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Isolated cerebral aspergillus abscess as a complication of pulmonary alveolar proteinosis in a child

Chinese Neurosurgical Journal 2019年第3期5卷 182-185页

作者： rachna khera Venkateswara Rao Mohan Krishna Pasam Ravindranath Tagore Sudha SMurthy Challa Sundaram Department of Laboratory Medicine Basavatarakam Indo-American Cancer Hospital and Research InstituteHyderabadTelangana500034India Department of Neurosurgery Basavatarakam Indoamerican Cancer Hospital and Research InstituteHyderabadTelangana500034India

Pulmonary alveolar proteinosis (PAP) poses a risk of opportunistic infections with a variety of organisms with Nocardia being the most common pathogen followed by mycobacteria and fungi. Case presentation: A 7-year-old female child, presented with headache and multiple episodes of vomiting. There was no fever or altered sensorium. On examination, there were no focal deficits or cranial nerve palsies. An MRI brain showed a small T2 hyperintense lesion in the left superior parietal lobe suggestive of an abscess. She was diagnosed as PAP based on CT chest and bronchioloalveolar lavage 7 months earlier and treated with corticosteroids. A left parieto-occipital craniotomy was done with drainage of abscess and abscess wall excision. Histopathology revealed a suppurative lesion with slender septate acute angle branching hyphae which were positive on fungal stains. Culture done on the pus was positive for Aspergil us fumigatus. The patient was treated with voriconazole and stable at 1 year follow-up. Conclusion: Opportunistic infections are common in patients diagnosed with PAP. High index of clinical suspicion and early diagnosis are important for favorable outcome.

关键词： Pulmonary alveolar proteinosis Opportunistic infection Aspergillus fumigatus Cerebral abscess

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