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Cytotoxic T lymphocyte antigen-4 gene polymorphisms and susceptibility to type 1 autoimmune hepatitis in the Tunisian population

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Genes & Diseases 2018年第3期5卷 256-262页

作者： Marwa Chaouali Agostinho Carvalho Aymen Tezeghdenti Mouna Ben Azaiez Cristina Cunha Ezzeddine Ghazouani Radhia Kochkar Department of Immunology Military Hospital of TunisMontfleury 1008TunisTunisia El Manar University Laboratory of MycologyPathologies and Biomarkers 1092TunisTunisia Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoCampus de Gualtar 4710-057BragaPortugal ICVS/3B’s-PT Government Associate Laboratory Braga/Guimara˜esPortugal

Genetic factors and gene polymorphisms leading to the onset of autoimmune response in autoimmune hepatitis(AIH)are still not full elucidated.Since the CTLA-4 molecule is a key modulator of the lymphocytes responses we hypothezied that deficiencies or mutations in the gene encoding CTLA4 protein may be involved in AIH susceptibility and trigger the autoimmune response.We investigated 3 distinct polymorphic sites(t49A>G,CT60 G>A and e318C>T)of the CTLA4 gene in 50 AIH patients and 100 healthy controls using the KASP genotyping technology.A significant positive association with AIH susceptibility was found for the GG genotype in t49 position of the CTLA4 gene which was significantly higher in AIH patients compared to controls(28%vs 9%,pZ0.003,ORZ3.93[1.56e9.88]).The CTLA4 A/A genotype in position CT60 was more significantly frequent in controls comparing to AIH patients and could be considered as a protective genotype for the tunisian patients.CTLA4 genotyping in position318 did not show any statistically significant difference in genotype or allele distribution.The CTLA4 gene polymorphism in position t49 is associated to AIH susceptibility in the Tunisian population.Mutation in the CTLA4 gene may lead to a modification of the CTLA4 protein structure that could have functional relevance in AIH pathogenesis and onset.

关键词： Autoimmune hepatitis CTLA4 gene polymorphisms Cytotoxic Tlymphocyte antigen 4

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Correlation between Dietary Intake and Inflammatory Biomarkers in a Tunisian Obese Group

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Journal of Biosciences and Medicines 2015年第11期3卷 108-113页

作者： Manel Ayoub Chedia Zouaoui Nedra Grira Radhia Kochkar Nejla Stambouli Chaker Bouguerra Borni Zidi Ezzedine Ghazouani Chakib Mazigh Zied Aouni Biochemistry Department Research Unit Military Hospital of Tunis Tunis Tunisia Endocrinology Department Research Unit Military Hospital of Tunis Tunis Tunisia Immunology Department Military Hospital of Tunis Tunis Tunisia Epidemiology Department Research Unit Military Hospital of Tunis Tunis Tunisia

Aims: This study aims to determine the inflammatory status and evaluate the correlation between dietary intake and inflammatory biomarkers in a Tunisian obese group. Material and Methods: This is an open cross-sectional study that includes 81 individuals divided into two groups: a group of 42 obese patients recruited from the endocrinology department and a control group of 39 non-obese healthy subjects. All participants received a food survey, anthropometric measurements and blood sampling. Pro-inflammatory cytokines (IL-6, IL-8, TNF-α), and hs-CRP were measured in patients and controls. Results: Dietary data revealed significant increases in food intake in obese patients compared to controls. The results of the laboratory parameters showed a statistically significant increase in IL-8, TNF-α and blood glucose in obese compared to controls. The analysis of correlations among the parameters studied showed that the plasma level of IL-6 was positively correlated with dietary fat intake (r = 0.70;p -3) and carbohydrate (r = 0.54;p = 0.03) and the dietary intake expressed in calories (r = 0.64;p -3). Conclusion: dietary imbalances in obese were observed and characterized by an excessive intake of calories, fat and carbohydrates. The excessive carbohydrate and fat intake is associated with increased IL-6 and TNF-α plasma levels.

关键词： Obesity Dietary Intake Inflammatory Biomarkers

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