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Tamanu Oil in Acne Management: Potential Anti-Inflammatory and Wound-Healing Properties for Scar Reduction

Journal of Biomedical Science and Engineering 2024年第10期17卷 185-193页

作者： rachel marciano Alexandra Loperfito Maddie Moll Allison Liu Yuna Huh Nicole Werpachowski Kelly Frasier Julia Vinagolu-Baur Norton College of Medicine SUNY Upstate Medical University Syracuse NY USA Edward via College of Osteopathic Medicine Blacksburg VA USA Medical College of Georgia Augusta University Augusta GA USA School of Sciences Texas Womans University Denton TX USA Philadelphia College of Osteopathic Medicine Philadelphia PA USA College of Osteopathic Medicine New York Institute of Technology Old Westbury NY USA Department of Dermatology Northwell Health New Hyde Park NY USA

Tamanu oil, derived from the nuts of Calophyllum inophyllum, has gained increasing attention for its potential in acne management due to its purported anti-inflammatory and wound-healing properties. This analysis evaluates the efficacy of tamanu oil in acne treatment with a specific focus on its impact on inflammation and scar reduction. The novelty of this research lies in its comprehensive analysis of tamanu oil’s dual mechanism of action: reducing acne-related inflammation and promoting the healing of acne scars. Clinical trials and laboratory analyses were conducted to assess the oil’s effectiveness in diminishing erythema, swelling, and post-acne scarring compared to conventional treatments. Preliminary findings demonstrate that tamanu oil significantly reduces inflammation and accelerates wound healing, potentially offering a promising adjunct or alternative to standard acne therapies. Future research should aim to optimize formulation and application protocols, long-term effects, and comparative therapeutic efficacy with other anti-inflammatory agents. Tamanu oil offers a novel and effective approach to acne management, with potential advantages that go beyond inflammation reduction to include enhanced scar reduction, making it a subject that warrants further investigation.

关键词： Tamanu Oil Calophyllum inophyllum Acne Management Anti-Inflammatory Properties Wound Healing Acne Scars Erythema Reduction Inflammation Reduction Scar Reduction Alternative Acne Therapies Natural Acne Treatments Dermatological Applications of Tamanu Oil

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Quantum ekpyrotic mechanism in Fermi-bounce curvaton cosmology

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Chinese Physics C 2020年第10期44卷 142-151页

作者： Andrea Addazi Antonino marciano Center for Field Theory and Particle Physics&Department of Physics Fudan UniversityShanghai 200433China

Within the context of the Fermi-bounce curvaton mechanism,we analyze the one-loop radiative corrections to the four-fermion interaction,generated by the non-dynamical torsion field in the Einstein-Cartan-Holst-Sciama-Kibble *** show that contributions that arise from the one-loop radiative corrections modify the energy-momentum tensor,mimicking an effective Ekpyrotic fluid ***,we call this effect quantum Ekpyrotic *** leads to the dynamical washing out of anisotropic contributions to the energy-momentum tensor,without introducing any new extra Ekpyrotic *** discuss the stability of the bouncing mechanism and derive the renormalization group flow of the dimensional coupling constantξ,checking whether any change of its sign takes place towards the *** enforces the theoretical motivations in favor of the torsion curvaton bounce cosmology as an alternative candidate to the inflation paradigm.

关键词： bounce cosmology fermion bounce ekpyrotic bounce non-dynamical torsion

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NANOGrav results and dark first order phase transitions

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Science China(Physics,Mechanics & Astronomy) 2021年第9期64卷 9-14页

作者： Andrea Addazi Yi-Fu Cai Qingyu Gan Antonino marciano Kaiqiang Zeng Center for Theoretical Physics College of PhysicsSichuan UniversityChengdu 610065China Istituto Nazionale di Fisica Nucleare sezione Roma Tor VergataRome I-00133Italy Department of Astronomy School of Physical SciencesUniversity of Science and Technology of ChinaHefei 230026China Chinese Academy of Sciences Key Laboratory for Researches in Galaxies and CosmologyUniversity of Science and Technology of ChinaHefei 230026China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Department of Physics&Center for Field Theory and Particle Physics Fudan UniversityShanghai 200433China Laboratori Nazionali di Frascati Istituto Nazionale di Fisica Nucleare Via Enrico Fermi 54Frascati(Roma)I-00044Italy

The recent NANOGrav evidence of a common-source stochastic background provides a hint to gravitational waves(GW)radiation from the Early *** show that this result can be interpreted as a GW spectrum produced from first order phase transitions(FOPTs)around a temperature in the keV-MeV *** a class of FOPTs at temperatures much below the electroweak scale can be naturally envisaged in several warm dark matter models such as Majoron dark matter.

关键词： gravitational waves first order phase transitions warm dark matter effective field theory

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Muon g-2 discrepancy:new physics or a relatively light Higgs?

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Chinese Physics C 2010年第6期34卷 735-740页

作者： M.Passera W.J.marciano A.Sirlin Istituto Nazionale Fisica Nucleare Brookhaven National Laboratory Department of Physics New York University

After a brief review of the muon g-2 status, we discuss hypothetical errors in the Standard Model prediction that might explain the present discrepancy with the experimental value. None of them seems likely. In particular, a hypothetical increase of the hadroproduction cross section in low-energy e^＋e^- collisions could bridge the muon g-2 discrepancy, but it is shown to be unlikely in view of current experimental error estimates. If, nonetheless, this turns out to be the explanation of the discrepancy, then the 95% CL upper bound on the Higgs boson mass is reduced to about 135 GeV which, in conjunction with the experimental 114.4 GeV 95% CL lower bound, leaves a narrow window for the mass of this fundamental particle.

关键词： muon anomalous magnetic moment Standard Model Higgs boson

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Omics-based biomarkers as useful tools in metabolic dysfunctionassociated steatotic liver disease clinical practice:How far are we?

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World Journal of Gastroenterology 2024年第14期30卷 1982-1989页

作者： Julieta Trinks María F Mascardi Adrián Gadano Sebastián marciano Instituto de Medicina Traslacional e Ingeniería Biomédica-Consejo Nacional de Investigaciones Científicas y Técnicas-Instituto Universitario del Hospital Italiano-Hospital Italiano de Buenos Aires Ciudad Autónoma de Buenos Aires C1199ACLArgentina Consejo Nacional de Investigaciones Científicas y Técnicas Ciudad Autónoma de Buenos Aires C1425FQBArgentina Liver Unit Hospital Italiano de Buenos AiresCiudad Autónoma de Buenos Aires C1199DFArgentina Department of Research Hospital Italiano de Buenos AiresCiudad Autónoma de Buenos Aires C1199DFArgentina

Unmet needs exist in metabolic dysfunction-associated steatotic liver disease(MASLD)risk *** ability to identify patients with MASLD with advanced fibrosis and at higher risk for adverse outcomes is still *** novel biomarkers could represent a meaningful improvement to current risk *** this aim,omics technologies have revolutionized the process of MASLD biomarker discovery over the past *** the research in this field is thriving,much of the publication has been haphazard,often using single-omics data and specimen sets of convenience,with many identified candidate biomarkers but lacking clinical validation and *** we incorporate these biomarkers to direct patients’management,it should be considered that the roadmap for translating a newly discovered omics-based signature to an actual,analytically valid test useful in MASLD clinical practice is rigorous and,therefore,not easily *** article presents an overview of this area’s current state,the conceivable opportunities and challenges of omics-based laboratory diagnostics,and a roadmap for improving MASLD biomarker research.

关键词： Metabolic dysfunction-associated steatotic liver disease Non-alcoholic steatohepatitis Biomarker Risk stratification Omics

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THE GREENING OF THE PARKING INDUSTRY–BEST PRACTICES,AND A NEW CERTIFICATION PROGRAM FOR PARKING STRUCTURES

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Journal of Green Building 2014年第4期9卷 61-77页

作者： rachel Yoka Program Development International Parking Institute

Sustainable building design is now *** United States Green Building Council(USGBC)and the LEED Ratings Systems have moved the market,proving that“a rising tide lifts all boats.”Consumers now factor environmental effect into their buying decisions,a trend that looks to continue and intensify with the millennial *** and homeowners are willing to pay more for high-performing and better quality housing based on environmental *** recognize that indoor air quality and daylighting improve employee performance and boost retention *** even bottom-line businesses are investing in benchmarking and efficiency projects that have the right return on investment *** Urban Land Institute’s Greenprint Center for Building Performance serves as a prime example of the ways developers implement benchmarking,energy efficiency,and high-performance standards in the major real estate sectors:office,retail,industrial,multifamily,and *** efficiency gains and higher-quality buildings in each of these sectors will be essential to reducing emissions and energy *** the transportation sector implements its own standards and benchmarking tools to achieve greater levels of sustainability across all modes of transportation,one industry that stands at the nexus of every building type and the transportation modes used to access them is *** is a key consideration that links land use and transportation:Parking is often the connection between where we are and where we want to *** may not have been at the forefront of the sustainability discussion or the media surrounding it in previous years,but the professionals who work in the world of parking know exactly how important the role of their industry is to the success of our cities,towns,institutions,and *** is big business;it is conservatively estimated to be a$30 billion *** directly contributes to the economic vitality and accessibility of where we

关键词： Sustainability triple bottom line rating system parking garages transportation TDM

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On the effects of spatial resolution on effective distance measurement in digital landscapes

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Ecological Processes 2021年第1期10卷 659-677页

作者： rachel Mundeli Murekatete Takeshi Shirabe KTH Royal Institute of Technology School of Architecture and the Built EnvironmentTeknikringen 10A11428 StockholmSweden University of Rwanda College of Science and TechnologyCentre for Geographic Information Systems and Remote SensingKN 67 Street NyarugengeKigaliRwanda

Background:Connectivity is an important landscape attribute in ecological studies and conservation practices and is often expressed in terms of effective *** the cost of movement of an organism over a landscape is effectively represented by a raster surface,effective distances can be equated with the cost-weighted distance of least-cost *** is generally recognized that this measure is sensitive to the grid’s cell size,but little is known if it is always sensitive in the same way and to the same degree and if not,what makes it more(or less)*** conducted computational experiments with both synthetic and real landscape data,in which we generated and analyzed large samples of effective distances measured on cost surfaces of varying cell sizes derived from those *** particular focus was on the statistical behavior of the ratio—referred to as‘accuracy indicator’—of the effective distance measured on a lower-resolution cost surface to that measured on a higher-resolution cost ***:In the experiment with synthetic cost surfaces,the sample values of the accuracy indicator were generally clustered around 1,but slightly greater with the absence of linear sequences(or barriers)of high-cost or inadmissible cells and smaller with the presence of such *** latter tendency was more dominant,and both tendencies became more pronounced as the difference between the spatial resolutions of the associated cost surfaces *** two real satellite images(of different resolutions with fairly large discrepancies)were used as the basis of cost estimation,the variation of the accuracy indicator was found to be substantially large in the vicinity(1500 m)of the source but decreases quickly with an increase in distance from ***:Effective distances measured on lower-resolution cost surfaces are generally highly correlated with—and useful predictors of—effective distances measured on higher-resolution cost *** relationship t

关键词： Landscape connectivity Effective distance Raster-based least-cost path model Accuracy Spatial resolution

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Pharmacological inhibition of cation-chloride cotransporters for neurological diseases

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Neural Regeneration Research 2015年第12期10卷 1924-1925页

作者： rachel Nepomuceno Dandan Sun Department of Neurology University of Pittsburgh Veterans Affairs Pittsburgh Health Care System Geriatric ResearchEducational and Clinical Center

γ-Aminobutyric acid（GABA）is a major neurotransmitter and plays important roles in both the developing and mature central nervous system（CNS）.One way that GABA can act is by binding to fast,ionotropic GABAA recept... 详细信息

关键词： Cl Pharmacological inhibition of cation-chloride cotransporters for neurological diseases GABAA

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The key piece of the airway remodeling puzzle revealed-LIGHT signaling in the lung

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Genes & Diseases 2023年第4期10卷 1131-1132页

作者： Ziyan rachel Chen Jim Hu Programmes in Translational Medicine Research InstituteHospital for Sick ChildrenTorontoOntario M5G 0A4Canada Department of Laboratory Medicine and Pathobiology University of TorontoTorontoOntario M5S 1A8Canada Department of Paediatrics University of TorontoTorontoOntario M5S 1A8Canada

Asthma is a chronic lung disease that primarily affects the lower respiratory tract in more than 300 million people *** is often triggered by exposure to certain substances or conditions,such as allergens or cold *** overreaction to the allergens causes inflammation and narrowing of the airway,which leads to episodic or persistent symptoms including shortness of breath,nocturnal cough,chest tightness,and wheezing.

关键词： airway lung inflammation

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Von Hippel-Lindau tumor suppressor pathways&corresponding therapeutics in kidney cancer

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Journal of Genetics and Genomics 2021年第7期48卷 552-559页

作者： Maxwell Shulman rachel Shi Qing Zhang Department of Pathology University of Texas Southwestern Medical CenterDallasTXUSA

The identification and application of the Von Hippel-Lindau(VHL)gene is a seminal breakthrough in kidney cancer *** and its protein p VHL are the root cause of most kidney cancers,and the cascading pathway below them is crucial for understanding hypoxia,in addition to the aforementioned tumorigenesis routes and *** reviewed the history and functions of VHL/pVHL and Hypoxia-inducible factor(HIF),their well-known activities under low-oxygen environments as an E3 ubiquitin ligase and as a transcription factor,respectively,as well as their non-canonical functions revealed ***,we discussed how their dysregulation promotes tumorigenesis:beginning with chromosome 3 p-arm(3p)loss/epigenetic methylation,followed by two-allele knockout,before the loss of complimentary tumor suppressor genes leads cells down predictable oncological *** different pathways can ultimately determine the grade,outcome,and severity of the deadliest genitourinary *** finished by investigating current and proposed schemes to therapeutically treat clear cell renal cell carcinoma(cc RCC)by manipulating the hypoxic pathway utilizing Vascular Endothelial Growth Factor(VEGF)inhibitors,mammalian target of rapamycin complex 1(mTORC1)inhibitors,small molecule HIF inhibitors,immune checkpoint blockade therapy,and synthetic lethality.

关键词： VHL HIF ccRCC Kidney cancer Hypoxia

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