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Mole.ular e.gine.ring binucle.r coppe. catalysts for se.e.tive.CO_(2) re.uction to C_(2) products

Journal of e.e.gy Che.istry 2024年第6期93卷 166-173,I0005页

作者： Qi Zhao Kai Le. Bao Yu Xia rachel Cre.po-Ote.o De.is Di Tommaso De.artme.t of Che.istry School of Physical and Chemical SciencesQueen Mary University of LondonLondonE14NSUK Ke. Laboratory of Mate.ial Che.istry for e.e.gy Conve.sion and Storage.Ministry of e.ucation) Hubei Key Laboratory of Material Chemistry and Service FailureState Key Laboratory of Materials Processing and Die&Mould TechnologySchool of Chemistry and Chemical EngineeringHuazhong University of Science and Technology(HUST)Wuhan 430074HubeiChina De.artme.t of Che.istry University College LondonLondonWC1H 0AJUK Digital e.vironme.t Re.e.rch Institute Queen Mary University of LondonEmpire HouseLondon E11HHUK

Mole.ular coppe. catalysts se.ve.as e.e.plary mode.s for corre.ating the.structure.re.ction-me.hanism re.ationship in the.e.e.troche.ical CO_(2) re.uction(e.O_(2)R),owing to the.r adaptable.e.vironme.ts surrounding the.coppe. me.al *** inve.tigation,e.ploying de.sity functional the.ry calculations,focuse. on a nove. family of binucle.r Cu mole.ular *** modulation of the.r coordination configuration through the.introduction of organic groups aims to asse.s the.r e.ficacy in conve.ting CO_(2) to C_(2)*** findings highlight the.crucial role.of che.ical vale.ce.state.in shaping the.characte.istics of binucle.r Cu catalysts,conse.ue.tly influe.cing the.e.O_(2)R be.aviour,Notably,the.Cu(Ⅱ)Cu(Ⅱ)macrocycle.catalyst e.hibits e.hance. suppre.sion of the.hydroge. e.olution re.ction(He.),facilitating proton trans fe. and the.e.O_(2)R *** rthe.more.we.e.plo re.the.impact of dive.se.e.e.tro n-withdrawing and e.e.tron-donating groups coordinate. to the.macrocycle.R=-F,-H,and-OCH_3)on the.e.e.tron distribution in the.mole.ular *** place.e.t of-OCH_3 groups in the.macrocycle. le.ds to a favourable.oxidation state.of the.Cu ce.tre. and subse.ue.t C-C coupling to form C_(2) *** re.e.rch provide. fundame.tal insights into the.de.ign and optimization of binucle.r Cu mole.ular catalysts for the.e.e.troche.ical conve.sion of CO_(2) to value.adde. C_(2) products.

关键词： Mole.ular catalyst de.ign Se.e.tive.CO_(2)re.uction C_(2)products De.sity functional the.ry calculations

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小鼠生命早期砷暴露与A型流感病毒感染的急性和长期反应

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环境与职业医学 2014年第2期31卷 103-103页

作者： Kathryn A. Ramse. rachel e. foong Pe.e. D. Sly Ale.ande. N. Larcombe.Grae.e.R. Zosky

[背景]砷是一个重要的全球环境健康问题。已有研究显示,生命早期砷暴露会导致婴儿期呼吸道感染发生率增加、儿童期肺功能下降、成年早期支气管扩张发生率增加。[目的]确定小鼠在生命早期的砷暴露是否会加剧其生命早期流感病毒感染的反... 详细信息

[背景]砷是一个重要的全球环境健康问题。已有研究显示,生命早期砷暴露会导致婴儿期呼吸道感染发生率增加、儿童期肺功能下降、成年早期支气管扩张发生率增加。[目的]确定小鼠在生命早期的砷暴露是否会加剧其生命早期流感病毒感染的反应性。[方法]在宫内与整个产后生活中均使C57BL/6小鼠处于砷暴露状态。在1周龄时,令小鼠的一个亚组感染A型流感,然后评估砷暴露对病毒的清除、炎症、肺部结构和肺功能的急性和长期影响。[结果]生命早期的砷暴露使得小鼠对A型流感病毒的清除率下降、炎症反应加剧,并导致呼吸力学和气道结构的急性和长期性改变。[结论]在整个生命早期,砷暴露群体呼吸道感染的易感性增加合并炎症反应加剧可能会导致支气管扩张。

关键词：生命早期流感病毒感染砷暴露感染发生率反应急性 A型小鼠

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Robust Machine.Le.rning Mapping of se.G Signals to Future.Actuator Commands in Biome.hatronic De.ice.

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Journal of Bionic e.gine.ring 2024年第1期21卷 270-287页

作者： Ali Nasr Sydne. Be.l rachel L.Whittake. Clark R.Dicke.son John McPhe. Syste.s De.ign e.gine.ring University of WaterlooWaterloo N2L 3G1Canada Kine.iology and He.lth Scie.ce. University of WaterlooWaterloo N2L3G3Canada

A machine.le.rning mode. for re.re.sion of inte.rupte. Surface.e.e.tromyography(se.G)signals to future.control-orie.te. signals(e.g.,robot’s joint angle.and assistive.torque.of an active.biome.hatronic de.ice.for high-le.e. myoe.e.tric-base. hie.archical control is propose..A Re.urre.t Ne.ral Ne.work(RNN)was traine. using output data,initially obtaine. from offline.optimization of the.biome.hatronic(human–robot)de.ice.and shifte. by the.pre.iction *** input of the.RNN consiste. of inte.rupte. se.G signals(to mimic signal disconne.tions)and pre.ious kine.atic signals of the.assistive.*** RNN with a 0.1-s pre.iction horizon could pre.ict the.control-orie.te. joint angle.and assistive.torque.with 92%and 86.5%re.re.sion accuracy,re.pe.tive.y,for the.te.t *** propose. approach pe.mits a fast,pre.ictive.and dire.t e.timation of control-orie.te. signals inste.d of an ite.ative.proce.s that optimize. assistive.torque.in the.inve.se.dynamic simulation of a multibody human–robot *** with the.e.inte.rupte. input signals significantly improve. the.re.re.sion accuracy in the.case.of se.G signal *** Robust Pre.ictive.Control-orie.te. Machine.Le.rning(Robust-Muscle.e.)mode. can support volitional high-le.e. myoe.e.tric-base. control of biome.hatronic de.ice.,such as e.oske.e.ons,prosthe.e.,and assistive.re.istive.*** work should study the.application to prosthe.is control as we.l as the.re.e.tability of the.high-le.e. controlle. with e.e.trode.*** low-le.e. hie.archical controlle. that manage. the.human–robot inte.action,the.assistance.re.istance.strate.y,and the.actuator coordination should also be.studie..

关键词： Myoe.e.tric-base. control-Surface.e.e.tromyography Machine.le.rning Multibody syste. dynamics e.oske.e.on Bionic

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The.Ukiyo”of Moxibustion Re.le.te. in the.Ukiyo-e

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Chine.e.Me.icine.and Culture 2024年第3期7卷 213-221页

作者： JIANG Shan Hong foong Wong(Translate.) School of Me.ical Humanitie. and Social Scie.ce. Peking Union Medical CollegeBeijing 100730China Inte.national Re.e.rch Ce.te. for Japane.e.Studie. Kyoto 610-1192Japan 不详

Ukiyo-e.浮世絵)was a ge.re.of popular art during the.e.o and Me.ji pe.iods in ***,which was originally introduce. from China,was also in its he.day and be.ame.one.of the.popular topics for ukiyo-e.artists at that *** the.image. as historical e.ide.ce.pe.spe.tive.this article.focuse. on the.moxibustion use. in daily life.in Japan de.icte. in the.ukiyo-e.*** the.pe.spe.tive.of acu-moxa the.apy,one.may ide.tify some.spe.ific issue. in the.acupoint se.e.tion,le.ding to the.discove.y of spe.ial application of moxibustion use. by the.group of yūjo(遊女)at that *** article.conclude. by e.ploring ge.de. issue. in ukiyo-e.arts and the.implications of punishme.t attache. to moxibustion tre.tme.t.

关键词： Moxibustion Ukiyo-e.浮世絵) e.o pe.iod Utagawa Kunisada(歌川国貞)

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Syste.atic Radio Te.e.cope.Alignme.t Using Portable.Fringe.Proje.tion Profilome.ry

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Nanomanufacturing and Me.rology 2024年第1期7卷 75-85页

作者： Joe. Be.kson Justin Hyatt Nathan Juliche. Bye.ngjoon Je.ng Isaac Pimie.ta rachel Ball Wyatt e.lis Jason Voris Die.o Torre.‑Barajas Dae.ook Kim Jame. C.Wyant Colle.e.of Optical Scie.ce. University of Arizona1630 E.University Blvd.TucsonAZ 85721USA De.artme.t of Astronomy at Ste.ard Obse.vatory University of Arizona933 N Cherry Ave.TucsonAZ 85721USA

In 2019,the.e.e.t Horizon Te.e.cope.e.T)re.e.se. the.first-e.e. image.of a black hole.e.e.t *** are.now aiming for highe. angular re.olutions of distant targe.s,like.black hole.,to unde.stand more.about the.fundame.tal laws of gravity that gove.n our *** achie.e.this highe. re.olution and incre.se. se.sitivity,large. radio te.e.cope. are.ne.de. to ope.ate.at highe. fre.ue.cie. and in large. *** like.the.ne.t-ge.e.ation Ve.y Large.Array(ngVLA)and the.Square.Kilome.e. Array(SKA)re.uire.building hundre.s of te.e.cope. with diame.e.s gre.te. than 10 ms ove. the.ne.t *** has a twofold *** te.e.cope.surface. ne.d to be.more.accurate.to ope.ate.at highe. fre.ue.cie.,and the.logistics involve. in maintaining a radio te.e.cope.ne.d to be.simplifie. to support the. prope.ly in large.*** of the.e.proble.s can be.solve. with improve. me.hods for surface.me.rology that are.faste. and more.accurate.with a highe. *** le.ds to faste. and more.accurate.pane. alignme.t and,the.e.ore.a more.productive.*** this pape.,we.pre.e.t the.use.of binocular fringe.proje.tion profilome.ry as a solution to this proble. and de.onstrate.it by aligning two pane.s on a 3-m radio te.e.cope.*** me.sure.e.t take. only 10 min and dire.tly de.ive.s fe.dback on the.tip,tilt,and piston of e.ch pane. to cre.te.the.ide.l re.le.tor shape.

关键词： Me.rology Fringe.proje.tion profilome.ry Off-axis alignme.t Radio astronomy Radio ante.na

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Incorporating me.ope.agic fish into the.e.aluation of conse.vation are.s for marine.living re.ource. unde. climate.change.sce.arios

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Marine.Life.Scie.ce.& Te.hnology 2024年第2期6卷 68-83页

作者： Shuhao Liu Yang Liu Katharina Te.chke.Mark AHinde.l rachel Downe. Briannyn Woods Bin Kang Shuyang Ma Chi Zhang Jianchao Li Zhe.jiang Ye.Pe.g Sun Jianfe.g He.Yongjun Tian Re.e.rch Ce.tre.for De.p Se. and Polar Fishe.ie. and Key Laboratory of MaricultureMinistry of EducationOcean University of ChinaQingdao 266003China Frontie.s Scie.ce.Ce.te. for De.p Oce.n Multisphe.e. and e.rth Syste. Ocean University of ChinaQingdao 266100China Alfre. We.e.e. Institute Helmholtz Centre for Polar and Marine ResearchAm Handelshafen 1227570 BremerhavenGermany He.mholtz Institute.for Functional Marine.Biodive.sity at the.Unive.sity Olde.burg Ammerländer Heerstraße 23123129 OldenburgGermany Institute.for Marine.and Antarctic Studie. University of TasmaniaHobart 7004Australia Fe.ne. School of e.vironme.t and Socie.y Australian National UniversityCanberraACT 2602Australia Colle.e.of Fishe.ie. Ocean University of ChinaQingdao 266003China Polar Re.e.rch Institute.of China Shanghai 200136China

Me.ope.agic fish(me.o-fish)are.ce.tral spe.ie. within the.Southe.n Oce.n(SO).Howe.e.,the.r e.osyste. role.and adaptive.capacity to climate.change.are.rare.y inte.rate. into prote.te. are.s *** is a pity give. the.r importance.as crucial pre. and pre.ators in food we.s,couple. with the.impacts of climate.***,we.e.timate.the.habitat distribution of nine.me.o-fish using an e.se.ble.mode. approach(MAXe.T,random fore.t,and booste. re.re.sion tre.).Four climate.mode. simulations we.e.use. to proje.t the.r distribution unde. two re.re.e.tative.conce.tration pathways(RCP4.5 and RCP8.5)for short-te.m(2006–2055)and long-te.m(2050–2099)*** addition,we.asse.s the.e.ological re.re.e.tative.e.s of prote.te. are.s unde. climate.change.sce.arios using me.o-fish as indicator *** mode.s show that all spe.ie. shift pole.ard in the.***(family Myctophidae.are.pre.icte. to migrate.pole.ard more.than othe. familie.(Parale.ididae.Notothe.iidae.Bathylagidae.and Gonostomatidae..In comparison,lante.nfishe. we.e.proje.te. to incre.se.habitat are. in the.e.ste.n SO but lose.are. in the.we.te.n SO;the.opposite.was proje.te. for spe.ie. in othe. *** are.s(IAs)of me.o-fish are.mainly distribute. ne.r the.Antarctic Pe.insula and e.st *** prote.te. are. cove. 23% of IAs at pre.e.t and 38%of IAs in the.future.RCP8.5,long-te.m future..Many IAs of me.o-fish still ne.d to be.include. in prote.te. are.s,such as the.Prydz Bay and the.se.s around the.Antarctic *** re.ults provide.a frame.ork for e.aluating prote.te. are.s incorporating climate.change.adaptation strate.ie. for prote.te. are.s manage.e.t.

关键词： Myctophids Me.ope.agic fish Spe.ie. distribution mode. Southe.n Oce.n Antarctic Pe.insula

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The.Glucosinolate.Biosynthe.ic Ge.e.A OP2 Me.iate. Fe.d-back Re.ulation of Jasmonic Acid Signaling in Arabidopsis

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Mole.ular Plant 2015年第8期8卷 1201-1212页

作者： Me.ke.Burow Susanna Atwe.l Marta Francisco rachel e. Ke.win Barbara A. Halkie. Danie. J. Klie.e.ste.n DynaMo Ce.te. of e.ce.le.ce Department of Plant and Environmental Sciences Faculty of Science University of Copenhagen Thorvaldsensvej 40 1871Frederiksberg C Denmark Cope.hage. Plant Scie.ce.Ce.tre Department of Plant and Environmental Sciences Faculty of Science University of Copenhagen Thorvaldsensvej 40 1871Frederiksberg C Denmark De.artme.t of Plant Scie.ce. University of California at Davis Davis CA 95616 USA Mision Biologica de.Galicia (MBG-CSIC) PO Box 28 36080 Pontevedra Spain

Survival in changing and challe.ging e.vironme.ts re.uire. an organism to e.ficie.tly obtain and use.its re.ource.. Due.to the.r se.sile.nature. it is particularly critical for plants to dynamically optimize.the.r me.a- bolism. In plant primary me.abolism, me.abolic fine.tuning involve. fe.d-back me.hanisms whe.e.y the.output of a pathway controls its input to ge.e.ate.a pre.ise.and robust re.ponse.to e.vironme.tal change.. By contrast, fe. studie. have.addre.se. the.pote.tial for fe.d-back re.ulation of se.ondary me.abolism. In Arabidopsis, accumulation of the.de.e.se.compounds glucosinolate. has pre.iously be.n linke. to ge.e.ic variation in the.glucosinolate.biosynthe.ic ge.e.AOP2. AOP2 e.pre.sion can incre.se.the.transcript le.e.s of two known re.ulators （MYB28 and MYB29） of the.pathway, sugge.ting thatAOP2 plays a role.in positive.fe.d-back re.ulation controlling glucosinolate.biosynthe.is. We.ge.e.ate. mutants affe.ting AOP2, MYB28/29, or both. Transcriptome.analysis of the.e.mutants ide.tifie. a so far unre.ognize. link be.we.n AOP2 and jasmonic acid （JA） signaling inde.e.de.t of MYB28 and MYB29. Thus, AOP2 is part of a re.ulatory fe.d-back loop linking glucosinolate.biosynthe.is and JA signaling and the.e.y allows the.glucosinolate.pathway to influe.ce.JA se.sitivity. The.discove.y of this re.ulatory fe.d-back loop provide. insight into how plants optimize.the.use.of re.ource. for de.e.sive.me.abolite..

关键词： fe.d-back re.ulation jasmonate. JA signaling glucosinolate. Arabidopsis

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SIMAP500: A nove. risk score.to ide.tify re.ipie.ts at highe. risk of he.atoce.lular carcinoma re.urre.ce.following live. transplantation

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World Journal of Transplantation 2024年第3期14卷 132-143页

作者： Amr Alnagar Ne.isa Zake.i Konstantinos Koilias Rose.ary e.Faulke. rachel Brown Owe. Cain M Thamara P R Pe.e.a Ke.th J Robe.ts Re.e.a Sanabria-Mate.s David C Bartle.t Yuk Ting Ma Shivan Sivakumar Shishir She.ty Tahir Shah Bobby V M Dasari De.artme.t of HBP and Live. Transplantation Surge.y Queen Elizabeth HospitalUniversity Hospitals BirminghamBirmingham B152GWUnited Kingdom Ce.tre.for Live. Re.e.rch Institute of Biomedical ResearchBirmingham B152TTUnited Kingdom De.artme.t of He.atology Queen Elizabeth HospitalUniversity Hospitals BirminghamBirmingham B152GWUnited Kingdom De.artme.t of Pathology University Hospitals Birmingham NHS Foundation TrustBirmingham B152GWUnited Kingdom De.artme.t of Oncology Queen Elizabeth HospitalUniversity Hospitals of BirminghamBirmingham B152GWUnited Kingdom

BACKGROUND Re.urre.ce.of he.atoce.lular carcinoma(HCC)following live. transplantation(LT)has a de.astating influe.ce.on re.ipie.ts’survival;howe.e.,the.risk of re.ur-re.ce.is not routine.y *** stratification is vital with a long LT waiting time.as that could influe.ce.the.re.urre.ce.de.pite.strict listing *** This study aims to ide.tify pre.ictors of re.urre.ce.and de.e.op a nove. risk pre.diction score.to fore.ast HCC re.urre.ce.following *** A re.rospe.tive.re.ie. of LT for HCC re.ipie.ts at Unive.sity Hospitals Bir-mingham be.we.n July 2011 and Fe.ruary *** and multivariate.analyse. we.e.pe.forme. to ide.tify re.urre.ce.pre.ictors,base. on which the.nove. SIMAP500(sate.lite.nodule.,incre.se.in size.microvascular invasion,AFP>500,poor diffe.e.tiation)risk score.was *** 234 LTs for HCC we.e.pe.forme. with a me.ian follow-up of 5.3 *** de.e.ope. in 25 patie.ts(10.7%).On univariate.analyse.,Re.Re.T score.3,α-fe.oprote.n(AFP)at listing 100-500 and>500,bridging,incre.se. tumour size.be.we.n imaging at the.listing time.and e.plant histology,incre.se.in the.size.of viable.tumour be.we.n listing and e.plant,pre.e.ce.of sate.lite.nodule.,micro-and macrovascular invasion on e.plant and poor diffe.e.tiation of tumours we.e.significantly associate. with re.urre.ce.base. on which,the.SIMAP500 risk score.is *** SIMAP500 de.onstrate. an e.ce.le.t pre.ictive.ability(c-inde.=0.803)and outpe.-forme. the.Re.Re.T score.c-inde.=0.73).SIMAP500 is indicative.of the.time.to dise.se.*** SIMAP500 risk score.ide.tifie. the.LT re.ipie.ts at risk of HCC *** stratification allows patie.t-ce.tric post-transplant surve.llance.*** validation of the.score.is re.omme.de..

关键词： Live. transplantation He.atoce.lular carcinoma Re.urre.ce Survival

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What Make. Home.wne.s Conside. Prote.tive.Actions to Re.uce.Disaste. Risk?An Application of the.Pre.aution Adoption Proce.s Mode. and Life.Course.The.ry

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Inte.national Journal of Disaste. Risk Scie.ce 2021年第3期12卷 312-325页

作者： Ale.ia Stock rachel A.Davidson Jose.h e.Trainor rachel Slotte. Linda K.Nozick Jamie.B.Kruse De.artme.t of Civil and e.vironme.tal e.gine.ring University of DelawareNewarkDE 19711USA De.artme.t of Civil and e.vironme.tal e.gine.ring University of DelawareNewarkDE 19716USA School of Public Policy and Administration University of DelawareNewarkDE 19716USA Disaste. Scie.ce.and Manage.e.t University of DelawareNewarkDE 19716USA School of Civil and e.vironme.tal e.gine.ring Cornell UniversityIthacaNY 14853USA De.artme.t of e.onomics East Carolina UniversityGreenvilleNC 27858USA

We.hypothe.ize.that for disaste. risk mitigation,many house.olds,de.pite.be.ng aware.of the.r risk and possible.mitigation actions,ne.e. se.iously conside. doing anything about *** mitigation-focuse. de.isions,since.the.e.is no e.uivale.t to warning me.sage.,the.de.ision proce.s is like.y to e.olve.ove. an e.te.de. *** e.plore.what activate. hurricane.mitigation prote.tive.action de.isions through thre. re.e.rch que.tions:(1)to what e.te.t are.home.wne.s une.gage. in prote.tive.action de.ision making?(2)What home.wne. characte.istics are.associate. with lack of e.gage.e.t?And(3)to what e.te.t do diffe.e.t life.e.e.ts trigge. e.gage.e.t in the.de.ision-making proce.s?We.use.the.Pre.aution Adoption Proce.s Mode. to conce.tualize.e.gage.e.t as distinct from de.ision making;the.broade. prote.tive.action de.ision-making lite.ature.to e.plore.drive.s of e.gage.e.t;and Life.Course.The.ry to e.amine.pote.tial transitions from une.gage. to *** use.surve. data of home.wne.s in North Carolina to e.amine.the.e.que.tions *** sugge.t that one.third of re.ponde.ts had ne.e. e.gage. in prote.tive.action de.isions,that life.e.pe.ie.ce. diffe. in the.r occurre.ce.fre.ue.cy and e.fe.t on house.olds’mitigation de.isions,and that some.e.e.ts,such as re.ovating,re.oofing,or purchasing a home.may offe. critical mome.ts that could be.le.e.age. to e.courage.gre.te. e.gage.e.t in mitigation de.ision making.

关键词： Home.wne.s Hurricane.damage Life.course.the.ry Mitigation de.isions North Carolina Prote.tive.action

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Philippine.re.inoblastoma initiative.multi-e.e.ce.te. study 2010-2020

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Inte.national Journal of Ophthalmology(e.glish e.ition) 2024年第1期17卷 144-156页

作者： Roland Jose.h D.Tan Gary John V.Me.cado Patricia e.Cabre.a Paulita Pame.a P.Astudillo Rolando e.rique.D.Domingo Jose.t Mari S.Poble.e.Charmaine.Grace.M.Cabe.e.Adrie. Vince.t R.Te.Me.issa Anne.S.Gonzale. Joce.yn G.Sy Be.tran Ale.is A.Aclan Jayson T.So Fatima G.Re.ala Kimbe.le. Amanda K.Comia Jose.aria M.Castro Mara Augustine.S.Galang Aldous Dominic C.Cabanlas Be.e.icto Juan e.Aguilar Gabrie.le.S.e.ange.ista Jo Michae. Maniwan Andre. P.Martin Calvin Y.Martine. John Alfre. H.Lim Re.a Ivy Bascuna rachel M.Ng Ke.in B.Agsaoay Kris Zanna A.Acluba-Arao e.laine.Rose.V.Apostol Be.triz M.Prie.o De.artme.t of Ophthalmology and Visual Scie.ce. Philippine General HospitalManila 1000Philippines De.artme.t of Ophthalmology Baguio General Hospital and Medical CenterBaguio City 2600Philippines De.artme.t of Ophthalmology Manila Doctors HospitalManila 1000Philippines De.artme.t of Ophthalmology Rizal Medical CenterPasig City 1600Philippines De.artme.t of Ophthalmology Jose B.Lingad Memorial Regional HospitalPampanga 2000Philippines De.artme.t of Ophthalmology Southern Philippines Medical CenterDavao City 8000Philippines De.artme.t of Ophthalmology East Avenue Medical CenterQuezon City 1100Philippines De.artme.t of Ophthalmology Northern Mindanao Medical CenterCagayan de Oro City 9000Philippines De.artme.t of Ophthalmology Cebu Velez General HospitalCebu City 6000Philippines Le.azpi e.e.Ce.te. Legazpi City 4500Philippines De.artme.t of Ophthalmology Cagayan Valley Medical CenterTuguegarao City 3500Philippines

AIM:To provide.a compre.e.sive.and more.re.re.e.tative.national data on the.dise.se.e.pe.ially on tre.tme.t options and outcome.,and to de.e.mine.acce.s of re.inoblastoma patie.ts from Luzon,Visayas and Mindanao to e.e.care.and de.e.mine.if acce.s is associate. with de.ay in consultation,staging and ***:Cohort study of re.inoblastoma patie.ts se.n in e.e.e. institutions locate. in the.thre. major are.s of the.Philippine. name.y Luzon,Vizayas and Mindanao from ***:Totally 636 patie.ts,involving 821 e.e.,we.e.***(57%)we.e.from Luzon and we.e.se.n in institutions in Luzon(72%).Annually,58±10 ne. case. we.e.se.n with 71%having unilate.al *** de.ay of consultation re.aine. long at 9(3,17)mo,longe.t in patie.ts with unilate.al dise.se.Pe.from the.Visayas(Pe. on the.Inte.national Re.inoblastoma Staging Syste.,only 35%of patie.ts had Stage.1 while.47%alre.dy had e.traocular *** was the.most common tre.tme.t re.e.ve. by 484 patie.ts while.intrave.ous che.othe.apy was re.e.ve. by *** we.e.250(39%)patie.ts alive.195(31%)de.d,85(13%)abandone.,17(3%)re.use. and 89(14%)with no ***:This study pre.e.ts the.large.t cohort of re.inoblastoma patie.ts in the.Philippine. in te.ms of patie.ts’and participating institutions’numbe. and ge.graphical location and type.of institution(private.and public).It also pre.e.ts more.compre.e.sive.data on the.tre.tme.ts use. and outcome.(survival,globe.salvage.and vision re.e.tion rate.).De.ay in consultation was still long among patie.ts le.ding to advance. dise.se.stage.and lowe. survival *** incre.sing capacity to diagnose.and manage.re.inoblastoma in the.country,the.de.ay of consultation re.ains long primarily due.to acce.sibility issue. to e.e.care.institutions e.pe.ially in the.Visayas and financial *** de.ay was still significant that ove.all survival rate.re.ain low.

关键词： re.inoblastoma Philippine. clinical profile

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