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Obesity and weight loss could alter the properties of adipose stem cells?

World Journal of Stem Cells 2015年第1期7卷 165-173页

作者： Leandra S Baptista Karina R Silva radovan borojevic Laboratorio de bioengenharia de tecidos Instituto Nacional de Metrologia Qualidade e Tecnologia (Inmetro) Duque de Caxias 25250-020 Brazil Nucleo Multidisciplinar de Pesquisa em Xerem (Numpex-Bio) Universidade Federal do Rio de Janeiro (UFRJ) Campus de Xerem Rio de Janeiro 21941-590 Brazil Programa de Pos-graduacao em Clinica Medica Universidade Federal do Rio de Janeiro (UFRJ) Hospital Universitario Clementino Fraga Filho (HUCFF) Rio de Janeiro 21941-590 Brazil

The discovery that adipose tissue represents an interesting source of multipotent stem cells has led to many studies exploring the clinical potential of these cells in cell-based therapies. Recent advances in understanding the secretory capacity of adipose tissue and the role of adipokines in the development of obesity and associated disorders have added a new dimension to the study of adipose tissue biology in normal and diseased states. Subcutaneous adipose tissue forms the interface between the clinical application of regenerative medicine and the establishment of the pathological condition of obesity. These two facets of adipose tissue should be understood as potentially related phenomena. Because of the functional characteristics of adipose stem cells, these cells represent a fundamental tool for understanding how these two facets are interconnected and could be important for therapeutic applications. In fact, adipose tissue stem cells have multiple functions in obesity related to adipogenic, angiogenic and secretory capacities. In addition, we have also previously described a predominance of larger blood vessels and an adipogenic memory in the subcutaneous adipose tissue after massive weight loss subsequent to bariatric surgery(ex-obese patients). Understanding the reversibility of the behavior of adipose stem cells in obeses and in weight loss is relevant to both physiological studies and the potential use of these cells in regenerative medicine.

关键词： Adipose stem cells Subcutaneousadipose tissue Obesity Weight loss Regenerative medicine

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