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Saudi Consensus for GLP-1 RAs Switching Guidance: Consensus Report

International Journal of Clinical Medicine 2022年第1期13卷 22-35页

作者： Saud Alsifri Hussein Elbadawi Fahad Alsabaan Abdulraouf Almahfouz Khalid Alyahya Eman Shesha Laila Abu Esba Meshal Alnais raed Aldahash Turky Alharbi Saleh Aljaser Emad R. Issak Endocrinology Department Alhada & Taif Armed Forces Hospitals Taif Saudi Arabia My Clinic Medical Center Jeddah Saudi Arabia Endocrinology Department Security Forces Hospital Riyadh Saudi Arabia Section of Endocrinology Department of Medicine The King Faisal Specialist Hospital and Research Centre Riyadh Saudi Arabia Pharmacy Department Prince Sultan Military Medical City Riyadh Saudi Arabia Diabetes Center King Salman Hospital Riyadh Saudi Arabia King Abdulaziz Medical City Riyadh Saudi Arabia Internal Medicine and Diabetes King Khalid Hospital Hail Saudi Arabia Department of Medicine King Abdulaziz Medical City National Guard Riyadh Saudi Arabia Family Medicine Department Prince Sultan Military Medical City Riyadh Saudi Arabia King Saud bin Abdulaziz University for Health Science Riyadh Saudi Arabia Medicine Department Faculty of Medicine Ain-Shams University Cairo Egypt

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) provide adequate glycemic control, weight reduction, low risk of hypoglycemia, and CV risk reduction. Their usage for type 2 DM (T2DM) is recommended mainly when hypoglycemia or weight gain should be considered, also, whenever initial therapy is failed. There are many recent updates in the treatment paradigm of T2DM. There are many types of GLP-1RAs, with a knowledge gap regarding switching between the different types. A Saudi task force gathered to develop an explicit, evidence-based consensus for switching between GLP-1RAs, when, why, and how? This article contains the expert panel’s recommendations as a contribution to complement the knowledge gap in this area from the national perspective. As an alternative to intensifying therapy, switching from one GLP-1RA to another has various advantages. Improvements in glycemic control, weight loss, adherence, and medications with established cardiovascular benefits are among them. Also, switching needs to be individualized upon many discussed factors like the dose of the previous GLP1-RA and gastrointestinal adverse effects. Discussion with patients about the why and how to switch is critical.

关键词： Glucagon-Like Peptide-1 Receptor Agonists Switching Type 2 DM Glycemic Control

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Nitric oxide synthase in the human airway epithelium

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Acta Pharmacologica Sinica 1997年第6期 70-72页

作者： raed A DWEIK1, Fuhua H GUO1,2, Kohsaku UETANI1,2, Serpil C ERZURUM1,2\ (1Departments of Pulmonary and Critical Care Medicine, and\ 2Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195,

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关键词： synthase the epithelium human oxide Nitric airway

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The Use of Standardized Reporting and Time-in-Range in the Management of Diabetes: A Consensus Report

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International Journal of Clinical Medicine 2021年第8期12卷 316-327页

作者： Saud Al Sifri Adnan Alshaikh Bassam Bin-Abbas Eman Sheshah Fahad Al Sabaan Mohammed Al-Dawish Mohammed Al-Dubayee Naweed Al-Zaman raed A. Al-Dahash Saad Alzahrani Emad R. Issak Endocrinology and Diabetes Department Alhada and Taif Armed Forces Hospitals Taif Saudi Arabia Pediatrics Department King Abdulaziz Medical City—Ministry of National Guard Health Affairs King Khalid National Guard Hospital Jeddah Saudi Arabia Pediatrics Department King Faisal Specialist Hospital and Research Center Riyadh Saudi Arabia Endocrinology Department King Salman hospital Riyadh Saudi Arabia Endocrinology Department Security forces hospital program Riyadh Saudi Arabia Endocrinology Department Prince Sultan Military Medical City (PSMMC) Riyadh Saudi Arabia Pediatrics Department Ministry of National Guard Health Affairs-Riyadh Riyadh Saudi Arabia Endocrinology Department Taibah University Madina Saudi Arabia Internal Medicine Department King Abdulaziz Medical City—National Guard Riyadh Saudi Arabia Endocrinology Department Medical Director OEMC King Fahad Medical City Riyadh Saudi Arabia Internal Medicine Department Faculty of Medicine Ain-Shams University Cairo Egypt

Introduction: The exhaustion of healthcare resources due to the rising prevalence in Saudi Arabia mandates the search for each method that can help in better control of diabetes. Methods: The gathered task force gath-ered to develop an explicit, evidence-based consensus for the use of time-in-range targets as guidance for better glycemic control while using continuous glucose monitoring (CGM). This article has the recommenda-tions of this expert panel. Results: HbA1c and self-monitoring blood glu-cose (SMBG) are not enough to detect blood glucose (BG) fluctuations on a daily basis. The incorporation of technology like FreeStyle Libre with its applications like Libre View is now used in many institutes in Saudi Ara-bia. This system is comprehensive and has all the standardized metrics needed. However, training and support are always needed. Barriers and challenges include the awareness & experience of the technology, the time barrier, the patients’ barriers, the technical barriers, and of course, the availability barrier. All the barriers and challenges should be dealt with by designing new training programs. Conclusion: The expert panel recom-mended using CGMs technology in people with type 1 diabetes (T1DM) children and adults, type 2 diabetes (T2DM) on multiple insulin injections, gestational diabetes (GDM) who need further glycemic control, and those at high risk for hypoglycemia. In addition, we recommend using them for a short period for those who require intensive BG control or during acute illness or stress. In addition, Ambulatory Glucose Profile (AGP) could be used as an educational tool for any individuals with DM to study the im-pact of certain elements of lifestyle modifications on their immediate BG level.

关键词： Diabetes Time in Range Glycemic Control HbA1c

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Saudi Arabia, Breast Plastic Surgery, Breast Construction

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Modern Plastic Surgery 2017年第4期7卷 50-64页

作者： Bassam Ahmed ALmutlaq Mohammad Al-Qattan raed Dawood Almansour Awad Nafel Al Harbi Ali Dawood Almansour Omar Abdullah AL-Noqaidan Abdul Rahman Ali Al-Sogair Abdullah Abdulaziz Bin Jariyd Hussain Gadelkarim Ahmed College of Medicine University of Hail Hail KSA Head Division of Plastic Surgery Head of Research Centre College of Medicine King Saud University Riyadh KSA Faculty of Medicine Al Imam Mohammad Ibn Saud Islamic University Riyadh KSA

In this review article, various preferences in breast plastic surgery particularly after breast cancer will be discussed in view of the diverse indications for the different construction procedures. The various conditions that necessitate the need for reconstruction are appraised, the important reconstructive procedures are discussed. The most important indications procedures discussed in this review include;Prophylactic subcutaneous mastectomy, Lumpectomy and Radiation, Modified Mastectomy with Axillary Sampling, Nipple reconstruction, and the contralateral breast. These procedures are discussed in view of plastic surgeon practice and patients acceptability in Saudi Arabia. Data from Saudi Arabia in particular was identified through searches of the EMBASE, and MEDLINE database, using the keywords: Saudi Arabia, breast plastic Surgery, breast reconstruction, autologous breast reconstruction, breast augmentation. Advances in prosthetic technologies and modifications in autologous flap techniques, and the development of novel tissue alternatives have allowed for sustained developments in breast reconstruction results. A variety of attitudes has been accessible for addressing the difficulties that endure after resection of breast cancer in Saudi Arabia. Patients should be educated to accept different process in this context.

关键词： Options in Breast Reconstruction and Plastic Surgery in Regard to Surgeon Perceptions and Patients Acceptance in Saudi Arabia

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Synthesis and Characterization of Polyurethane/POT Dopant and Study Its Electrical Properties

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材料科学与工程（中英文A版） 2015年第11期5卷 391-397页

作者： raed Kadhum Fakher Alfahed K. I. Ajeel Salah Shakir Physics Department College of Education for Pure Science University of Basrah Basrah- 61004 Iraq College of Science Basrah University Basrah- 61004 Iraq

The Toluene 2, 4-diisocyanate (TDI) (C9 H6 N? O?) and polyethylene glycol (PEG) [H(OCH?CH?)? OH] were used to prepare the poly urethane (PU), and then it is doped by different weight ratios of poly (o-toluidine) as (20%, 30%, and 50% w/w). The current-voltage (I-V) characterization of prepared thin films (deposited by spin coating method) showed ohmic behavior and the electrical conductivity increased with respect to increasing the ratio of dopant and all samples reflect a semi-conductor material.

关键词： Toluene 2, 4-diisocyanate (TDI) polyethylene glycol (PEG) poly (o-Toluidine) (POT) electrical conductivity

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Treating extended stage IV ischial pressure ulcer in patient with spinal cord injury utilizing a multidisciplinary approach:a case report

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Clinical Research Communications 2023年第2期6卷 28-32页

作者： Rami Abu Anza Osama Alshana Hafez Abu Khousa raed Rubaei Rasha Aqeel Burn and Plastic Unit Nasser Medical ComplexKhan Younis P9439028Palestine Department of Physiotherapy Nasser Medical ComplexKhan Younis P9439028Palestine Department of Rehabilitation Science University College of Applied SciencesGaza Strip P9439028Palestine Plastic Surgery Al-Awda HospitalNorth Gaza Strip P8178548Palestine Department of Orthopedic Al-Aqsa Martyrs HospitalGaza Strip P9025263Palestine Médecins Sans Frontières Gaza Strip P8524000Palestine.

Background:Pressure ulcers are one of the most common and dangerous sequelae of spinal cord *** ulcers treatment represents one of the most challenging clinical problems faced by ***:This report examines a case of complicated stage-4 pressure ulcers in a young adult who had gunshot injury in his spine above T-11 level treated following a multidisciplinary approach.A multidisciplinary team formulated a multifaceted program that includes meticulous pressure relief program,wound care and flap reconstructive surgery,osteomyelitis treatment,nutrition optimization,post-operative physiotherapy,patient education,and psychological support,that recruited for this patient over the course of his stay at our ***:During the third day postoperatively showed good blood circulation without necrosis or hematoma and site of ulcer completely has ***:Implementation of a multidisciplinary approach was key to optimizing surgical outcomes in spinal cord injury patients who have pressure sores,achieving a low recurrence rate and reducing readmissions.

关键词： pressure ulcer multidisciplinary team spinal cord injury ischial ulcer grade IV management

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Performance Assessment of Mobile OFDM-based Systems： Variability within Given Wideband Channel Categories

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通讯和计算机（中英文版） 2010年第7期7卷 64-74页

作者： Khalid G. Samarah Steve M.R. Jones raed A. Abd-Alhameed Electrical Engineering Department Mutah University Al-Ramtha P.O. Box 354 Jordan Mobile and Satellite Communications Research Centre Bradford University West Yorkshire BD7 1DP UK

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Clinical Practice Guideline for the Management of Overweight and Obesity in Adults in Saudi Arabia

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International Journal of Clinical Medicine 2022年第12期13卷 590-649页

作者： Abdulrahman Alshaikh Ahmed Aljedai Assim Alfadda Abdulrahman Alrobayan Abdulwahab Bawahab Shaza Abou Ouf Ali Sultan Amani Alhozali Mohammed Bawazeer Eman Sheshah Fahad Alqahtani Hala Mosli Hussein Elbadawi Khaled Alamri Khalid Alshali Mohammed Aldawish Mohammed Alsofiani raed Aldahash Rasha Alfawaz Reem Alamoudi Wessam Jamal Hajer Almudaiheem Emad R. Issak Saud Alsifri King Abdulaziz University Hospital Jeddah Saudi Arabia Ministry of Health Riyadh Saudi Arabia King Saud University Medical City Riyadh Saudi Arabia Prince Sultan Military Medical City Riyadh Saudi Arabia King Fahad General Hospital Jeddah Saudi Arabia International Medical Center Jeddah Saudi Arabia King Salman Hospital Riyadh Saudi Arabia King Fahad Medical Center Riyadh Saudi Arabia My Clinic Medical Center Jeddah Saudi Arabia King Abdulaziz Medical City Riyadh Saudi Arabia Saudi Centre for Disease Prevention and Control Riyadh Saudi Arabia Aslam Center Cairo Egypt Al Hada Armed Forces Hospital Taif Saudi Arabia

Obesity and overweight are prevalent in Saudi Arabia (24.95% & 31.80%). Also, childhood obesity in the country is a challenge, with 6% - 10% of preschool and school-age children. The burden of being overweight and obese is disastrous. Therefore, the Saudi Diabetes Scientific Society constituted a team to develop a guideline. The team reviewed the local Clinical Practice Guidelines for the Prevention and Management of Obesity in Saudi Arabia;and conducted a rigorous review of relevant evidence-based scientific literature. After a thorough assessment, a consensus was reached to use the Australian guideline as the main guideline to be adapted and localized to be suitable for the Saudi people. To avoid duplication of efforts, the team adopted the grading of evidence used by the Australian guideline. The updated version was presented in a workshop, and the recommendation of the participants was included. The final draft was distributed for review, and comments were included. This document presents the result of such an effort as a local guideline.

关键词： Obesity Overweight Disease Burden Management Guideline Saudi Arabia

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