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Association of hepatitis C virus infection and diabetes

World Journal of Gastroenterology 2009年第40期15卷 5114-5115页

作者： Samir Rouabhia rachid malek Hocine Bounecer Department of Internal Medicine University Hospital Center Touhami Benflis Department of Internal Medicine University Hospital Center Saadna Abdenour Department of Epidemiology and Preventive Medicine University Hospital Center Touhami Benflis

Epidemiologic studies have suggested a relation between hepatitis C virus (HCV) infection and diabetes mellitus. HCV infection is emerging as a metabolic disease, and diabetes mellitus as a risk factor for HCV infection. However, some data on the prevalence of antibodies to HCV in patients with diabetes are conflicting. These seroprevalence data should be interpreted with caution. Some potential bias may occur in those clinic-based studies that target a specif ic disease group. In this letter we explain some reasons for these conflicting studies.

关键词： Prevalence Hepatitis C Diabetes mellitus

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Prevalence of type 2 diabetes in Algerian patients with hepatitis C virus infection

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World Journal of Gastroenterology 2010年第27期16卷 3427-3431页

作者： Samir Rouabhia rachid malek Hocine Bounecer Aoulia Dekaken Fouzia Bendali Amor Mourad Sadelaoud Abderrahmene Benouar Department of Internal Medicine University Hospital Center Touhami Benflis Department of Internal Medicine University Hospital Center Saadna Abdenour Department of Epidemiology and Preventive Medicine University Hospital Center Touhami Benflis Department of Pathology University Hospital Center Touhami Benflis Sadelaoud Laboratory of Medical Biology La verdureBatna 05000Algeria Department of Radiology University Hospital Center Touhami Benflis

AIM:To investigate the prevalence of,and risk factors for,diabetes mellitus(DM) in Algerian patients with chronic hepatitis C virus(HCV) infection and in a control ***:A cross-sectional study was undertaken.A total of 416 consecutive patients with viral chronic hepatitis attending the Internal Medicine Department of the University Hospital Center Touhami Benflis in Batna [290 HCV-infected and 126 hepatitis B virus(HBV)-infected patients] were prospectively ***:The prevalence of DM was higher in HCV-infected patients in comparison with HBV-infected patients(39.1% vs 5%,P < 0.0001).Among patients without cirrhosis,diabetes was more prevalent in HCV-infected patients than in HBV-infected patients(33.5% vs 4.3%,P < 0.0001).Among patients with cirrhosis,diabetes was more prevalent in HCV-infected patients,but the difference was not significant(67.4% vs 20%,P = 0.058).The logistic regression analysis showed that HCV infection [odds ratio(OR) 4.73,95% CI:1.7-13.2],metabolic syndrome(OR 12.35,95% CI:6.18-24.67),family history of diabetes(OR 3.2,95% CI:1.67-6.13) and increased hepatic enzymes(OR 2.22,95% CI:1.1-4.5) were independently related to DM in these ***:The high prevalence of diabetes in HCV-infected patients,and its occurrence at early stages of hepatic disease,suggest that screening for glucose abnormalities should be indicated in these patients.

关键词： Prevalence Hepatitis C virus Hepatitis B virus Diabetes mellitus Algeria

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