期76卷 108-120页

作者： Z Yousaf U A Khokhar Nasser Bin turki t Suzuki department of Mathematics University of the Punjab Quaid-i-Azam Campus department of Mathematics College of Science King Saud University department of regional Management Faculty of Management Fukushima College

this study focuses on the effects of a polytropic fluid on a charged gravitational source within f(t) gravity, where t is the torsion scalar. We investigate how the electromagnetic field affects the flow of energy in spherically symmetric and static celestial objects that contain relativistic fluids. By using the gravitational decoupling technique, we analyze the effects of polytropic fluid on the dynamics of the gravitational source, accompanied by the matching of the interior geometry with an exterior at the hypersurface Σ. Finally, with the help of the tolman ⅡV solution, we observe the conduct of energy conditions with the existence of charge using f(t)field equations and got the intended outcomes.

关键词： anisotropy complexity energy exchange hydrodynamics self-gravitating systems

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top priority current path between SiC particles during ultra-high temperature flash sintering: Presence of PyC “bridges”

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Journal of Advanced Ceramics 2024年第2期13卷 255-262页

作者： le Lu tianlong Liu Zhaofeng Chen Fei Wang Mengmeng Yang Qiong Wu Lixia Yang Huanyong Li International Laboratory for Insulation and energy efficiency Materials College of Materials Science and TechnologyNanjing University of Aeronautics and AstronauticsNanjing 211106China State Key Laboratory of Solidification Processing School of Materials and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China

Flash sintering(FS)is a novel technique for rapidly densifying silicon carbide(SiC)*** work achieved a rapid sintering of SiC ceramics by the utilization of ultra-high temperature flash sintering within 60 *** carbon(PyC)“bridges”were constructed between SiC particles through the carbonisation of phenolic resin,providing a large number of current *** incubation time of the flash sintering process was significantly reduced,and the sintering difference between the centre and the edge regions of the ceramics was minimized,with an average particle size of the centre region and edge region being 12.31 and 9.02μm,*** results showed that the porosity of the SiC ceramics after the flash sintering was reduced to 14.79% with PyC“bridges”introduced,and the Vickers hardness reached 19.62 ***“bridges”gradually evolved from amorphous eddy current carbon to oriented graphite carbon,indicating that the ultra-high temperature environment in which the sample was located during the flash sintering was successfully ***-high temperature flash sintering of SiC is expected to be applied to the local repair of matrix damage in SiC ceramic matrix composites.

关键词： silicon carbide(SiC) flash sintering(FS) pyrolytic carbon(PyC)"bridges" current path instantaneous

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Magnetoresistance hysteresis in the superconducting state of kagome CsV_(3)Sb_(5)

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Chinese Physics B 2024年第10期33卷 30-34页

作者： tian le Jinjin Liu Zhiwei Wang Xiao Lin Institute of Natural Sciences Westlake Institute for Advanced StudyHangzhou 310024China Key Laboratory for Quantum Materials of Zhejiang Province Department of PhysicsSchool of Science and Research Center for Industries of the FutureWestlake UniversityHangzhou 310030China Centre for Quantum Physics Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement(MOE)School of PhysicsBeijing Institute of TechnologyBeijing 100081China Beijing Key Laboratory of Nanophotonics and Ultrafine Optoelectronic Systems Beijing Institute of TechnologyBeijing 100081China Material Science Center Yangtze Delta Region Academy of Beijing Institute of TechnologyJiaxing 314011China

the hysteresis of magnetoresistance observed in superconductors is of great interest due to its potential connectionwith unconventional *** this study,we perform electrical transport measurements on kagome superconductorCsV_(3)Sb_(5)nanoflakes and uncover unusual hysteretic behavior of magnetoresistance in the superconducting *** hysteresis can be induced by applying either a large DC or AC current at temperatures(t)well below the superconductingtransition temperature(t_(c)).As t approaches t_(c),similar weak hysteresis is also detected by applying a *** scenarios are discussed,with particular focus on the effects of vortex pinning and the presence of timereversal-symmtery-breaking superconducting *** findings support the latter,hinting at chiral superconductivityin kagome superconductors.

关键词： hysteresis magnetoresistance kagome superconductor chiral superconductor

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Data-driven analysis of chemicals,proteins and pathways associated with peanut allergy:from molecular networking to biological interpretation

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Food Science and Human Wellness 2024年第3期13卷 1322-1335页

作者： emmanuel Kemmler Julian Braun Florent Fauchère Sabine Dölle-Bierke Kirsten Beyer Robert Preissner Margitta Worm Priyanka Banerjee Institute for Physiology Charité-University Medicine BerlinBerlin 10115Germany Member of the KFO339 FOOD@Berlin 10115Germany Si-M/“der Simulierte Mensch”a science framework of technische Universität Berlin and Charité-Universitätsmedizin Berlin Berlin 10115Germany Charité-Universitätsmedizin Berlin corporate member of Freie Universität BerlinHumboldt-Universität zu Berlinand Berlin Institute of HealthBerlin 10115Germany Division of Allergy and Immunology Department of DermatologyVenerology and AllergyCharité-Universitätsmedizin Berlincorporate member of Freie Universität Berlin and Humboldt-Universität zu BerlinBerlin 10115Germany Pediatrics Campus VirchowCharité-University Medicine BerlinBerlin 10115Germany

Peanut allergy is majorly related to severe food induced allergic *** food including cow's milk,hen's eggs,soy,wheat,peanuts,tree nuts(walnuts,hazelnuts,almonds,cashews,pecans and pistachios),fish and shellfish are responsible for more than 90%of food ***,we provide promising insights using a large-scale data-driven analysis,comparing the mechanistic feature and biological relevance of different ingredients presents in peanuts,tree nuts(walnuts,almonds,cashews,pecans and pistachios)and ***,we have analysed the chemical compositions of peanuts in different processed form raw,boiled and *** the data-driven approach we are able to generate new hypotheses to explain why nuclear receptors like the peroxisome proliferator-activated receptors(PPARs)and its isoform and their interaction with dietary lipids may have significant effect on allergic *** results obtained from this study will direct future experimeantal and clinical studies to understand the role of dietary lipids and PPARisoforms to exert pro-inflammatory or anti-inflammatory functions on cells of the innate immunity and influence antigen presentation to the cells of the adaptive immunity.

关键词： Allergy informatics Knowledge-graph Data analysis Food allergy Peroxisome proliferator-activated receptors Fatty acids

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Postbiotics from Saccharomyces cerevisiae fermentation stabilize microbiota in rumen liquid digesta during grain-based subacute ruminal acidosis(SARA) in lactating dairy cows

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Journal of Animal Science and Biotechnology 2024年第5期15卷 2059-2080页

作者： Junfei Guo Zhengxiao Zhang le Luo Guan Ilkyu Yoon Jan C.Plaizier ehsan Khafipour department of Animal Science University of ManitobaWinnipegMB R3T 2N2Canada Present Address:College of Food and Biological engineering Jimei UniversityXiamenFujian 361021China department of Agriculture Food and Nutrition DepartmentUniversity of AlbertaEdmontonAB T6G 2R3Canada Faculty of Land and Food Systems University of British ColumbiaVancouverBC V6T 1Z4Canada Diamond V Cedar RapidsIA 52404United States Present Address:Cargill Animal Nutrition 15407 McGinty Road WestWayzataMN 55391USA

Background Subacute ruminal acidosis(SARA)is a common metabolic disorder of high yielding dairy cows,and it is associated with dysbiosis of the rumen and gut microbiome and host *** study evaluated the impact of two postbiotics from Saccharomyces cerevisiae fermentation products(SCFP)on rumen liquid associated microbiota of lactating dairy cows subjected to repeated grain-based SARA challenges.A total of 32 rumen cannulated cows were randomly assigned to 4 treatments from 4 weeks before until 12 weeks after *** groups included a Control diet or diets supplemented with postbiotics(SCFPa,14 g/d Original XPC;SCFPb-1X,19 g/d Nutri tek;SCFPb-2X,38 g/d Nutri tek,Diamond V,Cedar Rapids,IA,USA).Grain-based SARA challenges were conducted during week 5(SARA1)and week 8(SARA2)after parturition by replacing 20%DM of the base total mixed ration(tMR)with pellets containing 50%ground barley and 50%ground *** DNA from rumen liquid samples was subjected to V3–V416S r RNA gene amplicon *** of rumen microbiota were compared among treatments and SARA *** Both SARA challenges reduced the diversity and richness of rumen liquid microbiota,altered the overall composition(β-diversity),and its predicted functionality including carbohydrates and amino acids metabolic *** SARA challenges also reduced the number of significant associations among different taxa,number of hub taxa and their composition in the microbial co-occurrence *** with SCFP postbiotics,in particular SCFPb-2X,enhanced the robustness of the rumen *** SCFP supplemented cows had less fluctuation in relative abundances of community members when exposed to SARA *** SCFP supplementation promoted the populations of lactate utilizing and fibrolytic bacteria,including members of Ruminococcaceae and Lachnospiraceae,and also increased the numbers of hub taxa during non-SARA and SARA *** with S

关键词： Postbiotics Rumen microbiota Saccharomyces cerevisiae fermentation products SARA

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CD4^(+)t cells produce IFN-I to license cDC1s for induction of cytotoxic t-cell activity in human tumors

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Cellular & Molecular Immunology 2024年第4期21卷 374-392页

作者： Xin lei Daniël C.de Groot Marij J.P.Welters tom de Wit ellen Schrama Hans van eenennaam Saskia J.Santegoets timo Oosenbrug Annemarthe van der Veen Joris L.Vos Charlotte L.Zuur Noel F.C.C.de Miranda Heinz Jacobs Sjoerd H.van der Burg Jannie Borst Yanling Xiao department of Immunology Leiden University Medical CenterLeidenThe Netherlands Oncode Institute Leiden University Medical CenterLeidenThe Netherlands department of tumor Biology and Immunology The Netherlands Cancer InstituteAmsterdamThe Netherlands department of Medical Oncology Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands IMMIOS B.V. OssThe Netherlands Division of Medical Oncology The Netherlands Cancer InstituteAmsterdamThe Netherlands department of Otorhinolaryngology leiden University Medical Center LeidenThe Netherlands department of Pathology Leiden University Medical CenterLeidenThe Netherlands

CD4^(+)t cells can"help"or"license" conventional type 1 dendritic cells(cDC1s)to induce CD8^(+)cytotoxic t lymphocyte(CtL)anticancer responses,as proven in mouse *** recently identified cDC1s with a transcriptomic imprint of CD4^(+)t-cell help,specifically in t-cell-infiltrated human cancers,and these cells were associated with a good prognosis and response to PD-1-targeting ***,we delineate the mechanism of cDC1 licensing by CD4^(+)t cells in *** CD4^(+)t cells produce IFNβvia the StING pathway,which promotes MHC-I antigen(cross-)presentation by cDC1s and thereby improves their ability to induce CtL anticancer *** cooperation with CD40 ligand(L),IFNβalso optimizes the costimulatory and other functions of cDC1s required for CtL response ***-I-producing CD4^(+)t cells are present in diverse t-cell-infiltrated cancers and likely deliver“help”signals to CtLs locally,according to their transcriptomic profile and colocalization with“helped/licensed”cDCs and tumor-reactive CD8^(+)t *** agreement with this scenario,the presence of IFN-I-producing CD4^(+)t cells in the tMe is associated with overall survival and the response to PD-1 checkpoint blockade in cancer patients.

关键词： CD4^(+)t-cell help cDC1 licensing IFN-I signaling CD40 costimulation (cross-)presentation CtL priming tumor control

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Mental retardation,seizures and language delay caused by new SetD1B mutations:three case reports

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World Journal of Clinical Cases 2024年第2期12卷 383-391页

作者： le Ding Li-Wan Wei tai-Song Li Jing Chen department of Neurology Children’s Hospital of Nanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina Chigene(Beijing)translational Medical research Center Co.Ltd.Beijing 101111China

BACKGROUND the SetD1B gene is instrumental in human intelligence and nerve *** in the SetD1B gene have been linked in recent studies to neurodevelopmental disorders,seizures,and language *** SUMMARY this study aimed to analyze the clinical manifestations and treatment of three patients suffering from mental retardation,epilepsy,and language delay resulting from a new mutation in the SetD1B *** individuals with these symptoms were selected,and their clinical symptoms,gene test results,and treatment were *** article discusses the impact of the SetD1B gene mutation on patients and outlines the treatment *** the three patients(two females and one male,aged 8,4,and 1,respectively),all exhibited psychomotor retardation,attention deficit,and hyperactivity disorder,and two had *** treatment with sodium tripolyvalproate halted the seizures in the affected child,although mental development remained somewhat *** exome sequencing revealed new mutations in the SetD1B gene for all patients,specifically with c.5473C>t(***1825trp),c.4120C>t(***1374*,593),c.14_15insC(***5Hisfs*33).CONCLUSION Possessing the SetD1B gene mutation may cause mental retardation accompanied by seizures and language *** the exact mechanism is not fully understood,interventions such as drug therapy,rehabilitation training,and family support can assist patients in managing their symptoms and enhancing their quality of ***,genetic testing supplies healthcare providers with more precise diagnostic and therapeutic guidance,informs families about genetic disease risks,and contributes to understanding disease pathogenesis and drug research and development.

关键词： Neurodevelopmental disorder Seizure SetD1B gene Whole-exome sequencing New mutation Case report

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Paper Analytical device for the Colourimetric detection of Alkaline Phosphatase in Serum and Saliva

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Journal of Analysis and testing 2024年第3期8卷 385-394页

作者： D.Alageswari A.Lakshmidevi P.e.resmi P.V.Suneesh AarathiPradeep t.G.SatheeshBabu department of Chemistry Amrita School of Physical Sciences Coimbatore Amrita Vishwa Vidyapeetham Amrita Biosensor research Lab Amrita School of Engineering Coimbatore Amrita Vishwa Vidyapeetham Amrita Biomedical engineering Centre Amrita School of Engineering Coimbatore Amrita Vishwa Vidyapeetham

A paper analytical device (PAD) was developed for the colourimetric estimation of alkaline phosphatase (ALP). ALP catalyzes the hydrolysis of disodium phenyl phosphate (DSPP) to phenol, which then undergoes oxidative coupling with4-aminoantipyrine (4-AAP) producing a reddish brown-coloured quinone imine. the colourimetric reaction tested in solution has been translated onto a PAD for the point of care (PoC) testing of ALP. A uniform colour was obtained in 25 min with the introduction of ALP onto the reagent drop cast paper device. the images obtained by scanning the PAD were processed using ImageJ software. the colour intensity obtained by image processing was proportional to the concentration of ALP present in the sample. ALP in serum and saliva samples were tested using the PAD in the range of 0 to 528 U/L and0 to 187 U/L, respectively. the interference studies revealed that the PAD was selective to ALP in the presence of other biomolecules. the PAD exhibited a limit of detection (LOD) of 3.3 U/L and a sensitivity of 48.36 a.u/Log(U/L) for serum ALP and LOD of 1.69 U/L and a sensitivity of 28.5 a.u/Log (U/L) for salivary ALP. the PAD showed good agreement with the clinical methods for real samples.

关键词： Alkaline phosphatase Colourimetry ImageJ Paper analytical device Point of care testing

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development and characterization of 3D-printed electroconductive pHeMA-co-MAA NP-laden hydrogels for tissue engineering

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Bio-design and Manufacturing 2024年第3期7卷 262-276页

作者： Sara de Nitto Aleksandra Serafin Alexandra Karadimou Achim Schmalenberger John J.eMulvihill Maurice N.Collins DIBRIS Polytechnic Inter-School Section University of Genoa16126 GenoaItaly School of engineering Bernal InstituteUniversity of LimerickLimerick V94 T9PXIreland School of Natural Sciences Department of Biological SciencesUniversity of LimerickLimerick V94 T9PXIreland Health research Institute University of LimerickLimerick V94 T9PXIreland AMBeR University of LimerickLimerick V94 T9PXIreland

tissue engineering(te)continues to be widely explored as a potential solution to meet critical clinical needs for diseased tissue replacement and tissue *** this study,we developed a poly(2-hydroxyethyl methacrylate-co-methacrylic acid)(pHeMA-co-MAA)based hydrogel loaded with newly synthesized conductive poly(3,4-ethylene-dioxythiophene)(PeDOt)and polypyrrole(PPy)nanoparticles(NPs),and subsequently processed these hydrogels into tissue engineered constructs via three-dimensional(3D)*** presence of the NPs was critical as they altered the rheological properties during ***,all samples exhibited suitable shear thinning properties,allowing for the development of an optimized processing window for 3D *** were 3D printed into pre-determined disk-shaped configurations of 2 and 10 mm in height and diameter,*** observed that the NPs disrupted the gel crosslinking efficiencies,leading to shorter degradation times and compressive mechanical properties ranging between 450 and 550 *** conductivity of the printed hydrogels increased along with the NP concentration to(5.10±0.37)×10^(−7)S/*** vitro studies with cortical astrocyte cell cultures demonstrated that exposure to the pHeMA-co-MAA NP hydrogels yielded high cellular viability and proliferation ***,hydrogel antimicrobial studies with staphylococcus epidermidis bacteria revealed that the developed hydrogels affected bacterial *** together,these materials show promise for various te strategies.

关键词： Conductive nanoparticles Hydroxyethyl methacrylate(HeMA) Ultraviolet(UV)polymerization 3D printing

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