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Journal of Energy Chemistry 2023年第10期85卷 490-500,I0013页

作者： Qi Zhao rachel Crespo-Otero Devis Di Tommaso Department of Chemistry School of Physical and Chemical SciencesQueen Mary University of LondonLondon E14NSUK Department of Chemistry University College LondonLondon WC1H 0AJUK

Diatomic catalysts(DACs)with two adjacent metal atoms supported on graphene can offer diverse functionalities,overcoming the inherent limitations of single atom catalysts(SACs).In this study,density functional theory calculations were conducted to investigate the reactivity of the carbon dioxide(CO_(2))reduction reaction(CO_(2)RR)on metal sites of both DACs and SACs,as well as their synergistic effects on activity and *** of the Gibbs free energies of CO_(2)RR and associated values of the limiting potentials to generate C_(1) products showed that Cu acts as a promoter rather than an active catalytic centre in the catalytic CO_(2)conversion on heteronuclear DACs(CuN_(4)-MN_(4)),improving the catalytic activity on the other metal compared to the related SAC MN_(4).Cu enhances the initial reduction of CO_(2)by promoting orbital hybridization between the key intermediate*COOH 2p-orbitals and the metals 3d-orbitals around the Fermi *** degree of hybridization in the DACs CuN_(4)-MN_(4) decreases from Fe to Co,Ni,and *** work demonstrates how Cu regulates the CO_(2)RR performance of heteronuclear DACs,offering an effective approach to designing practical,stable,and high-performing diatomic catalysts for CO_(2)electroreduction.

关键词： Electrocatalytic CO_(2)reduction Single atom catalysts Diatomic catalysts Graphene Density functional theory calculations

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濒死的意识体验

环球科学 2024年第13期 40-47页

作者：蕾切尔·努维尔金烨(翻译) 不详

濒死体验是一根能够揭示意识和大脑最本质真相的为探寻那些生命隐藏在最深处的秘密带来一丝光芒。几十年来,弗朗索瓦·德达斯基(Francois d'Adesky)从未向任何人讲述过自己的濒死体验(near-death experience)。这名生活在比利时布鲁塞... 详细信息

濒死体验是一根能够揭示意识和大脑最本质真相的为探寻那些生命隐藏在最深处的秘密带来一丝光芒。几十年来,弗朗索瓦·德达斯基(Francois d'Adesky)从未向任何人讲述过自己的濒死体验(near-death experience)。这名生活在比利时布鲁塞尔的退休外交官兼公务员经历濒死体验时只有13岁,当时他因为急性阑尾炎被送进了医院。德达斯基生动地回忆起当时他看到自己的身体躺在手术台上,然后他穿过了一条隧道,在那里遇到了奇异的生灵,他们全身散发着光辉与神性。“你的死期还没到”,其中一位长者这么告诉他,德达斯基直觉地认为“他”就是上帝,后者说:“你在地球上的使命还没开始。”

关键词：濒死体验急性阑尾炎弗朗索瓦达斯意识体验

SIMAP500: A novel risk score to identify recipients at higher risk of hepatocellular carcinoma recurrence following liver transplantation

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World Journal of Transplantation 2024年第3期14卷 132-143页

作者： Amr Alnagar Nekisa Zakeri Konstantinos Koilias Rosemary E Faulkes rachel Brown Owen Cain M Thamara P R Perera Keith J Roberts Rebeca Sanabria-Mateos David C Bartlett Yuk Ting Ma Shivan Sivakumar Shishir Shetty Tahir Shah Bobby V M Dasari Department of HBP and Liver Transplantation Surgery Queen Elizabeth HospitalUniversity Hospitals BirminghamBirmingham B152GWUnited Kingdom Centre for Liver Research Institute of Biomedical ResearchBirmingham B152TTUnited Kingdom Department of Hepatology Queen Elizabeth HospitalUniversity Hospitals BirminghamBirmingham B152GWUnited Kingdom Department of Pathology University Hospitals Birmingham NHS Foundation TrustBirmingham B152GWUnited Kingdom Department of Oncology Queen Elizabeth HospitalUniversity Hospitals of BirminghamBirmingham B152GWUnited Kingdom

BACKGROUND Recurrence of hepatocellular carcinoma(HCC)following liver transplantation(LT)has a devastating influence on recipients’survival;however,the risk of recur-rence is not routinely *** stratification is vital with a long LT waiting time,as that could influence the recurrence despite strict listing *** This study aims to identify predictors of recurrence and develop a novel risk pre-diction score to forecast HCC recurrence following *** A retrospective review of LT for HCC recipients at University Hospitals Bir-mingham between July 2011 and February *** and multivariate analyses were performed to identify recurrence predictors,based on which the novel SIMAP500(satellite nodules,increase in size,microvascular invasion,AFP>500,poor differentiation)risk score was *** 234 LTs for HCC were performed with a median follow-up of 5.3 *** developed in 25 patients(10.7%).On univariate analyses,RETREAT score>3,α-fetoprotein(AFP)at listing 100-500 and>500,bridging,increased tumour size between imaging at the listing time and explant histology,increase in the size of viable tumour between listing and explant,presence of satellite nodules,micro-and macrovascular invasion on explant and poor differentiation of tumours were significantly associated with recurrence,based on which,the SIMAP500 risk score is *** SIMAP500 demonstrated an excellent predictive ability(c-index=0.803)and outper-formed the RETREAT score(c-index=0.73).SIMAP500 is indicative of the time to disease *** SIMAP500 risk score identifies the LT recipients at risk of HCC *** stratification allows patient-centric post-transplant surveillance *** validation of the score is recommended.

关键词： Liver transplantation Hepatocellular carcinoma Recurrence Survival

Regulation of enolase activation to promote neural protection and regeneration in spinal cord injury

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Neural Regeneration Research 2023年第7期18卷 1457-1462页

作者： Hannah MMcCoy rachel Polcyn Naren LBanik Azizul Haque Department of Microbiology and Immunology Medical University of South CarolinaCharlestonSCUSA Department of Neurosurgery Medical University of South CarolinaCharlestonSCUSA Ralph H.Johnson Veterans Administration Medical Center CharlestonSCUSA

Spinal cord injury(SCI)is a debilitating condition characterized by damage to the spinal cord resulting in loss of function,mobility,and sensation with no *** and Drug Administration-approved ***,a multifunctional glycolytic enzyme upregulated after SCI,promotes pro-and anti-inflammatory events and regulates functional recovery in *** is normally expressed in the cytosol,but the expression is upregulated at the cell surface following cellular injury,promoting glial cell activation and signal transduction pathway ***-induced microglia activation triggers pro-inflammatory mediators at the injury site,activating other immune cells and metabolic events,i.e.,Rho-associated kinase,contributing to the neuroinflammation found in *** surface expression also activates cathepsin X,resulting in cleavage of the C-terminal end of neuron-specific enolase(NSE)and non-neuronal enolase(NNE).Fully functional enolase is necessary as NSE/NNE C-terminal proteins activate many neurotrophic processes,i.e.,the plasminogen activation system,phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B,and mitogen-activated protein kinase/extracellular signal-regulated *** here suggest an enolase inhibitor,ENOblock,attenuates the activation of Rho-associated kinase,which may decrease glial cell activation and promote functional recovery following ***,ENOblock inhibits cathepsin X,which may help prevent the cleavage of the neurotrophic C-terminal protein allowing full plasminogen activation and phosphatidylinositol-4,5-bisphosphate 3-kinase/mitogen-activated protein kinase *** combined NSE/cathepsin X inhibition may serve as a potential therapeutic strategy for preventing neuroinflammation/degeneration and promoting neural cell regeneration and recovery following *** role of cell membrane-expressed enolase and associated metabolic events should be investigated to determine if the same strategies can be applied to other neu

关键词： cathepsin X ENOblock enolase glia mitogen-activated protein kinase/extracellular signal-regulated kinase neurodegeneration neuroinflammation phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B Rho-associated protein kinase spinal cord injury

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阶梯停车场芬兰郝尔辛基

世界建筑导报 2024年第2期39卷 117-119页

作者： uho Grönholm Antti Nousjoki Samuli Woolston Pekka Tainio Tuulikki Tanska rachel Murray Anssi Luodemäki Harri Humppi Tuomas Uusheimo(摄影) Marc Goodwin(摄影) ALA建筑师事务所不详

新的五角形、五层高的Saukonlaituri停车设施包括六条流线,可停放600辆私家车,中央庭院被布满巨石、苔藓和蕨类植物的景观环绕。其中五个停车场有顶棚,第六个停车场位于屋顶。庭院具有双重功能:它既是一个采光井,阳光可通过庭院照射到... 详细信息

新的五角形、五层高的Saukonlaituri停车设施包括六条流线,可停放600辆私家车,中央庭院被布满巨石、苔藓和蕨类植物的景观环绕。其中五个停车场有顶棚,第六个停车场位于屋顶。庭院具有双重功能:它既是一个采光井,阳光可通过庭院照射到较低的停车场,又是雨水蓄水池和积雪堆积地。建筑的南侧从入口广场后退,将地面公共空间延伸为阶梯式公园,一直延伸到屋顶。这种解决方案使周围公寓楼的居民可以沿着阶梯走到正确的楼层取车,而不是乘坐电梯。阶梯区域也可以用于野餐和日光浴。

关键词：入口广场空间延伸采光井停车设施公寓楼停车场阶梯式电梯

S-wave crustal and upper mantle's velocity structure in the eastern Tibetan Plateau——Deep environment of lower crustal flow

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Science China Earth Sciences 2008年第2期51卷 263-274页

作者： Paul silver Carnegie Institution of Washington Washington DC 20015 USA

A teleseismic profile consisting of 26 stations was deployed along 30°N latitude in the eastern Tibetan Plateau. By use of the inversion of P-wave receiver function, the S-wave velocity structures at depth from surface to 80 km beneath the profile have been determined. The inversion results reveal that there is significant lateral variation of the crustal structure between the tectonic blocks on the profile. From Linzhi north of the eastern Himalayan Syntaxis, the crust is gradually thickened in NE direction; the crustal thickness reaches to the maximum value (~72 km) at the Bangong-Nujiang suture, and then decreased to 65 km in the Qiangtang block, to 57―64 km in the Bayan Har block, and to 40―45 km in the Sichuan Basin. The eastern segment of the teleseismic profile (to the east of Batang) coincides geographically with the Zhubalong-Zizhong deep seismic sounding profile carried out in 2000, and the S-wave velocity structure determined from receiver functions is consistent with the P-wave velocity structure obtained by deep seismic sounding in respect of the depths of Moho and major crustal interfaces. In the Qiangtang and the Bayan Har blocks, the lower velocity layer is widespread in the lower crust (at depth of 30―60 km) along the profile, while there is a normal velocity distribution in lower crust in the Sichuan Basin. On an average, the crustal velocity ratio (Poisson ratio) in tectonic blocks on the profile is 1.73 (σ = 0.247) in the Lhasa block, 1.78 (σ = 0.269) in the Banggong-Nujiang suture, 1.80 (σ = 0.275) in the Qiangtang block, 1.86 (σ = 0.294) in the Bayan Har blocks, and 1.77 (σ = 0.265) in the Yangtze block, respectively. The Qiangtang and the Bayan Har blocks are characterized by lower S-wave velocity anomaly in lower crust, complicated Moho transition, and higher crustal Poisson ratio, indicating that there is a hot and weak medium in lower crust. These are considered as the deep environment of lower crustal flow in the eastern Tibetan Plateau. F

关键词： eastern Tibetan Plateau crustal and upper mantle’s structure teleseismic receiver function lower crustal flow

Microstructure refinement in biodegradable Zn-Cu-Ca alloy for enhanced mechanical properties,degradation homogeneity,and strength retention in simulated physiological condition

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Journal of Materials Science & Technology 2022年第30期125卷 1-14页

作者： Nan Yang Nagasivamuni Balasubramani Jeffrey Venezuela Helle Bielefeldt-Ohmann rachel Allavena Sharifah Almathami Matthew Dargusch Queensland Centre for Advanced Materials Processing and Manufacturing(AMPAM)School of Mechanical and Mining Engineering The University of QueenslandAdvanced Engineering BuildingBld 49Staff House Rd.St LuciaQLD 4072Australia School of Veterinary Science The University of QueenslandGattonQLD 4343Australia School of Chemistry and Molecular Biosciences The University of QueenslandQLD 4072Australia

Zn-1.0Cu-0.5Ca(TA15)alloy has shown promising characteristics of enhanced mechanical properties and biodegradability for absorbable cardiovascular stents,endovascular devices,and wound closure devices *** this study,the TA15 alloy for bioabsorbable biomedical applications is *** the conventionally cast TA15(TA15-C)alloy,CaZn_(13) phase are present as a large dendritic network with an average size of 73.25±112.84μm,Hot rolling of the TA15-C alloy has broken the long and dendritic network of the CaZn_(13) phases,however,the refined phases are observed as segregations and the distribution is *** segregated CaZn_(13) suffered heavy localised corrosion which lead to poor mechanical properties in the as-fabricated condition and after *** treatment(UST)during casting is identified as an effective technique for the refinement and redistribution of CaZn_(13) particles in TA15 alloy,which successfully reduce the size of the CaZn_(13) phase to 10.91±4.65μm in the as-solidified *** hot rolling,the UST processed TA15(TA15-UST)shows improved mechanical properties due to grain refinement and the reduction in microstructural defects,*** broken CaZn_(13) *** of 8-week immersion corrosion tests showed that both alloys possess very similar corrosion ***,TA15-UST has markedly improved corrosion homogeneity compared to TA15-N which favours the retention of mechanical properties even after prolonged exposure to physiological fluids.

关键词： Biodegradable Zn alloy Peritectic phase refinement In vitro corrosion Mechanical property retention Cytocompatibility

Effectiveness of overuse injury prevention programs on upper extremity performance in overhead youth athletes:A systematic review

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Sports Medicine and Health Science 2023年第2期5卷 91-100页

作者： rachel Y.Lau Swarup Mukherjee Physical Education and Sport Science Academic Group National Institute of EducationNanyang Technological University Singapore1 Nanyang Walk637616Singapore

Several targeted upper extremity injury prevention programs have been developed to mitigate the risk of upper extremity overuse injuries among youth athletes in overhead sports;however,their effectiveness on performance outcome measures has not been *** systematic review evaluated the effectiveness of existing upper extremity injury prevention programs that focused on modifying intrinsic risk factors,and performance outcome measures in overhead youth *** secondary aim was to identify the training components of these ***,Physiotherapy Evidence Database(PEDro),SPORTDiscus(via EBSCOhost),and Web of Science were searched from January 2000 to November 2020 for studies that implemented training programs or exercises for upper extremity injury prevention among youth athletes in overhead throwing or striking *** updated search was conducted from December 2020 to October 2022.A program was deemed effective for a performance outcome measure if significant improvements were observed in the intervention group as compared to the control *** the 1394 studies identified,five studies met the inclusion *** effectiveness of the injury prevention programs on the identified performance outcome measures of strength,mobility,and sport-specific measures were 30.4%,28.6%,and 22.2%,*** training components targeted were strength,mobility,and *** was the most common training component and was also the most widely investigated performance outcome ***,current upper extremity injury prevention programs seem effective at improving performance outcome measures of strength,mobility,and sport-specific outcomes with training components of strength,mobility and *** protocols are required for the measurement and reporting of performance outcomes measures,and the reporting of training components.

关键词： Youth sports Overhead athlete Overuse injury Injury prevention Shoulder Elbow

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音乐改变医疗警报

环球科学 2024年第5期 16-17页

作者：蕾切尔·伯科威茨仇艳菲(译) 不详

医院里嘟嘟作响的报警器关乎生死,但是,由于总是有太多警报声响起,医务人员可能会出现警报疲劳,从而影响医疗服务。研究人员现在发现,将嘟嘟声改为包含乐器属性的声音,能让警报在杂的环境中起到更有效的作用。

关键词：报警器医疗服务警报医务人员声音

Forecasting the spread of the COVID-19 pandemic in Kenya using SEIR and ARIMA models

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Infectious Disease Modelling 2022年第2期7卷 179-188页

作者： Joyce Kiarie Samuel Mwalili rachel Mbogo Institute of Mathematical Sciences Strathmore UniversityNairobiKenya School of Mathematical and Physical Sciences Jomo Kenyatta University of Agriculture and TechnologyNairobiKenya

COVID-19,a coronavirus disease 2019,is an ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The first case in Kenya was identified on March 13,2020,with the pandemic increasing to about 237,000 confirmed cases and 4,746 deaths by August *** developed an SEIR model forecasting the COVID-19 pandemic in Kenya using an Autoregressive Integrated moving averages(ARIMA)*** average time difference between the peaks of wave 1 to wave 4 was observed to be about 130 *** 4th wave was observed to have had the least number of daily cases at the *** to the forecasts made for the next 60 days,the pandemic is expected to continue for a *** 4th wave peaked on August 26,2021(498th day).By October 26,2021(60th day),the average number of daily infections will be 454 new cases and 40 severe cases,which would require hospitalization,and 16 critically ill cases requiring intensive care unit *** findings of this study are key in developing informed mitigation strategies to ensure that the pandemic is contained and inform the preparedness of policymakers and health care workers.

关键词： ARIMA COVID-19 Infectious disease model Forecasting SEIR Kenya pandemic