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Cerebral small vessel disease modifies outcomes after minimally invasive surgery for intracerebral haemorrhage

Stroke & Vascular Neurology 2024年第4期9卷 446-456,I0147页

作者： Yunke Li Sung-Min Cho radhika avadhani Hassan Ali Yi Hao Santosh B Murthy Joshua N Goldstein Fan Xia Xin Hu Natalie L Ullman Issam Awad Daniel Hanley Wendy C Ziai The George Institute for Global Health BeijingChina Department of Neurology Division of Neurocritical CareJohns Hopkins Medical InstitutionsBaltimoreMarylandUSA Department of Neurology Division of Brain Injury OutcomesJohns Hopkins Medical Institutions CampusBaltimoreMarylandUSA Department of Neurology Weill Cornell Medical CollegeNew YorkNew YorkUSA Department of Emergency Medicine Massachusetts General HospitalBostonMassachusettsUSA Department of Neurosurgery West China Hospital of MedicineChengduSichuanChina Department of Neurosurgery University of Chicago Pritzker School of MedicineChicagoIllinoisUSA

Background Minimally invasive surgery(MIS)for spontaneous supratentorial intracerebral haemorrhage(ICH)is controversial but may be beneficial if end-of-treatment(EOT)haematoma volume is reduced to≤15 *** explored whether MRI findings of cerebral small vessel disease(CSVD)modify the effect of MIS on long-term *** Prespecified blinded subgroup analysis of 288 subjects with qualified imaging sequences from the phase 3 Minimally Invasive Surgery Plus Alteplase for Intracerebral Haemorrhage Evacuation(MISTIE)*** tested for heterogeneity in the effects of MIS and MIS+EOT volume≤15 mL on the trial’s primary outcome of good versus poor function at 1 year by the presence of single CSVD features and CSVD scores using multivariable *** Of 499 patients enrolled in MISTIE III,288 patients had MRI,149(51.7%)randomised to MIS and 139(48.3%)to standard medical care(SMC).Median(IQR)ICH volume was 42(30–53)*** the full MRI cohort,there was no statistically significant heterogeneity in the effects of MIS versus SMC on 1-year outcomes by any specific CSVD feature or by CSVD scores(all P_(interaction)>0.05).In 94 MIS patients with EOT ICH volume≤15 mL,significant reduction in odds of poor outcome was found with cerebral amyloid angiopathy score<2(OR,0.14(0.05–0.42);P_(interaction)=0.006),absence of lacunes(OR,0.37(0.18–0.80);P_(interaction)=0.02)and absence of severe white matter hyperintensities(WMHs)(OR,0.22(0.08–0.58);P_(interaction)=0.03).Conclusions Following successful haematoma reduction by MIS,we found significantly lower odds of poor functional outcome with lower total burden of CSVD in addition to absence of lacunes and severe *** features may have utility for prognostication and patient selection in clinical trials of MIS.

关键词： Surgery surgery absence

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Influence of carbide ceramic reinforcements in improving tribological properties of A333 graded hybrid composites

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Defence Technology（防务技术） 2022年第7期18卷 1107-1123页

作者： Manu Sam N.radhika Department of Mechanical Engineering Amrita School of EngineeringCoimbatore641112Amrita Vishwa VidyapeethamIndia

Aluminium hybrid functionally graded metal matrix composites(FGMMCs),meet growing demands for supreme tribo-mechanical performance in automotive and aviation *** research experimentally compares the influence of carbide ceramics(B_(4)C,SiC,TiC)as reinforcements,in improving reciprocating tribology performance and mechanical strength of A333 hybrid composites against *** cylindrical samples of A333/6 wt%B_(4)C/4 wt%TiC and A333/6 wt%B_(4)C/4 wt%SiC hybrid FGMMCs were developed using horizontal centrifugal *** analysis on both composites revealed increasing ceramic gradient distribution towards outer composite *** rich zone of A333/B_(4)C/SiC hybrid FGMMC showed maximum micro-hardness(198.9 HV)and tensile strength(267.9 MPa).Elemental mapping confirmed effective distribution of ceramics and detected elemental composition of both *** rich layer of A333/B_(4)C/SiC hybrid FGMMC exhibited improved wear resistance in comparison with all three layers of A333/B_(4)C/TiC hybrid FGMMC and ***-body abrasion and tribo-chemical wear were the predominant mechanisms revealed for both composites during worn surface analysis.

关键词： Composites Functional Wear Carbide ceramics

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Modified Elliptic Curve Cryptography Multi-Signature Scheme to Enhance Security in Cryptocurrency

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Computer Systems Science & Engineering 2023年第4期45卷 641-658页

作者： G.Uganya radhika Baskar Department of Electronics and Communication Engineering Saveetha School of EngineeringSIMATSChennaiTamil NaduIndia

Internet of Things(IoT)is an emerging technology that moves the world in the direction of smart ***,IoT security is the complex problem due to its centralized architecture,and limited ***,blockchain technology has great attention due to its features of decentralized architecture,transparency,immutable records and cryptography hash functions when combining with *** hash algorithms are very important in blockchain technology for secure *** converts the variable size inputs to a fixed size hash output which is *** cryptography hash algorithms with digital signature have issues of single node accessibility and accessed up to 128 bytes of key size *** well as,if the attacker tries to hack the key,it cancels the *** paper presents the Modified Elliptic Curve Cryptography Multi Signature Scheme(MECC-MSS)for multiple node accessibility by finding nearest path for secure *** this work,the input key size can be extended up to 512 bytes to enhance the *** performance of the proposed algorithm is analyzed with other cryptography hash algorithms like Secure Hashing Algorithms(SHAs)such as SHA224,SHA256,SHA384,SHA512,SHA3-224,SHA3-256,SHA3-384,SHA3-512 and Message Digest5 by one-way analysis of variance test in terms of accuracy and time *** show that the MECC-MSS achieves 90.85%of accuracy and time complexity of 1.4 nano seconds with significance less than *** the statistical analysis,it is observed that the proposed algorithm is significantly better than other cryptography hash algorithms and also having less time complexity.

关键词： Internet of things blockchain technology secure hash algorithm accuracy time complexity

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Crop and weed discrimination using Laws’ texture masks

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International Journal of Agricultural and Biological Engineering 2020年第1期13卷 191-197页

作者： radhika Kamath Mamatha Balachandra Srikanth Prabhu Department of Computer Science and Engineering Manipal Institute of TechnologyManipal Academy of Higher EducationManipalIndia

Computers have become an integral part of human *** are used in almost every field even in *** like computer vision-based pattern recognition are being used to detect diseases and pests like weeds affecting the *** Weeds are unwanted plants growing among crops competing for nutrients,water,and *** can significantly reduce the quality and yield of the crops incurring a huge loss to the *** paper investigates the use of texture features extracted from Laws’texture masks for discrimination of Carrot crops and weeds in digital ***’texture method is one of the popular methods used to extract texture features in medical image processing,though not much explored in plant-based images or agricultural *** experiment was carried out on two categories of benchmark digital image datasets of Carrot crop and Carrot weed respectively,which are publicly available.A total of 70 texture features were *** dimensionality reduction technique was used to get the optimal *** features were then used to train the Random Forest *** results and observations from the experiment showed that the classifier achieved above 94%accuracy.

关键词： precision agriculture crop weed texture analysis classifier

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Effect of reinforcement content on the adhesive wear behavior of Cu10Sn5Ni/Si3N4 composites produced by stir casting

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International Journal of Minerals,Metallurgy and Materials 2017年第9期24卷 1052-1060页

作者： K.Sanesh S.Shiam Sunder N.radhika Department of Mechanical Engineering Amrita School of EngineeringCoimbatore 64112Amrita Vishwa VidyapeethamAmrita UniversityIndia

The main objective of this paper was to fabricate CuSnNi alloy and its composites reinforced with various contents of SiNparticles(5wt%, 10wt%, and 15wt%) and to investigate their dry sliding wear behavior using a pin-on-disk tribometer. Microstructural examinations of the specimens revealed a uniform dispersion of SiNparticles in the copper matrix. Wear experiments were performed for all combinations of parameters, such as load(10, 20, and 30 N), sliding distance(500, 1000, and 1500 m), and sliding velocity(1, 2, and 3 m/s), for the alloy and the composites. The results revealed that wear rate increased with increasing load and increasing sliding distance, whereas the wear rate decreased and then increased with increasing sliding velocity. The primary wear mechanism encountered at low loads was mild adhesive wear, whereas that at high loads was severe delamination wear. An oxide layer was formed at low velocities, whereas a combination of shear and plastic deformation occurred at high velocities. The mechanism at short sliding distances was ploughing action of SiNparticles, which act as protrusions; by contrast, at long sliding distances, direct metal–metal contact occurred. Among the investigated samples, the Cu/10wt% SiNcomposite exhibited the best wear resistance at a load of 10 N, a velocity of 2 m/s, and a sliding distance of 500 m.

关键词： copper matrix composites stir casting adhesive wear wear mechanisms

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Nicotinamide adenine dinucleotide phosphate oxidase activation and neuronal death after ischemic stroke

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Neural Regeneration Research 2019年第6期14卷 948-953页

作者： Jiamei Shen radhika Rastogi Xiaokun Geng Yuchuan Ding China-America Institute of Neuroscience Beijing Luhe HospitalCapital Medical University Department of Neurosurgery Wayne State University School of Medicine Department of Neurology Beijing Luhe HospitalCapital Medical University

Nicotinamide adenine dinucleotide phosphate oxidase(NOX) is a multisubunit enzyme complex that utilizes nicotinamide adenine dinucleotide phosphate to produce superoxide anions and other reactive oxygen species. Under normal circumstances, reactive oxygen species mediate a number of important cellular functions, including the facilitation of adaptive immunity. In pathogenic circumstances, however,excess reactive oxygen species generated by NOX promotes apoptotic cell death. In ischemic stroke, in particular, it has been shown that both NOX activation and derangements in glucose metabolism result in increased apoptosis. Moreover, recent studies have established that glucose, as a NOX substrate, plays a vital role in the pathogenesis of reperfusion injury. Thus, NOX inhibition has the potential to mitigate the deleterious impact of hyperglycemia on stroke. In this paper, we provide an overview of this research,coupled with a discussion of its implications for the development of NOX inhibition as a strategy for the treatment of ischemic stroke. Both inhibition using apocynin, as well as the prospect of developing more specific inhibitors based on what is now understood of the biology of NOX assembly and activation, will be highlighted in the course of our discussion.

关键词： nicotinamide adenine dinucleotide phosphate oxidase stroke nicotinamide adenine dinucleotide phosphate oxidase inhibitors reactive oxygen species ischemia/reperfusion neuroprotection hyperglycolysis NADPH NOX

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Biochar-mediated regulation of greenhouse gas emission and toxicity reduction in bioremediation of organophosphorus pesticide-contaminated soils

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Chinese Journal of Chemical Engineering 2018年第12期26卷 2592-2600页

作者： Meinan Zhen Benru Song Xiaomei Liu radhika Chandankere Jingchun Tang Key Laboratory of Pollution Processes and Environmental Criteria (Ministry of Education) Tianjin Engineering Center of Environmental Diagnosis and Contamination Remediation College of Environmental Science and Engineering Nankai University Department of Building Civil and Environmental Engineering Concordia University

Organophosphorus pesticides(OPPs) are a set of toxic persistent organic pollutants(POPs) present in the environment. Recently, biochar-mediated bioremediation has exhibited many advantages over conventional methods for the remediation of pesticide-contaminated soil. In the present study, biochar and nitrogen fertilizer(NH_4NO_3)were employed to remediate OPP-contaminated soil and the greenhouse gas(GHG) emission during 90 days of incubation was investigated. After thermal desorption treatment, the content of organophosphorus pesticides reduced from 175.61 μg·kg^(-1) to 62.68 μg·kg^(-1). The addition of NH_4NO_3 in the following bioremediation led to larger reduction(34.35%) of the pesticide concentration than that of biochar(31.90%) for the contaminated soils with thermal desorption treatment, while the simultaneous addition of biochar and NH_4NO_3 led to the largest reduction of pesticide concentration(11.07%) for the soil without thermal desorption treatment. The addition of biochar and NH_4NO_3 only slightly increased the emission rate of GHGs from the soil without thermal treatment,but remarkably increased the emission rate of GHGs from the soil after thermal treatment. In most cases, the addition of NH_4NO_3 is more effective than biochar to promote the degradation of pesticide, but also exhibited higher GHG emission. The microbial community analysis suggests that the enhanced degradation of pesticide is mainly owing to the increased activity of microorganism.

关键词： Organophosphorus pesticides Biochar NH3NO4 Remediation Greenhouse gas Microbial community

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Performance Analysis and Throughput Enhancement of the STET Technique for WLAN IEEE 802.11ad

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Computer Systems Science & Engineering 2022年第2期40卷 571-579页

作者： M.Vanitha J.Kirubakaran K.radhika Department of Electronics and Communication Engineering Saveetha Engineering CollegeChennai602105India Department of Electronics and Communication Engineering Muthayammal Engineering CollegeRasipuram637408India

The IEEE 802.11ad innovation has enabled the impact of remote devices in unauthorized 60 GHz unlicensed frequency band at Giga bits per second information transfer rate in speed concentrated 5G *** have presented an innovative work that deals with the upgradation of the ability of IEEE 802.11ad wireless LAN to make it suitable for wireless *** exact examination on the IEEE 802.11ad analysis has been carried out in this work to achieve the greatest *** has pulled attraction in broad consideration for accomplishing the pinnacle transmission rate of 8 Gbit/*** 802.11ad is a convention utilized for extremely high information rates(around 8 Gbit/s)and for short range remote correspondence of around 1 to 10 *** Multi-layer with Multi-User Multiple Input Multiple-Output(MLMU-MIMO)innovation has enabled transmission of multiple information packets all the while from the WLAN IEEE 802.11 ad Access Point(AP)to various receivers by means of different wireless *** help the MLMU-MIMO innovation at Medium Access Control(MAC),a new method called Simultaneous Transmission for Enhanced Throughput(STET)has been presented for enhancement of the transmission rate of the wireless standard.A mathematical model has been used for the evaluation of the performance of an IEEE 802.11ad AP empowering the STET allocation *** STET model can help determination of the throughput improvement of a STET technique,for example,audio information,images,good quality and foundation *** main goal of this work is to analyze the improvement of the STET allocation technique in regard to the usage of rare frequency band,when obtaining spectrum access between the various access *** theoretical and simulation outcomes are also confirmed by Riverbed modeler 17.5 simulation tool.

关键词： WLAN STET MAC

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Rare earth doped cobalt aluminate blue as an environmentally benign colorant

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Journal of Advanced Ceramics 2012年第4期1卷 301-309页

作者： Sri Parasara radhika Kalarical Janardhanan SREERAM Balachandran Unni NAIR Chemical Laboratory Central Leather Research InstituteCouncil of Scientific and Industrial ResearchAdyarChennai 600020India

Increasing energy cost calls for exterior coatings with high near infra-red reflectance,so as to reduce heat absorption and in turn cost of *** modulations of substrate,use of white metal oxides as pigments or under-layers has been reported in past,reports on metal oxide or doped metal oxide pigments with high NIR reflectance is *** report for the first time a blue colored cobalt aluminate type pigment prepared through doping of cerium,praseodymium or *** color measurements and calculation ofDE indicated that the Nd doped sample had crystal size of(36±1)nm,bandgap value of(2.4±0.2)eV and color coordinates similar to that of cobalt *** molar ratio as estimated by EDX was found to be Al:Cu:Co:Ce:Nd:O=2:0.06:0.06:0.012:0.00012:*** pigment was found to have potential applications as a cool blue colorant,owing to changes in optical properties arising out of crystal chemistry *** of rare earth metal ions was found to enhance the NIR reflectance by 10%,when compared to a conventional cobalt aluminate *** oxide has been well characterized and its performance as a pigment *** have proposed that changes in crystal lattice when neodymium enters into Ce4+sites enhance the NIR reflectance by about 9%as against the entry of praseodymium.

关键词： optical materials oxides chemical synthesis environmental coatings color centers crystal structure defects

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The 2020 US cancer screening deficit and the timing of adults’ most recent screen: a population-based cross-sectional study

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Family Medicine and Community Health 2023年第3期11卷 10-30页

作者： Jason Semprini radhika Ranganathan Health Management&Policy The University of Iowa College of Public HealthIowa CityIowaUSA Epidemiology/Biostatistics University of South Carolina Arnold School of Public HealthColumbiaSouth CarolinaUSA

Objective In 2020,cancer screenings declined,resulting in a cancer screening *** significance of this deficit,however,has yet to be quantified from a population health *** study addresses this evidence gap by examining how the pandemic changed the timing of American adults’most recent cancer *** We obtained population-based,cancer screening data from the Behavioural Risk Factor Surveillance System(BRFSS)(2010,2012,2014,2016,2018,2020).Mammograms,pap smears and colonoscopies were each specified as a variable of mutually exclusive categories to indicate the timing since the most recent screening(never,0–1 years,1–2 years,3+years).Our cross-sectional,quasi-experimental design restricts the sample to adults surveyed in January,February or *** then leverage a quirk in the BRFSS implementation and consider adults surveyed in the second year of the 2020 survey wave as exposed to the COVID-19 *** surveyed in January 2020–March 2020 were considered *** estimate the impact of exposure to the COVID-19 pandemic on the timing of recent cancer screenings,we constructed linear and logistic regression models which control for sociodemographic characteristics associated with screening patterns,and state fixed effects and temporal trend fixed effects to control for *** In 2020,the cancer screening deficit was largely due to a 1year delay among adults who receive annual screening,as the proportion of adults reporting a cancer screen in the past year declined by a nearly identical proportion of adults reporting their most recent cancer screen 1–2 years ago(3%–4%points).However,the relative change was higher for mammograms and pap smears(17%)than colonoscopies(4%).We also found some evidence that the proportion of women reporting never having completed a mammogram declined in 2020,but the mechanisms for this finding should be further explored with the release of future *** Our estimates for the

关键词： sectional screening founding

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