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Dietary habits, lifestyle factors and neurodegenerative diseases

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Neural Regeneration Research 2020年第3期15卷 394-400页

作者： Aurel popa-Wagner Dinu Iuliu Dumitrascu bogdan Capitanescu Eugen bogdan Petcu Roxana Surugiu Wen-Hui Fang Danut-Adrian Dumbrava Griffith University School of Medicine Gold Coast CampusQLDAustralia Department of Anatomy UMF“Iuliu Hatieganu”Cluj-NapocaRomania Department of Human Anatomy Faculty of MedicineUniversity of Medicine and PharmacyCraiovaRomania Center of Clinical and Experimental Medicine University of Medicine and PharmacyCraiovaRomania School of Healthcare Science Faculty of Science and EngineeringManchester Metropolitan UniversityManchesterUK

Worldwide stroke is increasing in parallel with modernization,changes in lifestyle,and the growing elderly *** review is focused on the link between diet,as part of‘modern lifestyle’,and health in the context of genetic predisposition of individuals to‘unhealthy’metabolic pathway *** is concluded that lifestyle including high sugar diets,alcohol and tobacco addiction or high fat diets as well as ageing,brain injury,oxidative stress and neuroinflammation,negatively influence the onset,severity and duration of neurodegenerative ***,there are several healthy dietary components such as polyunsaturated fatty acids and the anti-oxidants curcumin,resveratrol,blueberry polyphenols,sulphoraphane,salvionic acid as well as caloric restriction and physical activity,which may counteract ageing and associated neurodegenerative diseases via increased autophagy or increased neurogenesis in the adult brain.

关键词： brain injury dietary habits lifestyle metaflammation neurodegeneration oxidative stress type 2 diabetes mellitus

Neuroinflammation and comorbidities are frequently ignored factors in CNS pathology

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Neural Regeneration Research 2015年第9期10卷 1349-1355页

作者： Raluca Elena Sandu Ana Maria Buga Adriana Uzoni Eugen bogdan Petcu Aurel popa-Wagner Center of Clinical and Experimental Research University of Medicine and Pharmacy Craiova Department of Psychiatry University of Medicine Rostock Biochemistry Department University of Medicine and Pharmacy "Victor Babes" Timisoara Griffith University School of Medicine Regenerative Medicine Centre

Virtually all drug interventions that have been successful pre-clinically in experimental stroke have failed to prove their efficacy in a dinical setting. This could be partly explained by the complexity and heterogeneity of human diseases as well as the associated co-morbidities which may render neuroprotective drugs less efficacious in dinical practice. One aspect of crucial importance in the physiopathology of stroke which is not completely understood is neuroinflammation. At the pres- ent time, it is becoming evident that subtle, but continuous neuroinflammation can provide the ground for disorders such as cerebral small vessel disease. Moreover, advanced aging and a number of highly prevalent risk factors such as obesity, hypertension, diabetes and atherosclerosis could act as ＂silent contributors＂ promoting a chronic proinflammatory state. This could aggravate the out- come of various pathological entities and can contribute to a number of subsequent post-stroke complications such as dementia, depression and neurodegeneration creating a pathological vicious cycle. Moreover, recent data suggests that the inflammatory process might be dosely linked with multiple neurodegenerative pathways related to depression. In addition, pro-inflammatory cyto- kines could play a central role in the pathophysiology of both depression and dementia.

关键词： aging stroke neuroinflammation comorbidities depression dementia

Extrapancreatic necrosis volume:A new tool in acute pancreatitis severity assessment?

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World Journal of Clinical Cases 2021年第31期9卷 9395-9405页

作者： bogdan Cucuteanu DragoşNegru Otilia Gavrilescu Iolanda Valentina popa Mariana Floria Cătălina Mihai Cristina Cijevschi Prelipcean Mihaela Dranga Department of Radiology “Grigore T.Popa”University of Medicine and Pharmacy“Saint Spiridon”HospitalIaşi City 700115Romania Department of Gastroenterology “Grigore T.Popa”University of Medicine and Pharmacy“Saint Spiridon”HospitalIaşi City 700115Romania Department of Gastroenterology “Grigore T.Popa”University of Medicine and PharmacyIaşi City 700115Romania Department of Internal Medicine “Grigore T.Popa”University of Medicine and PharmacyIaşi City 700115Romania

BACKGROUND Many scores have been suggested to assess the severity of acute pancreatitis upon *** extrapancreatic necrosis volume is a novel,promising score that appears to be superior to other scores investigated so *** To evaluate the discriminatory power of extrapancreatic necrosis volume to identify severe cases of acute *** A total of 123 patients diagnosed with acute pancreatitis at Institute of Gastroenterology and Hepatology,St Spiridon Hospital between January 1,2017 and December 31,2019 were analyzed *** was classified according to the revised Atlanta classification(rAC)as mild,moderate,or *** was also evaluated by computed tomography and classified according to the computed tomography severity index(CTSI)and the modified CTSI(mCTSI).The results were compared with the extrapancreatic volume necrosis to establish the sensitivity and specificity of each *** The CTSI and mCTSI imaging scores and the extrapancreatic necrosis volume were highly correlated with the severity of pancreatitis estimated by the rAC(r=0.926,P<0.001 and r=0.950,P<0.001;r=0.784,P<0.001,respectively).The correlation of C-reactive protein with severity was positive but not as strong,and was not significant(r=0.133,P=0.154).The best predictor for the assessment of severe pancreatitis was the extrapancreatic necrosis volume[area under the curve(AUC)=0.993;95%confidence interval(CI):0.981-1.005],with a 99.5%sensitivity and 99.0%specificity at a cutoff value of 167 mL,followed by the mCTSI 2007 score(AUC=0.972;95%CI:0.946-0.999),with a 98.0%sensitivity and 96.5%specificity,and the CTSI 1990 score(AUC=0.969;95%CI:0.941-0.998),with a 97.0%sensitivity and 95.0%*** Radiological severity scores correlate strongly and positively with disease *** necrosis volume shows the best diagnostic accuracy for severe cases.

关键词： Acute pancreatitis Extrapancreatic necrosis volume Computed tomography index Modified computed tomography index C-reactive protein Severity score

Perception and Attitude of the General Population on the Risk of Infection with SARS-CoV-2

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Journal of Biosciences and Medicines 2021年第6期9卷 1-10页

作者： Cristian Cojocaru Elena Cojocaru Steluta radu bogdan Gurzu Medical III Department Faculty of Medicine “Grigore T. Popa” University of Medicine and Pharmacy Iasi Romania Morpho-Functional Sciences II Department Faculty of Medicine “Grigore T. Popa” University of Medicine and Pharmacy Iasi Romania Netconsult SRL Iasi Romania University of Agriculture Science and Veterinary Medicine Iasi Romania

Current state of knowledge on the impact of emotions and perceptions of the population towards the risk of infection with the SARS-CoV-2 should be the basis for disease control measures as well as for community awareness programs. Due to differences in perceptions, concerns, culture, beliefs, different populations may react differently to the same challenges. Ninety adults were interviewed, without symptoms suggestive of SARS-CoV-2 infection, using the Romanian version of the Fear of COVID-19 Scale. The emotional reactions expressed by various psychotic or mental disorders, the main actions are taken to protect against the SARS-CoV-2 infection, as well as the hypothetical illness behavior were investigated. The total score, as well as each item of the Fear of COVID-19 Scale, indicates a low-to-moderate emotional level regarding to the risk of coronavirus infection. The data are supported by the choice to be treated at home in case of illness. There are differences in perception between sexes and between professional categories (employees vs. retirees). Knowledge of social phenomena caused by major epidemiological crises such as SARS-CoV-2 infection should be the basis of education, disease prevention and control programs to avoid the occurrence of psychosocial risks in the population.

关键词： SARS-COV-2 Fear of COVID-19 Scale Psychosocial Risk Comorbidities Treatment

Oxaliplatin-induced neuropathy and colo-rectal cancer patient's quality of life:Practical lessons from a prospective cross-sectional,real-world study

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World Journal of Clinical Cases 2022年第10期10卷 3101-3112页

作者： Iulian Prutianu Teodora Alexa-Stratulat Elena Octaviana Cristea Andrei Nicolau Diana Cornelia Moisuc Alina Alexandra Covrig Karina Ivanov Adina Emilia Croitoru Monica Ionela Miron Mihaela Ioana Dinu Anca Viorica Ivanov Mihai Vasile Marinca Iulian radu bogdan Gafton SC MNT Healthcare Europe SRL Iasi 700021Romania University of Medicine and Pharmacy Grigore T popa Iasi Iasi 700483Romania Regional Oncology Institute Iasi Iasi 700483Romania Oral and Maxillo-facial Surgery University of Medicine and Pharmacy Grigore T Popa IasiIasi 700021Romania Department of Medical Oncology Fundeni Clinical InstituteBucuresti 022328Romania University of Medicine and Pharmacy“Grigore T popa” Iasi 700021Romania Department of Surgery Department of Surgical OncologyUniversity of Medicine and Pharmacy“Grigore T Popa”Regional Institute of OncologyIasi 700021Romania

BACKGROUND Colon cancer is one the most common forms of cancer in both *** to important progress in the field of early detection and effective treatment,colon and rectal cancer survivors currently account for 10%of cancer survivors ***,the effects of anti-cancer treatments,especially oxaliplatinbased chemotherapy,on the quality of life(QoL)have been less *** the incidence of severe chemotherapy-induced neuropathy(CIPN)in clinical studies is below 20%,data from real-world studies is scarce,and CIPN is probably under-reported due to patient selection and the patients’fear that reporting side-effects might lead to treatment *** To determine the impact of CIPN on QoL in colorectal cancer patients with a recent history of oxaliplatin-based *** We performed a prospective cross-sectional study in two major Romanian oncology tertiary hospitals—the Regional Institute of Oncology Ia?i(Iasi,Romania)and the Fundeni Clinical Oncology Institute(Bucharest,Romania).All consecutive patients with colon or rectal cancer,undergoing Oxaliplatin-based chemotherapy that consented to enroll in the study,were assessed by means of two questionnaires—the EORTC QQ-CR29(quality of life in colon and rectal cancer patients)and the QLQ-CIPN20(assessment of neuropathy).Several demographical,social,clinical and treatment data were also *** analysis was performed by means of SPSS *** student t test was used to assess the relationship between the QLQ-CIPN20 and QLQ-CR29 *** Meyer-curves were used to report 3-year progression-free survival(PFS)in patients that discontinued chemotherapy vs those that completed the recommended *** Of the 267 patients that fulfilled the inclusion criteria in the pre-specified time frame,101(37.8%)agreed to participate in the clinical *** the time of the enrolment in the study,over 50%of the patients had recently interrupted their oxaliplatin-based chemotherapy,mo

关键词： Colorectal cancer Oxaliplatin Neuropathy Quality of Life Recurrence-free survival Cross-sectional study

Modulation Possibilities of the Tissue Wettability, Marker of the Physical Modifications Produced by Senescence versus Photo Senescence at Tegument Level

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Journal of Biomedical Science and Engineering 2014年第13期7卷 1049-1055页

作者： Laurentiu Badescu Carmen Elena Cotrutz Raoul Lupusoru bogdan-Mihail Diaconescu Manuela Ciocoiu Magda Badescu Department of Cell and Molecular Biology University of Medicine and Pharmacy “Grigore T. Popa” Iasi Romania Department of Pathophysiology University of Medicine and Pharmacy “Grigore T. Popa” Iasi Romania Department of Pathophysiology University of Medicine and Pharmacy “Grigore T. Popa” Iasi Romania

We used an experimental model involving white Westar rats (young and old) who were subjected to precise doses of ultraviolet radiation (UV). The experiment aims to examine the influence of epidermis potential protection factors in photo senescence versus senescence. We have studied the in vivo effect of some natural polyphones extracted from black grapes seeds and zinc aspartate and in vitro effect of AED (deuterium depleted water). The substances were administered by intragastric gavages, at two days intervals for two weeks prior to UV irradiation and during the entire period of the experiment (28 days). In the end, we determined the degree of hydrophilicity of the skin, in vitro, by measuring the contact angle value, which was inversely proportional to the hydrophilicity of the tissue (the angle formed at the contact between a liquid and a solid surface). Using this method we found a large variability depending on the hydrophilicity of the epidermis (abdomen and back), the age of the animal and UV/non UV irradiation. The maintenance of the epidermis fragments in AED (for 6 hours) increased significantly the tissue wet ability degree both in the young rats subject to UV and in the senescent ones subject to UV (photo senescence).

关键词： Skin Photoimmunology Phototherapy